NF-κB activation by reactive oxygen species: Fifteen years later

Biochemical Pharmacology

Volumn 72, Issue 11, 2006, Pages 1493-1505

  Gloire, Geoffrey ^a   Legrand Poels, Sylvie ^a   Piette, Jacques ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Cellular signalling; Cytokines; LPS; NF B; Reactive oxygen species

Indexed keywords

CYTOKINE; EPIGALLOCATECHIN GALLATE; FAS ANTIGEN; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LYMPHOCYTE ANTIGEN RECEPTOR; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR; TROLOX C; TUMOR NECROSIS FACTOR ALPHA;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL TYPE; CYTOKINE PRODUCTION; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; NEUTROPHIL; OXIDATION REDUCTION REACTION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECT; EPITHELIUM CELL; HUMAN; METABOLISM; OXIDATIVE STRESS; REVIEW; T LYMPHOCYTE;

ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; I-KAPPA B KINASE; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; NF-KAPPA B; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750523632     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.04.011     Document Type: Article

References (137)

1. Adler V., Yin Z., Tew K.D., and Ronai Z. Role of redox potential and reactive oxygen species in stress signalling. Oncogene 18 45 (1999) 6104-6111
2. Haddad J.J. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cell Signal 14 11 (2002) 879-897
3. Ogawa Y., Kobayashi T., Nishioka A., Kariya S., Hamasato S., Seguchi H., et al. Radiation-induced oxidative DNA damage, 8-oxoguanine, in human peripheral T cells. Int J Mol Med 11 1 (2003) 27-32
4. Genova M.L., Pich M.M., Bernacchia A., Bianchi C., Biondi A., Bovina C., et al. The mitochondrial production of reactive oxygen species in relation to aging and pathology. Ann NY Acad Sci 1011 (2004) 86-100
5. Babior B.M. NADPH oxidase: an update. Blood 93 5 (1999) 1464-1476
6. Griendling K.K., and Harrison D.G. Dual role of reactive oxygen species in vascular growth. Circ Res 85 6 (1999) 562-563
7. Van Heerebeek L., Meischl C., Stooker W., Meijer C.J., Niessen H.W., and Roos D. NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?. J Clin Pathol 55 8 (2002) 561-568
8. Kuhn H., and Thiele B.J. The diversity of the lipoxygenase family. Many sequence data but little information on biological significance. FEBS Lett 449 1 (1999) 7-11
9. Kuehl Jr. F.A., and Egan R.W. Prostaglandins, arachidonic acid, and inflammation. Science 210 4473 (1980) 978-984
10. Hampton M.B., Kettle A.J., and Winterbourn C.C. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 92 9 (1998) 3007-3017
11. Volanti C., Matroule J.Y., and Piette J. Involvement of oxidative stress in NF-kappaB activation in endothelial cells treated by photodynamic therapy. Photochem Photobiol 75 1 (2002) 36-45
12. Engelhardt J.F. Redox-mediated gene therapies for environmental injury: approaches and concepts. Antioxid Redox Signal 1 1 (1999) 5-27
13. Rhee S.G., Chang T.S., Bae Y.S., Lee S.R., and Kang S.W. Cellular regulation by hydrogen peroxide. J Am Soc Nephrol 14 8 Suppl. 3 (2003) S211-S215
14. Hensley K., Robinson K.A., Gabbita S.P., Salsman S., and Floyd R.A. Reactive oxygen species, cell signaling, and cell injury. Free Rad Biol Med 28 10 (2000) 1456-1462
15. Lander H.M. An essential role for free radicals and derived species in signal transduction. FASEB J 11 2 (1997) 118-124
16. Tonks N.K. Redox redux: revisiting PTPs and the control of cell signalling. Cell 121 5 (2005) 667-670
17. Aslan M., and Ozben T. Oxidants in receptor tyrosine kinase signal transduction pathways. Antioxid Redox Signal 5 6 (2003) 781-788
18. Halliwell B., and Gutteridge J. Free radicals in biology and medicine (1999), Oxford University Press, Oxford
19. Schreck R., Rieber P., and Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10 8 (1991) 2247-2258
20. Legrand-Poels S., Vaira D., Pincemail J., van de Vorst A., and Piette J. Activation of human immunodeficiency virus type 1 by oxidative stress. AIDS Res Hum Retroviruses 6 12 (1990) 1389-1397
21. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev 18 18 (2004) 2195-2224
22. Martin M.U., and Wesche H. Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim Biophys Acta 1592 3 (2002) 265-280
23. Devin A., Cook A., Lin Y., Rodriguez Y., Kelliher M., and Liu Z. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12 4 (2000) 419-429
24. O'Neill L.A. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol 18 1 (2006) 3-9
25. Weil R., and Israel A. T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes. Curr Opin Immunol 16 3 (2004) 374-381
26. Bonizzi G., and Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25 6 (2004) 280-288
27. Weil R., and Israel A. Deciphering the pathway from the TCR to NF-kappaB. Cell Death Differ (2006)
28. Yamaoka S., Courtois G., Bessia C., Whiteside S.T., Weil R., Agou F., et al. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 93 7 (1998) 1231-1240
29. Zandi E., Rothwarf D.M., Delhase M., Hayakawa M., and Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91 2 (1997) 243-252
30. Claudio E., Brown K., Park S., Wang H., and Siebenlist U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat Immunol 3 10 (2002) 958-965
31. Dejardin E., Droin N.M., Delhase M., Haas E., Cao Y., Makris C., et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 17 4 (2002) 525-535
32. Coope H.J., Atkinson P.G., Huhse B., Belich M., Janzen J., Holman M.J., et al. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J 21 20 (2002) 5375-5385
33. Eliopoulos A.G., Caamano J.H., Flavell J., Reynolds G.M., Murray P.G., Poyet J.L., et al. Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway. Oncogene 22 48 (2003) 7557-7569
34. Xiao G., Cvijic M.E., Fong A., Harhaj E.W., Uhlik M.T., Waterfield M., et al. Retroviral oncoprotein tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 20 23 (2001) 6805-6815
35. Haddad J.J. Oxygen sensing and oxidant/redox-related pathways. Biochem Biophys Res Commun 316 4 (2004) 969-977
36. Li N., and Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J 13 10 (1999) 1137-1143
37. Devadas S., Zaritskaya L., Rhee S.G., Oberley L., and Williams M.S. Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med 195 1 (2002) 59-70
38. Hildeman D.A. Regulation of T-cell apoptosis by reactive oxygen species. Free Rad Biol Med 36 12 (2004) 1496-1504
39. Kim H., Kim Y.N., and Kim C.W. Oxidative stress attenuates Fas-mediated apoptosis in Jurkat T cell line through Bfl-1 induction. Oncogene 24 7 (2005) 1252-1261
40. Chou W.C., and Dang C.V. Acute promyelocytic leukemia: recent advances in therapy and molecular basis of response to arsenic therapies. Curr Opin Hematol 12 1 (2005) 1-6
41. Chandra J., Hackbarth J., Le S., Loegering D., Bone N., Bruzek L.M., et al. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood 102 13 (2003) 4512-4519
42. Schoonbroodt S., Ferreira V., Best-Belpomme M., Boelaert J.R., Legrand-Poels S., Korner M., et al. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress. J Immunol 164 8 (2000) 4292-4300
43. Takada Y., Mukhopadhyay A., Kundu G.C., Mahabeleshwar G.H., Singh S., and Aggarwal B.B. Hydrogen peroxide activates NF-{kappa}B through tyrosine phosphorylation of I{kappa}B{alpha} and serine phosphorylation of p65: evidence for the involvement of I{kappa}B{alpha} kinase and Syk protein-tyrosine kinase. J Biol Chem 278 26 (2003) 24233-24241
44. Livolsi A., Busuttil V., Imbert V., Abraham R.T., and Peyron J.F. Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem 268 5 (2001) 1508-1515
45. Imbert V., Rupec R.A., Livolsi A., Pahl H.L., Traenckner E.B., Mueller-Dieckmann C., et al. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86 5 (1996) 787-798
46. Beraud C., Henzel W.J., and Baeuerle P.A. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 96 2 (1999) 429-434
47. Gloire G, Charlier E, Rahmouni S, Volanti C, Erneux C and Piette J, Restoration of SHIP-1 activity in human leukemic cells modifies NF-kappaB activation pathway and cellular survival upon oxidative stress. Oncogene, in press.
