Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nature

Volumn 526, Issue 7575, 2015, Pages 666-671

  Kayagaki, Nobuhiko ^a   Stowe, Irma B ^a   Lee, Bettina L ^a   O'Rourke, Karen ^a   Anderson, Keith ^a   Warming, Søren ^a   Cuellar, Trinna ^a   Haley, Benjamin ^a   Roose Girma, Merone ^a   Phung, Qui T ^a   Liu, Peter S ^a   Lill, Jennie R ^a   Li, Hong ^a   Wu, Jiansheng ^a   Kummerfeld, Sarah ^a   Zhang, Juan ^a   Lee, Wyne P ^a   Snipas, Scott J ^b   Salvesen, Guy S ^b   Morris, Lucy X ^c   Fitzgerald, Linda ^c   Zhang, Yafei ^c   Bertram, Edward M ^c   Goodnow, Christopher C ^c,d,e   Dixit, Vishva M ^a   more..

^a GENENTECH INC   (United States)

^b BURNHAM INSTITUTE   (United States)

^c Biology and Environment   (Australia)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CRYOPYRIN; CYTOPLASM PROTEIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; ETHYLNITROSOUREA; GASDERMIN D; INFLAMMASOME; INTERLEUKIN 1BETA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CASP11 PROTEIN, MOUSE; CASPASE; GSDMD PROTEIN, HUMAN; GSDMD PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; TUMOR PROTEIN;

AMINO ACID; BACTERIUM; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; MATURATION; POLYSACCHARIDE; PROTEIN; RODENT;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE TARGETING; GENETIC SCREENING; HUMAN; LETHAL DOSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN PROCESSING; PYROPTOSIS; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; GENETICS; GRAM NEGATIVE BACTERIUM; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUTATION; NECROSIS; PERITONEUM MACROPHAGE; SECRETION (PROCESS); SEPSIS; SURVIVAL ANALYSIS;

BURKHOLDERIA THAILANDENSIS; ESCHERICHIA COLI; MUS; NEGIBACTERIA; SALMONELLA TYPHIMURIUM; SHIGELLA FLEXNERI;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELL LINE; FEMALE; GRAM-NEGATIVE BACTERIA; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MUTATION; NECROSIS; NEOPLASM PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

EID: 84942856523     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15541     Document Type: Article

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