-
2
-
-
77954018074
-
Dietary interventions to extend life span and health span based on calorie restriction
-
Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R. Dietary interventions to extend life span and health span based on calorie restriction. J Gerontol A Biol Sci Med Sci. 2010;65:695-703.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 695-703
-
-
Minor, R.K.1
Allard, J.S.2
Younts, C.M.3
Ward, T.M.4
De Cabo, R.5
-
3
-
-
13944253348
-
Calorie restriction - The SIR2 connection
-
Guarente L, Picard F. Calorie restriction-the SIR2 connection. Cell. 2005;120:473-482.
-
(2005)
Cell.
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
4
-
-
22744450382
-
Toward a unified theory of caloric restriction and longevity regulation
-
Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev. 2005;126:987-1002.
-
(2005)
Mech Ageing Dev.
, vol.126
, pp. 987-1002
-
-
Sinclair, D.A.1
-
5
-
-
84869398652
-
Calorie restriction enhances insulin-stimulated glucose uptake and Akt phosphorylation in both fast-twitch and slow-twitch skeletal muscle of 24-month-old rats
-
Sequea DA, Sharma N, Arias EB, Cartee GD. Calorie restriction enhances insulin-stimulated glucose uptake and Akt phosphorylation in both fast-twitch and slow-twitch skeletal muscle of 24-month-old rats. J Gerontol A Biol Sci Med Sci. 2012;67:1279-1285.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 1279-1285
-
-
Sequea, D.A.1
Sharma, N.2
Arias, E.B.3
Cartee, G.D.4
-
6
-
-
84869444066
-
Insulin resistance and aging: A cause or a protective response?
-
Barzilai N, Ferrucci L. Insulin resistance and aging: a cause or a protective response?. J Gerontol A Biol Sci Med Sci. 2012;67:1329-1331.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 1329-1331
-
-
Barzilai, N.1
Ferrucci, L.2
-
7
-
-
77953091249
-
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
-
Henis-Korenblit S, Zhang P, Hansen M, et al. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 2010;107:9730-9735.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 9730-9735
-
-
Henis-Korenblit, S.1
Zhang, P.2
Hansen, M.3
-
8
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011;17:179-188.
-
(2011)
Nat Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
-
9
-
-
84867509940
-
The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction
-
Chen Y, Hagopian K, McDonald RB, et al. The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction. J Gerontol A Biol Sci Med Sci. 2012;67:1121-1131.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 1121-1131
-
-
Chen, Y.1
Hagopian, K.2
McDonald, R.B.3
-
10
-
-
19944392873
-
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: The lesson of centenarians
-
Franceschi C, Olivieri F, Marchegiani F, et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev. 2005;126:351-361.
-
(2005)
Mech Ageing Dev.
, vol.126
, pp. 351-361
-
-
Franceschi, C.1
Olivieri, F.2
Marchegiani, F.3
-
11
-
-
84879516992
-
Mitochondrial metabolic reprogramming induced by calorie restriction
-
Martin-Montalvo A, Cabo RD. Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal 2013;19:310-320.
-
(2013)
Antioxid Redox Signal
, vol.19
, pp. 310-320
-
-
Martin-Montalvo, A.1
Cabo, R.D.2
-
12
-
-
38649132337
-
Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
-
Guarente L. Mitochondria - a nexus for aging, calorie restriction, and sirtuins?. Cell. 2008;132:171-176.
-
(2008)
Cell.
, vol.132
, pp. 171-176
-
-
Guarente, L.1
-
13
-
-
84866426621
-
Testing the oxidative stress hypothesis of aging in primate fibroblasts: Is there a correlation between species longevity and cellular ROS production?
-
Csiszar A, Podlutsky A, Podlutskaya N, et al. Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?. J Gerontol A Biol Sci Med Sci. 2012;67:841-852.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 841-852
-
-
Csiszar, A.1
Podlutsky, A.2
Podlutskaya, N.3
-
14
-
-
84876267265
-
Calorie restriction does not increase short-term or long-term protein synthesis
-
Miller BF, Robinson MM, Reuland DJ, et al. Calorie restriction does not increase short-term or long-term protein synthesis. J Gerontol A Biol Sci Med Sci. 2013;68:530-538.
-
(2013)
J Gerontol A Biol Sci Med Sci.
, vol.68
, pp. 530-538
-
-
Miller, B.F.1
Robinson, M.M.2
Reuland, D.J.3
-
15
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996;273:59-63.
-
(1996)
Science.
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
16
-
-
84871812881
-
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice
-
Fok WC, Zhang Y, Salmon AB, et al. Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci. 2013;68:108-116.
-
(2013)
J Gerontol A Biol Sci Med Sci.