48. Krystal G. Lipid phosphatases in the immune system. Semin Immunol 12 4 (2000) 397-403
49. Freeburn R.W., Wright K.L., Burgess S.J., Astoul E., Cantrell D.A., and Ward S.G. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. J Immunol 169 10 (2002) 5441-5450
50. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 5573 (2002) 1655-1657
51. Anderson M.T., Staal F.J., Gitler C., and Herzenberg L.A. Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway. Proc Natl Acad Sci USA 91 24 (1994) 11527-11531
52. Sen C.K., Roy S., and Packer L. Involvement of intracellular Ca2+ in oxidant-induced NF-kappa B activation. FEBS Lett 385 1-2 (1996) 58-62
53. Storz P., Doppler H., and Toker A. Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol 24 7 (2004) 2614-2626
54. Storz P., and Toker A. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J 22 1 (2003) 109-120
55. Fan C., Li Q., Ross D., and Engelhardt J.F. Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem 278 3 (2003) 2072-2080
56. Korn S.H., Wouters E.F., Vos N., and Janssen-Heininger Y.M. Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase. J Biol Chem 276 38 (2001) 35693-35700
57. Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403 6765 (2000) 103-108
58. Kapahi P., Takahashi T., Natoli G., Adams S.R., Chen Y., Tsien R.Y., et al. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 275 46 (2000) 36062-36066
59. Moodie F.M., Marwick J.A., Anderson C.S., Szulakowski P., Biswas S.K., Bauter M.R., et al. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J 18 15 (2004) 1897-1899
60. Hawkins C.L., and Davies M.J. Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation. Biochem J 340 Pt. 2 (1999) 539-548
61. Schoonbroodt S., Legrand-Poels S., Best-Belpomme M., and Piette J. Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem J 321 Pt. 3 (1997) 777-785
62. Barua M., Liu Y., and Quinn M.R. Taurine chloramine inhibits inducible nitric oxide synthase and TNF-alpha gene expression in activated alveolar macrophages: decreased NF-kappaB activation and IkappaB kinase activity. J Immunol 167 4 (2001) 2275-2281
63. Kanayama A., Inoue J., Sugita-Konishi Y., Shimizu M., and Miyamoto Y. Oxidation of Ikappa Balpha at methionine 45 is one cause of taurine chloramine-induced inhibition of NF-kappa B activation. J Biol Chem 277 27 (2002) 24049-24056
64. Ogino T., Hosako M., Hiramatsu K., Omori M., Ozaki M., and Okada S. Oxidative modification of IkappaB by monochloramine inhibits tumor necrosis factor alpha-induced NF-kappaB activation. Biochim Biophys Acta 1746 2 (2005) 135-142
65. Thomas E.L., Grisham M.B., and Jefferson M.M. Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils. J Clin Invest 72 2 (1983) 441-454
66. Midwinter R.G., Cheah F.C., Moskovitz J., Vissers M.C., and Winterbourn C.C. IkappaB is a sensitive target for oxidation by cell-permeable chloramines: inhibition of NF-kappaB activity by glycine chloramine through methionine oxidation. Biochem J 396 May (1) (2006) 71-78
67. Peskin A.V., Midwinter R.G., Harwood D.T., and Winterbourn C.C. Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity. Free Rad Biol Med 37 10 (2004) 1622-1630
68. Reelfs O., Tyrrell R.M., and Pourzand C. Ultraviolet a radiation-induced immediate iron release is a key modulator of the activation of NF-kappaB in human skin fibroblasts. J Invest Dermatol 122 6 (2004) 1440-1447
69. Matroule JY, Volanti C, Piette J, NF-kappaB in Photodynamic therapy: duality of a master regulator. Photochem Photobiol, in press.
