SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells

Circulation Research

Volumn 106, Issue 8, 2010, Pages 1384-1393

  Zu, Yi ^a   Liu, Ling ^a   Lee, Mary Y K ^a   Xu, Cheng ^a   Liang, Yan ^a   Man, Ricky Y ^a   Vanhoutte, Paul M ^a   Wang, Yu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Acetylation; AMPK; Endothelial senescence; LKB1; SIRT1

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; PROTEIN KINASE B; PROTEIN KINASE LKB1; SIRTUIN 1; PARAQUAT; PROTEASOME; PROTEIN SERINE THREONINE KINASE; SIRT1 PROTEIN, HUMAN; STK11 PROTEIN, MOUSE; THREONINE;

ANIMAL CELL; AORTA; ARTICLE; CELL AGING; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELL PROTECTION; CLINICAL ASSESSMENT; DEACETYLATION; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE OVEREXPRESSION; IN VITRO STUDY; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; UBIQUITINATION; ACETYLATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOUSE; MUTATION; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SWINE; TIME; TRANSGENIC MOUSE; UPREGULATION;

ACETYLATION; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FEMALE; GENOTYPE; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PARAQUAT; PHENOTYPE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIRTUIN 1; SWINE; THREONINE; TIME FACTORS; TRANSFECTION; UBIQUITINATION; UP-REGULATION;

EID: 77952496696     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.215483     Document Type: Article

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