Discovery of a viral NLR homolog that inhibits the inflammasome

Science

Volumn 331, Issue 6015, 2011, Pages 330-334

  Gregory, Sean M ^a,b   Davis, Beckley K ^a   West, John A ^a,b   Taxman, Debra J ^a,b   Matsuzawa, Shu Ichi ^c   Reed, John C ^c   Ting, Jenny P Y ^a,b   Damania, Blossom ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MULTIPROTEIN COMPLEX; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

IMMUNE RESPONSE; INHIBITION; INHIBITOR; PERSISTENCE; PROTEIN; VIRUS;

ARTICLE; AUTOINFLAMMATORY DISEASE; CYTOKINE PRODUCTION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN HERPESVIRUS 8; IMMUNOMODULATION; IMMUNOPATHOLOGY; IMMUNOREGULATION; INNATE IMMUNITY; NONHUMAN; OPEN READING FRAME; PATHOGEN CLEARANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; CELL LINE; CELL LINE, TUMOR; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; MOLECULAR SEQUENCE DATA; MONOCYTES; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; TRANSFECTION; VIRAL PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 8;

EID: 78751680633     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1199478     Document Type: Article

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30. We thank S. Krall for assistance with tissue culture, Y. Matsuzawa for plasmid preparation, and D. Dittmer for proofreading. Supported by NIH grants DE018281 and CA096500, American Heart Association grant 0640041N, and a Burroughs Wellcome Fund grant (B.D.); NIH grants AI057157, AI077437, and CA156330 and the UNC University Cancer Research Fund (J.P.Y.T.); NIH grants AI56324 and AI91967 ( J.C.R.); NIH training grants T32-AI007419 and T32-AI007001 (S.M.G.); the Crohn's & Colitis Foundation of America and NIH grant 5R21CA131645 (B.K.D.); and NIH grant F32-AI78735 ( J.A.W.). B.D. is a Leukemia & Lymphoma Society Scholar and Burroughs Wellcome Fund Investigator in Infectious Disease. The NLRP1 and mutant NLRP1 expression plasmids as well as purified GST-NLRP1 protein were obtained from J.C.R. and require a material transfer agreement. The NLRP3, NOD1, NOD2, mutant NOD2, ASC, procaspase-1, and pro-IL-1β expression plasmids were obtained from J.P.Y.T. and also require a material transfer agreement. B.D., J.P.Y.T., and S.M.G. have filed a provisional patent on the KSHV Orf63 protein and/or any peptides derived from this protein in treatment for human disease.