메뉴 건너뛰기




Volumn 20, Issue 6, 2014, Pages 953-966

Metformin: From mechanisms of action to therapies

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; ANTIDIABETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

EID: 84919615360     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.09.018     Document Type: Review
Times cited : (1076)

References (122)
  • 1
    • 79952538201 scopus 로고    scopus 로고
    • Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
    • C. Algire, L. Amrein, M. Bazile, S. David, M. Zakikhani, and M. Pollak Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo Oncogene 30 2011 1174 1182
    • (2011) Oncogene , vol.30 , pp. 1174-1182
    • Algire, C.1    Amrein, L.2    Bazile, M.3    David, S.4    Zakikhani, M.5    Pollak, M.6
  • 2
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2014
    • American Diabetes Association
    • American Diabetes Association Standards of medical care in diabetes - 2014 Diabetes Care 37 Suppl 1 2014 S14 S80
    • (2014) Diabetes Care , vol.37 , pp. 14-S80
  • 3
    • 84918583229 scopus 로고    scopus 로고
    • Metformin directly acts on mitochondria to alter cellular bioenergetics
    • Published online August 28, 2014
    • S. Andrzejewski, S.P. Gravel, M. Pollak, and J. St-Pierre Metformin directly acts on mitochondria to alter cellular bioenergetics Cancer Metab. 2 2014 10.1186/2049-3002-2-12 Published online August 28, 2014
    • (2014) Cancer Metab. , vol.2
    • Andrzejewski, S.1    Gravel, S.P.2    Pollak, M.3    St-Pierre, J.4
  • 4
    • 84897353217 scopus 로고    scopus 로고
    • Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts
    • J. Bai, N. Zhang, Y. Hua, B. Wang, L. Ling, A. Ferro, and B. Xu Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts PLoS ONE 8 2013 e72120
    • (2013) PLoS ONE , vol.8 , pp. 72120
    • Bai, J.1    Zhang, N.2    Hua, Y.3    Wang, B.4    Ling, L.5    Ferro, A.6    Xu, B.7
  • 8
    • 84891591832 scopus 로고    scopus 로고
    • Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells
    • B. Batchuluun, T. Inoguchi, N. Sonoda, S. Sasaki, T. Inoue, Y. Fujimura, D. Miura, and R. Takayanagi Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells Atherosclerosis 232 2014 156 164
    • (2014) Atherosclerosis , vol.232 , pp. 156-164
    • Batchuluun, B.1    Inoguchi, T.2    Sonoda, N.3    Sasaki, S.4    Inoue, T.5    Fujimura, Y.6    Miura, D.7    Takayanagi, R.8
  • 9
    • 62749133967 scopus 로고    scopus 로고
    • Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: A preliminary study
    • M.L. Becker, L.E. Visser, R.H. van Schaik, A. Hofman, A.G. Uitterlinden, and B.H. Stricker Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study Diabetes 58 2009 745 749
    • (2009) Diabetes , vol.58 , pp. 745-749
    • Becker, M.L.1    Visser, L.E.2    Van Schaik, R.H.3    Hofman, A.4    Uitterlinden, A.G.5    Stricker, B.H.6
  • 11
    • 33745684376 scopus 로고    scopus 로고
    • AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
    • L. Bertrand, A. Ginion, C. Beauloye, A.D. Hebert, B. Guigas, L. Hue, and J.L. Vanoverschelde AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B Am. J. Physiol. Heart Circ. Physiol. 291 2006 H239 H250
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , pp. 239-H250
    • Bertrand, L.1    Ginion, A.2    Beauloye, C.3    Hebert, A.D.4    Guigas, B.5    Hue, L.6    Vanoverschelde, J.L.7
  • 13
    • 84891350009 scopus 로고    scopus 로고
    • C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes
    • M.P. Bhatt, Y.C. Lim, Y.M. Kim, and K.S. Ha C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes Diabetes 62 2013 3851 3862
    • (2013) Diabetes , vol.62 , pp. 3851-3862
