-
1
-
-
79952538201
-
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
-
C. Algire, L. Amrein, M. Bazile, S. David, M. Zakikhani, and M. Pollak Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo Oncogene 30 2011 1174 1182
-
(2011)
Oncogene
, vol.30
, pp. 1174-1182
-
-
Algire, C.1
Amrein, L.2
Bazile, M.3
David, S.4
Zakikhani, M.5
Pollak, M.6
-
2
-
-
84892649479
-
Standards of medical care in diabetes - 2014
-
American Diabetes Association
-
American Diabetes Association Standards of medical care in diabetes - 2014 Diabetes Care 37 Suppl 1 2014 S14 S80
-
(2014)
Diabetes Care
, vol.37
, pp. 14-S80
-
-
-
3
-
-
84918583229
-
Metformin directly acts on mitochondria to alter cellular bioenergetics
-
Published online August 28, 2014
-
S. Andrzejewski, S.P. Gravel, M. Pollak, and J. St-Pierre Metformin directly acts on mitochondria to alter cellular bioenergetics Cancer Metab. 2 2014 10.1186/2049-3002-2-12 Published online August 28, 2014
-
(2014)
Cancer Metab.
, vol.2
-
-
Andrzejewski, S.1
Gravel, S.P.2
Pollak, M.3
St-Pierre, J.4
-
4
-
-
84897353217
-
Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts
-
J. Bai, N. Zhang, Y. Hua, B. Wang, L. Ling, A. Ferro, and B. Xu Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts PLoS ONE 8 2013 e72120
-
(2013)
PLoS ONE
, vol.8
, pp. 72120
-
-
Bai, J.1
Zhang, N.2
Hua, Y.3
Wang, B.4
Ling, L.5
Ferro, A.6
Xu, B.7
-
5
-
-
80054122252
-
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
-
M. Balteau, N. Tajeddine, C. de Meester, A. Ginion, C. Des Rosiers, N.R. Brady, C. Sommereyns, S. Horman, J.L. Vanoverschelde, and P. Gailly NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1 Cardiovasc. Res. 92 2011 237 246
-
(2011)
Cardiovasc. Res.
, vol.92
, pp. 237-246
-
-
Balteau, M.1
Tajeddine, N.2
De Meester, C.3
Ginion, A.4
Des Rosiers, C.5
Brady, N.R.6
Sommereyns, C.7
Horman, S.8
Vanoverschelde, J.L.9
Gailly, P.10
-
6
-
-
84908101883
-
AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes
-
Published online August 15, 2014
-
M. Balteau, A. Van Steenbergen, A.D. Timmermans, C. Dessy, G. Behets-Wydemans, N. Tajeddine, D. Castanares-Zapatero, P. Gilon, J.L. Vanoverschelde, and S. Horman AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes Am. J. Physiol. Heart Circ. Physiol. 2014 Published online August 15, 2014
-
(2014)
Am. J. Physiol. Heart Circ. Physiol.
-
-
Balteau, M.1
Van Steenbergen, A.2
Timmermans, A.D.3
Dessy, C.4
Behets-Wydemans, G.5
Tajeddine, N.6
Castanares-Zapatero, D.7
Gilon, P.8
Vanoverschelde, J.L.9
Horman, S.10
-
7
-
-
33746102508
-
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin
-
C. Batandier, B. Guigas, D. Detaille, M.Y. El-Mir, E. Fontaine, M. Rigoulet, and X.M. Leverve The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin J. Bioenerg. Biomembr. 38 2006 33 42
-
(2006)
J. Bioenerg. Biomembr.
, vol.38
, pp. 33-42
-
-
Batandier, C.1
Guigas, B.2
Detaille, D.3
El-Mir, M.Y.4
Fontaine, E.5
Rigoulet, M.6
Leverve, X.M.7
-
8
-
-
84891591832
-
Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells
-
B. Batchuluun, T. Inoguchi, N. Sonoda, S. Sasaki, T. Inoue, Y. Fujimura, D. Miura, and R. Takayanagi Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells Atherosclerosis 232 2014 156 164
-
(2014)
Atherosclerosis
, vol.232
, pp. 156-164
-
-
Batchuluun, B.1
Inoguchi, T.2
Sonoda, N.3
Sasaki, S.4
Inoue, T.5
Fujimura, Y.6
Miura, D.7
Takayanagi, R.8
-
9
-
-
62749133967
-
Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: A preliminary study
-
M.L. Becker, L.E. Visser, R.H. van Schaik, A. Hofman, A.G. Uitterlinden, and B.H. Stricker Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study Diabetes 58 2009 745 749
-
(2009)
Diabetes
, vol.58
, pp. 745-749
-
-
Becker, M.L.1
Visser, L.E.2
Van Schaik, R.H.3
Hofman, A.4
Uitterlinden, A.G.5
Stricker, B.H.6
-
10
-
-
77950191479
-
Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
-
I. Ben Sahra, K. Laurent, S. Giuliano, F. Larbret, G. Ponzio, P. Gounon, Y. Le Marchand-Brustel, S. Giorgetti-Peraldi, M. Cormont, and C. Bertolotto Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells Cancer Res. 70 2010 2465 2475
-
(2010)
Cancer Res.
, vol.70
, pp. 2465-2475
-
-
Ben Sahra, I.1
Laurent, K.2
Giuliano, S.3
Larbret, F.4
Ponzio, G.5
Gounon, P.6
Le Marchand-Brustel, Y.7
Giorgetti-Peraldi, S.8
Cormont, M.9
Bertolotto, C.10
-
11
-
-
33745684376
-
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
-
L. Bertrand, A. Ginion, C. Beauloye, A.D. Hebert, B. Guigas, L. Hue, and J.L. Vanoverschelde AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B Am. J. Physiol. Heart Circ. Physiol. 291 2006 H239 H250
-
(2006)
Am. J. Physiol. Heart Circ. Physiol.
, vol.291
, pp. 239-H250
-
-
Bertrand, L.1
Ginion, A.2
Beauloye, C.3
Hebert, A.D.4
Guigas, B.5
Hue, L.6
Vanoverschelde, J.L.7
-
12
-
-
42249101542
-
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening
-
G.S. Bhamra, D.J. Hausenloy, S.M. Davidson, R.D. Carr, M. Paiva, A.M. Wynne, M.M. Mocanu, and D.M. Yellon Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening Basic Res. Cardiol. 103 2008 274 284
-
(2008)
Basic Res. Cardiol.
, vol.103
, pp. 274-284
-
-
Bhamra, G.S.1
Hausenloy, D.J.2
Davidson, S.M.3
Carr, R.D.4
Paiva, M.5
Wynne, A.M.6
Mocanu, M.M.7
Yellon, D.M.8
-
13
-
-
84891350009
-
C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes
-
M.P. Bhatt, Y.C. Lim, Y.M. Kim, and K.S. Ha C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes Diabetes 62 2013 3851 3862
-
(2013)
Diabetes
, vol.62
, pp. 3851-3862
-
-
Bhatt, M.P.1
Lim, Y.C.2
Kim, Y.M.3
Ha, K.S.4
-
14
-
-
84897537717
-
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
-
K. Birsoy, R. Possemato, F.K. Lorbeer, E.C. Bayraktar, P. Thiru, B. Yucel, T. Wang, W.W. Chen, C.B. Clish, and D.M. Sabatini Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Nature 508 2014 108 112
-
(2014)
Nature
, vol.508
, pp. 108-112
-
-
Birsoy, K.1
Possemato, R.2
Lorbeer, F.K.3
Bayraktar, E.C.4
Thiru, P.5
Yucel, B.6
Wang, T.7
Chen, W.W.8
Clish, C.B.9
Sabatini, D.M.10
-
15
-
-
84860167144
-
Reappraisal of metformin efficacy in the treatment of type 2 diabetes: A meta-analysis of randomised controlled trials
-
R. Boussageon, I. Supper, T. Bejan-Angoulvant, N. Kellou, M. Cucherat, J.P. Boissel, B. Kassai, A. Moreau, F. Gueyffier, and C. Cornu Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials PLoS Med. 9 2012 e1001204
-
(2012)
PLoS Med.
