-
1
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky, D. K. Inflammatory bowel disease. N. Engl. J. Med. 347, 417-429 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 417-429
-
-
Podolsky, D.K.1
-
2
-
-
2442563304
-
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
-
Loftus, E. V. Jr Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126, 1504-1517 (2004).
-
(2004)
Gastroenterology
, vol.126
, pp. 1504-1517
-
-
Loftus Jr, E.V.1
-
3
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier, R. J. & Podolsky, D. K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007).
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
4
-
-
23344449020
-
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
-
Elson, C. O. et al. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol. Rev. 206, 260-276 (2005).
-
(2005)
Immunol. Rev
, vol.206
, pp. 260-276
-
-
Elson, C.O.1
-
5
-
-
35348983887
-
-
Frazer, K. A. et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007). Data from the HapMap project provided the basis for the advent of GWA studies.
-
Frazer, K. A. et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007). Data from the HapMap project provided the basis for the advent of GWA studies.
-
-
-
-
6
-
-
13144265739
-
Genome-wide association studies: Theoretical and practical concerns
-
Wang, W. Y., Barratt, B. J., Clayton, D. G. & Todd, J. A. Genome-wide association studies: theoretical and practical concerns. Nature Rev. Genet. 6, 109-118 (2005).
-
(2005)
Nature Rev. Genet
, vol.6
, pp. 109-118
-
-
Wang, W.Y.1
Barratt, B.J.2
Clayton, D.G.3
Todd, J.A.4
-
7
-
-
13144306071
-
Genome-wide association studies for common diseases and complex traits
-
Hirschhorn, J. N. & Daly, M. J. Genome-wide association studies for common diseases and complex traits. Nature Rev. Genet. 6, 95-108 (2005).
-
(2005)
Nature Rev. Genet
, vol.6
, pp. 95-108
-
-
Hirschhorn, J.N.1
Daly, M.J.2
-
8
-
-
34848850085
-
The genetics of inflammatory bowel disease
-
Cho, J. H. & Weaver, C. T. The genetics of inflammatory bowel disease. Gastroenterology 133, 1327-1339 (2007).
-
(2007)
Gastroenterology
, vol.133
, pp. 1327-1339
-
-
Cho, J.H.1
Weaver, C.T.2
-
9
-
-
0032198308
-
Genetic epidemiology in inflammatory bowel disease
-
Binder, V. Genetic epidemiology in inflammatory bowel disease. Digest. Dis. 16, 351-355 (1998).
-
(1998)
Digest. Dis
, vol.16
, pp. 351-355
-
-
Binder, V.1
-
10
-
-
44349136821
-
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
-
27 April, doi:10.1038/ng.145
-
Fisher, S. A. et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genet. 27 April 2008 (doi:10.1038/ng.145).
-
(2008)
Nature Genet
-
-
Fisher, S.A.1
-
11
-
-
44349173654
-
-
Franke, A. et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nature Genet. 27 April 2008 (doi:10.1038/ng.148). Together with reference 10, this study identifies an overlap between susceptibility loci in Crohn's disease and ulcerative colitis.
-
Franke, A. et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nature Genet. 27 April 2008 (doi:10.1038/ng.148). Together with reference 10, this study identifies an overlap between susceptibility loci in Crohn's disease and ulcerative colitis.
-
-
-
-
12
-
-
84969213492
-
-
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007). A landmark article defining the GWAs for seven common diseases, including Crohn's disease.
-
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007). A landmark article defining the GWAs for seven common diseases, including Crohn's disease.
-
-
-
-
13
-
-
0037446534
-
Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses
-
Tarlinton, D., Light, A., Metcalf, D., Harvey, R. P. & Robb, L. Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses. J. Immunol. 170, 4002-4010 (2003).
-
(2003)
J. Immunol
, vol.170
, pp. 4002-4010
-
-
Tarlinton, D.1
Light, A.2
Metcalf, D.3
Harvey, R.P.4
Robb, L.5
-
14
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J. P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
15
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
16
-
-
0142180157
-
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
-
Girardin, S. E. et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J. Biol. Chem. 278, 41702-41708 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41702-41708
-
-
Girardin, S.E.1
-
17
-
-
0037458665
-
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
-
Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278, 5509-5512 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 5509-5512
-
-
Inohara, N.1
-
18
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi, K. S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
-
19
-
-
0037265610
-
Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
-
Croucher, P. J. et al. Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations. Eur. J. Hum. Genet. 11, 6-16 (2003).
