Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis

Chemico-Biological Interactions

Volumn 210, Issue 1, 2014, Pages 26-33

  Shaker, Mohamed E ^a   Ashamallah, Sylvia A ^b   Houssen, Maha E ^c  

^a MANSOURA UNIVERSITY   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

^c Damanhour University   (Egypt)

Author keywords

Celastrol; Colitis; Inflammasome; Intestinal homeostasis

Indexed keywords

4 HYDROXYNONENAL; CD98 ANTIGEN; CELASTROL; CRYOPYRIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 23; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; DRUG MECHANISM; HISTOPATHOLOGY; LIPID PEROXIDATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS;

CELASTROL; COLITIS; INFLAMMASOME; INTESTINAL HOMEOSTASIS;

ANIMALS; COLITIS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED BALB C; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; TRITERPENES;

EID: 84892779067     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.12.007     Document Type: Article

References (47)

1. B. Khor, A. Gardet, and R.J. Xavier Genetics and pathogenesis of inflammatory bowel disease Nature 474 2011 307 317
2. M. Asquith, and F. Powrie An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer J. Exp. Med. 207 2010 1573 1577
3. E.M. Palsson-McDermott, and L.A. O'Neill Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4 Immunology 113 2004 153 162 (Pubitemid 39312442)
4. G.Y. Melmed, and S.R. Targan Future biologic targets for IBD: potentials and pitfalls Nat. Rev. Gastroenterol. Hepatol. 7 2010 110 117
5. O.H. Nielsen, and M.A. Ainsworth Tumor necrosis factor inhibitors for inflammatory bowel disease N. Engl. J. Med. 369 2013 754 762
6. X. Pang, Z. Yi, J. Zhang, B. Lu, B. Sung, and W. Qu et al. Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway Cancer Res. 70 2010 1951 1959
7. K.F. Wong, Y. Yuan, and J.M. Luk Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents Clin. Exp. Pharmacol. Physiol. 39 2012 311 320
8. A. Salminen, M. Lehtonen, T. Paimela, and K. Kaarniranta Celastrol: molecular targets of thunder god vine Biochem. Biophys. Res. Commun. 394 2010 439 442
9. R. Kannaiyan, M.K. Shanmugam, and G. Sethi Molecular targets of celastrol derived from thunder of god vine: potential role in the treatment of inflammatory disorders and cancer Cancer Lett. 303 2011 9 20
10. M. Perse, and A. Cerar Dextran sodium sulphate colitis mouse model: traps and tricks J. Biomed. Biotechnol. 2012 2012 718617
11. H.S. Cooper, S.N. Murthy, R.S. Shah, and D.J. Sedergran Clinicopathologic study of dextran sulfate sodium experimental murine colitis Lab. Invest. 69 1993 238 249
12. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
13. C. Schierwagen, A.C. Bylund-Fellenius, and C. Lundberg Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity J. Pharmacol. Methods 23 1990 179 186 (Pubitemid 20134912)
14. R.E. Beyer A rapid biuret assay for protein of whole fatty tissues Anal. Biochem. 129 1983 483 485 (Pubitemid 13101155)
15. M.S. Moron, J.W. Depierre, and B. Mannervik Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver Biochim. Biophys. Acta 582 1979 67 78 (Pubitemid 9065588)
16. W.H. Habig, M.J. Pabst, and W.B. Jakoby Glutathione S-transferases. The first enzymatic step in mercapturic acid formation J. Biol. Chem. 249 1974 7130 7139
17. D. Gerard-Monnier, I. Erdelmeier, K. Regnard, N. Moze-Henry, J.C. Yadan, and J. Chaudiere Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation Chem. Res. Toxicol. 11 1998 1176 1183 (Pubitemid 28500798)
18. S. Marklund, and G. Marklund Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase Eur. J. Biochem. 47 1974 469 474
19. K.M. Miranda, M.G. Espey, and D.A. Wink A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite Nitric Oxide 5 2001 62 71 (Pubitemid 34146173)
20. C. Bauer, P. Duewell, C. Mayer, H.A. Lehr, K.A. Fitzgerald, and M. Dauer et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome Gut 59 2010 1192 1199
21. M. Coccia, O.J. Harrison, C. Schiering, M.J. Asquith, B. Becher, and F. Powrie et al. IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells J. Exp. Med. 209 2012 1595 1609
22. M. Onizawa, T. Nagaishi, T. Kanai, K. Nagano, S. Oshima, and Y. Nemoto et al. Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 G850 859