, vol.9
, pp. 1001204
-
-
Boussageon, R.1
Supper, I.2
Bejan-Angoulvant, T.3
Kellou, N.4
Cucherat, M.5
Boissel, J.P.6
Kassai, B.7
Moreau, A.8
Gueyffier, F.9
Cornu, C.10
-
16
-
-
84907370814
-
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
-
H.R. Bridges, A.J. Jones, M.N. Pollak, and J. Hirst Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria Biochem. J. 462 2014 475 487
-
(2014)
Biochem. J.
, vol.462
, pp. 475-487
-
-
Bridges, H.R.1
Jones, A.J.2
Pollak, M.N.3
Hirst, J.4
-
17
-
-
12144291275
-
Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
-
B. Brunmair, K. Staniek, F. Gras, N. Scharf, A. Althaym, R. Clara, M. Roden, E. Gnaiger, H. Nohl, W. Waldhäusl, and C. Fürnsinn Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 53 2004 1052 1059
-
(2004)
Diabetes
, vol.53
, pp. 1052-1059
-
-
Brunmair, B.1
Staniek, K.2
Gras, F.3
Scharf, N.4
Althaym, A.5
Clara, R.6
Roden, M.7
Gnaiger, E.8
Nohl, H.9
Waldhäusl, W.10
Fürnsinn, C.11
-
18
-
-
84896092380
-
Molecular mechanisms of diabetic cardiomyopathy
-
H. Bugger, and E.D. Abel Molecular mechanisms of diabetic cardiomyopathy Diabetologia 57 2014 660 671
-
(2014)
Diabetologia
, vol.57
, pp. 660-671
-
-
Bugger, H.1
Abel, E.D.2
-
19
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
M. Buzzai, R.G. Jones, R.K. Amaravadi, J.J. Lum, R.J. DeBerardinis, F. Zhao, B. Viollet, and C.B. Thompson Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth Cancer Res. 67 2007 6745 6752
-
(2007)
Cancer Res.
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
Deberardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
20
-
-
84875738351
-
Metformin retards aging in C. Elegans by altering microbial folate and methionine metabolism
-
F. Cabreiro, C. Au, K.Y. Leung, N. Vergara-Irigaray, H.M. Cochemé, T. Noori, D. Weinkove, E. Schuster, N.D. Greene, and D. Gems Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism Cell 153 2013 228 239
-
(2013)
Cell
, vol.153
, pp. 228-239
-
-
Cabreiro, F.1
Au, C.2
Leung, K.Y.3
Vergara-Irigaray, N.4
Cochemé, H.M.5
Noori, T.6
Weinkove, D.7
Schuster, E.8
Greene, N.D.9
Gems, D.10
-
21
-
-
84905404389
-
Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)
-
J. Cao, S. Meng, E. Chang, K. Beckwith-Fickas, L. Xiong, R.N. Cole, S. Radovick, F.E. Wondisford, and L. He Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK) J. Biol. Chem. 289 2014 20435 20446
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 20435-20446
-
-
Cao, J.1
Meng, S.2
Chang, E.3
Beckwith-Fickas, K.4
Xiong, L.5
Cole, R.N.6
Radovick, S.7
Wondisford, F.E.8
He, L.9
-
22
-
-
77949493599
-
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
-
P.W. Caton, N.K. Nayuni, J. Kieswich, N.Q. Khan, M.M. Yaqoob, and R. Corder Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5 J. Endocrinol. 205 2010 97 106
-
(2010)
J. Endocrinol.
, vol.205
, pp. 97-106
-
-
Caton, P.W.1
Nayuni, N.K.2
Kieswich, J.3
Khan, N.Q.4
Yaqoob, M.M.5
Corder, R.6
-
23
-
-
84897398609
-
Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway
-
W.S. Cheang, X.Y. Tian, W.T. Wong, C.W. Lau, S.S. Lee, Z.Y. Chen, X. Yao, N. Wang, and Y. Huang Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5′ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway Arterioscler. Thromb. Vasc. Biol. 34 2014 830 836
-
(2014)
Arterioscler. Thromb. Vasc. Biol.
, vol.34
, pp. 830-836
-
-
Cheang, W.S.1
Tian, X.Y.2
Wong, W.T.3
Lau, C.W.4
Lee, S.S.5
Chen, Z.Y.6
Yao, X.7
Wang, N.8
Huang, Y.9
-
24
-
-
19944433033
-
Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: A randomized, placebo-controlled trial
-
J. De Jager, A. Kooy, P. Lehert, D. Bets, M.G. Wulffelé, T. Teerlink, P.G. Scheffer, C.G. Schalkwijk, A.J. Donker, and C.D. Stehouwer Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial J. Intern. Med. 257 2005 100 109
-
(2005)
J. Intern. Med.
, vol.257
, pp. 100-109
-
-
De Jager, J.1
Kooy, A.2
Lehert, P.3
Bets, D.4
Wulffelé, M.G.5
Teerlink, T.6
Scheffer, P.G.7
Schalkwijk, C.G.8
Donker, A.J.9
Stehouwer, C.D.10
-
25
-
-
21344462345
-
Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process
-
D. Detaille, B. Guigas, C. Chauvin, C. Batandier, E. Fontaine, N. Wiernsperger, and X. Leverve Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process Diabetes 54 2005 2179 2187
-
(2005)
Diabetes
, vol.54
, pp. 2179-2187
-
-
Detaille, D.1
Guigas, B.2
Chauvin, C.3
Batandier, C.4
Fontaine, E.5
Wiernsperger, N.6
Leverve, X.7
-
26
-
-
84896902461
-
Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties
-
Z. Drahota, E. Palenickova, R. Endlicher, M. Milerova, J. Brejchova, M. Vosahlikova, P. Svoboda, L. Kazdova, M. Kalous, Z. Cervinkova, and M. Cahova Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties Physiol. Res. 63 2014 1 11
-
(2014)
Physiol. Res.
, vol.63
, pp. 1-11
-
-
Drahota, Z.1
Palenickova, E.2
Endlicher, R.3
Milerova, M.4
Brejchova, J.5
Vosahlikova, M.6
Svoboda, P.7
Kazdova, L.8
Kalous, M.9
Cervinkova, Z.10
Cahova, M.11
-
27
-
-
56049086590
-
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
-
J.A. Dykens, J. Jamieson, L. Marroquin, S. Nadanaciva, P.A. Billis, and Y. Will Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro Toxicol. Appl. Pharmacol. 233 2008 203 210
-
(2008)
Toxicol. Appl. Pharmacol.
, vol.233
, pp. 203-210
-
-
Dykens, J.A.1
Jamieson, J.2
Marroquin, L.3
Nadanaciva, S.4
Billis, P.A.5
Will, Y.6
-
28
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
-
M.Y. El-Mir, V. Nogueira, E. Fontaine, N. Avéret, M. Rigoulet, and X. Leverve Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I J. Biol. Chem. 275 2000 223 228
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 223-228
-
-
El-Mir, M.Y.1
Nogueira, V.2
Fontaine, E.3
Avéret, N.4
Rigoulet, M.5
Leverve, X.6
-
29
-
-
40749133339
-
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons
-
M.Y. El-Mir, D. Detaille, G. R-Villanueva, M. Delgado-Esteban, B. Guigas, S. Attia, E. Fontaine, A. Almeida, and X. Leverve Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons J. Mol. Neurosci. 34 2008 77 87
-
(2008)
J. Mol. Neurosci.
, vol.34
, pp. 77-87
-
-
El-Mir, M.Y.1
Detaille, D.2
R-Villanueva, G.3
Delgado-Esteban, M.4
Guigas, B.5
Attia, S.6
Fontaine, E.7
Almeida, A.8
Leverve, X.9
-
30
-
-
84879207411
-
Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: Systematic review of observational studies involving 34,000 patients
-
D.T. Eurich, D.L. Weir, S.R. Majumdar, R.T. Tsuyuki, J.A. Johnson, L. Tjosvold, S.E. Vanderloo, and F.A. McAlister Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients Circ. Heart Fail. 6 2013 395 402
-
(2013)
Circ. Heart Fail.