    • Bhatt, M.P.1    Lim, Y.C.2    Kim, Y.M.3    Ha, K.S.4
  • 16
    • 84907370814 scopus 로고    scopus 로고
    • Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
    • H.R. Bridges, A.J. Jones, M.N. Pollak, and J. Hirst Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria Biochem. J. 462 2014 475 487
    • (2014) Biochem. J. , vol.462 , pp. 475-487
    • Bridges, H.R.1    Jones, A.J.2    Pollak, M.N.3    Hirst, J.4
  • 18
    • 84896092380 scopus 로고    scopus 로고
    • Molecular mechanisms of diabetic cardiomyopathy
    • H. Bugger, and E.D. Abel Molecular mechanisms of diabetic cardiomyopathy Diabetologia 57 2014 660 671
    • (2014) Diabetologia , vol.57 , pp. 660-671
    • Bugger, H.1    Abel, E.D.2
  • 21
    • 84905404389 scopus 로고    scopus 로고
    • Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)
    • J. Cao, S. Meng, E. Chang, K. Beckwith-Fickas, L. Xiong, R.N. Cole, S. Radovick, F.E. Wondisford, and L. He Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK) J. Biol. Chem. 289 2014 20435 20446
    • (2014) J. Biol. Chem. , vol.289 , pp. 20435-20446
    • Cao, J.1    Meng, S.2    Chang, E.3    Beckwith-Fickas, K.4    Xiong, L.5    Cole, R.N.6    Radovick, S.7    Wondisford, F.E.8    He, L.9
  • 23
    • 84897398609 scopus 로고    scopus 로고
    • Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway
    • W.S. Cheang, X.Y. Tian, W.T. Wong, C.W. Lau, S.S. Lee, Z.Y. Chen, X. Yao, N. Wang, and Y. Huang Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway Arterioscler. Thromb. Vasc. Biol. 34 2014 830 836
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 830-836
    • Cheang, W.S.1    Tian, X.Y.2    Wong, W.T.3    Lau, C.W.4    Lee, S.S.5    Chen, Z.Y.6    Yao, X.7    Wang, N.8    Huang, Y.9
  • 24
    • 19944433033 scopus 로고    scopus 로고
    • Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: A randomized, placebo-controlled trial
    • J. De Jager, A. Kooy, P. Lehert, D. Bets, M.G. Wulffelé, T. Teerlink, P.G. Scheffer, C.G. Schalkwijk, A.J. Donker, and C.D. Stehouwer Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial J. Intern. Med. 257 2005 100 109
    • (2005) J. Intern. Med. , vol.257 , pp. 100-109
    • De Jager, J.1    Kooy, A.2    Lehert, P.3    Bets, D.4    Wulffelé, M.G.5    Teerlink, T.6    Scheffer, P.G.7    Schalkwijk, C.G.8    Donker, A.J.9    Stehouwer, C.D.10
  • 25
    • 21344462345 scopus 로고    scopus 로고
    • Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process
    • D. Detaille, B. Guigas, C. Chauvin, C. Batandier, E. Fontaine, N. Wiernsperger, and X. Leverve Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process Diabetes 54 2005 2179 2187
    • (2005) Diabetes , vol.54 , pp. 2179-2187
    • Detaille, D.1    Guigas, B.2    Chauvin, C.3    Batandier, C.4    Fontaine, E.5    Wiernsperger, N.6    Leverve, X.7
  • 27
    • 56049086590 scopus 로고    scopus 로고
    • Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
    • J.A. Dykens, J. Jamieson, L. Marroquin, S. Nadanaciva, P.A. Billis, and Y. Will Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro Toxicol. Appl. Pharmacol. 233 2008 203 210
    • (2008) Toxicol. Appl. Pharmacol. , vol.233 , pp. 203-210
    • Dykens, J.A.1    Jamieson, J.2    Marroquin, L.3    Nadanaciva, S.4    Billis, P.A.5    Will, Y.6
  • 28
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
    • M.Y. El-Mir, V. Nogueira, E. Fontaine, N. Avéret, M. Rigoulet, and X. Leverve Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I J. Biol. Chem. 275 2000 223 228
    • (2000) J. Biol. Chem. , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Avéret, N.4    Rigoulet, M.5    Leverve, X.6
  • 30
    • 84879207411 scopus 로고    scopus 로고
    • Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: Systematic review of observational studies involving 34,000 patients
    • D.T. Eurich, D.L. Weir, S.R. Majumdar, R.T. Tsuyuki, J.A. Johnson, L. Tjosvold, S.E. Vanderloo, and F.A. McAlister Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients Circ. Heart Fail. 6 2013 395 402
    • (2013) Circ. Heart Fail. , vol.6 , pp. 395-402
    • Eurich, D.T.1    Weir, D.L.2    Majumdar, S.R.3    Tsuyuki, R.T.4    Johnson, J.A.5    Tjosvold, L.6    Vanderloo, S.E.7    McAlister, F.A.8
  • 42
    • 4744355266 scopus 로고    scopus 로고
    • Metformin inhibits mitochondrial permeability transition and cell death: A pharmacological in vitro study
    • B. Guigas, D. Detaille, C. Chauvin, C. Batandier, F. De Oliveira, E. Fontaine, and X. Leverve Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study Biochem. J. 382 2004 877 884
    • (2004) Biochem. J. , vol.382 , pp. 877-884
    • Guigas, B.1    Detaille, D.2    Chauvin, C.3    Batandier, C.4    De Oliveira, F.5    Fontaine, E.6    Leverve, X.7
  • 46
    • 65549136655 scopus 로고    scopus 로고
    • Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    • L. He, A. Sabet, S. Djedjos, R. Miller, X. Sun, M.A. Hussain, S. Radovick, and F.E. Wondisford Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein Cell 137 2009 635 646
    • (2009) Cell , vol.137 , pp. 635-646
    • He, L.1    Sabet, A.2    Djedjos, S.3    Miller, R.4    Sun, X.5    Hussain, M.A.6    Radovick, S.7    Wondisford, F.E.8
  • 47
    • 84875450015 scopus 로고    scopus 로고
    • Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes
    • C. He, H. Zhu, H. Li, M.H. Zou, and Z. Xie Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes Diabetes 62 2013 1270 1281
    • (2013) Diabetes , vol.62 , pp. 1270-1281
    • He, C.1    Zhu, H.2    Li, H.3    Zou, M.H.4    Xie, Z.5
  • 48
    • 34247185346 scopus 로고    scopus 로고
    • Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer
    • S.A. Hinke, G.A. Martens, Y. Cai, J. Finsi, H. Heimberg, D. Pipeleers, and M. Van de Casteele Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer Br. J. Pharmacol. 150 2007 1031 1043
    • (2007) Br. J. Pharmacol. , vol.150 , pp. 1031-1043
    • Hinke, S.A.1    Martens, G.A.2    Cai, Y.3    Finsi, J.4    Heimberg, H.5    Pipeleers, D.6    Van De Casteele, M.7
  • 49
    • 84865429928 scopus 로고    scopus 로고
    • Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex i activity of the respiratory chain
    • A. Hirsch, D. Hahn, P. Kempná, G. Hofer, J.M. Nuoffer, P.E. Mullis, and C.E. Flück Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain Endocrinology 153 2012 4354 4366
    • (2012) Endocrinology , vol.153 , pp. 4354-4366
    • Hirsch, A.1    Hahn, D.2    Kempná, P.3    Hofer, G.4    Nuoffer, J.M.5    Mullis, P.E.6    Flück, C.E.7
  • 50
  • 52
    • 84874357500 scopus 로고    scopus 로고
    • Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
    • SPREAD-DIMCAD Investigators
    • J. Hong, Y. Zhang, S. Lai, A. Lv, Q. Su, Y. Dong, Z. Zhou, W. Tang, J. Zhao, L. Cui SPREAD-DIMCAD Investigators Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease Diabetes Care 36 2013 1304 1311
    • (2013) Diabetes Care , vol.36 , pp. 1304-1311
    • Hong, J.1    Zhang, Y.2    Lai, S.3    Lv, A.4    Su, Q.5    Dong, Y.6    Zhou, Z.7    Tang, W.8    Zhao, J.9    Cui, L.10
  • 53
  • 56
    • 77957601724 scopus 로고    scopus 로고
    • Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program
    • Diabetes Prevention Program Research Group