-
(2003)
Eur. J. Hum. Genet
, vol.11
, pp. 6-16
-
-
Croucher, P.J.1
-
20
-
-
0038235697
-
NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population
-
Leong, R. W. et al. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol. Ther. 17, 1465-1470 (2003).
-
(2003)
Aliment Pharmacol. Ther
, vol.17
, pp. 1465-1470
-
-
Leong, R.W.1
-
21
-
-
0036373539
-
Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease
-
Yamazaki, K., Takazoe, M., Tanaka, T., Kazumori, T. & Nakamura, Y. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J. Hum. Genet. 47, 469-472 (2002).
-
(2002)
J. Hum. Genet
, vol.47
, pp. 469-472
-
-
Yamazaki, K.1
Takazoe, M.2
Tanaka, T.3
Kazumori, T.4
Nakamura, Y.5
-
22
-
-
21844440348
-
Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease
-
Kugathasan, S. et al. Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease. Inflamm. Bowel Dis. 11, 631-638 (2005).
-
(2005)
Inflamm. Bowel Dis
, vol.11
, pp. 631-638
-
-
Kugathasan, S.1
-
23
-
-
11144279151
-
Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: A metaanalysis
-
Economou, M., Trikalinos, T. A., Loizou, K. T., Tsianos, E. V. & Ioannidis, J. P. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am. J. Gastroenterol. 99, 2393-2404 (2004).
-
(2004)
Am. J. Gastroenterol
, vol.99
, pp. 2393-2404
-
-
Economou, M.1
Trikalinos, T.A.2
Loizou, K.T.3
Tsianos, E.V.4
Ioannidis, J.P.5
-
24
-
-
33745536739
-
Functional consequences of NOD2 (CARD15) mutations
-
Abraham, C. & Cho, J. H. Functional consequences of NOD2 (CARD15) mutations. Inflamm. Bowel Dis. 12, 641-650 (2006).
-
(2006)
Inflamm. Bowel Dis
, vol.12
, pp. 641-650
-
-
Abraham, C.1
Cho, J.H.2
-
25
-
-
34249017939
-
Prevalence of CARD15/NOD2 mutations in caucasian healthy people
-
Hugot, J. P. et al. Prevalence of CARD15/NOD2 mutations in caucasian healthy people. Am. J. Gastroenterol. 102, 1259-1267 (2007).
-
(2007)
Am. J. Gastroenterol
, vol.102
, pp. 1259-1267
-
-
Hugot, J.P.1
-
26
-
-
0142123222
-
Role of nod2 in the response of macrophages to Toll-like receptor agonists
-
Pauleau, A. L. & Murray, P. J. Role of nod2 in the response of macrophages to Toll-like receptor agonists. Mol. Cell Biol. 23, 7531-7539 (2003).
-
(2003)
Mol. Cell Biol
, vol.23
, pp. 7531-7539
-
-
Pauleau, A.L.1
Murray, P.J.2
-
27
-
-
0031925362
-
Activation of nuclear factor κB inflammatory bowel disease
-
Schreiber, S., Nikolaus, S. & Hampe, J. Activation of nuclear factor κB inflammatory bowel disease. Gut 42, 477-484 (1998).
-
(1998)
Gut
, vol.42
, pp. 477-484
-
-
Schreiber, S.1
Nikolaus, S.2
Hampe, J.3
-
28
-
-
37649013801
-
Chronic stimulation of Nod2 mediates tolerance to bacterial products
-
Hedl, M., Li, J., Cho, J. H. & Abraham, C. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc. Natl Acad. Sci. USA 104, 19440-19445 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19440-19445
-
-
Hedl, M.1
Li, J.2
Cho, J.H.3
Abraham, C.4
-
29
-
-
38849163741
-
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
-
Watanabe, T. et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest. 118, 545-559 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 545-559
-
-
Watanabe, T.1
-
30
-
-
0037380969
-
CARD15/NOD2 functions as an anti-bacterial factor in human intestinal epithelial cells
-
Hisamatsu, T. et al. CARD15/NOD2 functions as an anti-bacterial factor in human intestinal epithelial cells. Gastroenterology 124, 993-1000 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 993-1000
-
-
Hisamatsu, T.1
-
31
-
-
39149094587
-
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
-
Kim, Y. G. et al. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28, 246-257 (2008).