, vol.6
, pp. 395-402
-
-
Eurich, D.T.1
Weir, D.L.2
Majumdar, S.R.3
Tsuyuki, R.T.4
Johnson, J.A.5
Tjosvold, L.6
Vanderloo, S.E.7
McAlister, F.A.8
-
31
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
J.M. Evans, L.A. Donnelly, A.M. Emslie-Smith, D.R. Alessi, and A.D. Morris Metformin and reduced risk of cancer in diabetic patients BMJ 330 2005 1304 1305
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
32
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
-
B. Faubert, G. Boily, S. Izreig, T. Griss, B. Samborska, Z. Dong, F. Dupuy, C. Chambers, B.J. Fuerth, and B. Viollet AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo Cell Metab. 17 2013 113 124
-
(2013)
Cell Metab.
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
Dupuy, F.7
Chambers, C.8
Fuerth, B.J.9
Viollet, B.10
-
33
-
-
77954933558
-
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
-
M. Foretz, S. Hébrard, J. Leclerc, E. Zarrinpashneh, M. Soty, G. Mithieux, K. Sakamoto, F. Andreelli, and B. Viollet Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state J. Clin. Invest. 120 2010 2355 2369
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2355-2369
-
-
Foretz, M.1
Hébrard, S.2
Leclerc, J.3
Zarrinpashneh, E.4
Soty, M.5
Mithieux, G.6
Sakamoto, K.7
Andreelli, F.8
Viollet, B.9
-
34
-
-
84889887123
-
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
-
M.D. Fullerton, S. Galic, K. Marcinko, S. Sikkema, T. Pulinilkunnil, Z.P. Chen, H.M. O'Neill, R.J. Ford, R. Palanivel, and M. O'Brien Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin Nat. Med. 19 2013 1649 1654
-
(2013)
Nat. Med.
, vol.19
, pp. 1649-1654
-
-
Fullerton, M.D.1
Galic, S.2
Marcinko, K.3
Sikkema, S.4
Pulinilkunnil, T.5
Chen, Z.P.6
O'Neill, H.M.7
Ford, R.J.8
Palanivel, R.9
O'Brien, M.10
-
35
-
-
84907296915
-
Metformin and cancer risk and mortality: A systematic review and meta-analysis taking into account biases and confounders
-
S. Gandini, M. Puntoni, B.M. Heckman-Stoddard, B.K. Dunn, L. Ford, A. DeCensi, and E. Szabo Metformin and cancer risk and mortality: A systematic review and meta-analysis taking into account biases and confounders Cancer Prev. Res. (Phila). 7 2014 867 885
-
(2014)
Cancer Prev. Res. (Phila).
, vol.7
, pp. 867-885
-
-
Gandini, S.1
Puntoni, M.2
Heckman-Stoddard, B.M.3
Dunn, B.K.4
Ford, L.5
Decensi, A.6
Szabo, E.7
-
36
-
-
84894412290
-
Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice
-
J.J. Geerling, M.R. Boon, G.C. van der Zon, S.A. van den Berg, A.M. van den Hoek, M. Lombès, H.M. Princen, L.M. Havekes, P.C. Rensen, and B. Guigas Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice Diabetes 63 2014 880 891
-
(2014)
Diabetes
, vol.63
, pp. 880-891
-
-
Geerling, J.J.1
Boon, M.R.2
Van Der Zon, G.C.3
Van Den Berg, S.A.4
Van Den Hoek, A.M.5
Lombès, M.6
Princen, H.M.7
Havekes, L.M.8
Rensen, P.C.9
Guigas, B.10
-
37
-
-
79961075137
-
Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake
-
A. Ginion, J. Auquier, C.R. Benton, C. Mouton, J.L. Vanoverschelde, L. Hue, S. Horman, C. Beauloye, and L. Bertrand Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake Am. J. Physiol. Heart Circ. Physiol. 301 2011 H469 H477
-
(2011)
Am. J. Physiol. Heart Circ. Physiol.
, vol.301
, pp. 469-H477
-
-
Ginion, A.1
Auquier, J.2
Benton, C.R.3
Mouton, C.4
Vanoverschelde, J.L.5
Hue, L.6
Horman, S.7
Beauloye, C.8
Bertrand, L.9
-
38
-
-
84867575707
-
Metformin pathways: Pharmacokinetics and pharmacodynamics
-
L. Gong, S. Goswami, K.M. Giacomini, R.B. Altman, and T.E. Klein Metformin pathways: pharmacokinetics and pharmacodynamics Pharmacogenet. Genomics 22 2012 820 827
-
(2012)
Pharmacogenet. Genomics
, vol.22
, pp. 820-827
-
-
Gong, L.1
Goswami, S.2
Giacomini, K.M.3
Altman, R.B.4
Klein, T.E.5
-
39
-
-
36849091871
-
High and typical 18F-FDG bowel uptake in patients treated with metformin
-
E. Gontier, E. Fourme, M. Wartski, C. Blondet, G. Bonardel, E. Le Stanc, M. Mantzarides, H. Foehrenbach, A.P. Pecking, and J.L. Alberini High and typical 18F-FDG bowel uptake in patients treated with metformin Eur. J. Nucl. Med. Mol. Imaging 35 2008 95 99
-
(2008)
Eur. J. Nucl. Med. Mol. Imaging
, vol.35
, pp. 95-99
-
-
Gontier, E.1
Fourme, E.2
Wartski, M.3
Blondet, C.4
Bonardel, G.5
Le Stanc, E.6
Mantzarides, M.7
Foehrenbach, H.8
Pecking, A.P.9
Alberini, J.L.10
-
40
-
-
84903489573
-
IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism
-
A.R. Grassian, S.J. Parker, S.M. Davidson, A.S. Divakaruni, C.R. Green, X. Zhang, K.L. Slocum, M. Pu, F. Lin, and C. Vickers IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism Cancer Res. 74 2014 3317 3331
-
(2014)
Cancer Res.
, vol.74
, pp. 3317-3331
-
-
Grassian, A.R.1
Parker, S.J.2
Davidson, S.M.3
Divakaruni, A.S.4
Green, C.R.5
Zhang, X.6
Slocum, K.L.7
Pu, M.8
Lin, F.9
Vickers, C.10
-
41
-
-
0033533596
-
Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association
-
S.M. Grundy, I.J. Benjamin, G.L. Burke, A. Chait, R.H. Eckel, B.V. Howard, W. Mitch, S.C. Smith Jr.; and J.R. Sowers Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association Circulation 100 1999 1134 1146
-
(1999)
Circulation
, vol.100
, pp. 1134-1146
-
-
Grundy, S.M.1
Benjamin, I.J.2
Burke, G.L.3
Chait, A.4
Eckel, R.H.5
Howard, B.V.6
Mitch, W.7
Smith, S.C.8
Sowers, J.R.9
-
42
-
-
4744355266
-
Metformin inhibits mitochondrial permeability transition and cell death: A pharmacological in vitro study
-
B. Guigas, D. Detaille, C. Chauvin, C. Batandier, F. De Oliveira, E. Fontaine, and X. Leverve Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study Biochem. J. 382 2004 877 884
-
(2004)
Biochem. J.
, vol.382
, pp. 877-884
-
-
Guigas, B.1
Detaille, D.2
Chauvin, C.3
Batandier, C.4
De Oliveira, F.5
Fontaine, E.6
Leverve, X.7
-
43
-
-
61949300140
-
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
-
S. Gundewar, J.W. Calvert, S. Jha, I. Toedt-Pingel, S.Y. Ji, D. Nunez, A. Ramachandran, M. Anaya-Cisneros, R. Tian, and D.J. Lefer Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure Circ. Res. 104 2009 403 411
-
(2009)
Circ. Res.
