p300/CBP/p53 interaction and regulation of the p53 response

European Journal of Biochemistry

Volumn 268, Issue 10, 2001, Pages 2773-2778

  Grossman, Steven R ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Acetylation; CBP; Degradation; MDM2; p300; p53; Transactivation

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE ACETYLTRANSFERASE; PROTEIN MDM2; PROTEIN P300; PROTEIN P53; VIRUS PROTEIN;

ACETYLATION; APOPTOSIS; CELL GROWTH; DNA DAMAGE; HUMAN; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ACETYLATION; ANIMALS; CELL CYCLE; CREB-BINDING PROTEIN; DNA DAMAGE; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034824495     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02226.x     Document Type: Short Survey

References (50)

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2. The p300/CBP family: Integrating signals with transcription factors and chromatin
3. The p53 pathway
4. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
5. DNA damage activates p53 through a phosphorylation-acetylation cascade
6. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response DNA damage
7. Inhibition p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region
8. Adenovirus E1A proteins inhibit activation of transcription by p53
9. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
10. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
11. A family of transcriptional adaptor proteins targeted the E1A oncoprotein
12. Binding and modulation of p53 p300/CBP coactivators
13. Recruitment of p300/CBP in p53-dependent signal pathways
14. Synergistic activation transcription by CBP and p53
15. CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
16. Function for p300 and not CBP in the apoptotic response to DNA damage
17. Role for p300 in stabilization of p53 in the response to DNA damage
18. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
19. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
20. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
21. p53-independent DNA repair and cell cycle arrest in embryonic stem cells
22. Regulation of ES cell differentiation by functional and conformational modulation of p53
23. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
24. DNA damage induces phosphorylation of the amino terminus of p53
25. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
26. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
27. Phosphorylation of p53 serine 15 increases interaction with CBP
28. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
29. Identification of a region of p53 that confers lability
30. Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression
31. Regulation of the specific DNA binding function of p53
32. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity
33. The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300
34. The human papillomavirus type 16, E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300
35. MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
36. p300/CBP mediated-p53 acetylation is commonly induced by p53 activating agents and inhibited by MDM2
37. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
38. Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis
39. p300 binding by E1A cosegregates with p53 induction but is dispensible for apoptosis
40. Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function
41. Regulation of p53 stability by Mdm2
42. Mdm2 promotes the rapid degradation of p53
43. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
44. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
45. MDM2 suppresses p73 function without promoting p73 degradation
46. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
47. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
48. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
49. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
50. A novel cofactor for p300 that regulates the p53 response