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Volumn 24, Issue 1, 2008, Pages 32-37

Utility of the Citrobacter rodentium infection model in laboratory mice

Author keywords

Acute diarrheal illness; Citrobacter freundii biotype 4280; Colitis; Enterobacteriaceae infections; Transmissible murine colonic hyperplasia

Indexed keywords

ADAPTIVE IMMUNITY; CITROBACTER RODENTIUM; COLITIS; COLON MUCOSA; DIARRHEA; DISEASE COURSE; EPITHELIUM HYPERPLASIA; EXPERIMENTAL MOUSE; GASTROENTERITIS; INNATE IMMUNITY; NONHUMAN; PATHOGENESIS; REVIEW;

EID: 36549048075     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3282f2b0fb     Document Type: Review
Times cited : (113)

References (46)
  • 1
    • 0035029103 scopus 로고    scopus 로고
    • Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia
    • Luperchio SA, Schauer DB. Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia. Microbes Infect 2001; 3:333-340.
    • (2001) Microbes Infect , vol.3 , pp. 333-340
    • Luperchio, S.A.1    Schauer, D.B.2
  • 2
    • 28044461045 scopus 로고    scopus 로고
    • Citrobacter rodentium of mice and man
    • Mundy R, MacDonald TT, Dougan G, et al. Citrobacter rodentium of mice and man. Cell Microbiol 2005; 7:1697-1706.
    • (2005) Cell Microbiol , vol.7 , pp. 1697-1706
    • Mundy, R.1    MacDonald, T.T.2    Dougan, G.3
  • 3
    • 33749011189 scopus 로고    scopus 로고
    • Animal models of inflammatory bowel disease: Lessons from enteric infections
    • Eckmann L. Animal models of inflammatory bowel disease: lessons from enteric infections. Ann N Y Acad Sci 2006; 1072:28-38.
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 28-38
    • Eckmann, L.1
  • 4
    • 33750808143 scopus 로고    scopus 로고
    • Comparison of colonization dynamics and pathology of mice infected with enteropathogenic Escherichia coli, enterohaemorrhagic E. coli and Citrobacter rodentium
    • Mundy R, Girard F, FitzGerald AJ, Frankel G. Comparison of colonization dynamics and pathology of mice infected with enteropathogenic Escherichia coli, enterohaemorrhagic E. coli and Citrobacter rodentium. FEMS Microbiol Lett 2006; 265:126-132.
    • (2006) FEMS Microbiol Lett , vol.265 , pp. 126-132
    • Mundy, R.1    Girard, F.2    FitzGerald, A.J.3    Frankel, G.4
  • 5
    • 20144374672 scopus 로고    scopus 로고
    • Citrobacter rodentium lifA/efa1 is essential for colonic colonization and crypt cell hyperplasia in vivo
    • Klapproth JM, Sasaki M, Sherman M, et al. Citrobacter rodentium lifA/efa1 is essential for colonic colonization and crypt cell hyperplasia in vivo. Infect Immun 2005; 73:1441-1451.
    • (2005) Infect Immun , vol.73 , pp. 1441-1451
    • Klapproth, J.M.1    Sasaki, M.2    Sherman, M.3
  • 6
    • 12844285111 scopus 로고    scopus 로고
    • Mouse model of enteropathogenic Escherichia coli infection
    • Savkovic SD, Villanueva J, Turner JR, et al. Mouse model of enteropathogenic Escherichia coli infection. Infect Immun 2005; 73:1161-1170.
    • (2005) Infect Immun , vol.73 , pp. 1161-1170
    • Savkovic, S.D.1    Villanueva, J.2    Turner, J.R.3
  • 7
    • 29644435707 scopus 로고    scopus 로고
    • The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium
    • Tatsuno I, Mundy R, Frankel G, et al. The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium. Infect Immun 2006; 74:265-272.
    • (2006) Infect Immun , vol.74 , pp. 265-272
    • Tatsuno, I.1    Mundy, R.2    Frankel, G.3
  • 8
    • 33748486261 scopus 로고    scopus 로고
    • Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157:H7
    • Vlisidou I, Marches O, Dziva F, et al. Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157:H7. FEMS Microbiol Lett 2006; 263:32-40.
    • (2006) FEMS Microbiol Lett , vol.263 , pp. 32-40
    • Vlisidou, I.1    Marches, O.2    Dziva, F.3
  • 9
    • 33845395048 scopus 로고    scopus 로고
    • Identification and characterization of NleI, a new non-LEE-encoded effector of enteropathogenic Escherichia coli (EPEC)
    • Li M, Rosenshine I, Yu HB, et al. Identification and characterization of NleI, a new non-LEE-encoded effector of enteropathogenic Escherichia coli (EPEC). Microbes Infect 2006; 8:2890-2898.
