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Volumn 6, Issue 1, 2013, Pages 4-13

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 PROTEIN; CASPASE 11; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRC4 PROTEIN; NLRP1 PROTEIN; NLRP6 PROTEIN; UNCLASSIFIED DRUG;

EID: 84874028928     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2012.115     Document Type: Review
Times cited : (76)

References (79)
  • 1
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • DOI 10.1016/j.cell.2004.07.002, PII S0092867404006610
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004). (Pubitemid 38962578)
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 3
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745-757 (2011).
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1
  • 4
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia, J. et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179-185 (2012).
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 5
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 6
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J. & Alnemri, E.S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513 (2009).
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 7
    • 79956061094 scopus 로고    scopus 로고
    • IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
    • Kerur, N. et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe. 9, 363-375 (2011).
    • (2011) Cell Host Microbe. , vol.9 , pp. 363-375
    • Kerur, N.1
  • 8
    • 0036671894 scopus 로고    scopus 로고
    • The Inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
    • DOI 10.1016/S1097-2765(02)00599-3
    • Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10, 417-426 (2002). (Pubitemid 35007355)
    • (2002) Molecular Cell , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 9
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase- 1-activating inflammasome with ASC
    • Hornung, V. et al. AIM2 recognizes cytosolic dsDNA and forms a caspase- 1-activating inflammasome with ASC. Nature 458, 514-518 (2009).
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1
  • 10
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • Roberts, T.L. et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323, 1057-1060 (2009).
    • (2009) Science , vol.323 , pp. 1057-1060
    • Roberts, T.L.1
  • 11
    • 45549093755 scopus 로고    scopus 로고
    • A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    • Hsu, L.C. et al. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc. Natl. Acad. Sci. USA 105, 7803-7808 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7803-7808
    • Hsu, L.C.1
  • 12
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada, K. et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414 (2012).
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1
  • 13
    • 80053349020 scopus 로고    scopus 로고
    • The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    • Zhao, Y. et al. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477, 596-600 (2011).
    • (2011) Nature , vol.477 , pp. 596-600
    • Zhao, Y.1
  • 14
    • 80053379974 scopus 로고    scopus 로고
    • Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
    • Kofoed, E.M. & Vance, R.E. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477, 592-595 (2011).
    • (2011) Nature , vol.477 , pp. 592-595
    • Kofoed, E.M.1    Vance, R.E.2
  • 15
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxininteracting protein links oxidative stress to inflammasome activation
    • Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxininteracting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 16
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung, V. et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 847-856
    • Hornung, V.1
  • 19
    • 68349131301 scopus 로고    scopus 로고
    • The S Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation
    • Muller, A.J. et al. The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell HostMicrobe. 6, 125-136 (2009).
    • (2009) Cell HostMicrobe. , vol.6 , pp. 125-136
    • Muller, A.J.1
  • 20
    • 33746583965 scopus 로고    scopus 로고
    • Caspase-1-mediated activation of interleukin-1β (IL-1β) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar typhimurium infection
    • DOI 10.1128/IAI.00417-06
    • Raupach, B., Peuschel, S.K., Monack, D.M. & Zychlinsky, A. Caspase-1- mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection. Infect. Immun. 74, 4922-4926 (2006). (Pubitemid 44157282)
    • (2006) Infection and Immunity , vol.74 , Issue.8 , pp. 4922-4926
    • Raupach, B.1    Peuschel, S.-K.2    Monack, D.M.3    Zychlinsky, A.4
  • 21
    • 78449269290 scopus 로고    scopus 로고
    • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    • Miao, E.A. et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11, 1136-1142 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 1136-1142
    • Miao, E.A.1
  • 22
    • 33644985564 scopus 로고    scopus 로고
    • Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    • Sutterwala, F.S. et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24, 317-327 (2006).
    • (2006) Immunity , vol.24 , pp. 317-327
    • Sutterwala, F.S.1
  • 23
    • 84858677223 scopus 로고    scopus 로고
    • Sensing and reacting to microbes through the inflammasomes
    • Franchi, L., Munoz-Planillo, R. & Nunez, G. Sensing and reacting to microbes through the inflammasomes. Nat. Immunol. 13, 325-332 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 325-332
    • Franchi, L.1    Munoz-Planillo, R.2    Nunez, G.3
  • 24
    • 77955390094 scopus 로고    scopus 로고
    • Redundant roles for inflammasome receptorsNLRP3andNLRC4 in host defense against Salmonella
    • Broz,P. et al. Redundant roles for inflammasome receptorsNLRP3andNLRC4 in host defense against Salmonella. J. Exp. Med. 207, 1745-1755 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1745-1755
    • Broz, P.1
  • 25
    • 77649241461 scopus 로고    scopus 로고
    • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    • Miao, E.A. et al. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl. Acad. Sci.USA 107, 3076-3080 (2010).
    • (2010) Proc. Natl. Acad. Sci.USA , vol.107 , pp. 3076-3080
    • Miao, E.A.1
  • 26
    • 85046848553 scopus 로고    scopus 로고
    • Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
    • Suzuki, T. et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog. 3, e111 (2007).