    • K.A. Jablonski, J.B. McAteer, P.I. de Bakker, P.W. Franks, T.I. Pollin, R.L. Hanson, R. Saxena, S. Fowler, A.R. Shuldiner, W.C. Knowler Diabetes Prevention Program Research Group Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program Diabetes 59 2010 2672 2681
    • (2010) Diabetes , vol.59 , pp. 2672-2681
    • Jablonski, K.A.1    McAteer, J.B.2    De Bakker, P.I.3    Franks, P.W.4    Pollin, T.I.5    Hanson, R.L.6    Saxena, R.7    Fowler, S.8    Shuldiner, A.R.9    Knowler, W.C.10
  • 57
    • 84904686912 scopus 로고    scopus 로고
    • Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
    • A. Janzer, N.J. German, K.N. Gonzalez-Herrera, J.M. Asara, M.C. Haigis, and K. Struhl Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells Proc. Natl. Acad. Sci. USA 111 2014 10574 10579
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 10574-10579
    • Janzer, A.1    German, N.J.2    Gonzalez-Herrera, K.N.3    Asara, J.M.4    Haigis, M.C.5    Struhl, K.6
  • 58
    • 84863763440 scopus 로고    scopus 로고
    • AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    • S.M. Jeon, N.S. Chandel, and N. Hay AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Nature 485 2012 661 665
    • (2012) Nature , vol.485 , pp. 661-665
    • Jeon, S.M.1    Chandel, N.S.2    Hay, N.3
  • 59
    • 84885383560 scopus 로고    scopus 로고
    • Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
    • K.H. Kim, Y.T. Jeong, S.H. Kim, H.S. Jung, K.S. Park, H.Y. Lee, and M.S. Lee Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation Biochem. Biophys. Res. Commun. 440 2013 76 81
    • (2013) Biochem. Biophys. Res. Commun. , vol.440 , pp. 76-81
    • Kim, K.H.1    Jeong, Y.T.2    Kim, S.H.3    Jung, H.S.4    Park, K.S.5    Lee, H.Y.6    Lee, M.S.7
  • 60
    • 33644749330 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
    • D. Kukidome, T. Nishikawa, K. Sonoda, K. Imoto, K. Fujisawa, M. Yano, H. Motoshima, T. Taguchi, T. Matsumura, and E. Araki Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells Diabetes 55 2006 120 127
    • (2006) Diabetes , vol.55 , pp. 120-127
    • Kukidome, D.1    Nishikawa, T.2    Sonoda, K.3    Imoto, K.4    Fujisawa, K.5    Yano, M.6    Motoshima, H.7    Taguchi, T.8    Matsumura, T.9    Araki, E.10
  • 61
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
    • C. Lamanna, M. Monami, N. Marchionni, and E. Mannucci Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials Diabetes Obes. Metab. 13 2011 221 228
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 62
    • 77957768686 scopus 로고    scopus 로고
    • AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner
    • J.M. Lee, W.Y. Seo, K.H. Song, D. Chanda, Y.D. Kim, D.K. Kim, M.W. Lee, D. Ryu, Y.H. Kim, and J.R. Noh AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner J. Biol. Chem. 285 2010 32182 32191
    • (2010) J. Biol. Chem. , vol.285 , pp. 32182-32191
    • Lee, J.M.1    Seo, W.Y.2    Song, K.H.3    Chanda, D.4    Kim, Y.D.5    Kim, D.K.6    Lee, M.W.7    Ryu, D.8    Kim, Y.H.9    Noh, J.R.10
  • 63
    • 0036106040 scopus 로고    scopus 로고
    • Metformin improves cardiac functional recovery after ischemia in rats
    • R.J. Legtenberg, R.J. Houston, B. Oeseburg, and P. Smits Metformin improves cardiac functional recovery after ischemia in rats Horm. Metab. Res. 34 2002 182 185
    • (2002) Horm. Metab. Res. , vol.34 , pp. 182-185
    • Legtenberg, R.J.1    Houston, R.J.2    Oeseburg, B.3    Smits, P.4
  • 64
    • 84898607351 scopus 로고    scopus 로고
    • Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: The GIPS-III randomized clinical trial
    • GIPS-III Investigators
    • C.P. Lexis, I.C. van der Horst, E. Lipsic, W.G. Wieringa, R.A. de Boer, A.F. van den Heuvel, H.W. van der Werf, R.A. Schurer, G. Pundziute, E.S. Tan GIPS-III Investigators Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial JAMA 311 2014 1526 1535
