Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

Nature Medicine

Volumn 21, Issue 8, 2015, Pages 906-913

  Wilson, Justin E ^a,b   Petrucelli, Alex S ^a,b   Chen, Liang ^a,b   Koblansky, A Alicia ^a,b   Truax, Agnieszka D ^a,b   Oyama, Yoshitaka ^a,b   Rogers, Arlin B ^c   Brickey, W June ^a,b   Wang, Yuli ^d   Schneider, Monika ^e   Mühlbauer, Marcus ^f   Chou, Wei Chun ^a,b   Barker, Brianne R ^g   Jobin, Christian ^f   Allbritton, Nancy L ^d   Ramsden, Dale A ^a,b   Davis, Beckley K ^h   Ting, Jenny P Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY   (United States)

^d University of North Carolina at Chapel Hill   (United States)

^e American Association of Immunologists   (United States)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^g DREW UNIVERSITY   (United States)

^h FRANKLIN AND MARSHALL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT IN MELANOMA 2 INFLAMMASOME; ACTIN; AZOXYMETHANE; CASPASE 3; CASPASE 7; DEXTRAN SULFATE; DNA DEPENDENT PROTEIN KINASE; HLA DR ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; DNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; COLITIS; COLON CANCER; COLON POLYP; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FAMILIAL COLON POLYPOSIS; FEMALE; HCT116 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TUMOR VOLUME; ANIMAL; C57BL MOUSE; COLONIC NEOPLASMS; COMPLICATION; INTESTINAL POLYPS; MALE; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; COLITIS; COLONIC NEOPLASMS; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; HCT116 CELLS; HUMANS; INFLAMMASOMES; INTESTINAL POLYPS; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84938996802     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3908     Document Type: Article

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