-
1
-
-
2442563304
-
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
-
Loftus, E.V. Jr Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126, 1504-1517 (2004).
-
(2004)
Gastroenterology
, vol.126
, pp. 1504-1517
-
-
Loftus Jr, E.V.1
-
2
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky, D.K. Inflammatory bowel disease. N. Engl. J. Med. 347, 417-429 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 417-429
-
-
Podolsky, D.K.1
-
3
-
-
0038620498
-
Inflammatory bowel disease in a Swedish twin cohort: A long-term follow-up of concordance and clinical characteristics
-
Halfvarson, J., Bodin, L., Tysk, C., Lindberg, E. & Jarnerot, G. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology 124, 1767-1773 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 1767-1773
-
-
Halfvarson, J.1
Bodin, L.2
Tysk, C.3
Lindberg, E.4
Jarnerot, G.5
-
4
-
-
0030042271
-
Genetics versus environment in inflammatory bowel disease: Results of a British twin study
-
Thompson, N.P., Driscoll, R., Pounder, R.E. & Wakefield, A.J. Genetics versus environment in inflammatory bowel disease: results of a British twin study. Br. Med. J. 312, 95-96 (1996).
-
(1996)
Br. Med. J
, vol.312
, pp. 95-96
-
-
Thompson, N.P.1
Driscoll, R.2
Pounder, R.E.3
Wakefield, A.J.4
-
5
-
-
0023713859
-
Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
-
Tysk, C., Lindberg, E., Jarnerot, G. & Floderus-Myrhed, B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29, 990-996 (1988).
-
(1988)
Gut
, vol.29
, pp. 990-996
-
-
Tysk, C.1
Lindberg, E.2
Jarnerot, G.3
Floderus-Myrhed, B.4
-
6
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
7
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
8
-
-
0034785352
-
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
-
Rioux, J.D. et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat. Genet. 29, 223-228 (2001).
-
(2001)
Nat. Genet
, vol.29
, pp. 223-228
-
-
Rioux, J.D.1
-
9
-
-
0029787715
-
Crohn's disease: Concordance for site and clinical type in affected family members-potential hereditary influences
-
Bayless, T.M. et al. Crohn's disease: concordance for site and clinical type in affected family members-potential hereditary influences. Gastroenterology 111, 573-579 (1996).
-
(1996)
Gastroenterology
, vol.111
, pp. 573-579
-
-
Bayless, T.M.1
-
10
-
-
11144279151
-
Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: A metaanalysis
-
Economou, M., Trikalinos, T.A., Loizou, K.T., Tsianos, E.V. & Ioannidis, J.P. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am. J. Gastroenterol. 99, 2393-2404 (2004).
-
(2004)
Am. J. Gastroenterol
, vol.99
, pp. 2393-2404
-
-
Economou, M.1
Trikalinos, T.A.2
Loizou, K.T.3
Tsianos, E.V.4
Ioannidis, J.P.5
-
11
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr, R.H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006).
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
-
12
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207-211 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
-
13
-
-
18244375249
-
Egr-2 and Egr-3 are negative regulators of T cell activation
-
Safford, M. et al. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat. Immunol. 6, 472-480 (2005).
-
(2005)
Nat. Immunol
, vol.6
, pp. 472-480
-
-
Safford, M.1
-
14
-
-
27844464491
-
PHOX2B regulates its own expression by a transcriptional autoregulatory mechanism
-
Cargnin, F. et al. PHOX2B regulates its own expression by a transcriptional autoregulatory mechanism. J. Biol. Chem. 280, 37439-37448 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 37439-37448
-
-
Cargnin, F.1
-
15
-
-
0035074209
-
Homeobox gene mutations and brain-stem developmental disorders: Learning from knockout mice
-
Pasqualetti, M. & Rijli, F.M. Homeobox gene mutations and brain-stem developmental disorders: learning from knockout mice. Curr. Opin. Neurol. 14, 177-184 (2001).
-
(2001)
Curr. Opin. Neurol
, vol.14
, pp. 177-184
-
-
Pasqualetti, M.1
Rijli, F.M.2
-
16
-
-
0036668282
-
Phox2 genes - from patterning to connectivity
-
Brunet, J.F. & Pattyn, A. Phox2 genes - from patterning to connectivity. Curr. Opin. Genet. Dev. 12, 435-440 (2002).