    • (2014) JAMA , vol.311 , pp. 1526-1535
    • Lexis, C.P.1    Van Der Horst, I.C.2    Lipsic, E.3    Wieringa, W.G.4    De Boer, R.A.5    Van Den Heuvel, A.F.6    Van Der Werf, H.W.7    Schurer, R.A.8    Pundziute, G.9    Tan, E.S.10
  • 68
    • 78951476273 scopus 로고    scopus 로고
    • Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
    • A. Maida, B.J. Lamont, X. Cao, and D.J. Drucker Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice Diabetologia 54 2011 339 349
    • (2011) Diabetologia , vol.54 , pp. 339-349
    • Maida, A.1    Lamont, B.J.2    Cao, X.3    Drucker, D.J.4
  • 71
    • 13444272949 scopus 로고    scopus 로고
    • Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study
    • F.A. Masoudi, S.E. Inzucchi, Y. Wang, E.P. Havranek, J.M. Foody, and H.M. Krumholz Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study Circulation 111 2005 583 590
    • (2005) Circulation , vol.111 , pp. 583-590
    • Masoudi, F.A.1    Inzucchi, S.E.2    Wang, Y.3    Havranek, E.P.4    Foody, J.M.5    Krumholz, H.M.6
  • 73
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • R.A. Miller, Q. Chu, J. Xie, M. Foretz, B. Viollet, and M.J. Birnbaum Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Nature 494 2013 256 260
    • (2013) Nature , vol.494 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3    Foretz, M.4    Viollet, B.5    Birnbaum, M.J.6
  • 75
    • 82355165097 scopus 로고    scopus 로고
    • Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell
    • A.J. Mulherin, A.H. Oh, H. Kim, A. Grieco, L.M. Lauffer, and P.L. Brubaker Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell Endocrinology 152 2011 4610 4619
    • (2011) Endocrinology , vol.152 , pp. 4610-4619
    • Mulherin, A.J.1    Oh, A.H.2    Kim, H.3    Grieco, A.4    Lauffer, L.M.5    Brubaker, P.L.6
  • 77
    • 84902127946 scopus 로고    scopus 로고
    • Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment
    • K. Narise, K. Okuda, Y. Enomoto, T. Hirayama, and H. Nagasawa Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment Drug Des. Devel. Ther. 8 2014 701 717
    • (2014) Drug Des. Devel. Ther. , vol.8 , pp. 701-717
    • Narise, K.1    Okuda, K.2    Enomoto, Y.3    Hirayama, T.4    Nagasawa, H.5
  • 78
    • 33244464265 scopus 로고    scopus 로고
    • Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: A systematic review
    • A. Natali, and E. Ferrannini Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review Diabetologia 49 2006 434 441
    • (2006) Diabetologia , vol.49 , pp. 434-441
    • Natali, A.1    Ferrannini, E.2
  • 81
    • 33846786408 scopus 로고    scopus 로고
    • Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1
    • N. Ouslimani, M. Mahrouf, J. Peynet, D. Bonnefont-Rousselot, C. Cosson, A. Legrand, and J.L. Beaudeux Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1 Metabolism 56 2007 308 313
    • (2007) Metabolism , vol.56 , pp. 308-313
    • Ouslimani, N.1    Mahrouf, M.2    Peynet, J.3    Bonnefont-Rousselot, D.4    Cosson, C.5    Legrand, A.6    Beaudeux, J.L.7
  • 82
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem. J. 348 2000 607 614
    • (2000) Biochem. J. , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 85
    • 84940845680 scopus 로고    scopus 로고
    • Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex i inhibition
    • Published online May 6, 2014
    • S. Piel, J.K. Ehinger, E. Elmér, and M.J. Hansson Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition Acta Physiol. (Oxf.) 2014 10.1111/apha.12311 Published online May 6, 2014
    • (2014) Acta Physiol. (Oxf.)