-
(2008)
Immunity
, vol.28
, pp. 246-257
-
-
Kim, Y.G.1
-
32
-
-
29144483937
-
Reduced Paneth cell α-defensins in ileal Crohn's disease
-
Wehkamp, J. et al. Reduced Paneth cell α-defensins in ileal Crohn's disease. Proc. Natl Acad. Sci. USA 102, 18129-18134 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
-
33
-
-
4143069158
-
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
-
Darfeuille-Michaud, A. et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 127, 412-421 (2004).
-
(2004)
Gastroenterology
, vol.127
, pp. 412-421
-
-
Darfeuille-Michaud, A.1
-
34
-
-
46349102893
-
-
Simms, L. A. et al. Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 27 February 2008 (doi:10.1136/gut.2007.142588).
-
Simms, L. A. et al. Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 27 February 2008 (doi:10.1136/gut.2007.142588).
-
-
-
-
35
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nature Genet. 39, 207-211 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
-
36
-
-
0038325675
-
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
-
Mizushima, N. et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 116, 1679-1688 (2003).
-
(2003)
J. Cell Sci
, vol.116
, pp. 1679-1688
-
-
Mizushima, N.1
-
37
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux, J. D. et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature Genet. 39, 596-604 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
-
38
-
-
34548700796
-
Unveiling the roles of autophagy in innate and adaptive immunity
-
Levine, B. & Deretic, V. Unveiling the roles of autophagy in innate and adaptive immunity. Nature Rev. Immunol. 7, 767-777 (2007).
-
(2007)
Nature Rev. Immunol
, vol.7
, pp. 767-777
-
-
Levine, B.1
Deretic, V.2
-
39
-
-
33750322790
-
Autophagy in innate immunity against intracellular bacteria
-
Amano, A., Nakagawa, I. & Yoshimori, T. Autophagy in innate immunity against intracellular bacteria. J. Biochem. 140, 161-166 (2006).
-
(2006)
J. Biochem
, vol.140
, pp. 161-166
-
-
Amano, A.1
Nakagawa, I.2
Yoshimori, T.3
-
40
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes, M. et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genet. 39, 830-832 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 830-832
-
-
Parkes, M.1
-
41
-
-
0035898464
-
Inactivation of LRG-47 and IRG-47 reveals a family of interferon γ-inducible genes with essential, pathogen-specific roles in resistance to infection
-
Collazo, C. M. et al. Inactivation of LRG-47 and IRG-47 reveals a family of interferon γ-inducible genes with essential, pathogen-specific roles in resistance to infection. J. Exp. Med. 194, 181-188 (2001).
-
(2001)
J. Exp. Med
, vol.194
, pp. 181-188
-
-
Collazo, C.M.1
-
42
-
-
33748506089
-
Human IRGM induces autophagy to eliminate intracellular mycobacteria
-
Singh, S. B., Davis, A. S., Taylor, G. A. & Deretic, V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313, 1438-1441 (2006).
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
Deretic, V.4
-
43
-
-
0030209985
-
+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
-
A seminal article describing the distinct cytokine profiles that distinguish Crohn's disease from ulcerative colitis
-
+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157, 1261-1270 (1996). A seminal article describing the distinct cytokine profiles that distinguish Crohn's disease from ulcerative colitis.
-
(1996)
J. Immunol
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
-
44
-
-
0031573593
-
A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
-
Plevy, S. E. et al. A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J. Immunol. 159, 6276-6282 (1997).
-
(1997)
J. Immunol
, vol.159
, pp. 6276-6282
-
-
Plevy, S.E.1
-
45
-
-
33845340501
-
-
Duerr, R. H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-3 (2006). Initial description of association of variants in IL23R with a common, complex inflammatory disorder.
-
Duerr, R. H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-3 (2006). Initial description of association of variants in IL23R with a common, complex inflammatory disorder.
-
-
-
-
46
-
-
33846608131
-
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
-
Cargill, M. et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet. 80, 273-290 (2007).
-
(2007)
Am. J. Hum. Genet
, vol.80
, pp. 273-290
-
-
Cargill, M.1
-
47
-
-
35748981184
-
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
-
Burton, P. R. et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genet. 39, 1329-1337 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 1329-1337
-
-
Burton, P.R.1
-
48
-
-
0037216498
-
Increased expression of interleukin 17 in inflammatory bowel disease
-
Fujino, S. et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52, 65-70 (2003).
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
-
49
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
-
A seminal article identifying IL23R, its expression, its signalling pathway and its relationship to IL-12R signalling pathways
-
Parham, C. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168, 5699-5708 (2002). A seminal article identifying IL23R, its expression, its signalling pathway and its relationship to IL-12R signalling pathways.
