Critical role for calcium mobilization in activation of the NLRP3 inflammasome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11282-11287

  Murakami, Tomohiko ^a   Ockinger, Johan ^a   Yu, Jiujiu ^a   Byles, Vanessa ^a   McColl, Aisleen ^a   Hofer, Aldebaran M ^b   Horng, Tiffany ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Innate immunity; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CCAAT ENHANCER BINDING PROTEIN; CRYOPYRIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DAMAGE; CELL MITOCHONDRION DAMAGE; CELL STIMULATION; CELLULAR STRESS RESPONSE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM STRESS; MACROPHAGE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN INDUCTION; SEPSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 84863978096     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117765109     Document Type: Article

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