, vol.104
, pp. 403-411
-
-
Gundewar, S.1
Calvert, J.W.2
Jha, S.3
Toedt-Pingel, I.4
Ji, S.Y.5
Nunez, D.6
Ramachandran, A.7
Anaya-Cisneros, M.8
Tian, R.9
Lefer, D.J.10
-
44
-
-
84876436850
-
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
-
R. Haq, J. Shoag, P. Andreu-Perez, S. Yokoyama, H. Edelman, G.C. Rowe, D.T. Frederick, A.D. Hurley, A. Nellore, and A.L. Kung Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF Cancer Cell 23 2013 302 315
-
(2013)
Cancer Cell
, vol.23
, pp. 302-315
-
-
Haq, R.1
Shoag, J.2
Andreu-Perez, P.3
Yokoyama, S.4
Edelman, H.5
Rowe, G.C.6
Frederick, D.T.7
Hurley, A.D.8
Nellore, A.9
Kung, A.L.10
-
45
-
-
77956410464
-
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
-
S.A. Hawley, F.A. Ross, C. Chevtzoff, K.A. Green, A. Evans, S. Fogarty, M.C. Towler, L.J. Brown, O.A. Ogunbayo, A.M. Evans, and D.G. Hardie Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation Cell Metab. 11 2010 554 565
-
(2010)
Cell Metab.
, vol.11
, pp. 554-565
-
-
Hawley, S.A.1
Ross, F.A.2
Chevtzoff, C.3
Green, K.A.4
Evans, A.5
Fogarty, S.6
Towler, M.C.7
Brown, L.J.8
Ogunbayo, O.A.9
Evans, A.M.10
Hardie, D.G.11
-
46
-
-
65549136655
-
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
-
L. He, A. Sabet, S. Djedjos, R. Miller, X. Sun, M.A. Hussain, S. Radovick, and F.E. Wondisford Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein Cell 137 2009 635 646
-
(2009)
Cell
, vol.137
, pp. 635-646
-
-
He, L.1
Sabet, A.2
Djedjos, S.3
Miller, R.4
Sun, X.5
Hussain, M.A.6
Radovick, S.7
Wondisford, F.E.8
-
47
-
-
84875450015
-
Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes
-
C. He, H. Zhu, H. Li, M.H. Zou, and Z. Xie Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes Diabetes 62 2013 1270 1281
-
(2013)
Diabetes
, vol.62
, pp. 1270-1281
-
-
He, C.1
Zhu, H.2
Li, H.3
Zou, M.H.4
Xie, Z.5
-
48
-
-
34247185346
-
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer
-
S.A. Hinke, G.A. Martens, Y. Cai, J. Finsi, H. Heimberg, D. Pipeleers, and M. Van de Casteele Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer Br. J. Pharmacol. 150 2007 1031 1043
-
(2007)
Br. J. Pharmacol.
, vol.150
, pp. 1031-1043
-
-
Hinke, S.A.1
Martens, G.A.2
Cai, Y.3
Finsi, J.4
Heimberg, H.5
Pipeleers, D.6
Van De Casteele, M.7
-
49
-
-
84865429928
-
Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex i activity of the respiratory chain
-
A. Hirsch, D. Hahn, P. Kempná, G. Hofer, J.M. Nuoffer, P.E. Mullis, and C.E. Flück Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain Endocrinology 153 2012 4354 4366
-
(2012)
Endocrinology
, vol.153
, pp. 4354-4366
-
-
Hirsch, A.1
Hahn, D.2
Kempná, P.3
Hofer, G.4
Nuoffer, J.M.5
Mullis, P.E.6
Flück, C.E.7
-
50
-
-
84954950549
-
Guanidines and oxidative phosphorylations
-
G. Hollunger Guanidines and oxidative phosphorylations Acta Pharmacol. Toxicol. (Copenh.) 11 Suppl 1 1955 1 84
-
(1955)
Acta Pharmacol. Toxicol. (Copenh.)
, vol.11
, pp. 1-84
-
-
Hollunger, G.1
-
51
-
-
53749096863
-
10-year follow-up of intensive glucose control in type 2 diabetes
-
R.R. Holman, S.K. Paul, M.A. Bethel, D.R. Matthews, and H.A. Neil 10-year follow-up of intensive glucose control in type 2 diabetes N. Engl. J. Med. 359 2008 1577 1589
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1577-1589
-
-
Holman, R.R.1
Paul, S.K.2
Bethel, M.A.3
Matthews, D.R.4
Neil, H.A.5
-
52
-
-
84874357500
-
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
-
SPREAD-DIMCAD Investigators
-
J. Hong, Y. Zhang, S. Lai, A. Lv, Q. Su, Y. Dong, Z. Zhou, W. Tang, J. Zhao, L. Cui SPREAD-DIMCAD Investigators Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease Diabetes Care 36 2013 1304 1311
-
(2013)
Diabetes Care
, vol.36
, pp. 1304-1311
-
-
Hong, J.1
Zhang, Y.2
Lai, S.3
Lv, A.4
Su, Q.5
Dong, Y.6
Zhou, Z.7
Tang, W.8
Zhao, J.9
Cui, L.10
-
54
-
-
77956411030
-
Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
-
K. Hosono, H. Endo, H. Takahashi, M. Sugiyama, E. Sakai, T. Uchiyama, K. Suzuki, H. Iida, Y. Sakamoto, and K. Yoneda Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial Cancer Prev. Res. (Phila.) 3 2010 1077 1083
-
(2010)
Cancer Prev. Res. (Phila.)
, vol.3
, pp. 1077-1083
-
-
Hosono, K.1
Endo, H.2
Takahashi, H.3
Sugiyama, M.4
Sakai, E.5
Uchiyama, T.6
Suzuki, K.7
Iida, H.8
Sakamoto, Y.9
Yoneda, K.10
-
55
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
-
X. Huang, S. Wullschleger, N. Shpiro, V.A. McGuire, K. Sakamoto, Y.L. Woods, W. McBurnie, S. Fleming, and D.R. Alessi Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice Biochem. J. 412 2008 211 221
-
(2008)
Biochem. J.
, vol.412
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, N.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
McBurnie, W.7
Fleming, S.8
Alessi, D.R.9
-
56
-
-
77957601724
-
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program
-
Diabetes Prevention Program Research Group
-
K.A. Jablonski, J.B. McAteer, P.I. de Bakker, P.W. Franks, T.I. Pollin, R.L. Hanson, R. Saxena, S. Fowler, A.R. Shuldiner, W.C. Knowler Diabetes Prevention Program Research Group Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program Diabetes 59 2010 2672 2681
-
(2010)
Diabetes
, vol.59
, pp. 2672-2681
-
-
Jablonski, K.A.1
McAteer, J.B.2
De Bakker, P.I.3
Franks, P.W.4
Pollin, T.I.5
Hanson, R.L.6
Saxena, R.7
Fowler, S.8
Shuldiner, A.R.9
Knowler, W.C.10
-
57
-
-
84904686912
-
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
-
A. Janzer, N.J. German, K.N. Gonzalez-Herrera, J.M. Asara, M.C. Haigis, and K. Struhl Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells Proc. Natl. Acad. Sci. USA 111 2014 10574 10579
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 10574-10579
-
-
Janzer, A.1
German, N.J.2
Gonzalez-Herrera, K.N.3
Asara, J.M.4
Haigis, M.C.5
Struhl, K.6
-
58
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
S.M. Jeon, N.S. Chandel, and N. Hay AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Nature 485 2012 661 665
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
59
-
-
84885383560
-
Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
-
K.H. Kim, Y.T. Jeong, S.H. Kim, H.S. Jung, K.S. Park, H.Y. Lee, and M.S. Lee Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation Biochem. Biophys. Res. Commun. 440 2013 76 81
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.440
, pp. 76-81
-
-
Kim, K.H.1
Jeong, Y.T.2
Kim, S.H.3
Jung, H.S.4
Park, K.S.5
Lee, H.Y.6
Lee, M.S.7
-
60
-
-
33644749330
-
Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
-
D. Kukidome, T. Nishikawa, K. Sonoda, K. Imoto, K. Fujisawa, M. Yano, H. Motoshima, T. Taguchi, T. Matsumura, and E. Araki Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells Diabetes 55 2006 120 127
-
(2006)
Diabetes
, vol.55
, pp. 120-127
-
-
Kukidome, D.1
Nishikawa, T.2
Sonoda, K.3
Imoto, K.4
Fujisawa, K.5
Yano, M.6
Motoshima, H.7
Taguchi, T.8
Matsumura, T.9
Araki, E.10
-
61
-
-
78851470539
-
Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
-
C. Lamanna, M. Monami, N. Marchionni, and E. Mannucci Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials Diabetes Obes. Metab. 13 2011 221 228
-
(2011)
Diabetes Obes. Metab.
