The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Cell Reports

Volumn 13, Issue 9, 2015, Pages 1922-1936

  Hu, Shuiqing ^a   Peng, Lan ^a   Kwak, Youn Tae ^a   Tekippe, Erin McElvania ^a,b   Pasare, Chandrashekhar ^c   Malter, James S ^a   Hooper, Lora V ^c,d   Zaki, Md Hasan ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b CHILDREN S MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

AIM2; Antimicrobial peptides; Colitis; DNA sensor; Escherichia coli; Inflammasome; Inflammation; Inflammatory bowel diseases; Intestinal epithelium; Pattern recognition receptors

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; BACTERIAL DNA; DEXTRAN SULFATE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PATTERN RECOGNITION RECEPTOR; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; ANTIMICROBIAL CATIONIC PEPTIDE; CRYOPYRIN; CYTOKINE; DNA; DNA BINDING PROTEIN; NLRP3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYSBIOSIS; ENZYME ACTIVATION; ESCHERICHIA COLI; FEMALE; GERMFREE MOUSE; HOMEOSTASIS; HOST RESISTANCE; IMMUNOREGULATION; INFECTION SENSITIVITY; INTESTINAL HOMEOSTASIS; INTESTINE EPITHELIUM; INTESTINE FLORA; INTESTINE MUCOSA; MALE; MICROFLORA; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; COLON; DEFICIENCY; DISEASE PREDISPOSITION; FECES; GENETICS; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CASPASE 1; COLITIS; COLON; CYTOKINES; DEXTRAN SULFATE; DISEASE SUSCEPTIBILITY; DNA; DNA-BINDING PROTEINS; DYSBIOSIS; ESCHERICHIA COLI; FECES; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN;

EID: 84947447820     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.10.040     Document Type: Article

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