SIRT1 regulates HIV transcription via Tat deacetylation

PLoS Biology

Volumn 3, Issue 2, 2005, Pages 0210-0220

  Pagans, Sara ^a   Pedal, Angelika ^a   North, Brian J ^a   Kaehlcke, Katrin ^a   Marshall, Brett L ^a   Dorr, Alexander ^b   Hetzer Egger, Claudia ^b   Henklein, Peter ^c   Frye, Roy ^d   McBurney, Michael W ^e   Hruby, Henning ^f   Jung, Manfred ^f   Verdin, Eric ^a   Ott, Melanie ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e OTTAWA REGIONAL CANCER CENTRE   (Canada)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN INHIBITOR; PROTEIN P300; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN; SIRTUIN 1; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; HISTONE DEACETYLASE; PRIMER DNA; SIRT1 PROTEIN, HUMAN;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEACETYLATION; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOPRECIPITATION; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; VIRUS TRANSCRIPTION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

HUMAN IMMUNODEFICIENCY VIRUS;

ACETYLATION; BASE SEQUENCE; DNA PRIMERS; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; HISTONE DEACETYLASES; HIV; HUMANS; MOLECULAR SEQUENCE DATA; SIRTUIN 1; SIRTUINS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION, GENETIC;

EID: 20144372893     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0030041     Document Type: Article

References (64)

1. Kao SY, Calman AF, Luciw PA, Peterlin BM (1987) Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product. Nature 330: 489-493.
2. Toohey MG, Jones KA (1989) In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions. Genes Dev 3: 265-282.
3. Rosen CA, Sodroski JG, Haseltine WA (1985) The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell 41: 813-823.
4. Feng S, Holland EC (1988) HIV-1 tat trans-activation requires the loop sequence within tar. Nature 334: 165-167.
5. Wei P, Garber ME, Fang SM, Fischer WH, Jones KA (1998) A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 92: 451-462.
6. Zhu Y, Pe'ery T, Peng J, Ramanathan Y, Marshall N, et al. (1997) Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev 11: 2622-2632.
7. Kiernan RE, Vanhulle C, Schiltz L, Adam E, Xiao H, et al. (1999) HIV-1 tat transcriptional activity is regulated by acetylation. EMBO J 18: 6106-6118.
8. Ott M, Schnolzer M, Garnica J, Fischle W, Emiliani S, et al. (1999) Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Curr Biol 9: 1489-1492.
9. Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, et al. (2000) Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. Virology 277: 278-295.
10. Col E, Caron C, Seigneurin-Berny D, Gracia J, Favier A, et al. (2001) The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. J Biol Chem 276: 28179-28184.
11. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, et al. (2003) Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell 12: 167-176.
12. Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, et al. (2002) Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell 9: 575-586.
13. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, et al. (2002) Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J 21: 2715-2723.
14. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): Characterization of the classical HDAC family. Biochem J 370: 737-749.
15. Verdin E, Dequiedt F, Kasler HG (2003) Class II histone deacetylases: Versatile regulators. Trends Genet 19: 286-293.
16. Gasser SM, Cockell MM (2001) The molecular biology of the SIR proteins. Gene 279: 1-16.
17. Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
18. Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97: 5807-5811.
19. +-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97: 6658-6663.
20. North BJ, Verdin E (2004) Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol 5: 224.
21. Luo J, Nikolaev AY, Imai S, Chen D, Su F, et al. (2001) Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107: 137-148.
22. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
23. Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, et al. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J 21: 2383-2396.
24. I68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J 20: 1353-1362.
25. Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, et al. (2003) Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell 12: 51-62.
26. Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563.
27. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015.
28. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, et al. (2004) Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23: 2369-2380.
29. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, et al. (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392.
30. +-dependent tubulin deacetylase. Mol Cell 11: 437-444.
31. Schwer B, North BJ, Frye RA, Ott M, Verdin E (2002) The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 158: 647-657.
32. Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP (2002) SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A 99: 13653-13658.
33. Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, et al. (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16: 93-105.
34. + in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun 278: 685-690.
35. Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 277: 45099-45107.
36. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, et al. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
37. McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, et al. (2003) The mammalian SIR2α protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23: 38-54.
38. Garber ME, Wei P, KewalRamani VN, Mayall TP, Herrmann CH, et al. (1998) The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev 12: 3512-3527.
39. Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR (1998) Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. EMBO J 17: 7056-7065.
40. Roy S, Delling U, Chen CH, Rosen CA, Sonenberg N (1990) A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev 4: 1365-1373.
41. Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA (2001) Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A 98: 15113-15118.
42. +-dependent deacetylases using phenotypic screens in yeast. J Biol Chem 278: 52773-52782.
43. Jordan A, Bisgrove D, Verdin E (2003) HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J 22: 1868-1877.
44. Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, et al. (2003) Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem 278: 43041-43050.
45. Takata T, Ishikawa F (2003) Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun 301: 250-257.
46. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 429: 771-776.
47. Brooks CL, Gu W (2003) Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation. Curr Opin Cell Biol 15: 164-171.
48. Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, et al. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A 100: 10794-10799.
49. Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, et al. (2003) Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. EMBO J 22: 2156-2166.
50. Luo J, Su F, Chen D, Shiloh A, Gu W (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408: 377-381.
51. Coull JJ, Romerio F, Sun JM, Volker JL, Galvin KM, et al. (2000) The human factors YY1 and LSF repress the human immunode.ciency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J Virol 74: 6790-6799.
52. Witte V, Laffert B, Rosorius O, Lischka P, Blume K, et al. (2004) HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Mol Cell 13: 179-190.
53. Chen L, Fischle W, Verdin E, Greene WC (2001) Duration of nuclear NF-κB action regulated by reversible acetylation. Science 293: 1653-1657.
54. Van Lint C, Emiliani S, Ott M, Verdin E (1996) Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J 15: 1112-1120.
55. Emiliani S, Van Lint C, Fischle W, Paras P, Jr, Ott M, et al. (1996) A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency. Proc Natl Acad Sci U S A 93: 6377-6381.
56. Sheridan PL, Mayall TP, Verdin E, Jones KA (1997) Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes Dev 11: 3327-3340.
57. Sartorelli V, Puri PL, Hamamori Y, Ogryzko V, Chung G, et al. (1999) Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell 4: 725-734.
58. Emiliani S, Fischle W, Ott M, Van Lint C, Amella CA, et al. (1998) Mutations in the tat gene are responsible for human immunode.ciency virus type 1 postintegration latency in the U1 cell line. J Virol 72: 1666-1670.
59. Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, et al. (1999) Activation of PPARγ coactivator-1 through transcription factor docking. Science 286: 1368-1371.
60. Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, et al. (1997) Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science 275: 1481-1485.
61. Jacobs RT, Wright AD, Smith FX (1982) Condensation of monosubstituted isopropylidene malonates with mannich bases. J Org Chem 47: 3769-3772.
62. +-dependent deacetylases. J Biol Chem 277: 12632-12641.
63. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, et al. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263-267.
64. Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D (1997) Multiply attenuated lentiviral vector achieves ef.cient gene delivery in vivo. Nat Biotechnol 15: 871-875.