P16INK4A suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Li, Yuanyuan ^a   Tollefsbol, Trygve O ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUCOSE; PROTEIN KINASE B; S6 KINASE; SIRTUIN 1; SIRT1 PROTEIN, HUMAN;

ARTICLE; CALORIC RESTRICTION; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; EPIGENETICS; FETUS; FIBROBLAST CULTURE; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIFE EXTENSION; PROCESS DEVELOPMENT; PROMOTER REGION; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENE SILENCING; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALIA; MAMMALIA;

CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOWN-REGULATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 79952083769     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017421     Document Type: Article

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