    • Piel, S.1    Ehinger, J.K.2    Elmér, E.3    Hansson, M.J.4
  • 86
    • 84857640868 scopus 로고    scopus 로고
    • The insulin and insulin-like growth factor receptor family in neoplasia: An update
    • M. Pollak The insulin and insulin-like growth factor receptor family in neoplasia: an update Nat. Rev. Cancer 12 2012 159 169
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 159-169
    • Pollak, M.1
  • 87
    • 84866322945 scopus 로고    scopus 로고
    • Investigating metformin for cancer prevention and treatment: The end of the beginning
    • M.N. Pollak Investigating metformin for cancer prevention and treatment: the end of the beginning Cancer Discov. 2 2012 778 790
    • (2012) Cancer Discov. , vol.2 , pp. 778-790
    • Pollak, M.N.1
  • 88
    • 84883542202 scopus 로고    scopus 로고
    • Potential applications for biguanides in oncology
    • M. Pollak Potential applications for biguanides in oncology J. Clin. Invest. 123 2013 3693 3700
    • (2013) J. Clin. Invest. , vol.123 , pp. 3693-3700
    • Pollak, M.1
  • 89
    • 84876453885 scopus 로고    scopus 로고
    • Targeting oxidative phosphorylation: Why, when, and how
    • M. Pollak Targeting oxidative phosphorylation: why, when, and how Cancer Cell 23 2013 263 264
    • (2013) Cancer Cell , vol.23 , pp. 263-264
    • Pollak, M.1
  • 90
    • 84902110574 scopus 로고    scopus 로고
    • Overcoming Drug Development Bottlenecks with Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment
    • M. Pollak Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment Nat. Med. 20 2014 591 593
    • (2014) Nat. Med. , vol.20 , pp. 591-593
    • Pollak, M.1
  • 99
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • X. Stephenne, M. Foretz, N. Taleux, G.C. van der Zon, E. Sokal, L. Hue, B. Viollet, and B. Guigas Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status Diabetologia 54 2011 3101 3110
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3    Van Der Zon, G.C.4    Sokal, E.5    Hue, L.6    Viollet, B.7    Guigas, B.8
  • 100
    • 84903534977 scopus 로고    scopus 로고
    • Metformin and cancer: Mounting evidence against an association
    • S. Suissa, and L. Azoulay Metformin and cancer: mounting evidence against an association Diabetes Care 37 2014 1786 1788
    • (2014) Diabetes Care , vol.37 , pp. 1786-1788
    • Suissa, S.1    Azoulay, L.2
  • 103
    • 66849142125 scopus 로고    scopus 로고
    • Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin
    • M. Tsuda, T. Terada, T. Mizuno, T. Katsura, J. Shimakura, and K. Inui Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin Mol. Pharmacol. 75 2009 1280 1286
    • (2009) Mol. Pharmacol. , vol.75 , pp. 1280-1286
    • Tsuda, M.1    Terada, T.2    Mizuno, T.3    Katsura, T.4    Shimakura, J.5    Inui, K.6
  • 105
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) Lancet 352 1998 854 865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 109
    • 0028158709 scopus 로고
    • Accumulation of metformin by tissues of the normal and diabetic mouse
    • C. Wilcock, and C.J. Bailey Accumulation of metformin by tissues of the normal and diabetic mouse Xenobiotica 24 1994 49 57
    • (1994) Xenobiotica , vol.24 , pp. 49-57
    • Wilcock, C.1    Bailey, C.J.2
  • 110
    • 84898619692 scopus 로고    scopus 로고
    • Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity
    • S.L. Woo, H. Xu, H. Li, Y. Zhao, X. Hu, J. Zhao, X. Guo, T. Guo, R. Botchlett, and T. Qi Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity PLoS ONE 9 2014 e91111
    • (2014) PLoS ONE , vol.9 , pp. 91111