, vol.13
, pp. 221-228
-
-
Lamanna, C.1
Monami, M.2
Marchionni, N.3
Mannucci, E.4
-
62
-
-
77957768686
-
AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner
-
J.M. Lee, W.Y. Seo, K.H. Song, D. Chanda, Y.D. Kim, D.K. Kim, M.W. Lee, D. Ryu, Y.H. Kim, and J.R. Noh AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner J. Biol. Chem. 285 2010 32182 32191
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32182-32191
-
-
Lee, J.M.1
Seo, W.Y.2
Song, K.H.3
Chanda, D.4
Kim, Y.D.5
Kim, D.K.6
Lee, M.W.7
Ryu, D.8
Kim, Y.H.9
Noh, J.R.10
-
64
-
-
84898607351
-
Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: The GIPS-III randomized clinical trial
-
GIPS-III Investigators
-
C.P. Lexis, I.C. van der Horst, E. Lipsic, W.G. Wieringa, R.A. de Boer, A.F. van den Heuvel, H.W. van der Werf, R.A. Schurer, G. Pundziute, E.S. Tan GIPS-III Investigators Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial JAMA 311 2014 1526 1535
-
(2014)
JAMA
, vol.311
, pp. 1526-1535
-
-
Lexis, C.P.1
Van Der Horst, I.C.2
Lipsic, E.3
Wieringa, W.G.4
De Boer, R.A.5
Van Den Heuvel, A.F.6
Van Der Werf, H.W.7
Schurer, R.A.8
Pundziute, G.9
Tan, E.S.10
-
65
-
-
0012785395
-
Metformin reverses fatty liver disease in obese, leptin-deficient mice
-
H.Z. Lin, S.Q. Yang, C. Chuckaree, F. Kuhajda, G. Ronnet, and A.M. Diehl Metformin reverses fatty liver disease in obese, leptin-deficient mice Nat. Med. 6 2000 998 1003
-
(2000)
Nat. Med.
, vol.6
, pp. 998-1003
-
-
Lin, H.Z.1
Yang, S.Q.2
Chuckaree, C.3
Kuhajda, F.4
Ronnet, G.5
Diehl, A.M.6
-
66
-
-
84861887451
-
Cellular responses to the metal-binding properties of metformin
-
L. Logie, J. Harthill, K. Patel, S. Bacon, D.L. Hamilton, K. Macrae, G. McDougall, H.H. Wang, L. Xue, and H. Jiang Cellular responses to the metal-binding properties of metformin Diabetes 61 2012 1423 1433
-
(2012)
Diabetes
, vol.61
, pp. 1423-1433
-
-
Logie, L.1
Harthill, J.2
Patel, K.3
Bacon, S.4
Hamilton, D.L.5
Macrae, K.6
McDougall, G.7
Wang, H.H.8
Xue, L.9
Jiang, H.10
-
67
-
-
84903524608
-
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
-
A.K. Madiraju, D.M. Erion, Y. Rahimi, X.M. Zhang, D.T. Braddock, R.A. Albright, B.J. Prigaro, J.L. Wood, S. Bhanot, and M.J. MacDonald Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Nature 510 2014 542 546
-
(2014)
Nature
, vol.510
, pp. 542-546
-
-
Madiraju, A.K.1
Erion, D.M.2
Rahimi, Y.3
Zhang, X.M.4
Braddock, D.T.5
Albright, R.A.6
Prigaro, B.J.7
Wood, J.L.8
Bhanot, S.9
Macdonald, M.J.10
-
68
-
-
78951476273
-
Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
-
A. Maida, B.J. Lamont, X. Cao, and D.J. Drucker Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice Diabetologia 54 2011 339 349
-
(2011)
Diabetologia
, vol.54
, pp. 339-349
-
-
Maida, A.1
Lamont, B.J.2
Cao, X.3
Drucker, D.J.4
-
69
-
-
0035883890
-
Metformin in non-alcoholic steatohepatitis
-
G. Marchesini, M. Brizi, G. Bianchi, S. Tomassetti, M. Zoli, and N. Melchionda Metformin in non-alcoholic steatohepatitis Lancet 358 2001 893 894
-
(2001)
Lancet
, vol.358
, pp. 893-894
-
-
Marchesini, G.1
Brizi, M.2
Bianchi, G.3
Tomassetti, S.4
Zoli, M.5
Melchionda, N.6
-
70
-
-
84886557970
-
Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes
-
D. Margel, D.R. Urbach, L.L. Lipscombe, C.M. Bell, G. Kulkarni, P.C. Austin, and N. Fleshner Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes J. Clin. Oncol. 31 2013 3069 3075
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 3069-3075
-
-
Margel, D.1
Urbach, D.R.2
Lipscombe, L.L.3
Bell, C.M.4
Kulkarni, G.5
Austin, P.C.6
Fleshner, N.7
-
71
-
-
13444272949
-
Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study
-
F.A. Masoudi, S.E. Inzucchi, Y. Wang, E.P. Havranek, J.M. Foody, and H.M. Krumholz Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study Circulation 111 2005 583 590
-
(2005)
Circulation
, vol.111
, pp. 583-590
-
-
Masoudi, F.A.1
Inzucchi, S.E.2
Wang, Y.3
Havranek, E.P.4
Foody, J.M.5
Krumholz, H.M.6
-
72
-
-
77956415337
-
Metformin prevents tobacco carcinogen - Induced lung tumorigenesis
-
R.M. Memmott, J.R. Mercado, C.R. Maier, S. Kawabata, S.D. Fox, and P.A. Dennis Metformin prevents tobacco carcinogen - induced lung tumorigenesis Cancer Prev. Res. (Phila.) 3 2010 1066 1076
-
(2010)
Cancer Prev. Res. (Phila.)
, vol.3
, pp. 1066-1076
-
-
Memmott, R.M.1
Mercado, J.R.2
Maier, C.R.3
Kawabata, S.4
Fox, S.D.5
Dennis, P.A.6
-
73
-
-
84873707522
-
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
-
R.A. Miller, Q. Chu, J. Xie, M. Foretz, B. Viollet, and M.J. Birnbaum Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Nature 494 2013 256 260
-
(2013)
Nature
, vol.494
, pp. 256-260
-
-
Miller, R.A.1
Chu, Q.2
Xie, J.3
Foretz, M.4
Viollet, B.5
Birnbaum, M.J.6
-
74
-
-
84877822086
-
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
-
O. Moiseeva, X. Deschênes-Simard, E. St-Germain, S. Igelmann, G. Huot, A.E. Cadar, V. Bourdeau, M.N. Pollak, and G. Ferbeyre Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation Aging Cell 12 2013 489 498
-
(2013)
Aging Cell
, vol.12
, pp. 489-498
-
-
Moiseeva, O.1
Deschênes-Simard, X.2
St-Germain, E.3
Igelmann, S.4
Huot, G.5
Cadar, A.E.6
Bourdeau, V.7
Pollak, M.N.8
Ferbeyre, G.9
-
75
-
-
82355165097
-
Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell
-
A.J. Mulherin, A.H. Oh, H. Kim, A. Grieco, L.M. Lauffer, and P.L. Brubaker Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell Endocrinology 152 2011 4610 4619
-
(2011)
Endocrinology
, vol.152
, pp. 4610-4619
-
-
Mulherin, A.J.1
Oh, A.H.2
Kim, H.3
Grieco, A.4
Lauffer, L.M.5
Brubaker, P.L.6
-
76
-
-
0030815226
-
Action of metformin on erythrocyte membrane fluidity in vitro and in vivo
-
S. Muller, S. Denet, H. Candiloros, R. Barrois, N. Wiernsperger, M. Donner, and P. Drouin Action of metformin on erythrocyte membrane fluidity in vitro and in vivo Eur. J. Pharmacol. 337 1997 103 110
-
(1997)
Eur. J. Pharmacol.