-
(2002)
Curr. Opin. Genet. Dev
, vol.12
, pp. 435-440
-
-
Brunet, J.F.1
Pattyn, A.2
-
17
-
-
0033609337
-
The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
-
Pattyn, A., Morin, X., Cremer, H., Goridis, C. & Brunet, J.F. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399, 366-370 (1999).
-
(1999)
Nature
, vol.399
, pp. 366-370
-
-
Pattyn, A.1
Morin, X.2
Cremer, H.3
Goridis, C.4
Brunet, J.F.5
-
18
-
-
33746885455
-
Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
-
Ellson, C.D. et al. Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J. Exp. Med. 203, 1927-1937 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 1927-1937
-
-
Ellson, C.D.1
-
19
-
-
33746896166
-
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis
-
Suh, C.I. et al. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J. Exp. Med. 203, 1915-1925 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 1915-1925
-
-
Suh, C.I.1
-
20
-
-
0029842074
-
Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex
-
Zhan, S. et al. Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex. Blood 88, 2714-2721 (1996).
-
(1996)
Blood
, vol.88
, pp. 2714-2721
-
-
Zhan, S.1
-
21
-
-
0037166241
-
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
-
Kuma, A., Mizushima, N., Ishihara, N. & Ohsumi, Y. Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 277, 18619-18625 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 18619-18625
-
-
Kuma, A.1
Mizushima, N.2
Ishihara, N.3
Ohsumi, Y.4
-
22
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
-
23
-
-
33744958258
-
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
-
Birmingham, C.L., Smith, A.C., Bakowski, M.A., Yoshimori, T. & Brumell, J.H. Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J. Biol. Chem. 281, 11374-11383 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 11374-11383
-
-
Birmingham, C.L.1
Smith, A.C.2
Bakowski, M.A.3
Yoshimori, T.4
Brumell, J.H.5
-
24
-
-
34247572790
-
-
Libioulle, C. et al. A novel susceptibility locus for Crohn's disease identified by whole genome association maps to a gene desert on chromosome 5p13.1 and modulates the level of expression of the prostaglandin receptor EP4. PLoS Genet. published online 5 March 2007 (doi:10.1371/journal.pgen.0030058.eor).
-
Libioulle, C. et al. A novel susceptibility locus for Crohn's disease identified by whole genome association maps to a gene desert on chromosome 5p13.1 and modulates the level of expression of the prostaglandin receptor EP4. PLoS Genet. published online 5 March 2007 (doi:10.1371/journal.pgen.0030058.eor).
-
-
-
-
25
-
-
13144265739
-
Genome-wide association studies: Theoretical and practical concerns
-
Wang, W.Y., Barratt, B.J., Clayton, D.G. & Todd, J.A. Genome-wide association studies: theoretical and practical concerns. Nat. Rev. Genet. 6, 109-118 (2005).
-
(2005)
Nat. Rev. Genet
, vol.6
, pp. 109-118
-
-
Wang, W.Y.1
Barratt, B.J.2
Clayton, D.G.3
Todd, J.A.4
-
26
-
-
2442521455
-
New approaches to gene hunting in IBD
-
Daly, M.J. & Rioux, J.D. New approaches to gene hunting in IBD. Inflamm. Bowel Dis. 10, 312-317 (2004).
-
(2004)
Inflamm. Bowel Dis
, vol.10
, pp. 312-317
-
-
Daly, M.J.1
Rioux, J.D.2
-
27
-
-
33847212513
-
Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease
-
Silverberg, M.S. et al. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. Eur. J. Hum. Genet. 15, 328-335 (2007).
-
(2007)
Eur. J. Hum. Genet
, vol.15
, pp. 328-335
-
-
Silverberg, M.S.1
-
28
-
-
20444438369
-
Paths to understanding the genetic basis of autoimmune disease
-
Rioux, J.D. & Abbas, A.K. Paths to understanding the genetic basis of autoimmune disease. Nature 435, 584-589 (2005).
-
(2005)
Nature
, vol.435
, pp. 584-589
-
-
Rioux, J.D.1
Abbas, A.K.2
-
29
-
-
24744463111
-
Autophagy in innate and adaptive immunity
-
Deretic, V. Autophagy in innate and adaptive immunity. Trends Immunol. 26, 523-528 (2005).
-
(2005)
Trends Immunol
, vol.26
, pp. 523-528
-
-
Deretic, V.1
-
30
-
-
19644388051
-
Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes
-
Amer, A.O., Byrne, B.G. & Swanson, M.S. Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes. Autophagy 1, 53-58 (2005).
