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Volumn 10, Issue 4, 2017, Pages 865-883

Inflammasomes and intestinal inflammation

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 PROTEIN; CRYOPYRIN; DEXTRAN SULFATE; INFLAMMASOME; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NLRC4 PROTEIN; NLRP1 PROTEIN; NLRP12 PROTEIN; NLRP6 PROTEIN; OXAZOLONE; UNCLASSIFIED DRUG;

EID: 85020846957     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2017.19     Document Type: Review
Times cited : (84)

References (228)
  • 1
    • 84978115999 scopus 로고    scopus 로고
    • The microbiome and innate immunity
    • Thaiss, C. A., Zmora, N., Levy, M. & Elinav, E. The microbiome and innate immunity. Nature 535, 65-74 (2016).
    • (2016) Nature , vol.535 , pp. 65-74
    • Thaiss, C.A.1    Zmora, N.2    Levy, M.3    Elinav, E.4
  • 2
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov, R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1, 135-145 (2001).
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 3
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 4
    • 34249941913 scopus 로고    scopus 로고
    • Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling
    • Duncan, J. A. et al. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc. Natl Acad. Sci. USA 104, 8041-8046 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 8041-8046
    • Duncan, J.A.1
  • 5
    • 84869504451 scopus 로고    scopus 로고
    • Inflammasomes and their roles in health and disease
    • Lamkanfi, M. & Dixit, V. M. Inflammasomes and their roles in health and disease. Annu. Rev. Cell Dev. Biol. 28, 137-161 (2012).
    • (2012) Annu. Rev. Cell Dev. Biol. , vol.28 , pp. 137-161
    • Lamkanfi, M.1    Dixit, V.M.2
  • 6
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10, 417-426 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 7
    • 84901310586 scopus 로고    scopus 로고
    • Mechanisms and functions of inflammasomes
    • Lamkanfi, M. & Dixit, V. M. Mechanisms and functions of inflammasomes. Cell 157, 1013-1022 (2014).
    • (2014) Cell , vol.157 , pp. 1013-1022
    • Lamkanfi, M.1    Dixit, V.M.2
  • 8
    • 84881627553 scopus 로고    scopus 로고
    • The expanding role of NLRs in antiviral immunity
    • Lupfer, C. & Kanneganti, T.-D. The expanding role of NLRs in antiviral immunity. Immunol. Rev. 255, 13-24 (2013).
    • (2013) Immunol. Rev. , vol.255 , pp. 13-24
    • Lupfer, C.1    Kanneganti, T.-D.2
  • 9
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820 (2010).
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 10
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K. et al. The inflammasomes. Cell 140, 821-832 (2010).
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1
  • 11
    • 79953084107 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome: Contributions to intestinal homeostasis
    • Zaki, M. H., Lamkanfi, M. & Kanneganti, T.-D. The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol. 32, 171-179 (2011).
    • (2011) Trends Immunol. , vol.32 , pp. 171-179
    • Zaki, M.H.1    Lamkanfi, M.2    Kanneganti, T.-D.3
  • 12
    • 84880745984 scopus 로고    scopus 로고
    • The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome
    • Mitoma, H. et al. The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity 39, 123-135 (2013).
    • (2013) Immunity , vol.39 , pp. 123-135
    • Mitoma, H.1
  • 13
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada, K. et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414 (2012).
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1
  • 14
    • 84863978096 scopus 로고    scopus 로고
    • Critical role for calcium mobilization in activation of the NLRP3 inflammasome
    • Murakami, T. et al. Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc. Natl Acad. Sci. USA 109, 11282-11287 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 11282-11287
    • Murakami, T.1
  • 15
    • 84866512376 scopus 로고    scopus 로고
    • Cell volume regulation modulates NLRP3 inflammasome activation
    • Compan, V. et al. Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 37, 487-500 (2012).
    • (2012) Immunity , vol.37 , pp. 487-500
    • Compan, V.1
  • 17
    • 84879596906 scopus 로고    scopus 로고
    • K efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
    • Muñoz-Planillo, R. et al. K efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38, 1142-1153 (2013).
    • (2013) Immunity , vol.38 , pp. 1142-1153
    • Muñoz-Planillo, R.1
  • 18
    • 84958971929 scopus 로고    scopus 로고
    • NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
    • He, Y., Zeng, M. Y., Yang, D., Motro, B. & Núñez, G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530, 354-357 (2016).
    • (2016) Nature , vol.530 , pp. 354-357
    • He, Y.1    Zeng, M.Y.2    Yang, D.3    Motro, B.4    Núñez, G.5
  • 19
    • 85006056503 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
    • Song, H. et al. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. Nat. Commun. 7, 13727 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 13727
    • Song, H.1
  • 20
    • 0030698127 scopus 로고    scopus 로고
    • The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    • Roy, N., Deveraux, Q. L., Takahashi, R., Salvesen, G. S. & Reed, J. C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16, 6914-6925 (1997).
    • (1997) EMBO J. , vol.16 , pp. 6914-6925
    • Roy, N.1    Deveraux, Q.L.2    Takahashi, R.3    Salvesen, G.S.4    Reed, J.C.5
  • 21
    • 84903761551 scopus 로고    scopus 로고
    • The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
    • Rodgers, M. A. et al. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. J. Exp. Med. 211, 1333-1347 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1333-1347
    • Rodgers, M.A.1
  • 22
    • 84873834109 scopus 로고    scopus 로고
    • Deubiquitinases regulate the activity of caspase-1 and interleukin-1b secretion via assembly of the inflammasome
    • Lopez-Castejon, G. et al. Deubiquitinases regulate the activity of caspase-1 and interleukin-1b secretion via assembly of the inflammasome. J. Biol. Chem. 288, 2721-2733 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 2721-2733
    • Lopez-Castejon, G.1
  • 23
    • 84872782298 scopus 로고    scopus 로고
    • Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
    • Py, B. F., Kim, M.-S., Vakifahmetoglu-Norberg, H. & Yuan, J. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol. Cell 49, 331-338 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 331-338
    • Py, B.F.1    Kim, M.-S.2    Vakifahmetoglu-Norberg, H.3    Yuan, J.4
  • 24
    • 79955846705 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
    • Hirota, S. A. et al. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel Dis. 17, 1359-1372 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1359-1372
    • Hirota, S.A.1
  • 25
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki, M. H. et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32, 379-391 (2010).
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1
  • 26
    • 77952303410 scopus 로고    scopus 로고
    • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    • Allen, I. C. et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 207, 1045-1056 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1045-1056
    • Allen, I.C.1
  • 27
    • 85006152635 scopus 로고    scopus 로고
    • NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: A possible role in ulcerative colitis
    • Itani, S. et al. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis. Sci. Rep. 6, 39075 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 39075
    • Itani, S.1
  • 28
    • 77956128040 scopus 로고    scopus 로고
    • Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
    • Bauer, C. et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 59, 1192-1199 (2010).
    • (2010) Gut , vol.59 , pp. 1192-1199
    • Bauer, C.1
  • 29
    • 84867716442 scopus 로고    scopus 로고
    • Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: Influence of genetic and environmental factors
    • Bauer, C., Duewell, P., Lehr, H.-A., Endres, S. & Schnurr, M. Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors. Dig. Dis. 30 (Suppl 1), 82-90 (2012).
    • (2012) Dig. Dis. , vol.30 , pp. 82-90
    • Bauer, C.1    Duewell, P.2    Lehr, H.-A.3    Endres, S.4    Schnurr, M.5
  • 31
    • 0042855191 scopus 로고    scopus 로고
    • Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice
    • Ishikura, T. et al. Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice. J. Gastroenterol. Hepatol. 18, 960-969 (2003).
    • (2003) J. Gastroenterol. Hepatol. , vol.18 , pp. 960-969
    • Ishikura, T.1
  • 32
    • 84893655572 scopus 로고    scopus 로고
    • Probiotic Escherichia coli nissle 1917 and commensal E. Coli K12 differentially affect the inflammasome in intestinal epithelial cells
    • Becker, H. M., Apladas, A., Scharl, M., Fried, M. & Rogler, G. Probiotic Escherichia coli Nissle 1917 and commensal E. coli K12 differentially affect the inflammasome in intestinal epithelial cells. Digestion 89, 110-118 (2014).
