Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 19, 2007, Pages 8041-8046

  Duncan, Joseph A ^a   Bergstralh, Daniel T ^b   Wang, Yanhong ^a   Willingham, Stephen B ^b   Ye, Zhengmao ^a   Zimmermann, Albert G ^a,b   Ting, Jenny Pan Yun ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

IL 1 ; Inflammation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATERPILLER PROTEIN; CRYOPYRIN; CYTOKINE; INTERLEUKIN 1BETA; NUCLEOTIDE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; CIAS1 PROTEIN, HUMAN;

ARTICLE; BACULOVIRUS; CELL DEATH; CELL STRAIN HEK293; COMPLEX FORMATION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; INSECT CELL; MACROMOLECULE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE BINDING DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELLS, CULTURED; CHROMATOGRAPHY, AFFINITY; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 34249941913     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0611496104     Document Type: Article

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