Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation

International Immunopharmacology

Volumn 24, Issue 2, 2015, Pages 232-238

  Guo, Wenjie ^a,b   Liu, Wen ^b   Jin, Biao ^b   Geng, Ji ^a   Li, Jing ^a   Ding, Hongqun ^a   Wu, Xuefeng ^b   Xu, Qiang ^b   Sun, Yang ^b   Gao, Jing ^a  

^a JIANGSU UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Asiatic acid; Colitis; IL 1 ; NLRP3 inflammasome; ROS

Indexed keywords

ASIATIC ACID; CRYOPYRIN; CYTOKINE; DEXTRAN SULFATE; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA; MYELOPEROXIDASE; PROTEIN; REACTIVE OXYGEN METABOLITE; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; PENTACYCLIC TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DISEASE ACTIVITY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN ASSEMBLY; RAT; TREATMENT RESPONSE; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CENTELLA; CHEMICALLY INDUCED; COLITIS; COLON; DRUG EFFECTS; FEMALE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY BOWEL DISEASES; METABOLISM; MOUSE; PATHOLOGY;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; CENTELLA; COLITIS; COLON; CYTOKINES; DEXTRAN SULFATE; FEMALE; HUMANS; IMMUNOSUPPRESSION; INFLAMMASOMES; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MODELS, ANIMAL; PENTACYCLIC TRITERPENES;

EID: 84920445940     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.12.009     Document Type: Article

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