23. H.T. Nguyen, G. Dalmasso, L. Torkvist, J. Halfvarson, Y. Yan, and H. Laroui et al. CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice J. Clin. Invest. 121 2011 1733 1747
24. I. Okayasu, S. Hatakeyama, M. Yamada, T. Ohkusa, Y. Inagaki, and R. Nakaya A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology 98 1990 694 702 (Pubitemid 20069706)
25. L. Stevceva, P. Pavli, A.J. Husband, and W.F. Doe The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it BMC Clin. Pathol. 1 2001 3
26. Y. Naito, T. Takagi, and T. Yoshikawa Neutrophil-dependent oxidative stress in ulcerative colitis J. Clin. Biochem. Nutr. 41 2007 18 26 (Pubitemid 47266169)
27. B.K. Davis, H. Wen, and J.P. Ting The inflammasome NLRs in immunity, inflammation, and associated diseases Annu. Rev. Immunol. 29 2011 707 735
28. F.G. Bauernfeind, G. Horvath, A. Stutz, E.S. Alnemri, K. MacDonald, and D. Speert et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression J. Immunol. 183 2009 787 791
29. L. Franchi, R. Munoz-Planillo, and G. Nunez Sensing and reacting to microbes through the inflammasomes Nat. Immunol. 13 2012 325 332
30. Y. Iwakura, and H. Ishigame The IL-23/IL-17 axis in inflammation J. Clin. Invest. 116 2006 1218 1222
31. R. Ito, M. Kita, M. Shin-Ya, T. Kishida, A. Urano, and R. Takada et al. Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice Biochem. Biophys. Res. Commun. 377 2008 12 16
32. Z. Zhang, M. Zheng, J. Bindas, P. Schwarzenberger, and J.K. Kolls Critical role of IL-17 receptor signaling in acute TNBS-induced colitis Inflamm. Bowel Dis. 12 2006 382 388
33. Y.S. Hyun, D.S. Han, A.R. Lee, C.S. Eun, J. Youn, and H.Y. Kim Role of IL-17A in the development of colitis-associated cancer Carcinogenesis 33 2012 931 936
34. W. Liu, X. Ouyang, J. Yang, J. Liu, Q. Li, and Y. Gu et al. AP-1 activated by toll-like receptors regulates expression of IL-23 p19 J. Biol. Chem. 284 2009 24006 24016
35. M. Noti, N. Corazza, C. Mueller, B. Berger, and T. Brunner TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis J. Exp. Med. 207 2010 1057 1066
36. Y. Naito, T. Takagi, O. Handa, T. Ishikawa, S. Nakagawa, and T. Yamaguchi et al. Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice J. Gastroenterol. Hepatol. 18 2003 560 569 (Pubitemid 36645291)
37. R. Stillie, and A.W. Stadnyk Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis Inflamm. Bowel Dis. 15 2009 1515 1525
38. Y. Aoi, S. Terashima, M. Ogura, H. Nishio, S. Kato, and K. Takeuchi Roles of nitric oxide (NO) and NO synthases in healing of dextran sulfate sodium-induced rat colitis J. Physiol. Pharmacol. 59 2008 315 336 (Pubitemid 351955755)
39. K.N. Bushell, S.E. Leeman, E. Gillespie, A.C. Gower, K.L. Reed, and A.F. Stucchi et al. LITAF mediation of increased TNF-alpha secretion from inflamed colonic lamina propria macrophages PLoS One 6 2011 e25849
40. D.M. Mosser The many faces of macrophage activation J. Leukoc. Biol. 73 2003 209 212 (Pubitemid 36158295)
41. S. Gordon Alternative activation of macrophages Nat. Rev. Immunol. 3 2003 23 35 (Pubitemid 37328697)
42. J.E. Ghia, F. Galeazzi, D.C. Ford, C.M. Hogaboam, B.A. Vallance, and S. Collins Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus Am. J. Physiol. Gastrointest. Liver Physiol. 294 2008 G770 777
43. I.C. Allen, E.M. TeKippe, R.M. Woodford, J.M. Uronis, E.K. Holl, and A.B. Rogers et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer J. Exp. Med. 207 2010 1045 1056
44. J. Dupaul-Chicoine, G. Yeretssian, K. Doiron, K.S. Bergstrom, C.R. McIntire, and P.M. LeBlanc et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases Immunity 32 2010 367 378
45. M.H. Zaki, K.L. Boyd, P. Vogel, M.B. Kastan, M. Lamkanfi, and T.D. Kanneganti The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis Immunity 32 2010 379 391
46. H.T. Nguyen, G. Dalmasso, Y. Yan, H. Laroui, M. Charania, and S. Ingersoll et al. Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice Lab. Invest. 92 2012 1203 1212
47. T. Kucharzik, A. Lugering, Y. Yan, A. Driss, L. Charrier, and S. Sitaraman et al. Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation Lab. Invest. 85 2005 932 941 (Pubitemid 41021301)