-
(2002)
J. Immunol
, vol.168
, pp. 5699-5708
-
-
Parham, C.1
-
50
-
-
33646560950
-
H17 lineage
-
H17 lineage. Nature 441, 231-234 (2006).
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
-
51
-
-
34547155467
-
Immunology: Narcissistic helpers
-
Palmer, M. T. & Weaver, C. T. Immunology: narcissistic helpers. Nature 448, 416-418 (2007).
-
(2007)
Nature
, vol.448
, pp. 416-418
-
-
Palmer, M.T.1
Weaver, C.T.2
-
52
-
-
33748588423
-
+ T helper cells
-
+ T helper cells. Cell 126, 1121-1133 (2006).
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
-
53
-
-
33646577466
-
H17 and regulatory T cells
-
H17 and regulatory T cells. Nature 441, 235-238 (2006).
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
54
-
-
32244442562
-
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006).
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
55
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski, M. T. et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166, 7563-7570 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
-
56
-
-
34250026960
-
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
-
Elson, C. O. et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132, 2359-2370 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 2359-2370
-
-
Elson, C.O.1
-
57
-
-
33750505009
-
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
-
Hue, S. et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203, 2473-2483 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2473-2483
-
-
Hue, S.1
-
58
-
-
33750530394
-
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
-
Kullberg, M. C. et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 203, 2485-2494 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2485-2494
-
-
Kullberg, M.C.1
-
59
-
-
33747089041
-
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
-
Uhlig, H. H. et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25, 309-318 (2006).
-
(2006)
Immunity
, vol.25
, pp. 309-318
-
-
Uhlig, H.H.1
-
60
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310-1316 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
-
61
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon, P. J. et al. Anti-interleukin-12 antibody for active Crohn's disease. N. Engl. J. Med. 351, 2069-2079 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 2069-2079
-
-
Mannon, P.J.1
-
62
-
-
9644257195
-
Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
-
Watford, W. T. et al. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 202, 139-156 (2004).
-
(2004)
Immunol. Rev
, vol.202
, pp. 139-156
-
-
Watford, W.T.1
-
63
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence, A. et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26, 371-381 (2007).
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
-
64
-
-
34547188748
-
H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nature Immunol. 8, 967-974 (2007).
-
(2007)
Nature Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
-
65
-
-
44349190850
-
Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease
-
in the press
-
Barrett, J. C. et al. Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease. Nature Genet. (in the press).
-
Nature Genet
-
-
Barrett, J.C.1
-
66
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
-
Fuss, I. J. et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12, 9-15 (2006).
-
(2006)
Inflamm. Bowel Dis
, vol.12
, pp. 9-15
-
-
Fuss, I.J.1
-
67
-
-
13944281011
-
Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: Elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis
-
Schmidt, C. et al. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm. Bowel Dis. 11, 16-23 (2005).
-
(2005)
Inflamm. Bowel Dis
, vol.11
, pp. 16-23
-
-
Schmidt, C.1
-
68
-
-
3042721899
-
Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease
-
Stallmach, A. et al. Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease. Int. J. Colorectal Dis. 19, 308-315 (2004).
-
(2004)
Int. J. Colorectal Dis
, vol.19
, pp. 308-315
-
-
Stallmach, A.1
-
69
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49 (1999).
-
(1999)
Immunity
, vol.10
, pp. 39-49
-
-
Takeda, K.1
-
70
-
-
34247556456
-
IL-22 induces lipopolysaccharide-binding protein in hepatocytes: A potential systemic role of IL-22 in Crohn's disease
-
Wolk, K. et al. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J. Immunol. 178, 5973-5981 (2007).
-
(2007)
J. Immunol
, vol.178
, pp. 5973-5981
-
-
Wolk, K.1
-
71
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
-
72
-
-
33747777440
-
Cutting Edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis
-
Becker, C. et al. Cutting Edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J. Immunol. 177, 2760-2764 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 2760-2764
-
-
Becker, C.1
-
73
-
-
34548133583
-
Development, cytokine profile and function of human interleukin 17-producing helper T cells
-
Wilson, N. J. et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nature Immunol. 8, 950-957 (2007).
-
(2007)
Nature Immunol
, vol.8
, pp. 950-957
-
-
Wilson, N.J.1
-
74
-
-
33847212513
-
Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease
-
Silverberg, M. S. et al. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. Eur. J. Hum. Genet. 15, 328-335 (2007).