    • (2014) Digestion , vol.89 , pp. 110-118
    • Becker, H.M.1    Apladas, A.2    Scharl, M.3    Fried, M.4    Rogler, G.5
  • 33
    • 9144222968 scopus 로고    scopus 로고
    • The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1T-cell activation
    • Loher, F. et al. The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1T-cell activation. J. Pharmacol. Exp. Ther. 308, 583-590 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 583-590
    • Loher, F.1
  • 34
    • 34249913692 scopus 로고    scopus 로고
    • The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-A mRNA expression
    • Bauer, C. et al. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-a mRNA expression. Dig. Dis. Sci. 52, 1642-1652 (2007).
    • (2007) Dig. Dis. Sci. , vol.52 , pp. 1642-1652
    • Bauer, C.1
  • 35
    • 0034795561 scopus 로고    scopus 로고
    • Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-g and TNF-a production
    • Siegmund, B. et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-g and TNF-a production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1264-R1273 (2001).
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.281 , pp. R1264-R1273
    • Siegmund, B.1
  • 36
    • 0036103112 scopus 로고    scopus 로고
    • Interleukin 18 is a primarymediator of the inflammation associated with dextran sulphate sodium induced colitis: Blocking interleukin 18 attenuates intestinal damage
    • Sivakumar, P. V. et al. Interleukin 18 is a primarymediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50, 812-820 (2002).
    • (2002) Gut , vol.50 , pp. 812-820
    • Sivakumar, P.V.1
  • 37
    • 85027693631 scopus 로고    scopus 로고
    • The pathogenic role of NLRP3 inflammasome activation in inflammatory bowel diseases of bothmice and humans
    • jjw219
    • Liu, L. et al. The pathogenic role of NLRP3 inflammasome activation in inflammatory bowel diseases of bothmice and humans. J. Crohn's Colitis, jjw219 (2016) (doi:10. 1093/ecco-jcc/jjw219).
    • (2016) J. Crohn's Colitis
    • Liu, L.1
  • 38
    • 84975810743 scopus 로고    scopus 로고
    • Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages
    • Filardy, A. A., He, J., Bennink, J., Yewdell, J. & Kelsall, B. L. Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages. Mucosal Immunol. 9, 850-858 (2016).
    • (2016) Mucosal Immunol. , vol.9 , pp. 850-858
    • Filardy, A.A.1    He, J.2    Bennink, J.3    Yewdell, J.4    Kelsall, B.L.5
  • 39
    • 84964982148 scopus 로고    scopus 로고
    • Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy
    • Higashimori, A. et al. Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy. Mucosal Immunol 9, 659-668 (2016).
    • (2016) Mucosal Immunol , vol.9 , pp. 659-668
    • Higashimori, A.1
  • 40
    • 84878245034 scopus 로고    scopus 로고
    • Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
    • Sokolovska, A. et al. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat. Immunol. 14, 543-553 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 543-553
    • Sokolovska, A.1
  • 41
    • 84928175356 scopus 로고    scopus 로고
    • Distinct commensals induce interleukin-1b via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury
    • Seo, S.-U. et al. Distinct commensals induce interleukin-1b via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury. Immunity 42, 744-755 (2015).
    • (2015) Immunity , vol.42 , pp. 744-755
    • Seo, S.-U.1
  • 42
    • 77955482224 scopus 로고    scopus 로고
    • Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
    • 552-3
    • Ng, J. et al. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 139, 542-552. 552-3 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 542-552
    • Ng, J.1
  • 43
    • 84906075102 scopus 로고    scopus 로고
    • Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells
    • Thinwa, J., Segovia, J. A., Bose, S. & Dube, P. H. Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells. J. Immunol. 193, 1373-1382 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 1373-1382
    • Thinwa, J.1    Segovia, J.A.2    Bose, S.3    Dube, P.H.4
  • 44
    • 77953562208 scopus 로고    scopus 로고
    • A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system
    • Brodsky, I. E. et al. A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe 7, 376-387 (2010).
    • (2010) Cell Host Microbe , vol.7 , pp. 376-387
    • Brodsky, I.E.1
  • 45
    • 36549048075 scopus 로고    scopus 로고
    • Utility of the Citrobacter rodentium infection model in laboratory mice
    • Borenshtein, D., McBee, M. E. & Schauer, D. B. Utility of the Citrobacter rodentium infection model in laboratory mice. Curr. Opin. Gastroenterol. 24, 32-37 (2008).
    • (2008) Curr. Opin. Gastroenterol. , vol.24 , pp. 32-37
    • Borenshtein, D.1    McBee, M.E.2    Schauer, D.B.3
  • 46
    • 33749011189 scopus 로고    scopus 로고
    • Animal models of inflammatory bowel disease: Lessons from enteric infections
    • Eckmann, L. Animal models of inflammatory bowel disease: lessons from enteric infections. Ann. N. Y. Acad. Sci. 1072, 28-38 (2006).
    • (2006) Ann. N. Y. Acad. Sci. , vol.1072 , pp. 28-38
    • Eckmann, L.1
  • 48
    • 84902588650 scopus 로고    scopus 로고
    • Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen
    • Song-Zhao, G. X. et al. Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen. Mucosal Immunol. 7, 763-774 (2013).
    • (2013) Mucosal Immunol. , vol.7 , pp. 763-774
    • Song-Zhao, G.X.1
  • 49
    • 85014673896 scopus 로고    scopus 로고
    • Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis
    • Jin, L., Batra, S. & Jeyaseelan, S. Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis. J. Immunol. 198, 1253-1262 (2016).
    • (2016) J. Immunol. , vol.198 , pp. 1253-1262
    • Jin, L.1    Batra, S.2    Jeyaseelan, S.3
  • 50
    • 84910075056 scopus 로고    scopus 로고
    • Limited role for ASC and NLRP3 during in vivo Salmonella typhimurium infection
    • Jong, H. K. De et al. Limited role for ASC and NLRP3 during in vivo Salmonella typhimurium infection. BMC Immunol. 15, 30 (2014).
    • (2014) BMC Immunol. , vol.15 , pp. 30
    • De Jong, H.K.1
  • 51
    • 84901008921 scopus 로고    scopus 로고
    • Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
    • Man, S. M. et al. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. Proc. Natl Acad. Sci. USA 111, 7403-7408 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 7403-7408
    • Man, S.M.1
  • 52
    • 84928966700 scopus 로고    scopus 로고
    • Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein
    • Suzuki, N. et al. Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein. Sci. Rep. 5, 10024 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 10024
    • Suzuki, N.1
  • 53
    • 84928172036 scopus 로고    scopus 로고
    • Helicobacter pylori-specific protection against inflammatory bowel disease requires the NLRP3 inflammasome and IL-18
    • Engler, D. B. et al. Helicobacter pylori-specific protection against inflammatory bowel disease requires the NLRP3 inflammasome and IL-18. Inflamm. Bowel Dis. 21, 854-861 (2015).
    • (2015) Inflamm. Bowel Dis. , vol.21 , pp. 854-861
    • Engler, D.B.1
  • 54
    • 84930385772 scopus 로고    scopus 로고
    • The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome
    • Ng, G. Z. et al. The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome. Gut 65, 1087-1099 (2016).
    • (2016) Gut , vol.65 , pp. 1087-1099
    • Ng, G.Z.1
  • 55
    • 84930321889 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is a pathogen sensor for invasive Entamoeba histolytica via activation of a5b1 integrin at the macrophage-amebae intercellular junction
    • Mortimer, L., Moreau, F., Cornick, S. & Chadee, K. The NLRP3 inflammasome is a pathogen sensor for invasive Entamoeba histolytica via activation of a5b1 integrin at the macrophage-amebae intercellular junction. PLoS Pathog. 11, e1004887 (2015).
    • (2015) PLoS Pathog. , vol.11 , pp. e1004887
    • Mortimer, L.1    Moreau, F.2    Cornick, S.3    Chadee, K.4
  • 56
    • 84902585157 scopus 로고    scopus 로고
    • Gal-lectin-dependent contact activates the inflammasome by invasive Entamoeba histolytica
    • Mortimer, L., Moreau, F., Cornick, S. & Chadee, K. Gal-lectin-dependent contact activates the inflammasome by invasive Entamoeba histolytica. Mucosal Immunol. 7, 829-841 (2014).
    • (2014) Mucosal Immunol. , vol.7 , pp. 829-841
    • Mortimer, L.1    Moreau, F.2    Cornick, S.3    Chadee, K.4
  • 57
    • 84890392687 scopus 로고    scopus 로고
    • Beneficial and detrimental roles of NLRs in carcinogenesis
    • Janowski, A. M., Kolb, R., Zhang, W. & Sutterwala, F. S. Beneficial and detrimental roles of NLRs in carcinogenesis. Front. Immunol 4, 370 (2013).
