Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

Cancer Cell

Volumn 14, Issue 4, 2008, Pages 312-323

  Wang, Rui Hong ^a   Sengupta, Kundan ^b   Li, Cuiling ^a   Kim, Hyun Seok ^a   Cao, Liu ^a   Xiao, Cuiying ^a   Kim, Sangsoo ^a   Xu, Xiaoling ^a   Zheng, Yin ^a   Chilton, Beverly ^c   Jia, Rong ^b   Zheng, Zhi Ming ^b   Appella, Ettore ^b   Wang, Xin Wei ^b   Ried, Thomas ^b   Deng, Chu Xia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

CELLCYCLE

Indexed keywords

RESVERATROL; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; FEMALE; GENE; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SIRT1 GENE; TUMOR;

EUKARYOTA; MUS;

EID: 53149137486     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2008.09.001     Document Type: Article

References (52)

1. Aggarwal B.B., Bhardwaj A., Aggarwal R.S., Seeram N.P., Shishodia S., and Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24 (2004) 2783-2840
2. Antoccia A., Ricordy R., Maraschio P., Prudente S., and Tanzarella C. Chromosomal sensitivity to clastogenic agents and cell cycle perturbations in Nijmegen breakage syndrome lymphoblastoid cell lines. Int. J. Radiat. Biol. 71 (1997) 41-49
3. Aziz M.H., Afaq F., and Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem. Photobiol. 81 (2005) 25-31
4. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
5. Blander G., and Guarente L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73 (2004) 417-435
6. Bradbury C.A., Khanim F.L., Hayden R., Bunce C.M., White D.A., Drayson M.T., Craddock C., and Turner B.M. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 19 (2005) 1751-1759
7. Celeste A., Difilippantonio S., Difilippantonio M.J., Fernandez-Capetillo O., Pilch D.R., Sedelnikova O.A., Eckhaus M., Ried T., Bonner W.M., and Nussenzweig A. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114 (2003) 371-383
8. Chen W.Y., Wang D.H., Yen R.C., Luo J., Gu W., and Baylin S.B. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 (2005) 437-448
9. Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., and Chua K.F. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100 (2003) 10794-10799
10. Delmas D., Lancon A., Colin D., Jannin B., and Latruffe N. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr. Drug Targets 7 (2006) 423-442
11. Deng C., Wynshaw-Boris A., Zhou F., Kuo A., and Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84 (1996) 911-921
12. Deng C.X. Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice. Mutat. Res. 477 (2001) 183-189
13. Deng C.X. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response, and cancer evolution. Nucleic Acids Res. 34 (2006) 1416-1426
14. Deng C.X., and Xu X. Generation and analysis of Brca1 conditional knockout mice. Methods Mol. Biol. 280 (2004) 185-200
15. Denu J.M. Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases. Trends Biochem. Sci. 28 (2003) 41-48
16. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery Jr. C.A., Butel J.S., and Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
17. Ferguson D.O., and Alt F.W. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 20 (2001) 5572-5579
18. Firestein R., Blander G., Michan S., Oberdoerffer P., Ogino S., Campbell J., Bhimavarapu A., Luikenhuis S., de Cabo R., Fuchs C., et al. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3 (2008) e2020
19. Gasser S.M., and Cockell M.M. The molecular biology of the SIR proteins. Gene 279 (2001) 1-16
20. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 14 (2000) 1021-1026
21. Haigis M.C., and Guarente L.P. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20 (2006) 2913-2921
22. Harper C.E., Patel B.B., Wang J., Arabshahi A., Eltoum I.A., and Lamartiniere C.A. Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 28 (2007) 1946-1953
23. Hida Y., Kubo Y., Murao K., and Arase S. Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch. Dermatol. Res. 299 (2007) 103-106
24. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003) 191-196