-
(2007)
Eur. J. Hum. Genet
, vol.15
, pp. 328-335
-
-
Silverberg, M.S.1
-
75
-
-
34247579326
-
A novel susceptibility locus for Crohn's disease identified by whole genome association maps to a gene desert on chromosome 5p13.1 and modulates the level of expression of the prostaglandin receptor EP4
-
Libioulle, C. et al. A novel susceptibility locus for Crohn's disease identified by whole genome association maps to a gene desert on chromosome 5p13.1 and modulates the level of expression of the prostaglandin receptor EP4. PLoS Genet. 3, e58 (2007).
-
(2007)
PLoS Genet
, vol.3
-
-
Libioulle, C.1
-
76
-
-
0036221333
-
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
-
Kabashima, K. et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J. Clin. Invest. 109, 883-893 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 883-893
-
-
Kabashima, K.1
-
77
-
-
2442585704
-
Functional variants of OCTN cation transporter genes are associated with Crohn disease
-
Peltekova, V. D. et al. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nature Genet. 36, 471-475 (2004).
-
(2004)
Nature Genet
, vol.36
, pp. 471-475
-
-
Peltekova, V.D.1
-
78
-
-
0033624575
-
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler, D. et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genet. 26, 76-80 (2000).
-
(2000)
Nature Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
-
79
-
-
0033103805
-
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
-
Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. & Kollias, G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387-398 (1999).
-
(1999)
Immunity
, vol.10
, pp. 387-398
-
-
Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
Cominelli, F.4
Kollias, G.5
-
80
-
-
34548427925
-
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
-
Remmers, E. F. et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N. Engl. J. Med. 357, 977-986 (2007).
-
(2007)
N. Engl. J. Med
, vol.357
, pp. 977-986
-
-
Remmers, E.F.1
-
81
-
-
34548367511
-
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
-
Lowe, C. E. et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nature Genet. 39, 1074-82 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 1074-1082
-
-
Lowe, C.E.1
-
82
-
-
34548299105
-
Risk alleles for multiple sclerosis identified by a genomewide study
-
Hafler, D. A. et al. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357, 851-862 (2007).
-
(2007)
N. Engl. J. Med
, vol.357
, pp. 851-862
-
-
Hafler, D.A.1
-
83
-
-
0031779092
-
Crohn's disease in Olmsted County, Minnesota, 1940-1993: Incidence, prevalence, and survival
-
Loftus, E. V. Jr et al. Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology 114, 1161-1168 (1998).
-
(1998)
Gastroenterology
, vol.114
, pp. 1161-1168
-
-
Loftus Jr, E.V.1
-
84
-
-
0034026626
-
Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: Incidence, prevalence, and survival
-
Loftus, E. V. Jr et al. Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gut 46, 336-343 (2000).
-
(2000)
Gut
, vol.46
, pp. 336-343
-
-
Loftus Jr, E.V.1
-
85
-
-
0033562383
-
Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: A population-based study
-
Bernstein, C. N., Blanchard, J. F., Rawsthorne, P. & Wajda, A. Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study. Am. J. Epidemiol. 149, 916-924 (1999).
-
(1999)
Am. J. Epidemiol
, vol.149
, pp. 916-924
-
-
Bernstein, C.N.1
Blanchard, J.F.2
Rawsthorne, P.3
Wajda, A.4
-
86
-
-
0002535871
-
-
eds Targan, S. R. & Shanahan, F, Williams and Wilkins, Baltimore
-
Sandler, R. S. in Inflammatory bowel disease: from bench to bedside (eds Targan, S. R. & Shanahan, F.) 5-30 (Williams and Wilkins, Baltimore, 1994).
-
(1994)
Inflammatory bowel disease: From bench to bedside
, pp. 5-30
-
-
Sandler, R.S.1
-
87
-
-
0000628744
-
-
eds Kirsner, J. B. & Shorter, R. G, Williams & Wilkins, Baltimore
-
Calkins, B. M. & Mendelhoff, A. I. in Inflammatory Bowel Disease (eds Kirsner, J. B. & Shorter, R. G.) 31-68 (Williams & Wilkins, Baltimore, 1995).
-
(1995)
Inflammatory Bowel Disease
, pp. 31-68
-
-
Calkins, B.M.1
Mendelhoff, A.I.2
-
88
-
-
0002234646
-
-
eds Targan, S. R. & Shanahan, F, Williams and Wilkins, Baltimore
-
Yang, H. & Rotter, J. I. in Inflammatory bowel disease: from bench to bedside (eds Targan, S. R. & Shanahan, F.) 32-64 (Williams and Wilkins, Baltimore, 1994).