, vol.68
, pp. 108-116
-
-
Fok, W.C.1
Zhang, Y.2
Salmon, A.B.3
-
17
-
-
84882379435
-
Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats
-
doi:10.1093/gerona/glt006
-
Khraiwesh H, Lopez-Dominguez JA, Lopez-Lluch G, et al. Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats. J Gerontol A Biol Sci Med Sci. 2013. doi:10.1093/gerona/glt006.
-
(2013)
J Gerontol A Biol Sci Med Sci.
-
-
Khraiwesh, H.1
Lopez-Dominguez, J.A.2
Lopez-Lluch, G.3
-
19
-
-
80053124740
-
Branched-chain amino acids, mitochondrial biogenesis, and healthspan: An evolutionary perspective
-
Valerio A, D'Antona G, Nisoli E. Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective. Aging (Albany NY). 2011;3:464-478.
-
(2011)
Aging (Albany NY).
, vol.3
, pp. 464-478
-
-
Valerio, A.1
D'antona, G.2
Nisoli, E.3
-
20
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli E, Tonello C, Cardile A, et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science. 2005;310:314-317.
-
(2005)
Science.
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
Tonello, C.2
Cardile, A.3
-
21
-
-
1342307974
-
The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption
-
Lambert AJ, Wang B, Yardley J, Edwards J, Merry BJ. The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption. Exp Gerontol. 2004;39:289-295.
-
(2004)
Exp Gerontol.
, vol.39
, pp. 289-295
-
-
Lambert, A.J.1
Wang, B.2
Yardley, J.3
Edwards, J.4
Merry, B.J.5
-
22
-
-
32444437067
-
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
-
López-Lluch G, Hunt N, Jones B, et al. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci U S A. 2006;103:1768-1773.
-
(2006)
Proc Natl Acad Sci U S A.
, vol.103
, pp. 1768-1773
-
-
López-Lluch, G.1
Hunt, N.2
Jones, B.3
-
23
-
-
84857921494
-
Calorie restriction increases cerebral mitochondrial respiratory capacity in a NO-mediated mechanism: Impact on neuronal survival
-
Cerqueira FM, Cunha FM, Laurindo FR, Kowaltowski AJ. Calorie restriction increases cerebral mitochondrial respiratory capacity in a NO-mediated mechanism: impact on neuronal survival. Free Radic Biol Med. 2012;52:1236-1241.
-
(2012)
Free Radic Biol Med.
, vol.52
, pp. 1236-1241
-
-
Cerqueira, F.M.1
Cunha, F.M.2
Laurindo, F.R.3
Kowaltowski, A.J.4
-
24
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature. 2009;460:587-591.
-
(2009)
Nature.
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
25
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol. 2005;6:298-305.
-
(2005)
Nat Rev Mol Cell Biol.
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
-
26
-
-
84875136721
-
Sirtuin activation: A role for plasma membrane in the cell growth puzzle
-
Crane FL, Navas P, Low H, Sun IL, de Cabo R. Sirtuin activation: a role for plasma membrane in the cell growth puzzle. J Gerontol A Biol Sci Med Sci. 2013;68:368-370.
-
(2013)
J Gerontol A Biol Sci Med Sci.
, vol.68
, pp. 368-370
-
-
Crane, F.L.1
Navas, P.2
Low, H.3
Sun, I.L.4
De Cabo, R.5
-
27
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010;12:662-667.
-
(2010)
Cell Metab.
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
28
-
-
84870352685
-
SIRT3 weighs heavily in the metabolic balance: A new role for SIRT3 in metabolic syndrome
-
Green MF, Hirschey MD. SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. J Gerontol A Biol Sci Med Sci. 2013;68:105-107.
-
(2013)
J Gerontol A Biol Sci Med Sci.
, vol.68
, pp. 105-107
-
-
Green, M.F.1
Hirschey, M.D.2
-
29
-
-
84859077841
-
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: A novel model of vascular aging
-
Bailey-Downs LC, Mitschelen M, Sosnowska D, et al. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 2012;67:313-329.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 313-329
-
-
Bailey-Downs, L.C.1
Mitschelen, M.2
Sosnowska, D.3
-
30
-
-
67651151249
-
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
-
Pawlikowska L, Hu D, Huntsman S, et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell. 2009;8:460-472.
-
(2009)
Aging Cell.
, vol.8
, pp. 460-472
-
-
Pawlikowska, L.1
Hu, D.2
Huntsman, S.3
-
31
-
-
0036856578
-
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
-
Rongvaux A, Shea RJ, Mulks MH, et al. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol. 2002;32:3225-3234.
-
(2002)
Eur J Immunol.