70. Swerlick R.A., and Korman N.J. U.V.A. and NF-kappaB activity: ironing out the details. J Invest Dermatol 122 6 (2004) xi-xii
71. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., and Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87 4 (1990) 1620-1624
72. Liaudet L., Soriano F.G., and Szabo C. Biology of nitric oxide signaling. Crit Care Med 28 4 Suppl. (2000) N37-N52
73. Liaudet L., Yang Z., Al-Affar E.B., and Szabo C. Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase. Mol Med 7 6 (2001) 406-417
74. Pacher P., Liaudet L., Mabley J., Komjati K., and Szabo C. Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. J Am Coll Cardiol 40 5 (2002) 1006-1016
75. Cooke C.L., and Davidge S.T. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am J Physiol Cell Physiol 282 2 (2002) C395-C402
76. Jozsef L., and Filep J.G. Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes. Free Rad Biol Med 35 9 (2003) 1018-1027
77. Hattori Y., Kasai K., and Gross S.S. NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovasc Res 63 1 (2004) 31-40
78. Levrand S., Pesse B., Feihl F., Waeber B., Pacher P., Rolli J., et al. Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. J Biol Chem 280 41 (2005) 34878-34887
79. Park S.W., Huq M.D., Hu X., and Wei L.N. Tyrosine nitration on p65: a novel mechanism to rapidly inactivate nuclear factor-kappaB. Mol Cell Proteomics 4 3 (2005) 300-309
80. Biswas S.K., and Lopes de Faria J.B. Does peroxynitrite sustain nuclear factor-kappaB?. Cardiovasc Res 67 4 (2005) 745-746 author reply 747-8
81. Los M., Schenk H., Hexel K., Baeuerle P.A., Droge W., and Schulze-Osthoff K. IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J 14 15 (1995) 3731-3740
82. Bonizzi G., Piette J., Merville M.P., and Bours V. Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by interleukin-1. Biochem Pharmacol 59 1 (2000) 7-11
83. Schreck R., Meier B., Mannel D.N., Droge W., and Baeuerle P.A. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 175 5 (1992) 1181-1194
84. Garg A.K., and Aggarwal B.B. Reactive oxygen intermediates in TNF signaling. Mol Immunol 39 9 (2002) 509-517
85. Brigelius-Flohe R., Banning A., Kny M., and Bol G.F. Redox events in interleukin-1 signaling. Arch Biochem Biophys 423 1 (2004) 66-73
86. Bowie A., and O'Neill L.A. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59 1 (2000) 13-23
87. Hayakawa M., Miyashita H., Sakamoto I., Kitagawa M., Tanaka H., Yasuda H., et al. Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J 22 13 (2003) 3356-3366
88. 2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells. J Biol Chem 272 41 (1997) 25941-25950
89. Brennan P., and O'Neill L.A. Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta 1260 2 (1995) 167-175
90. Muzio M., Ni J., Feng P., and Dixit V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278 5343 (1997) 1612-1615
91. Huang J., Gao X., Li S., and Cao Z. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci USA 94 24 (1997) 12829-12832
92. Burns K., Clatworthy J., Martin L., Martinon F., Plumpton C., Maschera B., et al. Tollip a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2 6 (2000) 346-351
93. Wesche H., Henzel W.J., Shillinglaw W., Li S., and Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7 6 (1997) 837-847
94. Qian Y., Commane M., Ninomiya-Tsuji J., Matsumoto K., and Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J Biol Chem 276 45 (2001) 41661-41667
95. Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., and Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412 6844 (2001) 346-351
96. Bonizzi G., Piette J., Schoonbroodt S., Greimers R., Havard L., Merville M.P., et al. Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. Mol Cell Biol 19 3 (1999) 1950-1960
97. 2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol 26 1 (2006) 140-154
98. 2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 281 3 (2006) 1495-1505
99. Yin L., Wu L., Wesche H., Arthur C.D., White J.M., Goeddel D.V., et al. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 291 5511 (2001) 2162-2165
100. Tracey K.J., and Cerami A. Tumor necrosis factor: an updated review of its biology. Crit Care Med 21 10 Suppl. (1993) S415-S422
101. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3 9 (2003) 745-756
102. Jiang Y., Woronicz J.D., Liu W., and Goeddel D.V. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 283 5401 (1999) 543-546
103. Dempsey P.W., Doyle S.E., He J.Q., and Cheng G. The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev 14 3-4 (2003) 193-209
104. Tada K., Okazaki T., Sakon S., Kobarai T., Kurosawa K., Yamaoka S., et al. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem 276 39 (2001) 36530-36534
