Direct activation of TERT transcription by c-MYC

Nature Genetics

Volumn 21, Issue 2, 1999, Pages 220-224

  Wu, Kou Juey ^a   Grandori, Carla ^b   Amacker, Mario ^c   Simon Vermot, Nathalie ^c   Polack, Axel ^d   Lingner, Joachim ^c   Dalla Favera, Riccardo ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL PROLIFERATION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

BINDING SITES; CELL LINE; DNA-BINDING PROTEINS; GENES, MYC; HUMANS; PROMOTER REGIONS (GENETICS); PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RNA; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 0032911694     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/6010     Document Type: Article

References (30)

1. Henriksson, M. & Luscher, B. Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv. Cancer. Res. 68, 109-182 (1996)
2. Bouchard, C., Staller, P. & Eilers, M. Control of cell proliferation by Myc. Trends Cell Biol. 8, 202-206 (1998).
3. Grandori, C. & Eisenman, R.N. Myc target genes. Trends Biochem. Sci. 22, 177-181 (1997)
4. Nugent, C.I. & Lundblad, V. The telomerase reverse transcriptase: components and regulation. Genes Dev. 12, 1073-1085 (1998).
5. Wright, W.E. & Shay, J.W. Time, telomere, and tumour: is cellular senescence more than an anticancer mechanism? Trends Cell Biol. 5, 293-297 (1995).
6. Lingner, J. & Cech, T. Telomerase and chromosome end maintenance. Curr. Opin. Genet. Dev. 8, 226-232 (1998).
7. Lingner, J. et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567 (1997).
8. Nakamura, T.M. et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 277, 955-959 (1997).
9. Meyerson, M. et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumour cells and during immortalization. Cell 90, 785-795 (1997).
10. Bodnar, A.G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 350-352 (1998).
11. Counter, C.M. et al. Telomerase activity is restored in human cells by ectopic expression of hTERT(hEST2), the catalytic subunit of telomerase. Oncogene 16, 1217-1222 (1998).
12. Ramakrishnan, S., Eppenberger, U., Mueller, H., Shinkai, Y. & Narayanan, R. Expression profile of the putative catalytic subunit of the telomerase gene. Cancer Res. 58, 622-625 (1998).
13. Greenberg, R.A., Allsopp, R.C., Chin, L., Morin, G.B. & DePinho, R.A. Expression of mouse telomerase reverse transcriptase during development, differentiation, and proliferation. Oncogene 16, 1723-1730 (1998).
14. Wang, J., Xie, L.Y., Allan, S., Beach, D. & Hannon, G.J. Myc activates telomerase. Genes Dev. 12, 1769-1774 (1998).
15. Gu, W., Cechova, K., Tassi, V. & Dalla-Favera, R. Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc. Natl Acad. Sci. USA 90, 2935-2939 (1993).
16. Larsson, L.-G. et al. Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-Myc oncogene. Proc. Natl Acad. Sci. USA 85, 2638-2642 (1988).
17. Kempkes, B. et al. B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J. 14, 88-96 (1995).
18. Holt, S.E., Wright, W.E. & Shay, J.W. Regulation of telomerase activity in immortal cell lines. Mol. Cell. Biol. 16, 2932-2939 (1996).
19. Igarashi, H. & Sakaguchi, N. Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor. Blood 89, 1299-1307 (1997).
20. Littlewood, T.D., Hancock, D.C., Danielian, P.C., Parker. M.G. & Evan, G.I. A modified estrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23, 1686-1690 (1995).
21. Sasson, S. Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol. Biol. 39, 59-69 (1991).
22. Grandori, C., Mac, J., Siebelt, F., Ayer, D.E. & Eisenman, R.N. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. EMBO J. 15, 4344-4357 (1996).
23. Ayer, D.E., Kretzner, L. & Eisenman, R.N. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72, 211-222 (1993).
24. Nordeen, S.K. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6, 454-458 (1988).
25. Kim, N.M. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
26. Pan, C., Xue, B.H., Ellis, T.M., Peace, D.J. & Diaz, M.O. Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp. Cell Res. 231, 346-353 (1997).
27. Polack, A. et al. c-Myc activation renders proliferation of Epstein-Barr virus(EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. Proc. Natl Acad. Sci. USA 93, 10411-10416 (1996).
28. Dalla-Favera, R. et al. Cloning and characterization of different human sequences related to the one gene (v-myc) of avian myelocytomatosis virus (MC29). Proc. Natl Acad. Sci. USA 79, 6497-6501 (1982).
29. Wu, K.J., Polack, A. & Dalla-Pavera, R. Coordinated regulation of iron controlling genes, H-ferritin and IRP2, by c-MYC. Science (in press).
30. Stone, J. et al. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol. Cell. Biol. 7, 1697-1709 (1987).