IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

Cell

Volumn 167, Issue 2, 2016, Pages 382-396.e17

  Man, Si Ming ^a   Karki, Rajendra ^a   Sasai, Miwa ^b   Place, David E ^a   Kesavardhana, Sannula ^a   Temirov, Jamshid ^a   Frase, Sharon ^a   Zhu, Qifan ^a,c   Malireddi, R K Subbarao ^a   Kuriakose, Teneema ^a   Peters, Jennifer L ^a   Neale, Geoffrey ^a   Brown, Scott A ^a   Yamamoto, Masahiro ^b   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

caspase 1; cell autonomous immunity; GBP2; GBP5; GBPs; immunity related GTPases; innate immunity; interferons; LPS; non canonical inflammasome

Indexed keywords

AIM2 PROTEIN; BACTERIAL DNA; CASPASE 11; CRYOPYRIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GUANINE NUCLEOTIDE BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INFLAMMASOME; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; CASP11 PROTEIN, MOUSE; CASPASE; DNA BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; IRGB10 PROTEIN, MOUSE; LIGAND; NLRP3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BACTERIAL MEMBRANE; BACTERIAL STRUCTURES; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; FRANCISELLA NOVICIDA; FRANCISELLA NOVICIDA INFECTION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; B LYMPHOCYTE; BONE MARROW CELL; CELLULAR IMMUNITY; CYTOSOL; FRANCISELLA; GENETICS; GRAM NEGATIVE INFECTION; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUTANT MOUSE STRAIN; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; CASPASES; CYTOSOL; DNA-BINDING PROTEINS; FRANCISELLA; GRAM-NEGATIVE BACTERIAL INFECTIONS; GTP PHOSPHOHYDROLASES; HOST-PATHOGEN INTERACTIONS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; INFLAMMASOMES; LIGANDS; MICE; MICE, MUTANT STRAINS; MYELOID CELLS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; T-LYMPHOCYTES;

EID: 84990856288     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.012     Document Type: Article

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