SIRT1 deacetylates TopBP1 and modulates intra-sphase checkpoint and DNA replication origin firing

International Journal of Biological Sciences

Volumn 10, Issue 10, 2014, Pages 1193-1202

  Wang, Rui Hong ^a,d   Lahusen, Tyler J ^a   Chen, Qiang ^a   Xu, Xiaoling ^a,d   Miller Jenkins, Lisa M ^b   Leo, Elisabetta ^c   Fu, Haiqing ^c   Aladjem, Mirit ^c   Pommier, Yves ^c   Appella, Ettore ^b   Deng, Chu Xia ^a,d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF MACAU   (Macao)

Author keywords

DNA replication fork; Genetic stability; Intra S phase checkpoint; SIRT1; TopBP1

Indexed keywords

MAMMALIA;

BROXURIDINE; CARRIER PROTEIN; SIRT1 PROTEIN, MOUSE; SIRTUIN 1; SMALL INTERFERING RNA; TOPBP1 PROTEIN, MOUSE;

ACETYLATION; ANIMAL; CHROMOSOME ANALYSIS; DNA REPLICATION ORIGIN; GENE VECTOR; GENETICS; GENOMIC INSTABILITY; HEK293 CELL LINE; HUMAN; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; LENTIVIRINAE; MASS SPECTROMETRY; METABOLISM; MOUSE; PHYSIOLOGY; S PHASE CELL CYCLE CHECKPOINT; WESTERN BLOTTING;

ACETYLATION; ANIMALS; BLOTTING, WESTERN; BROMODEOXYURIDINE; CARRIER PROTEINS; CYTOGENETIC ANALYSIS; GENETIC VECTORS; GENOMIC INSTABILITY; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; LENTIVIRUS; MASS SPECTROMETRY; MICE; MICE, KNOCKOUT; REPLICATION ORIGIN; RNA, SMALL INTERFERING; S PHASE CELL CYCLE CHECKPOINTS; SIRTUIN 1;

EID: 84916886805     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.11066     Document Type: Article

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