A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome

Biochemical Pharmacology

Volumn 85, Issue 10, 2013, Pages 1504-1512

  Liu, Wen ^a   Guo, Wenjie ^a   Wu, Jing ^a   Luo, Qiong ^a   Tao, Feifei ^a   Gu, Yanhong ^b   Shen, Yan ^a   Li, Jianxin ^a   Tan, Renxiang ^a   Xu, Qiang ^a   Sun, Yang ^a  

^a NANJING UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Experimental colitis; IL 1 ; Inflammatory bowel diseases; NLRP3 inflammasome; Ulcerative colitis

Indexed keywords

1 ETHYL 5 METHYL 2 PHENYL 1H BENZO[D]IMIDAZOLE; CRYOPYRIN; DEXTRAN SULFATE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; IMIDAZOLE DERIVATIVE; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; MYELOPEROXIDASE; SODIUM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DRUG TARGETING; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT REDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZIMIDAZOLES; CARRIER PROTEINS; CASPASE 1; CELL LINE; COLITIS; COLON; CYTOKINES; DEXTRAN SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMASOMES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NEUTROPHILS; PEROXIDASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876684569     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.03.008     Document Type: Article

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