, vol.32
, pp. 3225-3234
-
-
Rongvaux, A.1
Shea, R.J.2
Mulks, M.H.3
-
32
-
-
83455206803
-
Targeting sirtuin 1 to improve metabolism: All you need is NAD(+)?
-
Cantó C, Auwerx J. Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?. Pharmacol Rev. 2012;64:166-187.
-
(2012)
Pharmacol Rev.
, vol.64
, pp. 166-187
-
-
Cantó, C.1
Auwerx, J.2
-
33
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
-
Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14:528-536.
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
34
-
-
79957945033
-
Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction
-
Wang P, Yang FJ, Du H, et al. Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med. 2011;17:523-532.
-
(2011)
Mol Med.
, vol.17
, pp. 523-532
-
-
Wang, P.1
Yang, F.J.2
Du, H.3
-
35
-
-
79952537492
-
Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway
-
Wang P, Xu TY, Guan YF, et al. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol. 2011;69:360-374.
-
(2011)
Ann Neurol.
, vol.69
, pp. 360-374
-
-
Wang, P.1
Xu, T.Y.2
Guan, Y.F.3
-
36
-
-
58449109119
-
Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide
-
Wang P, Xu TY, Guan YF, et al. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovasc Res. 2009;81:370-380.
-
(2009)
Cardiovasc Res.
, vol.81
, pp. 370-380
-
-
Wang, P.1
Xu, T.Y.2
Guan, Y.F.3
-
37
-
-
80053198889
-
Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats
-
Wang P, Tian WW, Song J, Guan YF, Miao CY. Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats. CNS Neurosci Ther. 2011;17:327-332.
-
(2011)
CNS Neurosci Ther.
, vol.17
, pp. 327-332
-
-
Wang, P.1
Tian, W.W.2
Song, J.3
Guan, Y.F.4
Miao, C.Y.5
-
38
-
-
84860561281
-
Loss of AMP-activated protein kinase-?2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle
-
Wang P, Zhang RY, Song J, et al. Loss of AMP-activated protein kinase-?2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes. 2012;61:1051-1061.
-
(2012)
Diabetes.
, vol.61
, pp. 1051-1061
-
-
Wang, P.1
Zhang, R.Y.2
Song, J.3
-
39
-
-
79953651525
-
Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, Akt and mitochondrial biogenesis
-
Cerqueira FM, Laurindo FR, Kowaltowski AJ. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, Akt and mitochondrial biogenesis. PLoS One. 2011;6:e18433.
-
(2011)
PLoS One.
, vol.6
-
-
Cerqueira, F.M.1
Laurindo, F.R.2
Kowaltowski, A.J.3
-
40
-
-
84870538183
-
Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis
-
Lanza IR, Zabielski P, Klaus KA, et al. Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metab. 2012;16:777-788.
-
(2012)
Cell Metab.
, vol.16
, pp. 777-788
-
-
Lanza, I.R.1
Zabielski, P.2
Klaus, K.A.3
-
41
-
-
84860131782
-
Pilot study of resveratrol in older adults with impaired glucose tolerance
-
Crandall JP, Oram V, Trandafirescu G, et al. Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci. 2012;67:1307-1312.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 1307-1312
-
-
Crandall, J.P.1
Oram, V.2
Trandafirescu, G.3
-
42
-
-
84856171338
-
Challenges of translating basic research into therapeutics: Resveratrol as an example
-
Smoliga JM, Vang O, Baur JA. Challenges of translating basic research into therapeutics: resveratrol as an example. J Gerontol A Biol Sci Med Sci. 2012;67:158-167.
-
(2012)
J Gerontol A Biol Sci Med Sci.
, vol.67
, pp. 158-167
-
-
Smoliga, J.M.1
Vang, O.2
Baur, J.A.3
-
43
-
-
84886052315
-
Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes
-
doi: 10.1093/gerona/glt019
-
Mitterberger MC, Zwerschke W. Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes. J Gerontol A Biol Sci Med Sci. 2013. doi: 10.1093/gerona/glt019.
-
(2013)
J Gerontol A Biol Sci Med Sci.
-
-
Mitterberger, M.C.1
Zwerschke, W.2
-
44
-
-
84875145418
-
Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts
-
Pitozzi V, Mocali A, Laurenzana A, et al. Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts. J Gerontol A Biol Sci Med Sci. 2013;68:371-381.
-
(2013)
J Gerontol A Biol Sci Med Sci.
, vol.68
, pp. 371-381
-
-
Pitozzi, V.1
Mocali, A.2
Laurenzana, A.3
-
45
-
-
84871876229
-
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
-
Strong R, Miller RA, Astle CM, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2013;68:6-16.
-
(2013)
J Gerontol A Biol Sci Med Sci.
