Common genetic variants modulate pathogen-sensing responses in human dendritic cells

Science

Volumn 343, Issue 6175, 2014, Pages

  Lee, Mark N ^a,b,c   Ye, Chun ^a   Villani, Alexandra Chloé ^a,b   Raj, Towfique ^a,b,c   Li, Weibo ^a,c   Eisenhaure, Thomas M ^a,c   Imboywa, Selina H ^b   Chipendo, Portia I ^b   Ran, F Ann ^a,d,e,f,g   Slowikowski, Kamil ^h   Ward, Lucas D ^a,i   Raddassi, Khadir ^j   McCabe, Cristin ^a,c   Lee, Michelle H ^b   Frohlich, Irene Y ^b   Hafler, David A ^g   Kellis, Manolis ^a,i   Raychaudhuri, Soumya ^a,b,k,l   Zhang, Feng ^e,f,g   Stranger, Barbara E ^m,n   Benoist, Christophe O ^b   De Jager, Philip L ^a,b,c   Regev, Aviv ^a,f,o   Hacohen, Nir ^a,b,c   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD UNIVERSITY   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g Massachusetts Institute of Technology Cambridge   (United States)

^h HARVARD UNIVERSITY   (United States)

ⁱ MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^j YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k BRIGHAM AND WOMEN S HOSPITAL   (United States)

^l UNIVERSITY OF MANCHESTER   (United Kingdom)

^m UNIVERSITY OF CHICAGO   (United States)

ⁿ UNIVERSITY OF CHICAGO   (United States)

^o HOWARD HUGHES MEDICAL INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERFERON REGULATORY FACTOR 7; STAT PROTEIN; IRF7 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; TRANSCRIPTOME;

ALLELE; FECAL COLIFORM; GENE EXPRESSION; GENETIC VARIATION; HOST-PATHOGEN INTERACTION; PATHOLOGY; PUBLIC HEALTH;

AFRICAN AMERICAN; ARTICLE; ASIAN; BINDING SITE; CAUCASIAN; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; GENE INDUCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC ENGINEERING; GENETIC PROCEDURES; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN CELL; INFECTION; INFLAMMATORY DISEASE; INFLUENZA; INFLUENZA VIRUS; INNATE IMMUNITY; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; AUTOIMMUNE DISEASE; CELL STRAIN HEK293; COMMUNICABLE DISEASE; DRUG EFFECT; ESCHERICHIA COLI; FEMALE; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INFLUENZA VIRUS A; MALE; MIDDLE AGED; QUANTITATIVE TRAIT LOCUS; YOUNG ADULT;

ADULT; AUTOIMMUNE DISEASES; COMMUNICABLE DISEASES; DENDRITIC CELLS; ESCHERICHIA COLI; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS; INTERFERON REGULATORY FACTOR-7; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; STAT TRANSCRIPTION FACTORS; TRANSCRIPTOME; YOUNG ADULT;

EID: 84896759364     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1246980     Document Type: Article

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