, vol.337
, pp. 103-110
-
-
Muller, S.1
Denet, S.2
Candiloros, H.3
Barrois, R.4
Wiernsperger, N.5
Donner, M.6
Drouin, P.7
-
77
-
-
84902127946
-
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment
-
K. Narise, K. Okuda, Y. Enomoto, T. Hirayama, and H. Nagasawa Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment Drug Des. Devel. Ther. 8 2014 701 717
-
(2014)
Drug Des. Devel. Ther.
, vol.8
, pp. 701-717
-
-
Narise, K.1
Okuda, K.2
Enomoto, Y.3
Hirayama, T.4
Nagasawa, H.5
-
78
-
-
33244464265
-
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: A systematic review
-
A. Natali, and E. Ferrannini Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review Diabetologia 49 2006 434 441
-
(2006)
Diabetologia
, vol.49
, pp. 434-441
-
-
Natali, A.1
Ferrannini, E.2
-
79
-
-
84904758023
-
Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1
-
G. Noppe, C. Dufeys, P. Buchlin, N. Marquet, D. Castanares-Zapatero, M. Balteau, N. Hermida, C. Bouzin, H. Esfahani, and B. Viollet Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1 J. Mol. Cell. Cardiol. 74 2014 32 43
-
(2014)
J. Mol. Cell. Cardiol.
, vol.74
, pp. 32-43
-
-
Noppe, G.1
Dufeys, C.2
Buchlin, P.3
Marquet, N.4
Castanares-Zapatero, D.5
Balteau, M.6
Hermida, N.7
Bouzin, C.8
Esfahani, H.9
Viollet, B.10
-
80
-
-
19444380162
-
Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells
-
N. Ouslimani, J. Peynet, D. Bonnefont-Rousselot, P. Thérond, A. Legrand, and J.L. Beaudeux Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells Metabolism 54 2005 829 834
-
(2005)
Metabolism
, vol.54
, pp. 829-834
-
-
Ouslimani, N.1
Peynet, J.2
Bonnefont-Rousselot, D.3
Thérond, P.4
Legrand, A.5
Beaudeux, J.L.6
-
81
-
-
33846786408
-
Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1
-
N. Ouslimani, M. Mahrouf, J. Peynet, D. Bonnefont-Rousselot, C. Cosson, A. Legrand, and J.L. Beaudeux Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1 Metabolism 56 2007 308 313
-
(2007)
Metabolism
, vol.56
, pp. 308-313
-
-
Ouslimani, N.1
Mahrouf, M.2
Peynet, J.3
Bonnefont-Rousselot, D.4
Cosson, C.5
Legrand, A.6
Beaudeux, J.L.7
-
82
-
-
0034659785
-
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
-
M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem. J. 348 2000 607 614
-
(2000)
Biochem. J.
, vol.348
, pp. 607-614
-
-
Owen, M.R.1
Doran, E.2
Halestrap, A.P.3
-
83
-
-
67650921900
-
Metformin prevents myocardial reperfusion injury by activating the adenosine receptor
-
M. Paiva, N.P. Riksen, S.M. Davidson, D.J. Hausenloy, P. Monteiro, L. Gonçalves, L. Providência, G.A. Rongen, P. Smits, M.M. Mocanu, and D.M. Yellon Metformin prevents myocardial reperfusion injury by activating the adenosine receptor J. Cardiovasc. Pharmacol. 53 2009 373 378
-
(2009)
J. Cardiovasc. Pharmacol.
, vol.53
, pp. 373-378
-
-
Paiva, M.1
Riksen, N.P.2
Davidson, S.M.3
Hausenloy, D.J.4
Monteiro, P.5
Gonçalves, L.6
Providência, L.7
Rongen, G.A.8
Smits, P.9
Mocanu, M.M.10
Yellon, D.M.11
-
84
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
E.L. Pearce, M.C. Walsh, P.J. Cejas, G.M. Harms, H. Shen, L.S. Wang, R.G. Jones, and Y. Choi Enhancing CD8 T-cell memory by modulating fatty acid metabolism Nature 460 2009 103 107
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
Walsh, M.C.2
Cejas, P.J.3
Harms, G.M.4
Shen, H.5
Wang, L.S.6
Jones, R.G.7
Choi, Y.8
-
85
-
-
84940845680
-
Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex i inhibition
-
Published online May 6, 2014
-
S. Piel, J.K. Ehinger, E. Elmér, and M.J. Hansson Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition Acta Physiol. (Oxf.) 2014 10.1111/apha.12311 Published online May 6, 2014
-
(2014)
Acta Physiol. (Oxf.)
-
-
Piel, S.1
Ehinger, J.K.2
Elmér, E.3
Hansson, M.J.4
-
86
-
-
84857640868
-
The insulin and insulin-like growth factor receptor family in neoplasia: An update
-
M. Pollak The insulin and insulin-like growth factor receptor family in neoplasia: an update Nat. Rev. Cancer 12 2012 159 169
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 159-169
-
-
Pollak, M.1
-
87
-
-
84866322945
-
Investigating metformin for cancer prevention and treatment: The end of the beginning
-
M.N. Pollak Investigating metformin for cancer prevention and treatment: the end of the beginning Cancer Discov. 2 2012 778 790
-
(2012)
Cancer Discov.
, vol.2
, pp. 778-790
-
-
Pollak, M.N.1
-
88
-
-
84883542202
-
Potential applications for biguanides in oncology
-
M. Pollak Potential applications for biguanides in oncology J. Clin. Invest. 123 2013 3693 3700
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3693-3700
-
-
Pollak, M.1
-
89
-
-
84876453885
-
Targeting oxidative phosphorylation: Why, when, and how
-
M. Pollak Targeting oxidative phosphorylation: why, when, and how Cancer Cell 23 2013 263 264
-
(2013)
Cancer Cell
, vol.23
, pp. 263-264
-
-
Pollak, M.1
-
90
-
-
84902110574
-
Overcoming Drug Development Bottlenecks with Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment
-
M. Pollak Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment Nat. Med. 20 2014 591 593
-
(2014)
Nat. Med.
, vol.20
, pp. 591-593
-
-
Pollak, M.1
-
91
-
-
84894900806
-
Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): A randomised controlled trial
-
D. Preiss, S.M. Lloyd, I. Ford, J.J. McMurray, R.R. Holman, P. Welsh, M. Fisher, C.J. Packard, and N. Sattar Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial Lancet Diabetes Endocrinol. 2 2014 116 124
-
(2014)
Lancet Diabetes Endocrinol.
, vol.2
, pp. 116-124
-
-
Preiss, D.1
Lloyd, S.M.2
Ford, I.3
McMurray, J.J.4
Holman, R.R.5
Welsh, P.6
Fisher, M.7
Packard, C.J.8
Sattar, N.9
-
92
-
-
84909957984
-
Metformin Use and Prostate Cancer Risk
-
M.A. Preston, A.H. Riis, V. Ehrenstein, R.H. Breau, J.L. Batista, A.F. Olumi, L.A. Mucci, H.O. Adami, and H.T. Sørensen Metformin Use and Prostate Cancer Risk Eur. Urol. 2014
-
(2014)
Eur. Urol.