    • (2013) Front. Immunol , vol.4 , pp. 370
    • Janowski, A.M.1    Kolb, R.2    Zhang, W.3    Sutterwala, F.S.4
  • 58
    • 84902532048 scopus 로고    scopus 로고
    • The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: A case-control study and gene expression analyses
    • Castaño-Rodríguez, N., Kaakoush, N. O., Goh, K.-L., Fock, K. M. & Mitchell, H. M. The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses. PLoS ONE 9, e98899 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e98899
    • Castaño-Rodríguez, N.1    Kaakoush, N.O.2    Goh, K.-L.3    Fock, K.M.4    Mitchell, H.M.5
  • 59
    • 84868626486 scopus 로고    scopus 로고
    • Genetic variation and alterations of genes involved in NFkB/TNFAIP3-and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer
    • Ungerbäck, J. et al. Genetic variation and alterations of genes involved in NFkB/TNFAIP3-and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. Carcinogenesis 33, 2126-2134 (2012).
    • (2012) Carcinogenesis , vol.33 , pp. 2126-2134
    • Ungerbäck, J.1
  • 60
    • 84946020929 scopus 로고    scopus 로고
    • Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: Correlation with cancer stages and inflammasome components
    • Liu, R. et al. Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components. Oncotarget 6, 33456-33469 (2015).
    • (2015) Oncotarget , vol.6 , pp. 33456-33469
    • Liu, R.1
  • 61
    • 78049488908 scopus 로고    scopus 로고
    • IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
    • Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M. & Kanneganti, T.-D. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J. Immunol. 185, 4912-4920 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 4912-4920
    • Zaki, M.H.1    Vogel, P.2    Body-Malapel, M.3    Lamkanfi, M.4    Kanneganti, T.-D.5
  • 62
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: Two sides of a coin
    • Radtke, F. & Clevers, H. Self-renewal and cancer of the gut: two sides of a coin. Science 307, 1904-1909 (2005).
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 63
    • 84960345096 scopus 로고    scopus 로고
    • Dietary cholesterol promotes AOM-induced colorectal cancer through activating theNLRP3 inflammasome
    • Du, Q. et al. Dietary cholesterol promotes AOM-induced colorectal cancer through activating theNLRP3 inflammasome. Biochem. Pharmacol. 105, 42-54 (2016).
    • (2016) Biochem. Pharmacol. , vol.105 , pp. 42-54
    • Du, Q.1
  • 64
    • 84903599695 scopus 로고    scopus 로고
    • Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitisassociated cancer
    • Guo, W. et al. Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitisassociated cancer. Autophagy 10, 972-985 (2014).
    • (2014) Autophagy , vol.10 , pp. 972-985
    • Guo, W.1
  • 65
    • 84945444876 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity
    • Dupaul-Chicoine, J. et al. The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity. Immunity 43, 751-763 (2015).
    • (2015) Immunity , vol.43 , pp. 751-763
    • Dupaul-Chicoine, J.1
  • 66
    • 84872086179 scopus 로고    scopus 로고
    • Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
    • Bruchard, M. et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat. Med. 19, 57-64 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 57-64
    • Bruchard, M.1
  • 67
    • 84959900578 scopus 로고    scopus 로고
    • Saturated fatty acids engage an IRE1a-dependent pathway to activate the NLRP3 inflammasome in myeloid cells
    • Robblee, M. M. et al. Saturated fatty acids engage an IRE1a-dependent pathway to activate the NLRP3 inflammasome in myeloid cells. Cell Rep. 14, 2611-2623 (2016).
    • (2016) Cell Rep. , vol.14 , pp. 2611-2623
    • Robblee, M.M.1
  • 68
    • 84958093561 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles exacerbate DSS-induced colitis: Role of the NLRP3 inflammasome
    • gutjnl-2015-310297
    • Ruiz, P. A. et al. Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome. Gut, gutjnl-2015-310297 (2016) (doi:10. 1136/gutjnl-2015-310297).
    • (2016) Gut
    • Ruiz, P.A.1
  • 69
    • 85004060392 scopus 로고    scopus 로고
    • Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation
    • Progatzky, F. et al. Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Nat. Commun. 5, 5864 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5864
    • Progatzky, F.1
  • 70
    • 85007210853 scopus 로고    scopus 로고
    • Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo
    • Bitzer, Z. T. et al. Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo. J. Nutr. Biochem. 40, 201-208 (2017).
    • (2017) J. Nutr. Biochem. , vol.40 , pp. 201-208
    • Bitzer, Z.T.1
  • 71
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite b-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm, Y.-H. et al. The ketone metabolite b-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21, 263-269 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 263-269
    • Youm, Y.-H.1
  • 72
    • 84978483985 scopus 로고    scopus 로고
    • Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan
    • Wolf, A. J. et al. Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan. Cell 166, 624-636 (2016).
    • (2016) Cell , vol.166 , pp. 624-636
    • Wolf, A.J.1
  • 73
    • 84994817318 scopus 로고    scopus 로고
    • Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome
    • Guo, C. et al. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity 45, 944 (2016).
    • (2016) Immunity , vol.45 , pp. 944
    • Guo, C.1
  • 74
    • 85006100780 scopus 로고    scopus 로고
    • Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates dss-induced colitis in mice
    • Zhao, S. et al. Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates dss-induced colitis in mice. Front. Immunol. 7, 536 (2016).
    • (2016) Front. Immunol. , vol.7 , pp. 536
    • Zhao, S.1
  • 75
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia, L. et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6734
    • Macia, L.1
  • 76
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    • Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218 (2004).
    • (2004) Nature , vol.430 , pp. 213-218
    • Mariathasan, S.1
  • 77
    • 77649241461 scopus 로고    scopus 로고
    • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    • Miao, E. A. et al. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl Acad. Sci. USA 107, 3076-3080 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3076-3080
    • Miao, E.A.1
  • 78
    • 33744493091 scopus 로고    scopus 로고
    • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    • Miao, E. A. et al. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7, 569-575 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 569-575
    • Miao, E.A.1
  • 79
    • 57149102672 scopus 로고    scopus 로고
    • NLRC4/IPAF: A CARD carrying member of the NLR family
    • Sutterwala, F. S. & Flavell, R. A. NLRC4/IPAF: a CARD carrying member of the NLR family. Clin. Immunol. 130, 2-6 (2009).
    • (2009) Clin. Immunol. , vol.130 , pp. 2-6
    • Sutterwala, F.S.1    Flavell, R.A.2
  • 80
    • 13244252271 scopus 로고    scopus 로고
    • Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
    • Sadasivam, S. et al. Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis. Oncogene 24, 627-636 (2005).
    • (2005) Oncogene , vol.24 , pp. 627-636
    • Sadasivam, S.1
  • 81
    • 33745211768 scopus 로고    scopus 로고
    • Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis
    • Thalappilly, S., Sadasivam, S., Radha, V. & Swarup, G. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. FEBS J. 273, 2766-2778 (2006).
    • (2006) FEBS J. , vol.273 , pp. 2766-2778
    • Thalappilly, S.1    Sadasivam, S.2    Radha, V.3    Swarup, G.4
  • 82
    • 78650735879 scopus 로고    scopus 로고
    • Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    • Hu, B. et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc. Natl Acad. Sci. USA 107, 21635-21640 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 21635-21640
    • Hu, B.1
  • 83
    • 84859862381 scopus 로고    scopus 로고
    • Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
    • Carvalho, F. A. et al. Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges. Mucosal Immunol. 5, 288-298 (2012).
