Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1851-1856

  Case, Christopher L ^a   Kohler, Lara J ^a   Lima, Jonilson B ^b   Strowig, Till ^a   Zoete, Marcel R De ^a   Flavell, Richard A ^a,c   Zamboni, Dario S ^b   Roy, Craig R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c YALE UNIVERSITY   (United States)

Author keywords

Cell death; Inflammasome; Innate immunity

Indexed keywords

CASPASE 11; FLAGELLIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN NLRC4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; ENZYME ACTIVATION; ENZYME INDUCTION; LEGIONELLA PNEUMOPHILA; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYROPTOSIS; SIGNAL TRANSDUCTION; TYPE IV SECRETION SYSTEM; UPREGULATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BONE MARROW CELLS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CASPASE 1; CASPASES; CELLS, CULTURED; CYTOKINES; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; FLAGELLIN; HOST-PATHOGEN INTERACTIONS; IMMUNOBLOTTING; LEGIONELLA PNEUMOPHILA; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NECROSIS; RECEPTOR, INTERFERON ALPHA-BETA;

EID: 84873202976     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211521110     Document Type: Article

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