    • (2007) PLoS Pathog , vol.3
    • Suzuki, T.1
  • 27
    • 52549099416 scopus 로고    scopus 로고
    • Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    • Lightfield, K.L. et al. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat. Immunol. 9, 1171-1178 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1171-1178
    • Lightfield, K.L.1
  • 28
    • 79953315378 scopus 로고    scopus 로고
    • Differential requirements for NAIP5 in activation of the NLRC4 inflammasome
    • Lightfield, K.L. et al. Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. Infect. Immun. 79, 1606-1614 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 1606-1614
    • Lightfield, K.L.1
  • 29
    • 84860859210 scopus 로고    scopus 로고
    • Role of inflammasomes in host defense against citrobacter rodentium infection
    • Liu, Z. et al. Role of inflammasomes in host defense against citrobacter rodentium infection. J. Biol. Chem. 287, 16955-16964 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 16955-16964
    • Liu, Z.1
  • 30
    • 84860668802 scopus 로고    scopus 로고
    • Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota
    • Ayres, J.S., Trinidad, N.J. & Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat. Med. 18, 799-806 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 799-806
    • Ayres, J.S.1    Trinidad, N.J.2    Vance, R.E.3
  • 31
    • 84859911615 scopus 로고    scopus 로고
    • NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    • Franchi, L. et al. NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat. Immunol. 13, 449-456 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 449-456
    • Franchi, L.1
  • 33
    • 80455176839 scopus 로고    scopus 로고
    • Non-canonical inflammasome activation targets caspase-11
    • Kayagaki, N. et al. Non-canonical inflammasome activation targets caspase-11. Nature 479, 117-121 (2011).
    • (2011) Nature , vol.479 , pp. 117-121
    • Kayagaki, N.1
  • 38
    • 0034795561 scopus 로고    scopus 로고
    • Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    • Siegmund, B. et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1264-R1273 (2001).
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.281
    • Siegmund, B.1
  • 39
    • 0036135586 scopus 로고    scopus 로고
    • Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
    • Wirtz, S.,Becker,C., Blumberg,R., Galle, P.R.&Neurath,M.F. Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J. Immunol. 168, 411-420 (2002). (Pubitemid 34014143)
    • (2002) Journal of Immunology , vol.168 , Issue.1 , pp. 411-420
    • Wirtz, S.1    Becker, C.2    Blumberg, R.3    Galle, P.R.4    Neurath, M.F.5
  • 45
    • 42749096082 scopus 로고    scopus 로고
    • Genetic analysis of innate immunity inCrohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP
    • Zhernakova, A. et al. Genetic analysis of innate immunity inCrohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am. J. Hum. Genet. 82, 1202-1210 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 1202-1210
    • Zhernakova, A.1
  • 46
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • Villani, A.C. et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat. Genet. 41, 71-76 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 71-76
    • Villani, A.C.1
  • 47
    • 79955825352 scopus 로고    scopus 로고
    • Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel
    • Lewis, G.J. et al. Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel. Inflamm. Bowel Dis. 17, 1387-1391 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1387-1391
    • Lewis, G.J.1
  • 48
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine, J. et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378 (2010).
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 49
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki, M.H. et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32, 379-391 (2010).
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1
  • 50
    • 79955846705 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
    • Hirota, S.A. et al. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel Dis. 17, 1359-1372 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1359-1372
    • Hirota, S.A.1
  • 51
    • 77952303410 scopus 로고    scopus 로고
    • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    • Allen, I.C. et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 207, 1045-1056 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1045-1056
    • Allen, I.C.1
  • 52
    • 77956128040 scopus 로고    scopus 로고
    • Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
    • Bauer, C. et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 59, 1192-1199 (2010).
    • (2010) Gut , vol.59 , pp. 1192-1199
    • Bauer, C.1
  • 53
    • 77949982382 scopus 로고    scopus 로고
    • Interleukin-18 in intestinal inflammation: Friend and foe?
    • Siegmund, B. Interleukin-18 in intestinal inflammation: friend and foe?. Immunity 32, 300-302 (2010).
    • (2010) Immunity , vol.32 , pp. 300-302
    • Siegmund, B.1
  • 54
    • 79959540809 scopus 로고    scopus 로고
    • A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
    • Chen, G.Y., Liu, M., Wang, F., Bertin, J. & Nunez, G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186, 7187-7194 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 7187-7194
    • Chen, G.Y.1    Liu, M.2    Wang, F.3    Bertin, J.4    Nunez, G.5
  • 55
    • 79959369355 scopus 로고    scopus 로고
    • Nod-like receptor pyrin domain-containing protein 6 (nlrp6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
    • Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. USA 108, 9601-9606 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 9601-9606
    • Normand, S.1
  • 58
    • 83755186465 scopus 로고    scopus 로고
    • Linkage of gut microbiome with cognition in hepatic encephalopathy
    • Bajaj, J.S. et al. Linkage of gut microbiome with cognition in hepatic encephalopathy. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G168- G175 (2012).