-
(2005)
Autophagy
, vol.1
, pp. 53-58
-
-
Amer, A.O.1
Byrne, B.G.2
Swanson, M.S.3
-
31
-
-
8344247016
-
Autophagy defends cells against invading group A Streptococcus
-
Nakagawa, I. et al. Autophagy defends cells against invading group A Streptococcus. Science 306, 1037-1040 (2004).
-
(2004)
Science
, vol.306
, pp. 1037-1040
-
-
Nakagawa, I.1
-
32
-
-
33748506089
-
Human IRGM induces autophagy to eliminate intracellular mycobacteria
-
Singh, S.B., Davis, A.S., Taylor, G.A. & Deretic, V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313, 1438-1441 (2006).
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
Deretic, V.4
-
33
-
-
33749551769
-
Autophagy: Eating for good health
-
Swanson, M.S. Autophagy: eating for good health. J. Immunol. 177, 4945-4951 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 4945-4951
-
-
Swanson, M.S.1
-
34
-
-
2342646956
-
Bacterial flagellin is a dominant antigen in Crohn disease
-
Lodes, M.J. et al. Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Invest. 113, 1296-1306 (2004).
-
(2004)
J. Clin. Invest
, vol.113
, pp. 1296-1306
-
-
Lodes, M.J.1
-
35
-
-
33947134377
-
Autophagy-dependent viral recognition by plasmacytoid dendritic cells
-
Lee, H.K., Lund, J.M., Ramanathan, B., Mizushima, N. & Iwasaki, A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315, 1398-1401 (2007).
-
(2007)
Science
, vol.315
, pp. 1398-1401
-
-
Lee, H.K.1
Lund, J.M.2
Ramanathan, B.3
Mizushima, N.4
Iwasaki, A.5
-
36
-
-
33846224369
-
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
-
Schmid, D., Pypaert, M. & Munz, C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 26, 79-92 (2007).
-
(2007)
Immunity
, vol.26
, pp. 79-92
-
-
Schmid, D.1
Pypaert, M.2
Munz, C.3
-
37
-
-
20344361954
-
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
-
Dengjel, J. et al. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc. Natl. Acad. Sci. USA 102, 7922-7927 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7922-7927
-
-
Dengjel, J.1
-
38
-
-
33846461678
-
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
-
Pua, H.H., Dzhagalov, I., Chuck, M., Mizushima, N. & He, Y.W. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J. Exp. Med. 204, 25-31 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 25-31
-
-
Pua, H.H.1
Dzhagalov, I.2
Chuck, M.3
Mizushima, N.4
He, Y.W.5
-
39
-
-
0034897405
-
The Crohn's disease-associated bacterial protein I2 is a novel enteric t cell superantigen
-
Dalwadi, H., Wei, B., Kronenberg, M., Sutton, C.L. & Braun, J. The Crohn's disease-associated bacterial protein I2 is a novel enteric t cell superantigen. Immunity 15, 149-158 (2001).
-
(2001)
Immunity
, vol.15
, pp. 149-158
-
-
Dalwadi, H.1
Wei, B.2
Kronenberg, M.3
Sutton, C.L.4
Braun, J.5
-
40
-
-
0042834309
-
Generation and function of reactive oxygen species in dendritic cells during antigen presentation
-
Matsue, H. et al. Generation and function of reactive oxygen species in dendritic cells during antigen presentation. J. Immunol. 171, 3010-3018 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 3010-3018
-
-
Matsue, H.1
-
41
-
-
33749322644
-
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
-
Nakahira, K. et al. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J. Exp. Med. 203, 2377-2389 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2377-2389
-
-
Nakahira, K.1
-
42
-
-
0037434073
-
Olivocochlear innervation in the mouse: Immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization
-
Maison, S.F., Adams, J.C. & Liberman, M.C. Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J. Comp. Neurol. 455, 406-416 (2003).
-
(2003)
J. Comp. Neurol
, vol.455
, pp. 406-416
-
-
Maison, S.F.1
Adams, J.C.2
Liberman, M.C.3
-
43
-
-
0343517154
-
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA
-
Beuzon, C.R. et al. Salmonella maintains the integrity of its intracellular vacuole through the action of SifA. EMBO J. 19, 3235-3249 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 3235-3249
-
-
Beuzon, C.R.1
|