Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

Science

Volumn 307, Issue 5710, 2005, Pages 731-734

  Kobayashi, Koichi S ^a,c   Chamaillard, Mathias ^b   Ogura, Yasunori ^a   Henegariu, Octavian ^a   Inohara, Naohiro ^b   Nuñez, Gabriel ^b   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOLOGICAL ORGANS; DISEASES; LIVING SYSTEMS STUDIES; PATIENT MONITORING; PHYSIOLOGY; PROTEINS;

ADAPTIVE IMMUNITY; ANTI-MICROBIAL PEPTIDES; CRYPTDINS; INTESTINAL TRACTS;

GENES;

ALPHA DEFENSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MURAMYL DIPEPTIDE;

IMMUNITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL INFECTION; BACTERIUM DETECTION; CROHN DISEASE; ENZYME REGULATION; GENE MUTATION; GENETIC CODE; IMMUNOSTIMULATION; INNATE IMMUNITY; INTESTINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ALPHA-DEFENSINS; ANIMALS; ANTIBODY FORMATION; FEMALE; GENE EXPRESSION; GENE TARGETING; ILEUM; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; IMMUNOGLOBULINS; INTERLEUKINS; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LIPOPOLYSACCHARIDES; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LIVER; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; NOD2 SIGNALING ADAPTOR PROTEIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN PRECURSORS; RECEPTORS, CELL SURFACE; SERUM ALBUMIN; SIGNAL TRANSDUCTION; SPLEEN; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 13244292161     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1104911     Document Type: Article

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36. The authors thank C. L. Stewart for providing reagents; L. Evangelisti, M. Chen, and A. Ferrandino for technical assistance; and F. Manzo for manuscript preparation. Supported by grants from NIH (K.S.K., N.I., G.N., and R.A.F.), the Crohn's and Colitis Foundation of America (K.S.K., M.C., Y.O., and R.A.F.), the Ellison Foundation (R.A.F.), and the Eli and Edythe L. Broad Foundation (K.S.K. and G.N.). R.A.F. is an investigator of the Howard Hughes Medical Institute.