    • (2012) Mucosal Immunol. , vol.5 , pp. 288-298
    • Carvalho, F.A.1
  • 84
    • 84922008927 scopus 로고    scopus 로고
    • Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
    • Romberg, N. et al. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat. Genet. 46, 1135-1139 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 1135-1139
    • Romberg, N.1
  • 85
    • 84859911615 scopus 로고    scopus 로고
    • NLRC4-driven production of IL-1b discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    • Franchi, L. et al. NLRC4-driven production of IL-1b discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat. Immunol. 13, 449-456 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 449-456
    • Franchi, L.1
  • 86
    • 84908024529 scopus 로고    scopus 로고
    • Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict salmonella replication in the intestinal mucosa
    • Sellin, M. E. et al. Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict salmonella replication in the intestinal mucosa. Cell Host Microbe 16, 237-248 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 237-248
    • Sellin, M.E.1
  • 87
    • 12144289554 scopus 로고    scopus 로고
    • Dissecting virulence: Systematic and functional analyses of a pathogenicity island
    • Deng, W. et al. Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc. Natl Acad. Sci. USA 101, 3597-3602 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3597-3602
    • Deng, W.1
  • 88
    • 84860859210 scopus 로고    scopus 로고
    • Role of inflammasomes in host defense against Citrobacter rodentium infection
    • Liu, Z. et al. Role of inflammasomes in host defense against Citrobacter rodentium infection. J. Biol. Chem. 287, 16955-16964 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 16955-16964
    • Liu, Z.1
  • 89
    • 84902588358 scopus 로고    scopus 로고
    • NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen
    • Nordlander, S., Pott, J. & Maloy, K. J. NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen. Mucosal Immunol. 7, 775-785 (2013).
    • (2013) Mucosal Immunol. , vol.7 , pp. 775-785
    • Nordlander, S.1    Pott, J.2    Maloy, K.J.3
  • 90
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745-757 (2011).
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1
  • 91
    • 79959369355 scopus 로고    scopus 로고
    • Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
    • Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl Acad. Sci. USA 108, 9601-9606 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 9601-9606
    • Normand, S.1
  • 92
    • 84924299302 scopus 로고    scopus 로고
    • The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling
    • Gremel, G. et al. The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. J. Gastroenterol. 50, 46-57 (2015).
    • (2015) J. Gastroenterol. , vol.50 , pp. 46-57
    • Gremel, G.1
  • 93
    • 84896691062 scopus 로고    scopus 로고
    • NLRP6 inflammasome orchestrates the colonic hostmicrobial interface by regulating goblet cell mucus secretion
    • Wlodarska, M. et al. NLRP6 inflammasome orchestrates the colonic hostmicrobial interface by regulating goblet cell mucus secretion. Cell 156, 1045-1059 (2014).
    • (2014) Cell , vol.156 , pp. 1045-1059
    • Wlodarska, M.1
  • 94
    • 84976310851 scopus 로고    scopus 로고
    • A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
    • Birchenough, G. M. H., Nyström, E. E. L., Johansson, M. E. V. & Hansson, G. C. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542 (2016).
    • (2016) Science , vol.352 , pp. 1535-1542
    • Birchenough, G.M.H.1    Nyström, E.E.L.2    Johansson, M.E.V.3    Hansson, G.C.4
  • 95
    • 79251558406 scopus 로고    scopus 로고
    • Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine
    • Kempster, S. L. et al. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G253-G263 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300 , pp. G253-G263
    • Kempster, S.L.1
  • 96
    • 84946922380 scopus 로고    scopus 로고
    • Nlrp6 regulates intestinal antiviral innate immunity
    • Wang, P. et al. Nlrp6 regulates intestinal antiviral innate immunity. Science 350, 826-830 (2015).
    • (2015) Science , vol.350 , pp. 826-830
    • Wang, P.1
  • 97
    • 84949255269 scopus 로고    scopus 로고
    • Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
    • Levy, M. et al. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163, 1428-1443 (2015).
    • (2015) Cell , vol.163 , pp. 1428-1443
    • Levy, M.1
  • 98
    • 84990846993 scopus 로고    scopus 로고
    • Host-protozoan interactions protect from mucosal infections through activation of the inflammasome
    • e14
    • Chudnovskiy, A. et al. Host-protozoan interactions protect from mucosal infections through activation of the inflammasome. Cell 167, 444-456. e14 (2016).
    • (2016) Cell , vol.167 , pp. 444-456
    • Chudnovskiy, A.1
  • 99
    • 84876713274 scopus 로고    scopus 로고
    • Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice
    • 1487-8
    • Sun, Y. et al. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology 144, 1478-1487. 1487-8 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 1478-1487
    • Sun, Y.1
  • 100
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: A new class of microbicidal proteins involved in innate immunity
    • Hooper, L. V., Stappenbeck, T. S., Hong, C. V. & Gordon, J. I. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4, 269-273 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3    Gordon, J.I.4
  • 101
    • 84878971321 scopus 로고    scopus 로고
    • Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
    • Hu, B. et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc. Natl Acad. Sci. USA 110, 9862-9867 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9862-9867
    • Hu, B.1
  • 102
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia, J. et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179-185 (2012).
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 103
    • 79959540809 scopus 로고    scopus 로고
    • A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
    • Chen, G. Y., Liu, M., Wang, F., Bertin, J. & Núñez, G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186, 7187-7194 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 7187-7194
    • Chen, G.Y.1    Liu, M.2    Wang, F.3    Bertin, J.4    Núñez, G.5
  • 104
    • 84964312935 scopus 로고    scopus 로고
    • Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects
    • Mehta, R. et al. Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects. BMC Gastroenterol. 14, 208 (2014).
    • (2014) BMC Gastroenterol. , vol.14 , pp. 208
    • Mehta, R.1
  • 105
    • 85014547105 scopus 로고    scopus 로고
    • NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury
    • Seregin, S. S. et al. NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury. Mucosal Immunol. 10, 434-445 (2016).
    • (2016) Mucosal Immunol. , vol.10 , pp. 434-445
    • Seregin, S.S.1
  • 106
    • 84865130689 scopus 로고    scopus 로고
    • NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
    • Anand, P. K. et al. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488, 389-393 (2012).
    • (2012) Nature , vol.488 , pp. 389-393
    • Anand, P.K.1
  • 107
    • 62449101446 scopus 로고    scopus 로고
    • Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages
    • Nour, A. M. et al. Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect. Immun. 77, 1262-1271 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 1262-1271
    • Nour, A.M.1
  • 108
    • 33847376042 scopus 로고    scopus 로고
    • Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
    • Faustin, B. et al. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol. Cell 25, 713-724 (2007).
    • (2007) Mol. Cell , vol.25 , pp. 713-724
    • Faustin, B.1
  • 109
    • 84925850795 scopus 로고    scopus 로고
    • The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis
    • Williams, T. M. et al. The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis. J. Immunol. 194, 3369-3380 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 3369-3380
    • Williams, T.M.1
  • 110
    • 60749136484 scopus 로고    scopus 로고
    • An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
    • Bürckstümmer, T. et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10, 266-272 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 266-272
    • Bürckstümmer, T.1
  • 111
    • 77951263260 scopus 로고    scopus 로고
    • The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    • Fernandes-Alnemri, T. et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11, 385-393 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 385-393
    • Fernandes-Alnemri, T.1
  • 112
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • Hornung, V. et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514-518 (2009).
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1
  • 113
    • 84938996802 scopus 로고    scopus 로고
    • Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
    • Wilson, J. E. et al. Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat. Med. 21, 906-913 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 906-913
    • Wilson, J.E.1
  • 114
    • 84947447820 scopus 로고    scopus 로고
    • The DNA sensor AIM2 maintains intestinal homeostasis via regulation of epithelial antimicrobial host defense
    • Hu, S. et al. The DNA sensor AIM2 maintains intestinal homeostasis via regulation of epithelial antimicrobial host defense. Cell Rep. 13, 1922-1936 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 1922-1936
    • Hu, S.1
  • 115
    • 85007603424 scopus 로고    scopus 로고
    • The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway
    • Ratsimandresy, R. A., Indramohan, M., Dorfleutner, A. & Stehlik, C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell. Mol. Immunol. 14, 127-142 (2016).
    • (2016) Cell. Mol. Immunol. , vol.14 , pp. 127-142
    • Ratsimandresy, R.A.1    Indramohan, M.2    Dorfleutner, A.3    Stehlik, C.4
  • 116
    • 84994507182 scopus 로고    scopus 로고
    • The DNA-sensing AIM2 inflammasome controls radiationinduced cell death and tissue injury
    • Hu, B. et al. The DNA-sensing AIM2 inflammasome controls radiationinduced cell death and tissue injury. Science 354, 765-768 (2016).
    • (2016) Science , vol.354 , pp. 765-768
    • Hu, B.1
  • 117
    • 84982244545 scopus 로고    scopus 로고
    • AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection
    • Hu, G.-Q. et al. AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection. Mucosal Immunol. 9, 1330-1339 (2016).
