The NAIP/NLRC4 inflammasomes

Current Opinion in Immunology

Volumn 32, Issue , 2015, Pages 84-89

  Vance, Russell E ^a,b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b Department of Molecular and Cell Biology ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NEURONAL APOPTOSIS INHIBITORY PROTEIN 1; NEURONAL APOPTOSIS INHIBITORY PROTEIN 2; PROTEIN NLRC4; UNCLASSIFIED DRUG; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; PROTEIN BINDING;

AUTOINFLAMMATORY DISEASE; EPITHELIUM CELL; GAIN OF FUNCTION MUTATION; HOST RESISTANCE; HUMAN; INFECTION RESISTANCE; MACROPHAGE ACTIVATION SYNDROME; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SALMONELLOSIS; SEQUENCE HOMOLOGY; ANIMAL; CHEMISTRY; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; MUTATION;

ANIMALS; CARD SIGNALING ADAPTOR PROTEINS; EPITHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; MACROPHAGES; MUTATION; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; PROTEIN BINDING;

EID: 84921498910     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2015.01.010     Document Type: Review

References (35)

1. Diez E., Lee S.H., Gauthier S., Yaraghi Z., Tremblay M., Vidal S., Gros P. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nat Genet 2003, 33:55-60.
2. Wright E.K., Goodart S.A., Growney J.D., Hadinoto V., Endrizzi M.G., Long E.M., Sadigh K., Abney A.L., Bernstein-Hanley I., Dietrich W.F. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr Biol 2003, 13:27-36.
3. Kofoed E.M., Vance R.E. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 2011, 477:592-595.
4. Lightfield K.L., Persson J., Brubaker S.W., Witte C.E., von Moltke J., Dunipace E.A., Henry T., Sun Y.H., Cado D., Dietrich W.F., et al. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 2008, 9:1171-1178.
5. Molofsky A.B., Byrne B.G., Whitfield N.N., Madigan C.A., Fuse E.T., Tateda K., Swanson M.S. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med 2006, 203:1093-1104.
6. Ren T., Zamboni D.S., Roy C.R., Dietrich W.F., Vance R.E. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog 2006, 2:e18.
7. Zhao Y., Yang J., Shi J., Gong Y.N., Lu Q., Xu H., Liu L., Shao F. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 2011, 477:596-600.
8. Miao E.A., Mao D.P., Yudkovsky N., Bonneau R., Lorang C.G., Warren S.E., Leaf I.A., Aderem A. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A 2010, 107:3076-3080.
9. Rayamajhi M., Zak D.E., Chavarria-Smith J., Vance R.E., Miao E.A. Cutting edge: mouse NAIP1 detects the type III secretion system needle protein. J Immunol 2013, 191:3986-3989.
10. Yang J., Zhao Y., Shi J., Shao F. Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc Natl Acad Sci U S A 2013, 110:14408-14413.
11. Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K., Roose-Girma M., Lee W.P., Weinrauch Y., Monack D.M., Dixit V.M. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006, 440:228-232.
12. Zamboni D.S., Kobayashi K.S., Kohlsdorf T., Ogura Y., Long E.M., Vance R.E., Kuida K., Mariathasan S., Dixit V.M., Flavell R.A., et al. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol 2006, 7:318-325.
13. Bergsbaken T., Fink S.L., Cookson B.T. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 2009, 7:99-109.
14. Miao E.A., Leaf I.A., Treuting P.M., Mao D.P., Dors M., Sarkar A., Warren S.E., Wewers M.D., Aderem A. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010, 11:1136-1142.
15. Ting J.P., Lovering R.C., Alnemri E.S., Bertin J., Boss J.M., Davis B.K., Flavell R.A., Girardin S.E., Godzik A., Harton J.A., et al. The NLR gene family: a standard nomenclature. Immunity 2008, 28:285-287.
16. von Moltke J., Ayres J.S., Kofoed E.M., Chavarria-Smith J., Vance R.E. Recognition of bacteria by inflammasomes. Annu Rev Immunol 2013, 31:73-106.
17. Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002, 10:417-426.
18. Kofoed E.M., Vance R.E. NAIPs: building an innate immune barrier against bacterial pathogens: NAIPs function as sensors that initiate innate immunity by detection of bacterial proteins in the host cell cytosol. Bioessays 2012.
19. Damiano J.S., Oliveira V., Welsh K., Reed J.C. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J 2004, 381:213-219.
20. Broz P., von Moltke J., Jones J.W., Vance R.E., Monack D.M. Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 2010, 8:471-483.
21. Sellin M.E., Muller A.A., Felmy B., Dolowschiak T., Diard M., Tardivel A., Maslowski K.M., Hardt W.D. Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host Microbe 2014, 16:237-248.
22. Nordlander S., Pott J., Maloy K.J. NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen. Mucosal Immunol 2014, 7:775-785.
23. von Moltke J., Trinidad N.J., Moayeri M., Kintzer A.F., Wang S.B., van Rooijen N., Brown C.R., Krantz B.A., Leppla S.H., Gronert K., et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 2012, 490:107-111.
24. Chen K.W., Gross C.J., Sotomayor F.V., Stacey K.J., Tschopp J., Sweet M.J., Schroder K. The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge. Cell Rep 2014, 8:570-582.
25. Canna S.W., de Jesus A.A., Gouni S., Brooks S.R., Marrero B., Liu Y., DiMattia M.A., Zaal K.J., Sanchez G.A., Kim H., et al. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet 2014, 46:1140-1146.
26. Kitamura A., Sasaki Y., Abe T., Kano H., Yasutomo K. An inherited mutation in NLRC4 causes autoinflammation in human and mice. J Exp Med 2014, 211:2385-2396.
27. Romberg N., Al Moussawi K., Nelson-Williams C., Stiegler A.L., Loring E., Choi M., Overton J., Meffre E., Khokha M.K., Huttner A.J., et al. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat Genet 2014, 46:1135-1139.
28. Hoffman H.M., Simon A. Recurrent febrile syndromes: what a rheumatologist needs to know. Nat Rev Rheumatol 2009, 5:249-256.
29. Hu Z., Yan C., Liu P., Huang Z., Ma R., Zhang C., Wang R., Zhang Y., Martinon F., Miao D., et al. Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science 2013, 341:172-175.
30. Riedl S.J., Li W., Chao Y., Schwarzenbacher R., Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 2005, 434:926-933.
31. Reubold T.F., Wohlgemuth S., Eschenburg S. Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure 2011, 19:1074-1083.
32. Qu Y., Misaghi S., Izrael-Tomasevic A., Newton K., Gilmour L.L., Lamkanfi M., Louie S., Kayagaki N., Liu J., Komuves L., et al. Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 2012, 490:539-542.
33. Lechtenberg B.C., Mace P.D., Riedl S.J. Structural mechanisms in NLR inflammasome signaling. Curr Opin Struct Biol 2014, 29C:17-25.
34. Suzuki S., Franchi L., He Y., Munoz-Planillo R., Mimuro H., Suzuki T., Sasakawa C., Nunez G. Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcdelta. PLoS Pathog 2014, 10:e1003926.
35. Tenthorey J.L., Kofoed E.M., Daugherty M.D., Malik H.S., Vance R.E. Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Mol Cell 2014, 54:17-29.