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.302
    • Bajaj, J.S.1
  • 59
    • 45149094025 scopus 로고    scopus 로고
    • Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment
    • DOI 10.1111/j.1399-302X.2007.00426.x
    • Makiura, N. et al. Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiol. Immunol. 23, 348-351 (2008). (Pubitemid 351832173)
    • (2008) Oral Microbiology and Immunology , vol.23 , Issue.4 , pp. 348-351
    • Makiura, N.1    Ojima, M.2    Kou, Y.3    Furuta, N.4    Okahashi, N.5    Shizukuishi, S.6    Amano, A.7
  • 60
    • 60149102748 scopus 로고    scopus 로고
    • Mouse models for the study of colon carcinogenesis
    • Rosenberg, D.W., Giardina, C. & Tanaka, T. Mouse models for the study of colon carcinogenesis. Carcinogenesis 30, 183-196 (2009).
    • (2009) Carcinogenesis , vol.30 , pp. 183-196
    • Rosenberg, D.W.1    Giardina, C.2    Tanaka, T.3
  • 61
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • DOI 10.1126/science.1140488
    • Rakoff-Nahoum, S. & Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127 (2007). (Pubitemid 47056471)
    • (2007) Science , vol.317 , Issue.5834 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 63
    • 77953196709 scopus 로고    scopus 로고
    • ERK activation drives intestinal tumorigenesis in Apc(min/+) mice
    • Lee, S.H. et al. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat. Med. 16, 665-670 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 665-670
    • Lee, S.H.1
  • 64
    • 84861335956 scopus 로고    scopus 로고
    • Risk of colorectal cancer in patients with ulcerative colitis: Ameta-analysis of population-based cohort studies
    • Jess, T., Rungoe, C. & Peyrin-Biroulet, L. Risk of colorectal cancer in patients with ulcerative colitis: ameta-analysis of population-based cohort studies. Clin. Gastroenterol. Hepatol. 10, 639-645 (2012).
    • (2012) Clin. Gastroenterol. Hepatol. , vol.10 , pp. 639-645
    • Jess, T.1    Rungoe, C.2    Peyrin-Biroulet, L.3
  • 65
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: A meta-analysis
    • DOI 10.1136/gut.48.4.526
    • Eaden, J.A., Abrams, K.R. & Mayberry, J.F. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48, 526-535 (2001). (Pubitemid 32234798)
    • (2001) Gut , vol.48 , Issue.4 , pp. 526-535
    • Eaden, J.A.1    Abrams, K.R.2    Mayberry, J.F.3
  • 68
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath, J. et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15, 91-102 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1
  • 69
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1
  • 70
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • DOI 10.1016/j.cell.2004.07.013, PII S0092867404006713
    • Greten, F.R. et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296 (2004). (Pubitemid 39061110)
    • (2004) Cell , vol.118 , Issue.3 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.-W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 71
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
    • Salcedo, R. et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625-1636 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1625-1636
    • Salcedo, R.1
  • 72
    • 78049488908 scopus 로고    scopus 로고
    • IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
    • Zaki, M.H., Vogel, P., Body-Malapel, M., Lamkanfi, M. & Kanneganti, T.D. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J. Immunol. 185, 4912-4920 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 4912-4920
    • Zaki, M.H.1    Vogel, P.2    Body-Malapel, M.3    Lamkanfi, M.4    Kanneganti, T.D.5
  • 73
    • 79959540809 scopus 로고    scopus 로고
    • A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
    • Chen, G.Y., Liu, M., Wang, F., Bertin, J. & Nunez, G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186, 7187-7194 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 7187-7194
    • Chen, G.Y.1    Liu, M.2    Wang, F.3    Bertin, J.4    Nunez, G.5
  • 74
    • 79959369355 scopus 로고    scopus 로고
    • Nod-like receptor pyrin domain-containing protein 6 (nlrp6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
    • Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. USA 108, 9601-9606 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 9601-9606
    • Normand, S.1
  • 76
    • 84861460062 scopus 로고    scopus 로고
    • NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling
    • Allen, I.C. et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling. Immunity 36, 742-754 (2012).
    • (2012) Immunity , vol.36 , pp. 742-754
    • Allen, I.C.1
  • 77
    • 81255189478 scopus 로고    scopus 로고
    • The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis
    • Zaki, M.H. et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20, 649-660 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 649-660
    • Zaki, M.H.1
  • 78
    • 78650735879 scopus 로고    scopus 로고
    • Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    • Hu, B. et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc. Natl. Acad. Sci. USA 107, 21635-21640 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 21635-21640
    • Hu, B.1
  • 79
    • 79959221313 scopus 로고    scopus 로고
    • Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation
    • Hu, B., Elinav, E. & Flavell, R.A. Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation. Cell Cycle 10, 1936-1939 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 1936-1939
    • Hu, B.1    Elinav, E.2    Flavell, R.A.3


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