    • (2016) Mucosal Immunol. , vol.9 , pp. 1330-1339
    • Hu, G.-Q.1
  • 118
    • 20244387702 scopus 로고    scopus 로고
    • HNPCC-associated small bowel cancer: Clinical and molecular characteristics
    • Schulmann, K. et al. HNPCC-associated small bowel cancer: clinical and molecular characteristics. Gastroenterology 128, 590-599 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 590-599
    • Schulmann, K.1
  • 119
    • 35349011610 scopus 로고    scopus 로고
    • The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers
    • Woerner, S. M. et al. The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. Genes Chromosomes Cancer 46, 1080-1089 (2007).
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 1080-1089
    • Woerner, S.M.1
  • 120
    • 84909945799 scopus 로고    scopus 로고
    • Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients
    • Dihlmann, S. et al. Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients. Int. J. Cancer 135, 2387-2396 (2014).
    • (2014) Int. J. Cancer , vol.135 , pp. 2387-2396
    • Dihlmann, S.1
  • 121
    • 84934346989 scopus 로고    scopus 로고
    • Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer
    • Man, S. M. et al. Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer. Cell 162, 45-58 (2015).
    • (2015) Cell , vol.162 , pp. 45-58
    • Man, S.M.1
  • 122
    • 84944747007 scopus 로고    scopus 로고
    • Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
    • Zhang, L. et al. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350, 404-409 (2015).
    • (2015) Science , vol.350 , pp. 404-409
    • Zhang, L.1
  • 123
    • 84944748927 scopus 로고    scopus 로고
    • Structural and biochemical basis for induced self-propagation of NLRC4
    • Hu, Z. et al. Structural and biochemical basis for induced self-propagation of NLRC4. Science 350, 399-404 (2015).
    • (2015) Science , vol.350 , pp. 399-404
    • Hu, Z.1
  • 124
    • 84921498910 scopus 로고    scopus 로고
    • The NAIP/NLRC4 inflammasomes
    • Vance, R. E. The NAIP/NLRC4 inflammasomes. Curr. Opin. Immunol. 32, 84-89 (2015).
    • (2015) Curr. Opin. Immunol. , vol.32 , pp. 84-89
    • Vance, R.E.1
  • 125
    • 0037088904 scopus 로고    scopus 로고
    • The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7
    • Maier, J. K. X. et al. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J. Neurosci. 22, 2035-2043 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 2035-2043
    • Maier, J.K.X.1
  • 127
    • 84924706729 scopus 로고    scopus 로고
    • Epithelial NAIPs protect against colonic tumorigenesis
    • Allam, R. et al. Epithelial NAIPs protect against colonic tumorigenesis. J. Exp. Med. 212, 369-383 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 369-383
    • Allam, R.1
  • 128
    • 4344665866 scopus 로고    scopus 로고
    • Expression of IAP family proteins in colon cancers from patients with different age groups
    • Endo, T. et al. Expression of IAP family proteins in colon cancers from patients with different age groups. Cancer Immunol. Immunother. 53, 770-776 (2004).
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 770-776
    • Endo, T.1
  • 129
    • 0010464874 scopus 로고    scopus 로고
    • PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing
    • Wang, L. et al. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J. Biol. Chem. 277, 29874-29880 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 29874-29880
    • Wang, L.1
  • 130
    • 84971543386 scopus 로고    scopus 로고
    • Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1
    • Shi, F. et al. Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1. Oncotarget 7, 30575-30584 (2016).
    • (2016) Oncotarget , vol.7 , pp. 30575-30584
    • Shi, F.1
  • 132
    • 81255189478 scopus 로고    scopus 로고
    • The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis
    • Zaki, M. H. et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20, 649-660 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 649-660
    • Zaki, M.H.1
  • 133
    • 84861460062 scopus 로고    scopus 로고
    • NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kB signaling
    • Allen, I. C. et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kB signaling. Immunity 36, 742-754 (2012).
    • (2012) Immunity , vol.36 , pp. 742-754
    • Allen, I.C.1
  • 134
    • 84891906749 scopus 로고    scopus 로고
    • Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection
    • Zaki, M. H., Man, S. M., Vogel, P., Lamkanfi, M. & Kanneganti, T.-D. Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proc. Natl Acad. Sci. USA 111, 385-390 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 385-390
    • Zaki, M.H.1    Man, S.M.2    Vogel, P.3    Lamkanfi, M.4    Kanneganti, T.-D.5
  • 135
    • 85019406841 scopus 로고    scopus 로고
    • NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer
    • Karki, R. et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature 540, 583-587 (2016).
    • (2016) Nature , vol.540 , pp. 583-587
    • Karki, R.1
  • 136
    • 84928050252 scopus 로고    scopus 로고
    • Mechanisms of inflammasome activation: Recent advances and novel insights
    • Vanaja, S. K., Rathinam, V. A. K. & Fitzgerald, K. A. Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol. 25, 308-315 (2015).
    • (2015) Trends Cell Biol. , vol.25 , pp. 308-315
    • Vanaja, S.K.1    Rathinam, V.A.K.2    Fitzgerald, K.A.3
  • 137
    • 84906571225 scopus 로고    scopus 로고
    • Inflammatory caspases are innate immune receptors for intracellular LPS
    • Shi, J. et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514, 187-192 (2014).
    • (2014) Nature , vol.514 , pp. 187-192
    • Shi, J.1
  • 138
    • 84883790050 scopus 로고    scopus 로고
    • Cytoplasmic LPS activates caspase-11: Implications in TLR4-independent endotoxic shock
    • Hagar, J. A., Powell, D. A., Aachoui, Y., Ernst, R. K. & Miao, E. A. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 341, 1250-1253 (2013).
    • (2013) Science , vol.341 , pp. 1250-1253
    • Hagar, J.A.1    Powell, D.A.2    Aachoui, Y.3    Ernst, R.K.4    Miao, E.A.5
  • 139
    • 80455176839 scopus 로고    scopus 로고
    • Non-canonical inflammasome activation targets caspase-11
    • Kayagaki, N. et al. Non-canonical inflammasome activation targets caspase-11. Nature 479, 117-121 (2011).
    • (2011) Nature , vol.479 , pp. 117-121
    • Kayagaki, N.1
  • 140
    • 84883775365 scopus 로고    scopus 로고
    • Noncanonical inflammasome activation by intracellular LPS independent of TLR4
    • Kayagaki, N. et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341, 1246-1249 (2013).
    • (2013) Science , vol.341 , pp. 1246-1249
    • Kayagaki, N.1
  • 141
    • 84874189388 scopus 로고    scopus 로고
    • Caspase-11 protects against bacteria that escape the vacuole
    • Aachoui, Y. et al. Caspase-11 protects against bacteria that escape the vacuole. Science 339, 975-978 (2013).
    • (2013) Science , vol.339 , pp. 975-978
    • Aachoui, Y.1
  • 142
    • 84990856288 scopus 로고    scopus 로고
    • IRGB10 liberates bacterial ligands for sensing by the AIM2 and Caspase-11-NLRP3 inflammasomes
    • e17
    • Man, S. M. et al. IRGB10 liberates bacterial ligands for sensing by the AIM2 and Caspase-11-NLRP3 inflammasomes. Cell 167, 382-396. e17 (2016).
    • (2016) Cell , vol.167 , pp. 382-396
    • Man, S.M.1
  • 143
    • 84900564237 scopus 로고    scopus 로고
    • Caspase-11 activation requires lysis of pathogencontaining vacuoles by IFN-inducedGTPases
    • Meunier, E. et al. Caspase-11 activation requires lysis of pathogencontaining vacuoles by IFN-inducedGTPases. Nature 509, 366-370 (2014).
    • (2014) Nature , vol.509 , pp. 366-370
    • Meunier, E.1
  • 144
    • 84942856523 scopus 로고    scopus 로고
    • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    • Kayagaki, N. et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666-671 (2015).
    • (2015) Nature , vol.526 , pp. 666-671
    • Kayagaki, N.1
  • 145
    • 84943200249 scopus 로고    scopus 로고
    • Caspase-11 activates a canonical NLRP3 inflammasome by promoting K() efflux
    • Rühl, S. & Broz, P. Caspase-11 activates a canonical NLRP3 inflammasome by promoting K() efflux. Eur. J. Immunol. 45, 2927-2936 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 2927-2936
    • Rühl, S.1    Broz, P.2
  • 146
    • 84943198707 scopus 로고    scopus 로고
    • Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
    • Schmid-Burgk, J. L. et al. Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells. Eur. J. Immunol. 45, 2911-2917 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 2911-2917
    • Schmid-Burgk, J.L.1
  • 147
    • 84921464234 scopus 로고    scopus 로고
    • Caspase-11 attenuates gastrointestinal inflammation and experimental colitis pathogenesis
    • Williams, T. M. et al. Caspase-11 attenuates gastrointestinal inflammation and experimental colitis pathogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 308, G139-G150 (2015).