25. Huffman D.M., Grizzle W.E., Bamman M.M., Kim J.S., Eltoum I.A., Elgavish A., and Nagy T.R. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res. 67 (2007) 6612-6618
26. Jeong J., Juhn K., Lee H., Kim S.H., Min B.H., Lee K.M., Cho M.H., Park G.H., and Lee K.H. SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp. Mol. Med. 39 (2007) 8-13
27. Kim J.E., Chen J., and Lou Z. DBC1 is a negative regulator of SIRT1. Nature 451 (2008) 583-586
28. Kobayashi J. Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain. J. Radiat. Res. (Tokyo) 45 (2004) 473-478
29. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 (2006) 1109-1122
30. Lain S., Hollick J.J., Campbell J., Staples O.D., Higgins M., Aoubala M., McCarthy A., Appleyard V., Murray K.E., Baker L., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 (2008) 454-463
31. Lakso M., Pichel J.G., Gorman J.R., Sauer B., Okamoto Y., Lee E., Alt F.W., and Westphal H. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93 (1996) 5860-5865
32. Li T., Fan G.X., Wang W., and Yuan Y.K. Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. Int. Immunopharmacol. 7 (2007) 1221-1231
33. Lim C.S. SIRT1: tumor promoter or tumor suppressor?. Med. Hypotheses 67 (2006) 341-344
34. McAinsh A.D., Scott-Drew S., Murray J.A., and Jackson S.P. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr. Biol. 9 (1999) 963-966
35. McBurney M.W., Yang X., Jardine K., Hixon M., Boekelheide K., Webb J.R., Lansdorp P.M., and Lemieux M. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23 (2003) 38-54
36. Mills K.D., Sinclair D.A., and Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97 (1999) 609-620
37. Nagy A., Rossant J., Nagy R., Abramow-Newerly W., and Roder J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90 (1993) 8424-8428
38. Padilla-Nash H.M., Barenboim-Stapleton L., Difilippantonio M.J., and Ried T. Spectral karyotyping analysis of human and mouse chromosomes. Nat. Protoc. 1 (2006) 3129-3142
39. Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., and Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10 (2000) 886-895
40. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
41. Saunders L.R., and Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 26 (2007) 5489-5504
42. Shen S.X., Weaver Z., Xu X., Li C., Weinstein M., Chen L., Guan X.Y., Ried T., and Deng C.X. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 17 (1998) 3115-3124
43. Stunkel W., Peh B.K., Tan Y.C., Nayagam V.M., Wang X., Salto-Tellez M., Ni B., Entzeroth M., and Wood J. Function of the SIRT1 protein deacetylase in cancer. Biotechnol. J. 2 (2007) 1360-1368
44. Tsukamoto Y., Kato J., and Ikeda H. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388 (1997) 900-903
45. Turner J.M., Aprelikova O., Xu X., Wang R., Kim S., Chandramouli G.V., Barrett J.C., Burgoyne P.S., and Deng C.X. BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr. Biol. 14 (2004) 2135-2142
46. Vaquero A., Sternglanz R., and Reinberg D. NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 26 (2007) 5505-5520
47. Wang R.H., Yu H., and Deng C.X. A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc. Natl. Acad. Sci. USA 101 (2004) 17108-17113
48. Whitsett T., Carpenter M., and Lamartiniere C.A. Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats. J. Carcinog. 5 (2006) 15
49. Xu X., Qiao W., Linke S.P., Cao L., Li W.M., Furth P.A., Harris C.C., and Deng C.X. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat. Genet. 28 (2001) 266-271
50. Yamashita T., Forgues M., Wang W., Kim J.W., Ye Q., Jia H., Budhu A., Zanetti K.A., Chen Y., Qin L.X., et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 68 (2008) 1451-1461
51. Yuan Z., Zhang X., Sengupta N., Lane W.S., and Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27 (2007) 149-162
52. Zhao W., Kruse J.P., Tang Y., Jung S.Y., Qin J., and Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451 (2008) 587-590