Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

Nature

Volumn 490, Issue 7419, 2012, Pages 288-291

  Broz, Petr ^a   Ruby, Thomas ^a   Belhocine, Kamila ^a   Bouley, Donna M ^a   Kayagaki, Nobuhiko ^b   Dixit, Vishva M ^b   Monack, Denise M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CASPASE 11; INTERLEUKIN 1BETA CONVERTING ENZYME; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

ALLELE; BACTERIAL DISEASE; BACTERIUM; CELL ORGANELLE; CYTOLOGY; ENZYME ACTIVITY; EPIDEMIOLOGY; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNITY; INNATE BEHAVIOR; PATHOGEN; PHENOTYPE; PHYSIOLOGY; POLYSACCHARIDE; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM COLONY; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; INFECTION SENSITIVITY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SALMONELLOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CASPASES; CELL DEATH; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; GENE EXPRESSION REGULATION; INFLAMMASOMES; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); MUS; SALMONELLA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM;

EID: 84867333450     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11419     Document Type: Article

References (23)

1. Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
2. Lamkanfi, M. Emerging inflammasome effector mechanisms. Nature Rev. Immunol. 11, 213-220 (2011).
3. Kayagaki, N. et al. Non-canonical inflammasome activation targets caspase-11. Nature 479, 117-121 (2011).
4. Wang, S. et al. Identification and characterization of Ich-3, a member of the interleukin-1b converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271, 20580-20587 (1996).
5. Kang, S. J. et al. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J. Cell Biol. 149, 613-622 (2000).
6. Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1b converting enzyme. Science 267, 2000-2003 (1995).
7. Lara-Tejero, M. et al. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J. Exp. Med. 203, 1407-1412 (2006).
8. Raupach, B., Peuschel, S. K., Monack, D. M. & Zychlinsky, A. Caspase-1-mediated activation of interleukin-1b (IL-1b) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection. Infect. Immun. 74, 4922-4926 (2006).
9. Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218 (2004).
10. Broz, P. et al. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J. Exp. Med. 207, 1745-1755 (2010).
11. Monack, D. M., Detweiler, C. S. & Falkow, S. Salmonella pathogenicity island 2-dependent macrophage death ismediated in part by the host cysteine protease caspase-1. Cell Microbiol. 3 825-837 (2001).
12. Akhter, A. et al. Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity http://dx.doi.org/10.1016/j.immuni.2012.05.001 (31 May 2012).
13. Miao, E. A. et al. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1b via Ipaf. Nature Immunol. 7, 569-575 (2006).
14. Franchi, L. et al. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1b in Salmonella-infected macrophages. Nature Immunol. 7, 576-582 (2006).
15. Kofoed, E. M. & Vance, R. E. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 474, 592-595 (2011).
16. Zhao, Y. et al. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477, 596-600 (2011).
17. Schauvliege, R., Vanrobaeys, J., Schotte, P. & Beyaert, R. Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kB and signal transducer and activator of transcription (STAT) 1. J. Biol. Chem. 277, 41624-41630 (2002).
18. O"Neill, L. A. & Bowie, A. G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nature Rev. Immunol. 7, 353-364 (2007).
19. Franchi, L., Munoz-Planillo, R. & Nunez, G. Sensing and reacting to microbes through the inflammasomes. Nature Immunol. 13, 325-332 (2012).
20. Conlan, J. W. Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia enterocolitica. Infect. Immun. 65, 630-635 (1997).
21. Valdez, Y., Ferreira, R. B. & Finlay, B. B. Molecular mechanisms of Salmonella virulence and host resistance. Curr. Top. Microbiol. Immunol. 337, 93-127 (2009).
22. Miao, E. A. et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nature Immunol. 11, 1136-1142 (2010).
23. Conlan, J. W. Neutrophils prevent extracellular colonization of the liver microvasculature by Salmonella typhimurium. Infect. Immun. 64, 1043-1047 (1996).