NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

Nature Immunology

Volumn 13, Issue 5, 2012, Pages 449-456

  Franchi, Luigi ^a   Kamada, Nobuhiko ^a   Nakamura, Yuumi ^a   Burberry, Aaron ^a   Kuffa, Peter ^a   Suzuki, Shiho ^a   Shaw, Michael H ^a   Kim, Yun Gi ^a   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; NLRC4 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL MATURATION; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; HOST RESISTANCE; INTESTINE CELL; LETHALITY; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SALMONELLA;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CASPASE 1; CLONAL ANERGY; FLAGELLIN; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTESTINES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; NEUTROPHIL INFILTRATION; NEUTROPHILS; PHAGOCYTES; PSEUDOMONAS; PSEUDOMONAS INFECTIONS; RECEPTORS, INTERLEUKIN-1; SALMONELLA; SALMONELLA INFECTIONS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84859911615     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2263     Document Type: Article

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