    • (2006) Microbes Infect , vol.8 , pp. 2890-2898
    • Li, M.1    Rosenshine, I.2    Yu, H.B.3
  • 10
    • 0038687776 scopus 로고    scopus 로고
    • Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium
    • Mundy R, Pickard D, Wilson RK, et al. Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium. Mol Microbiol 2003; 48:795-809.
    • (2003) Mol Microbiol , vol.48 , pp. 795-809
    • Mundy, R.1    Pickard, D.2    Wilson, R.K.3
  • 11
    • 33645522456 scopus 로고    scopus 로고
    • Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium
    • Kelly M, Hart E, Mundy R, et al. Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium. Infect Immun 2006; 74:2328-2337.
    • (2006) Infect Immun , vol.74 , pp. 2328-2337
    • Kelly, M.1    Hart, E.2    Mundy, R.3
  • 12
    • 33748449456 scopus 로고    scopus 로고
    • ••]).
    • ••]).
  • 13
    • 33645310938 scopus 로고    scopus 로고
    • Simpson N, Shaw R, Crepin VF, et al. The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea. Mol Microbiol 2006; 60:349-363. An elegant study using yeast two-hybrid to identify the EPEC T3SS effector Map as a binding partner for EBP50 (NHERF1), which also clarifies the role of Map in ultrastructural changes (brush border effacement), decreased barrier function, and diarrhea in vitro and in vivo.
    • Simpson N, Shaw R, Crepin VF, et al. The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea. Mol Microbiol 2006; 60:349-363. An elegant study using yeast two-hybrid to identify the EPEC T3SS effector Map as a binding partner for EBP50 (NHERF1), which also clarifies the role of Map in ultrastructural changes (brush border effacement), decreased barrier function, and diarrhea in vitro and in vivo.
  • 14
    • 33748431496 scopus 로고    scopus 로고
    • Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection
    • Wickham ME, Lupp C, Mascarenhas M, et al. Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection. J Infect Dis 2006; 194:819-827.
    • (2006) J Infect Dis , vol.194 , pp. 819-827
    • Wickham, M.E.1    Lupp, C.2    Mascarenhas, M.3
  • 15
    • 33746074074 scopus 로고    scopus 로고
    • Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: Role of p65 (Ser536) phosphorylation
    • Wang Y, Xiang GS, Kourouma F, Umar S. Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation. Br J Pharmacol 2006; 148:814-824.
    • (2006) Br J Pharmacol , vol.148 , pp. 814-824
    • Wang, Y.1    Xiang, G.S.2    Kourouma, F.3    Umar, S.4
  • 16
    • 33847008637 scopus 로고    scopus 로고
    • Umar S, Wang Y, Morris AP, Sellin JH. Dual alterations in casein kinase I-epsilon and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epithelia. Am J Physiol Gastrointest Liver Physiol 2007; 292:G599-G607. This paper characterizes the in-vivo signaling events associated with epithelial hyperplasia caused by C. rodentium infection in Swiss Webster mice.
    • Umar S, Wang Y, Morris AP, Sellin JH. Dual alterations in casein kinase I-epsilon and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epithelia. Am J Physiol Gastrointest Liver Physiol 2007; 292:G599-G607. This paper characterizes the in-vivo signaling events associated with epithelial hyperplasia caused by C. rodentium infection in Swiss Webster mice.
  • 17
    • 0017606810 scopus 로고
    • Dietary, bacterial, and host genetic interactions in the pathogenesis of transmissible murine colonic hyperplasia
    • Barthold SW, Osbaldiston GW, Jonas AM. Dietary, bacterial, and host genetic interactions in the pathogenesis of transmissible murine colonic hyperplasia. Lab Anim Sci 1977; 27:938-945.
    • (1977) Lab Anim Sci , vol.27 , pp. 938-945
    • Barthold, S.W.1    Osbaldiston, G.W.2    Jonas, A.M.3
  • 18
    • 34447269492 scopus 로고    scopus 로고
    • Borenshtein D, Nambiar PR, Groff EB, et al. Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun 2007; 75:3271-3281. This paper documents fatal C. rodentium infection and colitis in adult inbred FVB mice and goes on to show that fluid therapy protects against mortality and allows for long-term resolution of colonic lesions. These results implicate alterations in fluid balance and electrolytes in the pathogenesis of fatal C. rodentium infection.