    • (2015) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.308 , pp. G139-G150
    • Williams, T.M.1
  • 148
    • 84921486975 scopus 로고    scopus 로고
    • Protective role for caspase-11 during acute experimental murine colitis
    • Oficjalska, K. et al. Protective role for caspase-11 during acute experimental murine colitis. J. Immunol. 194, 1252-1260 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 1252-1260
    • Oficjalska, K.1
  • 149
    • 84908160928 scopus 로고    scopus 로고
    • Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis
    • Demon, D. et al. Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis. Mucosal Immunol. 7, 1480-1491 (2014).
    • (2014) Mucosal Immunol. , vol.7 , pp. 1480-1491
    • Demon, D.1
  • 150
    • 84873202976 scopus 로고    scopus 로고
    • Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
    • Case, C. L. et al. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc. Natl Acad. Sci. USA 110, 1851-1856 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 1851-1856
    • Case, C.L.1
  • 151
    • 84867333450 scopus 로고    scopus 로고
    • Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
    • Broz, P. et al. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature 490, 288-291 (2012).
    • (2012) Nature , vol.490 , pp. 288-291
    • Broz, P.1
  • 152
    • 84928176611 scopus 로고    scopus 로고
    • Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response
    • Gabrielli, E. et al. Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infect. Immun. 83, 1940-1948 (2015).
    • (2015) Infect. Immun. , vol.83 , pp. 1940-1948
    • Gabrielli, E.1
  • 153
    • 84877844771 scopus 로고    scopus 로고
    • The Shigella OspC3 effector inhibits Caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection
    • Kobayashi, T. et al. The Shigella OspC3 effector inhibits Caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe 13, 570-583 (2013).
    • (2013) Cell Host Microbe , vol.13 , pp. 570-583
    • Kobayashi, T.1
  • 154
    • 84976558046 scopus 로고    scopus 로고
    • Caspase-11 modulates inflammation and attenuates Toxoplasma gondii pathogenesis
    • Coutermarsh-Ott, S. L. et al. Caspase-11 modulates inflammation and attenuates Toxoplasma gondii pathogenesis. Mediators Inflamm. 2016, 9848263 (2016).
    • (2016) Mediators Inflamm. , vol.2016 , pp. 9848263
    • Coutermarsh-Ott, S.L.1
  • 155
    • 85019838573 scopus 로고    scopus 로고
    • Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells
    • Pallett, M. A. et al. Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunol. 2016 (doi:10. 1038/mi. 2016. 77).
    • (2016) Mucosal Immunol.
    • Pallett, M.A.1
  • 156
    • 84911992879 scopus 로고    scopus 로고
    • Noncanonical inflammasome activation of Caspase-4/ Caspase-11 mediates epithelial defenses against enteric bacterial pathogens
    • Knodler, L. A. et al. Noncanonical inflammasome activation of Caspase-4/ Caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe 16, 249-256 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 249-256
    • Knodler, L.A.1
  • 157
    • 84907584408 scopus 로고    scopus 로고
    • Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection
    • Lupfer, C. R. et al. Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. PLoS Pathog. 10, e1004410 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004410
    • Lupfer, C.R.1
  • 158
    • 84858677223 scopus 로고    scopus 로고
    • Sensing and reacting to microbes through the inflammasomes
    • Franchi, L., Muñoz-Planillo, R. & Núñez, G. Sensing and reacting to microbes through the inflammasomes. Nat. Immunol. 13, 325-332 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 325-332
    • Franchi, L.1    Muñoz-Planillo, R.2    Núñez, G.3
  • 159
    • 84892610480 scopus 로고    scopus 로고
    • IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
    • Lin, K.-M. et al. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc. Natl Acad. Sci. USA 111, 775-780 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 775-780
    • Lin, K.-M.1
  • 160
    • 84874028928 scopus 로고    scopus 로고
    • Integrative inflammasome activity in the regulation of intestinal mucosal immune responses
    • Elinav, E., Henao-Mejia, J. & Flavell, R. A. Integrative inflammasome activity in the regulation of intestinal mucosal immune responses. Mucosal Immunol. 6, 4-13 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 4-13
    • Elinav, E.1    Henao-Mejia, J.2    Flavell, R.A.3
  • 161
    • 79956299492 scopus 로고    scopus 로고
    • Gain-of-function Pyrin mutations induce NLRP3 proteinindependent interleukin-1b activation and severe autoinflammation in mice
    • Chae, J. J. et al. Gain-of-function Pyrin mutations induce NLRP3 proteinindependent interleukin-1b activation and severe autoinflammation in mice. Immunity 34, 755-768 (2011).
    • (2011) Immunity , vol.34 , pp. 755-768
    • Chae, J.J.1
  • 162
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini, L. et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20, 319-325 (2004).
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1
  • 163
    • 84927126118 scopus 로고    scopus 로고
    • An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
    • Canna, S. W. et al. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat. Genet. 46, 1140-1146 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 1140-1146
    • Canna, S.W.1
  • 164
    • 84880777411 scopus 로고    scopus 로고
    • CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
    • Sheedy, F. J. et al. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat. Immunol. 14, 812-820 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 812-820
    • Sheedy, F.J.1
  • 165
    • 84961393640 scopus 로고    scopus 로고
    • Upregulation of inflammasomeactivity and increased gut permeability are associated with obesity in children and adolescents
    • Rainone, V. et al. Upregulation of inflammasomeactivity and increased gut permeability are associated with obesity in children and adolescents. Int. J. Obes. (Lond) 40, 1026-1033 (2016).
    • (2016) Int. J. Obes. (Lond) , vol.40 , pp. 1026-1033
    • Rainone, V.1
  • 166
    • 74549184092 scopus 로고    scopus 로고
    • TheNLRP3 inflammasome: A sensor for metabolic danger?
    • Schroder, K., Zhou, R. & Tschopp, J. TheNLRP3 inflammasome: a sensor for metabolic danger?. Science 327, 296-300 (2010).
    • (2010) Science , vol.327 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 167
    • 84861164794 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
    • Youm, Y.-H. et al. The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep. 1, 56-68 (2012).
    • (2012) Cell Rep. , vol.1 , pp. 56-68
    • Youm, Y.-H.1
  • 168
    • 84885167222 scopus 로고    scopus 로고
    • Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
    • Youm, Y.-H. et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 18, 519-532 (2013).
    • (2013) Cell Metab. , vol.18 , pp. 519-532
    • Youm, Y.-H.1
  • 169
    • 83755195135 scopus 로고    scopus 로고
    • The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
    • Mezzaroma, E. et al. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc. Natl Acad. Sci. USA 108, 19725-19730 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 19725-19730
    • Mezzaroma, E.1
  • 170
    • 84055187652 scopus 로고    scopus 로고
    • Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response
    • Malik, A. F. et al. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc. Natl Acad. Sci. USA 108, 20095-20100 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 20095-20100
    • Malik, A.F.1
  • 171
    • 0033152023 scopus 로고    scopus 로고
    • IL-18, a novel immunoregulatory cytokine, is upregulated in Crohn's disease: Expression and localization in intestinal mucosal cells
    • Pizarro, T. T. et al. IL-18, a novel immunoregulatory cytokine, is upregulated in Crohn's disease: expression and localization in intestinal mucosal cells. J. Immunol. 162, 6829-6835 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 6829-6835
    • Pizarro, T.T.1
  • 172
    • 0025442212 scopus 로고
    • Role of interleukin 1 in inflammatory bowel disease-enhanced production during active disease
    • Ligumsky, M., Simon, P. L., Karmeli, F. & Rachmilewitz, D. Role of interleukin 1 in inflammatory bowel disease-enhanced production during active disease. Gut 31, 686-689 (1990).
    • (1990) Gut , vol.31 , pp. 686-689
    • Ligumsky, M.1    Simon, P.L.2    Karmeli, F.3    Rachmilewitz, D.4
  • 173
    • 0024344814 scopus 로고
    • Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease
    • Mahida, Y. R., Wu, K. & Jewell, D. P. Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease. Gut 30, 835-838 (1989).
