p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding

Carcinogenesis

Volumn 22, Issue 6, 2001, Pages 851-860

  Liu, Y ^a   Kulesz Martin, M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT; DOUBLE STRANDED DNA; PROTEIN P53; SINGLE STRANDED DNA;

APOPTOSIS; COMPETITION; CONTROLLED STUDY; COORDINATION; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; ENVIRONMENT; NOTE; PATHOLOGY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

EID: 0034985847     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.6.851     Document Type: Note

References (121)

1. Checkpoints: Controls that ensure the order of cell cycle events
2. Inducible DNA repair systems
3. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
4. Clinical implications of the p53 tumor-suppressor gene
5. Database of p53 gene somatic mutations in human tumors and cell lines
6. Gain of function mutations in p53
7. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
8. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
9. Role of the human papillomaviruses in human cancer
10. Functional inactivation but not structural mutation of p53 causes liver cancer
11. Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex
12. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
13. Participation of p53 protein in the cellular response to DNA damage
14. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
15. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
16. WAF1, a potential mediator of p53 tumor suppression
17. Differential effects by the p21 CDK inhbitor on PCNA-dependent DNA replication and repair
18. Regulation of p53 downstream genes
19. Definition of a consensus binding site for p53
20. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
21. Mechanisms of switching on p53: A role for covalent modification?
22. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
23. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
24. Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53
25. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
26. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
27. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
28. DNA damage activates p53 through a phosphorylation-acetylation cascade
29. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
30. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
31. Allosteric activation of latent p53 tetramers
32. p53: Puzzle and paradigm
33. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
34. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
35. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms
36. Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization
37. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
38. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
39. Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA
40. Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner
41. Sequence-specific DNA binding by p53: Identification of target sites and lack of binding to p53-MDM2 complexes
42. Molecular characterization of the hdm2-p53 interaction
43. Cooperative DNA binding of p53 with TFIID (TBP): A possible mechanism for transcriptional activation
44. p53 modulation of TFIIH-associated nucleotide excision repair activity
45. Binding and modulation of p53 by p300/CBP coactivators
46. Histone acetylation: Chromatin in action
47. The p53-mdm-2 autoregulatory feedback loop
48. Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites
49. p53 oligomerization and DNA looping are linked with transcriptional activation
50. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53
51. High mobility group protein-1 (HMG-1) is a unique activator of p53
52. Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus
53. Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes
54. The nuclear matrix as a target for viral and cellular oncogenes
55. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
56. Redox regulation of transcriptional activators
57. Thioredoxin regulates the DNA binding activity of NFκB by reduction of a disulphide bond involving cysteine 62
58. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
59. Thioredoxin-dependent redox regulation of p53-mediated p21 activation
60. A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe
61. Deletion of the Saccharomyces cerevisiae TRR1 gene encoding thioredoxin reductase inhibits p53-dependent reporter gene expression
62. Identification of redox/repair protein Ref-1 as a potent activator of p53
63. Transcriptional activation of the human glutathione peroxidase promoter by p53
64. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
65. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
66. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer
67. p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
68. The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region
69. A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis
70. Cell cycle checkpoints: Preventing an identity crisis
71. The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation
72. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
73. Human p53 binds Holliday junctions strongly and facilitates their cleavage
74. Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination
75. Mutant p53 proteins bind DNA abnormally in vitro
76. High affinity insertion/deletion lesion binding by p53. Evidence for a role of the p53 central domain
77. Strand opening by the UvrA(2)B complex allows dynamic recognition of DNA damage
78. Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
79. DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
80. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
81. Maintenance of genomic integrity by p53: Complementary roles for activated and non-activated p53
82. Order of assembly of human DNA repair excision nuclease
83. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids
84. In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes
85. Inactivation of p53 results in high rates of homologous recombination
86. Wild-type and mutant forms of p53 activate human topoisomerase I: A possible mechanism for gain of function in mutants
87. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts
88. A role for p53 in DNA end rejoining by human cell extracts
89. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
90. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
91. Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery
92. p53 Protein exhibits 3′-to-5′ exonuclease activity
93. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
94. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
95. Drosophila p53 binds a damage response element at the reaper locus
96. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
97. Identification and characterization of a p53 homologue in Drosophila melanogaster
98. A matter of life and cell death
99. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
100. DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53
101. Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA
102. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
103. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
104. Induction of apoptosis in HeLa cells by trans-activation-deficient p53
105. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression
106. Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines
107. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
108. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
109. p53-mediated apoptosis is attenuated in Werner syndrome cells
110. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
111. A role for ATR in the DNA damage-induced phosphorylation of p53
112. Phosphorylation of p53 serine 15 increases interaction with CBP
113. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
114. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
115. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
116. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53
117. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
118. SUMO-1 modification activates the transcriptional response of p53
119. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
120. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation
121. Dissociation of DNA binding and in vitro transcriptional activities dependent upon the carboxy terminus of p53 proteins