3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome

Biochemical Pharmacology

Volumn 101, Issue , 2016, Pages 71-86

  Wang, Yajing ^a   Wang, Hong ^a   Qian, Chen ^a   Tang, Jingjing ^a   Zhou, Wei ^a   Liu, Xiuting ^a   You, Qidong ^a   Hu, Rong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

DSS; Inflammatory bowel disease; NLRP3 inflammasome; Nrf2; ROS

Indexed keywords

3 (2 OXO 2 PHENYLETHYLIDENE) 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH)ONE; ANTIINFLAMMATORY AGENT; CRYOPYRIN; DEXTRAN SULFATE; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; ISOQUINOLINE DERIVATIVE; MYELOPEROXIDASE; UNCLASSIFIED DRUG; 3-(2-OXO-2-PHENYLETHYLIDENE)-2,3,6,7-TETRAHYDRO-1H-PYRAZINO(2,1-A)ISOQUINOLIN-4(11BH)-ONE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; GASTROINTESTINAL AGENT; NFE2L2 PROTEIN, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; PYRAZINE DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MACROPHAGE; C57BL 6 MOUSE; CANCER PREVENTION; CELL INFILTRATION; COLORECTAL ADENOMA; CONTROLLED STUDY; CYTOKINE RELEASE; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DRUG MEGADOSE; DRUG POTENCY; ENZYME INHIBITION; FEMALE; GOBLET CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN WEIGHT; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIOXIDANT RESPONSIVE ELEMENT; C57BL MOUSE; CELL CULTURE; CELL LINE; COLITIS, ULCERATIVE; COLON; DOSE RESPONSE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; KNOCKOUT MOUSE; MACROPHAGE; MALE; METABOLISM; PATHOLOGY; REPORTER GENE; RNA INTERFERENCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANT RESPONSE ELEMENTS; CARRIER PROTEINS; CELL LINE; CELLS, CULTURED; COLITIS, ULCERATIVE; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL AGENTS; GENES, REPORTER; HUMANS; INFLAMMASOMES; INTESTINAL MUCOSA; ISOQUINOLINES; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; PYRAZINES; RNA INTERFERENCE;

EID: 84957577397     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.11.015     Document Type: Article

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