-
-
Preston, M.A.1
Riis, A.H.2
Ehrenstein, V.3
Breau, R.H.4
Batista, J.L.5
Olumi, A.F.6
Mucci, L.A.7
Adami, H.O.8
Sørensen, H.T.9
-
93
-
-
67749142348
-
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes
-
V.T. Samuel, S.A. Beddow, T. Iwasaki, X.M. Zhang, X. Chu, C.D. Still, G.S. Gerhard, and G.I. Shulman Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes Proc. Natl. Acad. Sci. USA 106 2009 12121 12126
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12121-12126
-
-
Samuel, V.T.1
Beddow, S.A.2
Iwasaki, T.3
Zhang, X.M.4
Chu, X.5
Still, C.D.6
Gerhard, G.S.7
Shulman, G.I.8
-
94
-
-
66349105917
-
Metformin prevents progression of heart failure in dogs: Role of AMP-activated protein kinase
-
H. Sasaki, H. Asanuma, M. Fujita, H. Takahama, M. Wakeno, S. Ito, A. Ogai, M. Asakura, J. Kim, and T. Minamino Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase Circulation 119 2009 2568 2577
-
(2009)
Circulation
, vol.119
, pp. 2568-2577
-
-
Sasaki, H.1
Asanuma, H.2
Fujita, M.3
Takahama, H.4
Wakeno, M.5
Ito, S.6
Ogai, A.7
Asakura, M.8
Kim, J.9
Minamino, T.10
-
95
-
-
84887320074
-
Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells
-
S. Scotland, E. Saland, N. Skuli, F. de Toni, H. Boutzen, E. Micklow, I. Sénégas, R. Peyraud, L. Peyriga, and F. Théodoro Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells Leukemia 27 2013 2129 2138
-
(2013)
Leukemia
, vol.27
, pp. 2129-2138
-
-
Scotland, S.1
Saland, E.2
Skuli, N.3
De Toni, F.4
Boutzen, H.5
Micklow, E.6
Sénégas, I.7
Peyraud, R.8
Peyriga, L.9
Théodoro, F.10
-
96
-
-
84873584845
-
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
-
D.B. Shackelford, E. Abt, L. Gerken, D.S. Vasquez, A. Seki, M. Leblanc, L. Wei, M.C. Fishbein, J. Czernin, P.S. Mischel, and R.J. Shaw LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin Cancer Cell 23 2013 143 158
-
(2013)
Cancer Cell
, vol.23
, pp. 143-158
-
-
Shackelford, D.B.1
Abt, E.2
Gerken, L.3
Vasquez, D.S.4
Seki, A.5
Leblanc, M.6
Wei, L.7
Fishbein, M.C.8
Czernin, J.9
Mischel, P.S.10
Shaw, R.J.11
-
97
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
R.J. Shaw, K.A. Lamia, D. Vasquez, S.H. Koo, N. Bardeesy, R.A. Depinho, M. Montminy, and L.C. Cantley The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 2005 1642 1646
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
98
-
-
34248156160
-
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
-
Y. Shu, S.A. Sheardown, C. Brown, R.P. Owen, S. Zhang, R.A. Castro, A.G. Ianculescu, L. Yue, J.C. Lo, and E.G. Burchard Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action J. Clin. Invest. 117 2007 1422 1431
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1422-1431
-
-
Shu, Y.1
Sheardown, S.A.2
Brown, C.3
Owen, R.P.4
Zhang, S.5
Castro, R.A.6
Ianculescu, A.G.7
Yue, L.8
Lo, J.C.9
Burchard, E.G.10
-
99
-
-
82455209029
-
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
-
X. Stephenne, M. Foretz, N. Taleux, G.C. van der Zon, E. Sokal, L. Hue, B. Viollet, and B. Guigas Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status Diabetologia 54 2011 3101 3110
-
(2011)
Diabetologia
, vol.54
, pp. 3101-3110
-
-
Stephenne, X.1
Foretz, M.2
Taleux, N.3
Van Der Zon, G.C.4
Sokal, E.5
Hue, L.6
Viollet, B.7
Guigas, B.8
-
100
-
-
84903534977
-
Metformin and cancer: Mounting evidence against an association
-
S. Suissa, and L. Azoulay Metformin and cancer: mounting evidence against an association Diabetes Care 37 2014 1786 1788
-
(2014)
Diabetes Care
, vol.37
, pp. 1786-1788
-
-
Suissa, S.1
Azoulay, L.2
-
101
-
-
84901332717
-
A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake
-
A.D. Timmermans, M. Balteau, R. Gélinas, E. Renguet, A. Ginion, C. de Meester, K. Sakamoto, J.L. Balligand, F. Bontemps, and J.L. Vanoverschelde A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake Am. J. Physiol. Heart Circ. Physiol. 306 2014 H1619 H1630
-
(2014)
Am. J. Physiol. Heart Circ. Physiol.
, vol.306
, pp. 1619-H1630
-
-
Timmermans, A.D.1
Balteau, M.2
Gélinas, R.3
Renguet, E.4
Ginion, A.5
De Meester, C.6
Sakamoto, K.7
Balligand, J.L.8
Bontemps, F.9
Vanoverschelde, J.L.10
-
102
-
-
84906691535
-
Metformin Does Not Affect Cancer Risk: A Cohort Study in the U.K. Clinical Practice Research Datalink Analyzed Like an Intention-to-Treat Trial
-
K.K. Tsilidis, D. Capothanassi, N.E. Allen, E.C. Rizos, D.S. Lopez, K. van Veldhoven, C. Sacerdote, D. Ashby, P. Vineis, I. Tzoulaki, and J.P. Ioannidis Metformin Does Not Affect Cancer Risk: A Cohort Study in the U.K. Clinical Practice Research Datalink Analyzed Like an Intention-to-Treat Trial Diabetes Care 37 2014 2522 2532
-
(2014)
Diabetes Care
, vol.37
, pp. 2522-2532
-
-
Tsilidis, K.K.1
Capothanassi, D.2
Allen, N.E.3
Rizos, E.C.4
Lopez, D.S.5
Van Veldhoven, K.6
Sacerdote, C.7
Ashby, D.8
Vineis, P.9
Tzoulaki, I.10
Ioannidis, J.P.11
-
103
-
-
66849142125
-
Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin
-
M. Tsuda, T. Terada, T. Mizuno, T. Katsura, J. Shimakura, and K. Inui Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin Mol. Pharmacol. 75 2009 1280 1286
-
(2009)
Mol. Pharmacol.
, vol.75
, pp. 1280-1286
-
-
Tsuda, M.1
Terada, T.2
Mizuno, T.3
Katsura, T.4
Shimakura, J.5
Inui, K.6
-
104
-
-
0019467428
-
Metformin kinetics in healthy subjects and in patients with diabetes mellitus
-
G.T. Tucker, C. Casey, P.J. Phillips, H. Connor, J.D. Ward, and H.F. Woods Metformin kinetics in healthy subjects and in patients with diabetes mellitus Br. J. Clin. Pharmacol. 12 1981 235 246
-
(1981)
Br. J. Clin. Pharmacol.
, vol.12
, pp. 235-246
-
-
Tucker, G.T.1
Casey, C.2
Phillips, P.J.3
Connor, H.4
Ward, J.D.5
Woods, H.F.6
-
105
-
-
0032511566
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
-
UK Prospective Diabetes Study (UKPDS) Group
-
UK Prospective Diabetes Study (UKPDS) Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) Lancet 352 1998 854 865
-
(1998)
Lancet
, vol.352
, pp. 854-865
-
-
-
106
-
-
84855603512
-
Cellular and molecular mechanisms of metformin: An overview
-
B. Viollet, B. Guigas, N. Sanz Garcia, J. Leclerc, M. Foretz, and F. Andreelli Cellular and molecular mechanisms of metformin: an overview Clin. Sci. 122 2012 253 270
-
(2012)
Clin. Sci.
, vol.122
, pp. 253-270
-
-
Viollet, B.1
Guigas, B.2
Sanz Garcia, N.3
Leclerc, J.4
Foretz, M.5
Andreelli, F.6
-
107
-
-
84900468450
-
Metformin inhibits mitochondrial complex i of cancer cells to reduce tumorigenesis
-
W.W. Wheaton, S.E. Weinberg, R.B. Hamanaka, S. Soberanes, L.B. Sullivan, E. Anso, A. Glasauer, E. Dufour, G.M. Mutlu, G.S. Budigner, and N.S. Chandel Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Elife 3 2014 e02242
-
(2014)
Elife
, vol.3
, pp. 02242
-
-
Wheaton, W.W.1
Weinberg, S.E.2
Hamanaka, R.B.3
Soberanes, S.4
Sullivan, L.B.5
Anso, E.6
Glasauer, A.7
Dufour, E.8
Mutlu, G.M.9
Budigner, G.S.10
Chandel, N.S.11
-
108
-
-
84873056313
-
Chronic metformin associated cardioprotection against infarction: Not just a glucose lowering phenomenon
-
H.J. Whittington, A.R. Hall, C.P. McLaughlin, D.J. Hausenloy, D.M. Yellon, and M.M. Mocanu Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon Cardiovasc. Drugs Ther. 27 2013 5 16
-
(2013)
Cardiovasc. Drugs Ther.
