Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 385-390

  Zaki, Md Hasan ^a,d   Man, Si Ming ^a   Vogel, Peter ^a   Lamkanfi, Mohamed ^b,c   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR FAMILY PYRIN DOMAIN CONTAINING 12; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HOST RESISTANCE; IMMUNE EVASION; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NF-KAPPA B; NITRIC OXIDE; NUCLEOTIDES; PROTEIN STRUCTURE, TERTIARY; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84891906749     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317643111     Document Type: Article

References (34)

1. Kanneganti TD, Lamkanfi M, Núñez G (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27(4): 549-559.
2. Girardin SE, et al. (2003) Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300(5625): 1584-1587.
3. Chamaillard M, et al. (2003) An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4(7): 702-707.
4. Inohara N, et al. (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278(8): 5509-5512.
5. Girardin SE, et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278(11): 8869-8872.
6. Schneider M, et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol 13(9): 823-831.
7. Allen IC, et al. (2011) NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity 34(6): 854-865.
8. Anand PK, et al. (2012) NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488(7411): 389-393.
9. Cui J, et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141(3): 483-496.
10. Wang L, et al. (2002) PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem 277(33): 29874-29880.
11. Williams KL, Taxman DJ, LinhoffMW, ReedW, Ting JP (2003) Cutting edge:Monarch-1: A pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. J Immunol 170(11): 5354-5358.
12. Zaki MH, et al. (2011) The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20(5): 649-660.
13. Allen IC, et al. (2013) Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PLoS ONE 8(4): e60842.
14. Jéru I, et al. (2011) Identification and functional consequences of a recurrent NLRP12 missense mutation in periodic fever syndromes. Arthritis Rheum 63(5): 1459-1464.
15. Jéru I, et al. (2008) Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci USA 105(5): 1614-1619.
16. Macaluso F, et al. (2007) Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis. Exp Dermatol 16(8): 692-698.
17. Allen IC, et al. (2012) NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity 36(5): 742-754.
18. Vladimer GI, et al. (2012) The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1): 96-107.
19. Majowicz SE, et al.; International Collaboration on Enteric Disease 'Burden of Illness' Studies (2010) The global burden of nontyphoidal Salmonella gastroenteritis. Clin Infect Dis 50(6): 882-889.
20. Barton Behravesh C, et al.; FoodNet Working Group (2011) Deaths associated with bacterial pathogens transmitted commonly through food: Foodborne diseases active surveillance network (FoodNet), 1996-2005. J Infect Dis 204(2): 263-267.
21. Vazquez-Torres A, et al. (2004) Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: Importance of the Kupffer cell network. J Immunol 172(10): 6202-6208.
22. Talbot S, et al. (2009) Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance. Immunology 128(4): 472-483.
23. Eckmann L, Kagnoff MF (2001) Cytokines in host defense against Salmonella. Microbes Infect 3(14-15): 1191-1200.
24. Mariathasan S, et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430(6996): 213-218.
25. Broz P, et al. (2010) Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med 207(8): 1745-1755.
26. Miao EA, et al. (2010) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11(12): 1136-1142.
27. Franchi L, et al. (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol 7(6): 576-582.
28. Zhao Y, et al. (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477(7366): 596-600.
29. Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477(7366): 592-595.
30. Yang J, Zhao Y, Shi J, Shao F (2013) Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc Natl Acad Sci USA 110(35): 14408-14413.
31. Elinav E, et al. (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145(5): 745-757.
32. Birmingham CL, Brumell JH (2006) Autophagy recognizes intracellular Salmonella enterica serovar Typhimurium in damaged vacuoles. Autophagy 2(3): 156-158.
33. Shiloh MU, et al. (1999) Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10(1): 29-38.
34. Ware CF (2008) Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways. Immunol Rev 223: 186-201.