    • Woo, S.L.1    Xu, H.2    Li, H.3    Zhao, Y.4    Hu, X.5    Zhao, J.6    Guo, X.7    Guo, T.8    Botchlett, R.9    Qi, T.10
  • 112
    • 77954777802 scopus 로고    scopus 로고
    • Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway
    • H. Xiao, X. Ma, W. Feng, Y. Fu, Z. Lu, M. Xu, Q. Shen, Y. Zhu, and Y. Zhang Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway Cardiovasc. Res. 87 2010 504 513
    • (2010) Cardiovasc. Res. , vol.87 , pp. 504-513
    • Xiao, H.1    Ma, X.2    Feng, W.3    Fu, Y.4    Lu, Z.5    Xu, M.6    Shen, Q.7    Zhu, Y.8    Zhang, Y.9
  • 113
    • 79959385996 scopus 로고    scopus 로고
    • Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
    • Z. Xie, K. Lau, B. Eby, P. Lozano, C. He, B. Pennington, H. Li, S. Rathi, Y. Dong, and R. Tian Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice Diabetes 60 2011 1770 1778
    • (2011) Diabetes , vol.60 , pp. 1770-1778
    • Xie, Z.1    Lau, K.2    Eby, B.3    Lozano, P.4    He, C.5    Pennington, B.6    Li, H.7    Rathi, S.8    Dong, Y.9    Tian, R.10
  • 114
    • 84897072824 scopus 로고    scopus 로고
    • Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2
    • X. Xu, Z. Lu, J. Fassett, P. Zhang, X. Hu, X. Liu, D. Kwak, J. Li, G. Zhu, and Y. Tao Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2 Hypertension 63 2014 723 728
    • (2014) Hypertension , vol.63 , pp. 723-728
    • Xu, X.1    Lu, Z.2    Fassett, J.3    Zhang, P.4    Hu, X.5    Liu, X.6    Kwak, D.7    Li, J.8    Zhu, G.9    Tao, Y.10
  • 115
    • 79953284583 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress
    • C.H. Yeh, T.P. Chen, Y.C. Wang, Y.M. Lin, and S.W. Fang AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress Mediators Inflamm. 2010 2010 130636
    • (2010) Mediators Inflamm. , vol.2010 , pp. 130636
    • Yeh, C.H.1    Chen, T.P.2    Wang, Y.C.3    Lin, Y.M.4    Fang, S.W.5
  • 117
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • M. Zakikhani, R. Dowling, I.G. Fantus, N. Sonenberg, and M. Pollak Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells Cancer Res. 66 2006 10269 10273
    • (2006) Cancer Res. , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 118
    • 9144271181 scopus 로고    scopus 로고
    • AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
    • M. Zang, A. Zuccollo, X. Hou, D. Nagata, K. Walsh, H. Herscovitz, P. Brecher, N.B. Ruderman, and R.A. Cohen AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells J. Biol. Chem. 279 2004 47898 47905
    • (2004) J. Biol. Chem. , vol.279 , pp. 47898-47905
    • Zang, M.1    Zuccollo, A.2    Hou, X.3    Nagata, D.4    Walsh, K.5    Herscovitz, H.6    Brecher, P.7    Ruderman, N.B.8    Cohen, R.A.9
  • 122
    • 79251612707 scopus 로고    scopus 로고
    • Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
    • GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group Wellcome Trust Case Control Consortium 2 MAGIC investigators
    • K. Zhou, C. Bellenguez, C.C. Spencer, A.J. Bennett, R.L. Coleman, R. Tavendale, S.A. Hawley, L.A. Donnelly, C. Schofield, C.J. Groves GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group Wellcome Trust Case Control Consortium 2 MAGIC investigators Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes Nat. Genet. 43 2011 117 120
    • (2011) Nat. Genet. , vol.43 , pp. 117-120
    • Zhou, K.1    Bellenguez, C.2    Spencer, C.C.3    Bennett, A.J.4    Coleman, R.L.5    Tavendale, R.6    Hawley, S.A.7    Donnelly, L.A.8    Schofield, C.9    Groves, C.J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.