, vol.27
, pp. 5-16
-
-
Whittington, H.J.1
Hall, A.R.2
McLaughlin, C.P.3
Hausenloy, D.J.4
Yellon, D.M.5
Mocanu, M.M.6
-
109
-
-
0028158709
-
Accumulation of metformin by tissues of the normal and diabetic mouse
-
C. Wilcock, and C.J. Bailey Accumulation of metformin by tissues of the normal and diabetic mouse Xenobiotica 24 1994 49 57
-
(1994)
Xenobiotica
, vol.24
, pp. 49-57
-
-
Wilcock, C.1
Bailey, C.J.2
-
110
-
-
84898619692
-
Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity
-
S.L. Woo, H. Xu, H. Li, Y. Zhao, X. Hu, J. Zhao, X. Guo, T. Guo, R. Botchlett, and T. Qi Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity PLoS ONE 9 2014 e91111
-
(2014)
PLoS ONE
, vol.9
, pp. 91111
-
-
Woo, S.L.1
Xu, H.2
Li, H.3
Zhao, Y.4
Hu, X.5
Zhao, J.6
Guo, X.7
Guo, T.8
Botchlett, R.9
Qi, T.10
-
111
-
-
84905226036
-
The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma
-
W. Wu, K. Merriman, A. Nabaah, N. Seval, D. Seval, H. Lin, M. Wang, M.H. Qazilbash, V. Baladandayuthapani, and D. Berry The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma Br. J. Cancer 111 2014 628 636
-
(2014)
Br. J. Cancer
, vol.111
, pp. 628-636
-
-
Wu, W.1
Merriman, K.2
Nabaah, A.3
Seval, N.4
Seval, D.5
Lin, H.6
Wang, M.7
Qazilbash, M.H.8
Baladandayuthapani, V.9
Berry, D.10
-
112
-
-
77954777802
-
Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway
-
H. Xiao, X. Ma, W. Feng, Y. Fu, Z. Lu, M. Xu, Q. Shen, Y. Zhu, and Y. Zhang Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway Cardiovasc. Res. 87 2010 504 513
-
(2010)
Cardiovasc. Res.
, vol.87
, pp. 504-513
-
-
Xiao, H.1
Ma, X.2
Feng, W.3
Fu, Y.4
Lu, Z.5
Xu, M.6
Shen, Q.7
Zhu, Y.8
Zhang, Y.9
-
113
-
-
79959385996
-
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
-
Z. Xie, K. Lau, B. Eby, P. Lozano, C. He, B. Pennington, H. Li, S. Rathi, Y. Dong, and R. Tian Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice Diabetes 60 2011 1770 1778
-
(2011)
Diabetes
, vol.60
, pp. 1770-1778
-
-
Xie, Z.1
Lau, K.2
Eby, B.3
Lozano, P.4
He, C.5
Pennington, B.6
Li, H.7
Rathi, S.8
Dong, Y.9
Tian, R.10
-
114
-
-
84897072824
-
Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2
-
X. Xu, Z. Lu, J. Fassett, P. Zhang, X. Hu, X. Liu, D. Kwak, J. Li, G. Zhu, and Y. Tao Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2 Hypertension 63 2014 723 728
-
(2014)
Hypertension
, vol.63
, pp. 723-728
-
-
Xu, X.1
Lu, Z.2
Fassett, J.3
Zhang, P.4
Hu, X.5
Liu, X.6
Kwak, D.7
Li, J.8
Zhu, G.9
Tao, Y.10
-
115
-
-
79953284583
-
AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress
-
C.H. Yeh, T.P. Chen, Y.C. Wang, Y.M. Lin, and S.W. Fang AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress Mediators Inflamm. 2010 2010 130636
-
(2010)
Mediators Inflamm.
, vol.2010
, pp. 130636
-
-
Yeh, C.H.1
Chen, T.P.2
Wang, Y.C.3
Lin, Y.M.4
Fang, S.W.5
-
116
-
-
79961041348
-
Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure
-
M. Yin, I.C. van der Horst, J.P. van Melle, C. Qian, W.H. van Gilst, H.H. Silljé, and R.A. de Boer Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure Am. J. Physiol. Heart Circ. Physiol. 301 2011 H459 H468
-
(2011)
Am. J. Physiol. Heart Circ. Physiol.
, vol.301
, pp. 459-H468
-
-
Yin, M.1
Van Der Horst, I.C.2
Van Melle, J.P.3
Qian, C.4
Van Gilst, W.H.5
Silljé, H.H.6
De Boer, R.A.7
-
117
-
-
33751284806
-
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
-
M. Zakikhani, R. Dowling, I.G. Fantus, N. Sonenberg, and M. Pollak Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells Cancer Res. 66 2006 10269 10273
-
(2006)
Cancer Res.
, vol.66
, pp. 10269-10273
-
-
Zakikhani, M.1
Dowling, R.2
Fantus, I.G.3
Sonenberg, N.4
Pollak, M.5
-
118
-
-
9144271181
-
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
-
M. Zang, A. Zuccollo, X. Hou, D. Nagata, K. Walsh, H. Herscovitz, P. Brecher, N.B. Ruderman, and R.A. Cohen AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells J. Biol. Chem. 279 2004 47898 47905
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47898-47905
-
-
Zang, M.1
Zuccollo, A.2
Hou, X.3
Nagata, D.4
Walsh, K.5
Herscovitz, H.6
Brecher, P.7
Ruderman, N.B.8
Cohen, R.A.9
-
119
-
-
78650658243
-
Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats
-
C.X. Zhang, S.N. Pan, R.S. Meng, C.Q. Peng, Z.J. Xiong, B.L. Chen, G.Q. Chen, F.J. Yao, Y.L. Chen, Y.D. Ma, and Y.G. Dong Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats Clin. Exp. Pharmacol. Physiol. 38 2011 55 62
-
(2011)
Clin. Exp. Pharmacol. Physiol.
, vol.38
, pp. 55-62
-
-
Zhang, C.X.1
Pan, S.N.2
Meng, R.S.3
Peng, C.Q.4
Xiong, Z.J.5
Chen, B.L.6
Chen, G.Q.7
Yao, F.J.8
Chen, Y.L.9
Ma, Y.D.10
Dong, Y.G.11
-
120
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, and N. Fujii Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest. 108 2001 1167 1174
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
-
121
-
-
66649121405
-
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: A GoDARTS study
-
K. Zhou, L.A. Donnelly, C.H. Kimber, P.T. Donnan, A.S. Doney, G. Leese, A.T. Hattersley, M.I. McCarthy, A.D. Morris, C.N. Palmer, and E.R. Pearson Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study Diabetes 58 2009 1434 1439
-
(2009)
Diabetes
, vol.58
, pp. 1434-1439
-
-
Zhou, K.1
Donnelly, L.A.2
Kimber, C.H.3
Donnan, P.T.4
Doney, A.S.5
Leese, G.6
Hattersley, A.T.7
McCarthy, M.I.8
Morris, A.D.9
Palmer, C.N.10
Pearson, E.R.11
-
122
-
-
79251612707
-
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
-
GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group Wellcome Trust Case Control Consortium 2 MAGIC investigators
-
K. Zhou, C. Bellenguez, C.C. Spencer, A.J. Bennett, R.L. Coleman, R. Tavendale, S.A. Hawley, L.A. Donnelly, C. Schofield, C.J. Groves GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group Wellcome Trust Case Control Consortium 2 MAGIC investigators Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes Nat. Genet. 43 2011 117 120
-
(2011)
Nat. Genet.
, vol.43
, pp. 117-120
-
-
Zhou, K.1
Bellenguez, C.2
Spencer, C.C.3
Bennett, A.J.4
Coleman, R.L.5
Tavendale, R.6
Hawley, S.A.7
Donnelly, L.A.8
Schofield, C.9
Groves, C.J.10
|