NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Nature

Volumn 530, Issue 7590, 2016, Pages 354-357

  He, Yuan ^a   Zeng, Melody Y ^a   Yang, Dahai ^a,b   Motro, Benny ^c   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN NEK7; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; NEK7 PROTEIN, HUMAN; NEK7 PROTEIN, MOUSE; NIMA RELATED KINASE; NLRP3 PROTEIN, MOUSE; POTASSIUM; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; PYCARD PROTEIN, MOUSE;

BIOCHEMISTRY; CELLS AND CELL COMPONENTS; DISEASE; ENZYME ACTIVITY; MUTATION; PATHOGENICITY; POTASSIUM; PROTEIN; RODENT;

ANIMAL CELL; ARTICLE; CATALYSIS; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVATION; HEMATOPOIETIC CELL; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OLIGOMERIZATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; ANIMAL; BIOCATALYSIS; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CINCA SYNDROME; DEFICIENCY; ENZYME ACTIVE SITE; GENETICS; HEK293 CELL LINE; HUMAN; MACROPHAGE; METABOLISM; PROTEIN MULTIMERIZATION; SECRETION (PROCESS);

CHIMAERIFORMES; MAMMALIA;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BIOCATALYSIS; CARRIER PROTEINS; CASPASE 1; CATALYTIC DOMAIN; CELLS, CULTURED; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; NIMA-RELATED KINASES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; POTASSIUM; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 84958971929     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16959     Document Type: Article

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