NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer

Nature

Volumn 540, Issue 7634, 2016, Pages 583-587

  Karki, Rajendra ^a   Man, Si Ming ^a   Malireddi, R K Subbarao ^a   Kesavardhana, Sannula ^a   Zhu, Qifan ^a,b   Burton, Amanda R ^a   Sharma, Bhesh Raj ^a   Qi, Xiaopeng ^a   Pelletier, Stephane ^a   Vogel, Peter ^a   Rosenstiel, Philip ^c   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BETA INTERFERON; CD11B ANTIGEN; CXCL1 CHEMOKINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; I KAPPA B KINASE ALPHA; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; LYMPHOID ENHANCER FACTOR 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEOTIDE BINDING DOMAIN AND LEUCINE RICH REPEAT C3; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; S6 KINASE; STAT3 PROTEIN; T CELL FACTOR PROTEIN 4; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR 7; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WNT1 PROTEIN;

CANCER; CELLS AND CELL COMPONENTS; CYTOPLASM; DISEASE INCIDENCE; GROWTH; IMMUNITY; INFECTIOUS DISEASE; INHIBITOR; PROTEIN; RODENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CARCINOGENESIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; EXPERIMENTAL COLON CARCINOGENESIS; FEMALE; FIBROBLAST; INTESTINAL STEM CELL; INTESTINE CELL; INTRACELLULAR SIGNALING; MALE; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; WNT SIGNALING PATHWAY;

MUS;

EID: 85019406841     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20597     Document Type: Article

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