105. Hsu H., Huang J., Shu H.B., Baichwal V., and Goeddel D.V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4 4 (1996) 387-396
106. Zhang S.Q., Kovalenko A., Cantarella G., and Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity 12 3 (2000) 301-311
107. Shrivastava A., and Aggarwal B.B. Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis. Antioxid Redox Signal 1 2 (1999) 181-191
108. Quivy V., and Van Lint C. Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation. Biochem Pharmacol 68 6 (2004) 1221-1229
109. Ito K., Lim S., Caramori G., Chung K.F., Barnes P.J., and Adcock I.M. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 15 6 (2001) 1110-1112
110. Rahman I., Marwick J., and Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol 68 6 (2004) 1255-1267
111. Schubert S.Y., Neeman I., and Resnick N. A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J 16 14 (2002) 1931-1933
112. Karin M., and Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 57 4-5 (2005) 283-295
113. Karin M., and Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 3 3 (2002) 221-227
114. De Smaele E., Zazzeroni F., Papa S., Nguyen D.U., Jin R., Jones J., et al. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature 414 6861 (2001) 308-313
115. Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z., Karin M., et al. Inhibition of JNK activation through NF-kappaB target genes. Nature 414 6861 (2001) 313-317
116. Papa S., Zazzeroni F., Bubici C., Jayawardena S., Alvarez K., Matsuda S., et al. Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol 6 2 (2004) 146-153
117. Amanullah A., Azam N., Balliet A., Hollander C., Hoffman B., Fornace A., et al. Cell signalling: cell survival and a Gadd45-factor deficiency. Nature 424 6950 (2003) 741 discussion 742
118. Kucharczak J., Simmons M.J., Fan Y., and Gelinas C. To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22 56 (2003) 8961-8982
119. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., et al. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22 15 (2003) 3898-3909
120. Ventura J.J., Cogswell P., Flavell R.A., Baldwin Jr. A.S., and Davis R.J. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 18 23 (2004) 2905-2915
121. Pham C.G., Bubici C., Zazzeroni F., Papa S., Jones J., Alvarez K., et al. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 119 4 (2004) 529-542
122. Kamata H., Honda S., Maeda S., Chang L., Hirata H., and Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120 5 (2005) 649-661
123. Nakano H., Nakajima A., Sakon-Komazawa S., Piao J.H., Xue X., and Okumura K. Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ (2005)
124. Papa S., Bubici C., Zazzeroni F., Pham C.G., Kuntzen C., Knabb J.R., et al. The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ (2006)
125. Sasazuki T., Okazaki T., Tada K., Sakon-Komazawa S., Katano M., Tanaka M., et al. Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS. Mol Immunol 41 5 (2004) 547-551
126. Medvedev A.E., Kopydlowski K.M., and Vogel S.N. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol 164 11 (2000) 5564-5574
127. Takeda K., and Akira S. TLR signaling pathways. Semin Immunol 16 1 (2004) 3-9
128. Akira S. Toll receptor families: structure and function. Semin Immunol 16 1 (2004) 1-2
129. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., and Mathison J.C. CD14 a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 4975 (1990) 1431-1433
130. Dentener M.A., Bazil V., Von Asmuth E.J., Ceska M., and Buurman W.A. Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha IL-6 and IL-8 release by human monocytes and alveolar macrophages. J Immunol 150 7 (1993) 2885-2891
131. Schumann R.R., Leong S.R., Flaggs G.W., Gray P.W., Wright S.D., Mathison J.C., et al. Structure and function of lipopolysaccharide binding protein. Science 249 4975 (1990) 1429-1431
132. Asehnoune K., Strassheim D., Mitra S., Kim J.Y., and Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol 172 4 (2004) 2522-2529
133. Ryan K.A., Smith Jr. M.F., Sanders M.K., and Ernst P.B. Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression. Infect Immun 72 4 (2004) 2123-2130
134. Sanlioglu S., Williams C.M., Samavati L., Butler N.S., Wang G., McCray Jr. P.B., et al. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem 276 32 (2001) 30188-30198
135. Park H.S., Jung H.Y., Park E.Y., Kim J., Lee W.J., and Bae Y.S. Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173 6 (2004) 3589-3593
136. Matsuzawa A., Saegusa K., Noguchi T., Sadamitsu C., Nishitoh H., Nagai S., et al. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6 6 (2005) 587-592
137. Halliwell B. Oxidative stress in cell culture: an under-appreciated problem?. FEBS Lett 540 1-3 (2003) 3-6