, vol.68
, pp. 6-16
-
-
Strong, R.1
Miller, R.A.2
Astle, C.M.3
-
46
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 2000;289:2126-2128.
-
(2000)
Science.
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
47
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone L, Cohen D, Robinson A, et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell. 2007;6:759-767.
-
(2007)
Aging Cell.
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
-
48
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004;305:390-392.
-
(2004)
Science.
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
-
49
-
-
80053168829
-
Absence of effects of Sir2 overexpression on lifespan in C. Elegans and Drosophila
-
Burnett C, Valentini S, Cabreiro F, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 2011;477:482-485.
-
(2011)
Nature.
, vol.477
, pp. 482-485
-
-
Burnett, C.1
Valentini, S.2
Cabreiro, F.3
-
50
-
-
10944270187
-
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
-
Revollo JR, Grimm AA, Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem. 2004;279:50754-50763.
-
(2004)
J Biol Chem.
, vol.279
, pp. 50754-50763
-
-
Revollo, J.R.1
Grimm, A.A.2
Imai, S.3
-
51
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 2003;423:181-185.
-
(2003)
Nature.
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
52
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D, Bruno J, Easlon E, et al. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008;22:1753-1757.
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
-
53
-
-
19944433652
-
Visfatin: A protein secreted by visceral fat that mimics the effects of insulin
-
Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005;307:426-430.
-
(2005)
Science.
, vol.307
, pp. 426-430
-
-
Fukuhara, A.1
Matsuda, M.2
Nishizawa, M.3
-
54
-
-
35549002189
-
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme
-
Revollo JR, Körner A, Mills KF, et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6:363-375.
-
(2007)
Cell Metab.
, vol.6
, pp. 363-375
-
-
Revollo, J.R.1
Körner, A.2
Mills, K.F.3
-
55
-
-
65549103855
-
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
-
Ramsey KM, Yoshino J, Brace CS, et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009;324:651-654.
-
(2009)
Science.
, vol.324
, pp. 651-654
-
-
Ramsey, K.M.1
Yoshino, J.2
Brace, C.S.3
-
56
-
-
65549118773
-
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
-
Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science. 2009;324:654-657.
-
(2009)
Science.
, vol.324
, pp. 654-657
-
-
Nakahata, Y.1
Sahar, S.2
Astarita, G.3
Kaluzova, M.4
Sassone-Corsi, P.5
-
57
-
-
59649117804
-
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
-
Van Gool F, Gallí M, Gueydan C, et al. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med. 2009;15:206-210.
-
(2009)
Nat Med.
, vol.15
, pp. 206-210
-
-
Van Gool, F.1
Gallí, M.2
Gueydan, C.3
-
58
-
-
67651085546
-
Treatment of viral hepatitis B infection in patients receiving intensive immunosuppressive therapies
-
Genet P, Touahri T, Morel V. Treatment of viral hepatitis B infection in patients receiving intensive immunosuppressive therapies. Blood. 2009;113:6034.
-
(2009)
Blood.
, vol.113
, pp. 6034
-
-
Genet, P.1
Touahri, T.2
Morel, V.3
-
59
-
-
38149105811
-
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
-
Holen K, Saltz LB, Hollywood E, Burk K, Hanauske AR. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs. 2008;26:45-51.
-
(2008)
Invest New Drugs.
, vol.26
, pp. 45-51
-
-
Holen, K.1
Saltz, L.B.2
Hollywood, E.3
Burk, K.4
Hanauske, A.R.5
-
60
-
-
33745817828
-
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents
-
Khan JA, Tao X, Tong L. Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat Struct Mol Biol. 2006;13:582-588.
-
(2006)
Nat Struct Mol Biol.
, vol.13
, pp. 582-588
-
-
Khan, J.A.1
Tao, X.2
Tong, L.3
-
61
-
-
0242526050
-
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
-
Hasmann M, Schemainda I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 2003;63:7436-7442.
-
(2003)
Cancer Res.
, vol.63
, pp. 7436-7442
-
-
Hasmann, M.1
Schemainda, I.2
-
62
-
-
84873291018
-
Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: Metabolic basis and potential clinical implications
-
Tan B, Young DA, Lu ZH, et al. Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. J Biol Chem. 2013;288:3500-3511.
-
(2013)
J Biol Chem.
, vol.288
, pp. 3500-3511
-
-
Tan, B.1
Young, D.A.2
Lu, Z.H.3
-
63
-
-
84862697493
-
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)- dependent manner
-
Cerna D, Li H, Flaherty S, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)- dependent manner. J Biol Chem. 2012;287:22408-22417.
-
(2012)
J Biol Chem.
, vol.287
, pp. 22408-22417
-
-
Cerna, D.1
Li, H.2
Flaherty, S.3
|