-
(1994)
Inflammatory bowel disease: From bench to bedside
, pp. 32-64
-
-
Yang, H.1
Rotter, J.I.2
-
89
-
-
0031903182
-
Inflammatory bowel disease in African-American children living in Georgia
-
Ogunbi, S. O., Ransom, J. A., Sullivan, K., Schoen, B. T. & Gold, B. D. Inflammatory bowel disease in African-American children living in Georgia. J. Pediatr. 133, 103-107 (1998).
-
(1998)
J. Pediatr
, vol.133
, pp. 103-107
-
-
Ogunbi, S.O.1
Ransom, J.A.2
Sullivan, K.3
Schoen, B.T.4
Gold, B.D.5
-
90
-
-
0032198308
-
Genetic epidemiology in inflammatory bowel disease
-
Binder, V. Genetic epidemiology in inflammatory bowel disease. Digest. Dis. 16, 351-355 (1998).
-
(1998)
Digest. Dis
, vol.16
, pp. 351-355
-
-
Binder, V.1
-
91
-
-
0000628744
-
-
eds Kirsner, J. B. & Shorter, R. G, Williams & Wilkins, Baltimore
-
Yang, H. & Rotter, J. I. in Inflammatory Bowel Disease (eds Kirsner, J. B. & Shorter, R. G.) 301-331 (Williams & Wilkins, Baltimore, 1995).
-
(1995)
Inflammatory Bowel Disease
, pp. 301-331
-
-
Yang, H.1
Rotter, J.I.2
-
92
-
-
0023713859
-
Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
-
Tysk, C., Lindberg, E., Jarnerot, G. & Floderus-Myrhed, B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29, 990-996 (1988).
-
(1988)
Gut
, vol.29
, pp. 990-996
-
-
Tysk, C.1
Lindberg, E.2
Jarnerot, G.3
Floderus-Myrhed, B.4
-
93
-
-
0038620498
-
Inflammatory bowel disease in a Swedish twin cohort: A long-term follow-up of concordance and clinical characteristics
-
Halfvarson, J., Bodin, L., Tysk, C., Lindberg, E. & Jarnerot, G. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology 124, 1767-1773 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 1767-1773
-
-
Halfvarson, J.1
Bodin, L.2
Tysk, C.3
Lindberg, E.4
Jarnerot, G.5
-
94
-
-
0030042271
-
Genetics versus environment in inflammatory bowel disease: Results of a British twin study
-
Thompson, N. P., Driscoll, R., Pounder, R. E. & Wakefield, A. J. Genetics versus environment in inflammatory bowel disease: results of a British twin study. BMJ 312, 95-96 (1996).
-
(1996)
BMJ
, vol.312
, pp. 95-96
-
-
Thompson, N.P.1
Driscoll, R.2
Pounder, R.E.3
Wakefield, A.J.4
-
95
-
-
0033773642
-
Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study
-
Orholm, M., Binder, V., Sorensen, T. I., Rasmussen, L. P. & Kyvik, K. O. Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study. Scand. J. Gastroenterol. 35, 1075-1081 (2000).
-
(2000)
Scand. J. Gastroenterol
, vol.35
, pp. 1075-1081
-
-
Orholm, M.1
Binder, V.2
Sorensen, T.I.3
Rasmussen, L.P.4
Kyvik, K.O.5
-
96
-
-
0028217167
-
Inflammatory bowel disease and domestic hygiene in infancy
-
Gent, A. E., Hellier, M. D., Grace, R. H., Swarbrick, E. T. & Coggon, D. Inflammatory bowel disease and domestic hygiene in infancy. Lancet 343, 766-767 (1994).
-
(1994)
Lancet
, vol.343
, pp. 766-767
-
-
Gent, A.E.1
Hellier, M.D.2
Grace, R.H.3
Swarbrick, E.T.4
Coggon, D.5
-
97
-
-
0023102657
-
Risk of ulcerative colitis among former and current cigarette smokers
-
Boyko, E. J., Koepsell, T. D., Perera, D. R. & Inui, T. S. Risk of ulcerative colitis among former and current cigarette smokers. N. Engl. J. Med. 316, 707-710 (1987).
-
(1987)
N. Engl. J. Med
, vol.316
, pp. 707-710
-
-
Boyko, E.J.1
Koepsell, T.D.2
Perera, D.R.3
Inui, T.S.4
|