    • Borenshtein D, Nambiar PR, Groff EB, et al. Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun 2007; 75:3271-3281. This paper documents fatal C. rodentium infection and colitis in adult inbred FVB mice and goes on to show that fluid therapy protects against mortality and allows for long-term resolution of colonic lesions. These results implicate alterations in fluid balance and electrolytes in the pathogenesis of fatal C. rodentium infection.
  • 19
    • 0038443912 scopus 로고    scopus 로고
    • Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium
    • Vallance BA, Deng W, Jacobson K, Finlay BB. Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect Immun 2003; 71:3443-3453.
    • (2003) Infect Immun , vol.71 , pp. 3443-3453
    • Vallance, B.A.1    Deng, W.2    Jacobson, K.3    Finlay, B.B.4
  • 20
    • 33646374141 scopus 로고    scopus 로고
    • Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice
    • Khan MA, Ma C, Knodler LA, et al. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 2006; 74:2522-2536.
    • (2006) Infect Immun , vol.74 , pp. 2522-2536
    • Khan, M.A.1    Ma, C.2    Knodler, L.A.3
  • 21
    • 34250814435 scopus 로고    scopus 로고
    • Lebeis SL, Bommarius B, Parkos CA, et al. TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol 2007; 179:566-577. This paper shows a critical role for TLR signaling in protective host responses that lead to clearance of C. rodentium infection and resolution of colitis.
    • Lebeis SL, Bommarius B, Parkos CA, et al. TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol 2007; 179:566-577. This paper shows a critical role for TLR signaling in protective host responses that lead to clearance of C. rodentium infection and resolution of colitis.
  • 22
    • 0034461754 scopus 로고    scopus 로고
    • Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia, exhibits clonality: Synonymy of C. rodentium and mouse-pathogenic Escherichia coli
    • Luperchio SA, Newman JV, Dangler CA, et al. Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia, exhibits clonality: synonymy of C. rodentium and mouse-pathogenic Escherichia coli. J Clin Microbiol 2000; 38:4343-4350.
    • (2000) J Clin Microbiol , vol.38 , pp. 4343-4350
    • Luperchio, S.A.1    Newman, J.V.2    Dangler, C.A.3
  • 23
    • 0035173175 scopus 로고    scopus 로고
    • Structural studies on the O-polysaccharide of the lipopolysaccharide produced by Citrobacter rodentium (ATCC 51459)
    • MacLean LL, Perry MB. Structural studies on the O-polysaccharide of the lipopolysaccharide produced by Citrobacter rodentium (ATCC 51459). Eur J Biochem 2001; 268:5740-5746.
    • (2001) Eur J Biochem , vol.268 , pp. 5740-5746
    • MacLean, L.L.1    Perry, M.B.2
  • 24
    • 0347364688 scopus 로고    scopus 로고
    • Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen
    • Bry L, Brenner MB. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 2004; 172:433-441.
    • (2004) J Immunol , vol.172 , pp. 433-441
    • Bry, L.1    Brenner, M.B.2
  • 25
    • 29644440606 scopus 로고    scopus 로고
    • CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium
    • Bry L, Brigl M, Brenner MB. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun 2006; 74:673-681.
    • (2006) Infect Immun , vol.74 , pp. 673-681
    • Bry, L.1    Brigl, M.2    Brenner, M.B.3
  • 26
    • 2542523184 scopus 로고    scopus 로고
    • Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
    • Maaser C, Housley MP, Iimura M, et al. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun 2004; 72:3315-3324.
    • (2004) Infect Immun , vol.72 , pp. 3315-3324
    • Maaser, C.1    Housley, M.P.2    Iimura, M.3
  • 27
    • 0041322730 scopus 로고    scopus 로고
    • Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium
    • Simmons CP, Clare S, Ghaem-Maghami M, et al. Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun 2003; 71:5077-5086.
    • (2003) Infect Immun , vol.71 , pp. 5077-5086
    • Simmons, C.P.1    Clare, S.2    Ghaem-Maghami, M.3
  • 28
    • 0036128828 scopus 로고    scopus 로고
    • Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
    • Vallance BA, Deng W, Knodler LA, Finlay BB. Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection. Infect Immun 2002; 70:2070-2081.
    • (2002) Infect Immun , vol.70 , pp. 2070-2081
    • Vallance, B.A.1    Deng, W.2    Knodler, L.A.3    Finlay, B.B.4
  • 30
    • 33646560950 scopus 로고    scopus 로고
    • Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the Th17 lineage. Nature 2006; 441:231-234. This paper shows that Th17 immune responses predominate early in C. rodentium infection, and uses IL-23p19-deficient mice to uncover a crucial role for IL-23 in controlling infection that is necessary for survival.
    • Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the Th17 lineage. Nature 2006; 441:231-234. This paper shows that Th17 immune responses predominate early in C. rodentium infection, and uses IL-23p19-deficient mice to uncover a crucial role for IL-23 in controlling infection that is necessary for survival.
  • 31
    • 33644813679 scopus 로고    scopus 로고
    • Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis
    • Chen CC, Louie S, Shi HN, Walker WA. Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis. Pediatr Res 2005; 58:1185-1191.
    • (2005) Pediatr Res , vol.58 , pp. 1185-1191
    • Chen, C.C.1    Louie, S.2    Shi, H.N.3    Walker, W.A.4
  • 32
    • 33749650749 scopus 로고    scopus 로고
    • Bacillus subtilis spores reduce susceptibility to Citrobacter rodentium-mediated enteropathy in a mouse model
    • D'Arienzo R, Maurano F, Mazzarella G, et al. Bacillus subtilis spores reduce susceptibility to Citrobacter rodentium-mediated enteropathy in a mouse model. Res Microbiol 2006; 157:891-897.
    • (2006) Res Microbiol , vol.157 , pp. 891-897
    • D'Arienzo, R.1    Maurano, F.2    Mazzarella, G.3
  • 33
    • 20444368389 scopus 로고    scopus 로고
    • Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics
    • Johnson-Henry KC, Nadjafi M, Avitzur Y, et al. Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics. J Infect Dis 2005; 191:2106-2117.
    • (2005) J Infect Dis , vol.191 , pp. 2106-2117
    • Johnson-Henry, K.C.1    Nadjafi, M.2    Avitzur, Y.3
  • 34
    • 23944492462 scopus 로고    scopus 로고
    • Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice
    • Chen CC, Louie S, McCormick B, et al. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun 2005; 73:5468-5481.
    • (2005) Infect Immun , vol.73 , pp. 5468-5481
    • Chen, C.C.1    Louie, S.2    McCormick, B.3
  • 35
    • 29644442357 scopus 로고    scopus 로고
    • Helminth-primed dendritic cells alter the host response to enteric bacterial infection
    • This paper characterizes crosstalk between innate and adaptive immunity and shows how dysregulation of innate immune cell function in concurrent infection can affect disease outcome
    • Chen CC, Louie S, McCormick BA, et al. Helminth-primed dendritic cells alter the host response to enteric bacterial infection. J Immunol 2006; 176:472-483. This paper characterizes crosstalk between innate and adaptive immunity and shows how dysregulation of innate immune cell function in concurrent infection can affect disease outcome.
    • (2006) J Immunol , vol.176 , pp. 472-483
    • Chen, C.C.1    Louie, S.2    McCormick, B.A.3
  • 36
    • 0346826270 scopus 로고    scopus 로고
    • The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000
    • Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ 2003; 81:197-204.
    • (2003) Bull World Health Organ , vol.81 , pp. 197-204
    • Kosek, M.1    Bern, C.2    Guerrant, R.L.3
  • 37
    • 33646799069 scopus 로고    scopus 로고
    • Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data
    • Lopez AD, Mathers CD, Ezzati M, et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006; 367:1747-1757.
    • (2006) Lancet , vol.367 , pp. 1747-1757
    • Lopez, A.D.1    Mathers, C.D.2    Ezzati, M.3
  • 38
    • 33644850203 scopus 로고    scopus 로고
    • Guttman JA, Li Y, Wickham ME, et al. Attaching and effacing pathogen-induced tight junction disruption in vivo. Cell Microbiol 2006; 8:634-645. The paper documents in-vivo redistribution of claudins 1, 3, and 5 in response to C. rodentium infection resulting in intestinal barrier dysfunction and diarrhea. These changes are dependent on EspF, but not Map.
    • Guttman JA, Li Y, Wickham ME, et al. Attaching and effacing pathogen-induced tight junction disruption in vivo. Cell Microbiol 2006; 8:634-645. The paper documents in-vivo redistribution of claudins 1, 3, and 5 in response to C. rodentium infection resulting in intestinal barrier dysfunction and diarrhea. These changes are dependent on EspF, but not Map.
  • 39
    • 33750436249 scopus 로고    scopus 로고
    • Guttman JA, Samji FN, Li Y, et al. Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo. Infect Immun 2006; 74:6075-6084. This paper shows that mucosal inflammation is not required for C. rodentium-induced alterations in tight junctions.
