NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

Immunity

Volumn 20, Issue 3, 2004, Pages 319-325

  Agostini, Laetitia ^a   Martinon, Fabio ^a   Burns, Kimberly ^a   McDermott, Michael F ^b   Hawkins, Philip N ^c   Tschopp, Jürg ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE RECRUITMENT DOMAIN; CARDINAL PROTEIN; CASPASE 5; CASPASE RECRUITMENT DOMAIN PROTEIN 7; COLD AUTOINFLAMMATORY SYNDROME 1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NACHT LRR PYD CONTAINING PROTEIN 2; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; MACROPHAGE; MUCKLE WELLS AUTOINFLAMMATORY DISORDER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SYMPTOM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOIMMUNE DISEASES; CARD SIGNALING ADAPTOR PROTEINS; CARRIER PROTEINS; CASPASE 1; CELL LINE; CELLS, CULTURED; CYTOSKELETAL PROTEINS; HUMANS; INFLAMMATION; INTERLEUKIN-1; MACROMOLECULAR SUBSTANCES; MACROPHAGES; MUTATION; NEOPLASM PROTEINS; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY;

EID: 1642285783     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(04)00046-9     Document Type: Article

References (28)

1. Aganna E., Martinon F., Hawkins P.N., Ross J.B., Swan D.C., Booth D.R., Lachmann H.J., Bybee A., Gaudet R., Woo P.et al. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum. 46:2002;2445-2452.
2. Aksentijevich I., Nowak M., Mallah M., Chae J.J., Watford W.T., Hofmann S.R., Stein L., Russo R., Goldsmith D., Dent P.et al. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID). a new member of the expanding family of pyrin-associated autoinflammatory diseases Arthritis Rheum. 46:2002;3340-3348.
3. Arend W.P., Guthridge C.J. Biological role of interleukin 1 receptor antagonist isoforms. Ann. Rheum. Dis. 59:2000;i60-i64.
4. Bertin J., DiStefano P.S. The PYRIN domain. a novel motif found in apoptosis and inflammation proteins Cell Death Differ. 7:2000;1273-1274.
5. Bouchier-Hayes L., Conroy H., Egan H., Adrain C., Creagh E.M., MacFarlane M., Martin S.J. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J. Biol. Chem. 276:2001;44069-44077.
6. Dinarello C.A. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann. N Y Acad. Sci. 856:1998;1-11.
7. Graziani-Bowering G.M., Graham J.M., Filion L.G. A quick, easy and inexpensive method for the isolation of human peripheral blood monocytes. J. Immunol. Methods. 207:1997;157-168.
8. Hawkins P.N., Lachmann H.J., McDermott M.F. Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N. Engl. J. Med. 348:2003;2583-2584.
9. Hawkins P.N., Lachmann H.J., Aganna E., McDermott M.F. Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum. 50:2004;607-612.
10. Hoffman H.M., Mueller J.L., Broide D.H., Wanderer A.A., Kolodner R.D. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29:2001;301-305.
11. Hull K.M., Shoham N., Chae J.J., Aksentijevich I., Kastner D.L. The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations. Curr. Opin. Rheumatol. 15:2003;61-69.
12. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
13. Manji G.A., Wang L., Geddes B.J., Brown M., Merriam S., Al-Garawi A., Mak S., Lora J.M., Briskin M., Jurman M.et al. PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. J. Biol. Chem. 277:2002;11570-11575.
14. Martinon F., Hofmann K., Tschopp J. The Pyrin domain. a possible member of the death domain-fold family implicated in apoptosis and inflammation Curr. Biol. 10:2001;R118-R120.
15. Martinon F., Burns K., Tschopp J. The inflammasome. A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell. 10:2002;417-426.
16. Masumoto J., Taniguchi S., Ayukawa K., Sarvotham H., Kishino T., Niikawa N., Hidaka E., Katsuyama T., Higuchi T., Sagara J. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J. Biol. Chem. 274:1999;33835-33838.
17. Masumoto J., Taniguchi S., Sagara J. Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC. Biochem. Biophys. Res. Commun. 280:2001;652-655.
18. McDermott M.F. Genetic clues to understanding periodic fevers, and possible therapies. Trends Mol. Med. 8:2002;550-554.
19. Pathan N., Marusawa H., Krajewska M., Matsuzawa S., Kim H., Okada K., Torii S., Kitada S., Krajewski S., Welsh K.et al. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. J. Biol. Chem. 276:2001;32220-32229.
20. Pawlowski K., Pio F., Chu Z., Reed J.C., Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem. Sci. 26:2001;85-87.
21. Poyet J.L., Srinivasula S.M., Tnani M., Razmara M., Fernandes-Alnemri T., Alnemri E.S. Identification of ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276:2001;28309-28313.
22. Razmara M., Srinivasula S.M., Wang L., Poyet J.L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J. Biol. Chem. 277:2002;13952-13958.
23. Srinivasula S.M., Poyet J.L., Razmara M., Datta P., Zhang Z., Alnemri E.S. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277:2002;21119-21122.
24. Stehlik C., Lee S.H., Dorfleutner A., Stassinopoulos A., Sagara J., Reed J.C. Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J. Immunol. 171:2003;6154-6163.
25. Thome M., Hofmann K., Burns K., Martinon F., Bodmer J.L., Mattmann C., Tschopp J. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol. 8:1998;885-888.
26. Thornberry N.A., Lazebnik Y. Caspases. enemies within Science. 281:1998;1312-1316.
27. Tschopp J., Martinon F., Burns K. Nalps. a novel protein family involved in inflammation Nat. Rev. Mol. Cell Biol. 4:2003;95-104.
28. Wang L., Manji G., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J. PYPAF7. a novel pyrin-containing apaf1-like protein that regulates activation of nf-kB and caspase-1-dependent cytokine processing J. Biol. Chem. 17:2002;29874-29880.