    • (1989) Gut , vol.30 , pp. 835-838
    • Mahida, Y.R.1    Wu, K.2    Jewell, D.P.3
  • 174
    • 0028898529 scopus 로고
    • Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation
    • Casini-Raggi, V. et al. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J. Immunol. 154, 2434-2440 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 2434-2440
    • Casini-Raggi, V.1
  • 175
    • 0034465943 scopus 로고    scopus 로고
    • Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease
    • Kanai, T. et al. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology 119, 1514-1523 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1514-1523
    • Kanai, T.1
  • 176
    • 77953302756 scopus 로고    scopus 로고
    • The genetics of NOD-like receptors in Crohn's disease
    • Cummings, J. R. F. et al. The genetics of NOD-like receptors in Crohn's disease. Tissue Antigens 76, 48-56 (2010).
    • (2010) Tissue Antigens , vol.76 , pp. 48-56
    • Cummings, J.R.F.1
  • 177
    • 78650936254 scopus 로고    scopus 로고
    • Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases
    • Ludicibus, S. De. et al. Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases. J. Clin. Gastroenterol. 45, e1-e7 (2011).
    • (2011) J. Clin. Gastroenterol. , vol.45 , pp. e1-e7
    • De Ludicibus, S.1
  • 178
    • 79958859708 scopus 로고    scopus 로고
    • Interleukin 1 b (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis
    • Yamamoto-Furusho, J. K. et al. Interleukin 1 b (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis. J. Clin. Gastroenterol. 45, 531-535 (2011).
    • (2011) J. Clin. Gastroenterol. , vol.45 , pp. 531-535
    • Yamamoto-Furusho, J.K.1
  • 179
    • 0032835884 scopus 로고    scopus 로고
    • Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis
    • Tountas, N. A. et al. Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. Gastroenterology 117, 806-813 (1999).
    • (1999) Gastroenterology , vol.117 , pp. 806-813
    • Tountas, N.A.1
  • 180
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • Villani, A.-C. et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat. Genet. 41, 71-76 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 71-76
    • Villani, A.-C.1
  • 181
    • 66949174089 scopus 로고    scopus 로고
    • Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men
    • Schoultz, I. et al. Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. Am. J. Gastroenterol. 104, 1180-1188 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1180-1188
    • Schoultz, I.1
  • 182
    • 77953122347 scopus 로고    scopus 로고
    • Evidence of interaction ofCARD8 rs2043211withNALP3 rs35829419 in Crohn's disease
    • Roberts, R. L. et al. Evidence of interaction ofCARD8 rs2043211withNALP3 rs35829419 in Crohn's disease. Genes Immun. 11, 351-356 (2010).
    • (2010) Genes Immun. , vol.11 , pp. 351-356
    • Roberts, R.L.1
  • 183
    • 33847774601 scopus 로고    scopus 로고
    • Interleukin-18 genetics and inflammatory disease susceptibility
    • Thompson, S. R. & Humphries, S. E. Interleukin-18 genetics and inflammatory disease susceptibility. Genes Immun. 8, 91-99 (2007).
    • (2007) Genes Immun. , vol.8 , pp. 91-99
    • Thompson, S.R.1    Humphries, S.E.2
  • 184
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • Cho, J. H. The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8, 458-466 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 185
    • 21144468350 scopus 로고    scopus 로고
    • Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    • London, England
    • van Heel, D. A. et al. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet (London, England) 365, 1794-1796 (2005).
    • (2005) Lancet , vol.365 , pp. 1794-1796
    • Van Heel, D.A.1
  • 187
    • 84865434771 scopus 로고    scopus 로고
    • The innate immune protein nod2 binds directly to MDP, a bacterial cell wall fragment
    • Grimes, C. L., Ariyananda, L. D. Z., Melnyk, J. E. & O'Shea, E. K. The innate immune protein nod2 binds directly to MDP, a bacterial cell wall fragment. J. Am. Chem. Soc. 134, 13535-13537 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 13535-13537
    • Grimes, C.L.1    Ariyananda, L.D.Z.2    Melnyk, J.E.3    O'Shea, E.K.4
  • 188
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L. & Hooper, L. V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl Acad. Sci. USA 105, 20858-20863 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 189
    • 84907597189 scopus 로고    scopus 로고
    • Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus
    • Ramanan, D., Tang, M. S., Bowcutt, R., Loke, P. & Cadwell, K. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity 41, 311-324 (2014).
    • (2014) Immunity , vol.41 , pp. 311-324
    • Ramanan, D.1    Tang, M.S.2    Bowcutt, R.3    Loke, P.4    Cadwell, K.5
  • 190
    • 70349468054 scopus 로고    scopus 로고
    • Nod2 is required for the regulation of commensal microbiota in the intestine
    • Petnicki-Ocwieja, T. et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl Acad. Sci. USA 106, 15813-15818 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15813-15818
    • Petnicki-Ocwieja, T.1
  • 191
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K. S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 192
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux, J. D. et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 39, 596-604 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 596-604
    • Rioux, J.D.1
  • 193
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207-211 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 207-211
    • Hampe, J.1
  • 194
    • 84901660514 scopus 로고    scopus 로고
    • Atg16L1 T300Avariant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
    • Lassen, K. G. et al. Atg16L1 T300Avariant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc. Natl Acad. Sci. USA 111, 7741-7746 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 7741-7746
    • Lassen, K.G.1
  • 195
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh, T. et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456, 264-268 (2008).
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1
  • 196
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    • Simms, L. A. et al. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 57, 903-910 (2008).
    • (2008) Gut , vol.57 , pp. 903-910
    • Simms, L.A.1
  • 197
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp, J. et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53, 1658-1664 (2004).
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1
  • 198
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber, S. et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259-263 (2012).
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1
  • 199
    • 84966429158 scopus 로고    scopus 로고
    • Mucosal barrier depletion and loss of bacterial diversity are primary abnormalities in paediatric ulcerative colitis
    • Alipour, M. et al. Mucosal barrier depletion and loss of bacterial diversity are primary abnormalities in paediatric ulcerative colitis. J. Crohn's Colitis 10, 462-471 (2016).
    • (2016) J. Crohn's Colitis , vol.10 , pp. 462-471
    • Alipour, M.1
  • 200
    • 84899639501 scopus 로고    scopus 로고
    • Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome
    • La Fuente, M. De. et al. Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. Int. J. Med. Microbiol. 304, 384-392 (2014).
    • (2014) Int. J. Med. Microbiol. , vol.304 , pp. 384-392
    • La Fuente, D.M.1
  • 201
    • 84945278159 scopus 로고    scopus 로고
    • Strong upregulation of AIM2 and IFI16 inflammasomes in the mucosa of patients with active inflammatory bowel disease
    • Vanhove, W. et al. Strong upregulation of AIM2 and IFI16 inflammasomes in the mucosa of patients with active inflammatory bowel disease. Inflamm. Bowel Dis. 21, 2673-2682 (2015).
    • (2015) Inflamm. Bowel Dis. , vol.21 , pp. 2673-2682
    • Vanhove, W.1
  • 202
    • 0043074846 scopus 로고    scopus 로고
    • Crohn disease worsened by anakinra administration
    • Carter, J. D., Valeriano, J. & Vasey, F. B. Crohn disease worsened by anakinra administration. J. Clin. Rheumatol. 9, 276-277 (2003).
    • (2003) J. Clin. Rheumatol. , vol.9 , pp. 276-277
    • Carter, J.D.1    Valeriano, J.2    Vasey, F.B.3
  • 203
    • 85008220560 scopus 로고    scopus 로고
    • Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition
    • pii: S0091-6749(16)31352-5
    • Canna, S. W. et al. Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. J. Allergy Clin. Immunol., pii: S0091-6749(16)31352-5 (2016) (doi:10. 1016/ j. jaci. 2016. 10. 022).
    • (2016) J. Allergy Clin. Immunol.
    • Canna, S.W.1
  • 204
    • 84979543880 scopus 로고    scopus 로고
    • NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
    • Moon, J.-S. et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat. Med. 22, 1002-1012 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 1002-1012
    • Moon, J.-S.1
  • 205
    • 84921305910 scopus 로고    scopus 로고
    • A20 restricts ubiquitination of pro-interleukin-1b protein complexes and suppresses NLRP3 inflammasome activity
    • Duong, B. H. et al. A20 restricts ubiquitination of pro-interleukin-1b protein complexes and suppresses NLRP3 inflammasome activity. Immunity 42, 55-67 (2015).