    • Guttman JA, Samji FN, Li Y, et al. Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo. Infect Immun 2006; 74:6075-6084. This paper shows that mucosal inflammation is not required for C. rodentium-induced alterations in tight junctions.
  • 40
    • 33947182957 scopus 로고    scopus 로고
    • Desmosomes are unaltered during infections by attaching and effacing pathogens
    • Guttman JA, Kazemi P, Lin AE, et al. Desmosomes are unaltered during infections by attaching and effacing pathogens. Anat Rec (Hoboken) 2007; 290:199-205.
    • (2007) Anat Rec (Hoboken) , vol.290 , pp. 199-205
    • Guttman, J.A.1    Kazemi, P.2    Lin, A.E.3
  • 41
    • 33845432262 scopus 로고    scopus 로고
    • Guttman JA, Samji FN, Li Y, et al. Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol 2007; 9:131-141. By characterizing EspF and EspG-dependent redistribution of water channels AQP2 and AQP3 following C. rodentium infection, this paper makes a substantial contribution to our understanding of the mechanistic basis of infectious diarrhea.
    • Guttman JA, Samji FN, Li Y, et al. Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol 2007; 9:131-141. By characterizing EspF and EspG-dependent redistribution of water channels AQP2 and AQP3 following C. rodentium infection, this paper makes a substantial contribution to our understanding of the mechanistic basis of infectious diarrhea.
  • 42
    • 33644864860 scopus 로고    scopus 로고
    • O'Hara JR, Skinn AC, MacNaughton WK, et al. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol 2006; 8:646-660. This paper shows changes in the structure and function of the enteric nervous system during C. rodentium infection, leading to alterations in signaling, gut motility, and secretion. A role for adaptive immunity in these changes was established by using severe combined immunodeficient (SCID) mice.
    • O'Hara JR, Skinn AC, MacNaughton WK, et al. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol 2006; 8:646-660. This paper shows changes in the structure and function of the enteric nervous system during C. rodentium infection, leading to alterations in signaling, gut motility, and secretion. A role for adaptive immunity in these changes was established by using severe combined immunodeficient (SCID) mice.
  • 43
    • 33344475548 scopus 로고    scopus 로고
    • •] are the first to explore the effects of acute C. rodentium infection on xenobioticmetabolism, by characterizing hepatic and renal expression of P450s, UGTs, cytokines, acute phase proteins, and nuclear receptors. Changes were compared with systemic administration of endotoxin.
    • •] are the first to explore the effects of acute C. rodentium infection on xenobioticmetabolism, by characterizing hepatic and renal expression of P450s, UGTs, cytokines, acute phase proteins, and nuclear receptors. Changes were compared with systemic administration of endotoxin.
  • 44
    • 33344476414 scopus 로고    scopus 로고
    • •] are the first to explore the effects of acute C. rodentium infection on xenobiotic metabolism, by characterizing hepatic and renal expression of P450s, UGTs, cytokines, acute phase proteins, and nuclear receptors. Changes were compared with systemic administration of endotoxin.
    • •] are the first to explore the effects of acute C. rodentium infection on xenobiotic metabolism, by characterizing hepatic and renal expression of P450s, UGTs, cytokines, acute phase proteins, and nuclear receptors. Changes were compared with systemic administration of endotoxin.
  • 45
    • 30944436663 scopus 로고    scopus 로고
    • Williams AE, Edwards L, Hussell T. Colonic bacterial infection abrogates eosinophilic pulmonary disease. J Infect Dis 2006; 193:223-230. This paper shows that C. rodentium infection in the colon modulates the outcome of fungal infection in the lung. Th1 immunity ameliorates C. neoformans disease, providing an exciting example of immune crosstalk between mucosal site that may have broad implications for a variety of infectious diseases.
    • Williams AE, Edwards L, Hussell T. Colonic bacterial infection abrogates eosinophilic pulmonary disease. J Infect Dis 2006; 193:223-230. This paper shows that C. rodentium infection in the colon modulates the outcome of fungal infection in the lung. Th1 immunity ameliorates C. neoformans disease, providing an exciting example of immune crosstalk between mucosal site that may have broad implications for a variety of infectious diseases.
  • 46
    • 0027492999 scopus 로고
    • The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia
    • Schauer DB, Falkow S. The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia. Infect Immun 1993; 61:4654-4661.
    • (1993) Infect Immun , vol.61 , pp. 4654-4661
    • Schauer, D.B.1    Falkow, S.2


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