    • (2015) Immunity , vol.42 , pp. 55-67
    • Duong, B.H.1
  • 206
    • 85001022213 scopus 로고    scopus 로고
    • Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling
    • Wei, W. et al. Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling. Int. Immunopharmacol. 42, 185-194 (2017).
    • (2017) Int. Immunopharmacol. , vol.42 , pp. 185-194
    • Wei, W.1
  • 207
    • 84924415042 scopus 로고    scopus 로고
    • A small-molecule inhibitor of the NLRP3 inflammasomefor the treatment of inflammatory diseases
    • Coll, R. C. et al. A small-molecule inhibitor of the NLRP3 inflammasomefor the treatment of inflammatory diseases. Nat. Med. 21, 248-255 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 248-255
    • Coll, R.C.1
  • 208
    • 84876684569 scopus 로고    scopus 로고
    • A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome
    • Liu, W. et al. A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome. Biochem. Pharmacol. 85, 1504-1512 (2013).
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1504-1512
    • Liu, W.1
  • 209
    • 84957577397 scopus 로고    scopus 로고
    • 3-(2-Oxo-2-phenylethylidene)-2, 3, 6, 7-tetrahydro-1Hpyrazino[ 2, 1-A]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome
    • Wang, Y. et al. 3-(2-Oxo-2-phenylethylidene)-2, 3, 6, 7-tetrahydro-1Hpyrazino[ 2, 1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome. Biochem. Pharmacol. 101, 71-86 (2016).
    • (2016) Biochem. Pharmacol. , vol.101 , pp. 71-86
    • Wang, Y.1
  • 210
    • 84920445940 scopus 로고    scopus 로고
    • Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation
    • Guo, W. et al. Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation. Int. Immunopharmacol. 24, 232-238 (2015).
    • (2015) Int. Immunopharmacol. , vol.24 , pp. 232-238
    • Guo, W.1
  • 211
    • 84991227970 scopus 로고    scopus 로고
    • Activation of cannabinoid receptor 2 ameliorates DSS-induced colitis through inhibiting nlrp3 inflammasome in macrophages
    • Ke, P. et al. Activation of cannabinoid receptor 2 ameliorates DSS-induced colitis through inhibiting nlrp3 inflammasome in macrophages. PLoS ONE 11, e0155076 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0155076
    • Ke, P.1
  • 212
    • 84892779067 scopus 로고    scopus 로고
    • Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis
    • Shaker, M. E., Ashamallah, S. A. & Houssen, M. E. Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis. Chem. Biol. Interact. 210, 26-33 (2014).
    • (2014) Chem. Biol. Interact. , vol.210 , pp. 26-33
    • Shaker, M.E.1    Ashamallah, S.A.2    Houssen, M.E.3
  • 213
    • 84986213314 scopus 로고    scopus 로고
    • Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome
    • Otani, K. et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci. Rep. 6, 32587 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 32587
    • Otani, K.1
  • 214
    • 84988637657 scopus 로고    scopus 로고
    • Oligomannan prebiotic attenuates immunological, clinical and behavioral symptoms in mouse model of inflammatory bowel disease
    • Ferenczi, S., Szegi, K., Winkler, Z., Barna, T. & Kovács, K. J. Oligomannan prebiotic attenuates immunological, clinical and behavioral symptoms in mouse model of inflammatory bowel disease. Sci. Rep. 6, 34132 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 34132
    • Ferenczi, S.1    Szegi, K.2    Winkler, Z.3    Barna, T.4    Kovács, K.J.5
  • 215
    • 84879582536 scopus 로고    scopus 로고
    • Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
    • Yan, Y. et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 38, 1154-1163 (2013).
    • (2013) Immunity , vol.38 , pp. 1154-1163
    • Yan, Y.1
  • 216
    • 84975462653 scopus 로고    scopus 로고
    • Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis
    • He, X. et al. Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis. Sci. Rep. 6, 28370 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 28370
    • He, X.1
  • 217
    • 84962106536 scopus 로고    scopus 로고
    • Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways
    • Márquez-Flores, Y. K., Villegas, I., Cárdeno, A., Rosillo, M. Á. & Alarcón-de-la-Lastra, C. Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. J. Nutr. Biochem. 30, 143-152 (2016).
    • (2016) J. Nutr. Biochem. , vol.30 , pp. 143-152
    • Márquez-Flores, Y.K.1    Villegas, I.2    Cárdeno, A.3    Rosillo, M.Á.4    Alarcón-de-La-Lastra, C.5
  • 218
    • 84948383762 scopus 로고    scopus 로고
    • Fumigaclavine C ameliorates dextran sulfate sodiuminduced murine experimental colitis via NLRP3 inflammasome inhibition
    • Guo, W. et al. Fumigaclavine C ameliorates dextran sulfate sodiuminduced murine experimental colitis via NLRP3 inflammasome inhibition. J. Pharmacol. Sci. 129, 101-106 (2015).
    • (2015) J. Pharmacol. Sci. , vol.129 , pp. 101-106
    • Guo, W.1
  • 219
    • 78751680633 scopus 로고    scopus 로고
    • Discovery of a viral NLR homolog that inhibits the inflammasome
    • Gregory, S. M. et al. Discovery of a viral NLR homolog that inhibits the inflammasome. Science 331, 330-334 (2011).
    • (2011) Science , vol.331 , pp. 330-334
    • Gregory, S.M.1
  • 220
    • 84995678287 scopus 로고    scopus 로고
    • A functional genomics approach to understand variation in cytokine production in humans
    • Li, Y. et al. A functional genomics approach to understand variation in cytokine production in humans. Cell 167, 1099-1110. e14 (2016).
    • (2016) Cell , vol.167 , pp. 1099-1110e14
    • Li, Y.1
  • 221
    • 84896759364 scopus 로고    scopus 로고
    • Common genetic variants modulate pathogen-sensing responses in human dendritic cells
    • Lee, M. N. et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 343, 1246980-1246980 (2014).
    • (2014) Science , vol.343 , pp. 1246980
    • Lee, M.N.1
  • 222
    • 84907984250 scopus 로고    scopus 로고
    • Genetics of immune-mediated disorders: From genome-wide association to molecular mechanism
    • Kumar, V., Wijmenga, C. & Xavier, R. J. Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism. Curr. Opin. Immunol. 31, 51-57 (2014).
    • (2014) Curr. Opin. Immunol. , vol.31 , pp. 51-57
    • Kumar, V.1    Wijmenga, C.2    Xavier, R.J.3
  • 223
    • 84976892875 scopus 로고    scopus 로고
    • Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
    • Li, Y. et al. Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nat. Med. 22, 952-960 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 952-960
    • Li, Y.1
  • 224
    • 84862068459 scopus 로고    scopus 로고
    • Genetic variation in Toll-like receptors and disease susceptibility
    • Netea, M. G., Wijmenga, C. & O'Neill, L. A. J. Genetic variation in Toll-like receptors and disease susceptibility. Nat. Immunol. 13, 535-542 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 535-542
    • Netea, M.G.1    Wijmenga, C.2    O'Neill, L.A.J.3
  • 225
    • 84996635686 scopus 로고    scopus 로고
    • Differential effects of environmental and genetic factors on T and B cell immune traits
    • Aguirre-Gamboa, R. et al. Differential effects of environmental and genetic factors on T and B cell immune traits. Cell Rep. 17, 2474-2487 (2016).
    • (2016) Cell Rep. , vol.17 , pp. 2474-2487
    • Aguirre-Gamboa, R.1
  • 226
    • 84902649784 scopus 로고    scopus 로고
    • Mining the human gutmicrobiota for effector strains that shape the immune system
    • Ahern, P. P., Faith, J. J. & Gordon, J. I. Mining the human gutmicrobiota for effector strains that shape the immune system. Immunity 40, 815-823 (2014).
    • (2014) Immunity , vol.40 , pp. 815-823
    • Ahern, P.P.1    Faith, J.J.2    Gordon, J.I.3
  • 227
    • 84947812071 scopus 로고    scopus 로고
    • Personalized nutrition by prediction of glycemic responses
    • Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079-1094 (2015).
    • (2015) Cell , vol.163 , pp. 1079-1094
    • Zeevi, D.1
  • 228
    • 84994747507 scopus 로고    scopus 로고
    • Host and environmental factors influencing individual human cytokine responses
    • e13
    • Horst, R. T. et al. Host and environmental factors influencing individual human cytokine responses. Cell 167, 1111-1124. e13 (2016).
    • (2016) Cell , vol.167 , pp. 1111-1124
    • Horst, R.T.1


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