-
2
-
-
84962204026
-
Global epidemiology of nonalcoholic fatty liver disease and perspectives on US minority populations
-
Sherif, Z. A. et al. Global epidemiology of nonalcoholic fatty liver disease and perspectives on US minority populations. Dig. Dis. Sci. 61, 1214-1225 (2016).
-
(2016)
Dig. Dis. Sci.
, vol.61
, pp. 1214-1225
-
-
Sherif, Z.A.1
-
3
-
-
84912031921
-
Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
-
Yoon, H. J. & Cha, B. S. Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease. World J. Hepatol 6, 800-811 (2014).
-
(2014)
World J. Hepatol
, vol.6
, pp. 800-811
-
-
Yoon, H.J.1
Cha, B.S.2
-
4
-
-
0031947715
-
Steatohepatitis: A tale of two 'hits'?
-
Day, C. P. & James, O. F. Steatohepatitis: a tale of two 'hits'? Gastroenterology 114, 842-845 (1998).
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
5
-
-
84862669638
-
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
-
Leroux, A. et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J. Hepatol. 57, 141-149 (2012).
-
(2012)
J. Hepatol.
, vol.57
, pp. 141-149
-
-
Leroux, A.1
-
6
-
-
84959104290
-
Ceramides dissociate steatosis and insulin resistance in the human liver in non-alcoholic fatty liver disease
-
Luukkonen, P. K. et al. Ceramides dissociate steatosis and insulin resistance in the human liver in non-alcoholic fatty liver disease. J. Hepatol. 64, 1167-1175 (2016).
-
(2016)
J. Hepatol.
, vol.64
, pp. 1167-1175
-
-
Luukkonen, P.K.1
-
7
-
-
36349024819
-
A lipidomic analysis of nonalcoholic fatty liver disease
-
Puri, P. et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 46, 1081-1090 (2007).
-
(2007)
Hepatology
, vol.46
, pp. 1081-1090
-
-
Puri, P.1
-
8
-
-
0029964729
-
Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/ hyperinsulinemia in normal man
-
Aarsland, A., Chinkes, D. & Wolfe, R. R. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/ hyperinsulinemia in normal man. J. Clin. Invest. 98, 2008-2017 (1996).
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 2008-2017
-
-
Aarsland, A.1
Chinkes, D.2
Wolfe, R.R.3
-
9
-
-
0031033070
-
Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: Use of simple gas chromatographic/ mass spectrometric techniques
-
Diraison, F., Pachiaudi, C. & Beylot, M. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/ mass spectrometric techniques. J. Mass Spectrom. 32, 81-86 (1997).
-
(1997)
J. Mass Spectrom.
, vol.32
, pp. 81-86
-
-
Diraison, F.1
Pachiaudi, C.2
Beylot, M.3
-
10
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly, K. L. et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
-
11
-
-
70449698539
-
Liver fat and lipid oxidation in humans
-
Kotronen, A. et al. Liver fat and lipid oxidation in humans. Liver Int. 29, 1439-1446 (2009).
-
(2009)
Liver Int.
, vol.29
, pp. 1439-1446
-
-
Kotronen, A.1
-
12
-
-
84927671391
-
Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD
-
Fuchs, C. D., Claudel, T. & Trauner, M. Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD. Trends Endocrinol. Metab. 25, 576-585 (2014).
-
(2014)
Trends Endocrinol. Metab.
, vol.25
, pp. 576-585
-
-
Fuchs, C.D.1
Claudel, T.2
Trauner, M.3
-
13
-
-
84908871564
-
Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations
-
Milic, S., Lulic, D. & Stimac, D. Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. World J. Gastroenterol. 20, 9330-9337 (2014).
-
(2014)
World J. Gastroenterol.
, vol.20
, pp. 9330-9337
-
-
Milic, S.1
Lulic, D.2
Stimac, D.3
-
14
-
-
56049098214
-
Impact of visceral fat on the metabolic syndrome and nonalcoholic fatty liver disease
-
Jeong, S. K., Kim, Y. K., Park, J. W., Shin, Y. J. & Kim, D. S. Impact of visceral fat on the metabolic syndrome and nonalcoholic fatty liver disease. J. Korean Med. Sci. 23, 789-795 (2008).
-
(2008)
J. Korean Med. Sci.
, vol.23
, pp. 789-795
-
-
Jeong, S.K.1
Kim, Y.K.2
Park, J.W.3
Shin, Y.J.4
Kim, D.S.5
-
15
-
-
80052596785
-
Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C
-
Miquilena-Colina, M. E. et al. Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C. Gut 60, 1394-1402 (2011).
-
(2011)
Gut
, vol.60
, pp. 1394-1402
-
-
Miquilena-Colina, M.E.1
-
16
-
-
84860497397
-
Diacylglycerol activation of protein kinase Cϵ and hepatic insulin resistance
-
Jornayvaz, F. R. & Shulman, G. I. Diacylglycerol activation of protein kinase Cϵ and hepatic insulin resistance. Cell Metab. 15, 574-584 (2012).
-
(2012)
Cell Metab.
, vol.15
, pp. 574-584
-
-
Jornayvaz, F.R.1
Shulman, G.I.2
-
17
-
-
84874741669
-
Diabetes and nonalcoholic fatty liver disease: A pathogenic duo
-
Williams, K. H., Shackel, N. A., Gorrell, M. D., McLennan, S. V. & Twigg, S. M. Diabetes and nonalcoholic fatty liver disease: a pathogenic duo. Endocr. Rev. 34, 84-129 (2013).
-
(2013)
Endocr. Rev.
, vol.34
, pp. 84-129
-
-
Williams, K.H.1
Shackel, N.A.2
Gorrell, M.D.3
McLennan, S.V.4
Twigg, S.M.5
-
18
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo, S. et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40, 1461-1465 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
-
19
-
-
70350550096
-
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
-
Kantartzis, K. et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 58, 2616-2623 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 2616-2623
-
-
Kantartzis, K.1
-
20
-
-
84902672359
-
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
-
Yki-Jarvinen, H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2, 901-910 (2014).
-
(2014)
Lancet Diabetes Endocrinol.
, vol.2
, pp. 901-910
-
-
Yki-Jarvinen, H.1
-
21
-
-
78651376861
-
Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance
-
Turban, S. & Hajduch, E. Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance. FEBS Lett. 585, 269-274 (2011).
-
(2011)
FEBS Lett.
, vol.585
, pp. 269-274
-
-
Turban, S.1
Hajduch, E.2
-
22
-
-
84861647226
-
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
-
e2
-
Magkos, F. et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology 142, 1444-1446.e2 (2012).
-
(2012)
Gastroenterology
, vol.142
, pp. 1444-1446
-
-
Magkos, F.1
-
23
-
-
33746778834
-
Rough sheets and smooth tubules
-
Shibata, Y., Voeltz, G. K. & Rapoport, T. A. Rough sheets and smooth tubules. Cell 126, 435-439 (2006).
-
(2006)
Cell
, vol.126
, pp. 435-439
-
-
Shibata, Y.1
Voeltz, G.K.2
Rapoport, T.A.3
-
24
-
-
0036776098
-
Structural organization of the endoplasmic reticulum
-
Voeltz, G. K., Rolls, M. M. & Rapoport, T. A. Structural organization of the endoplasmic reticulum. EMBO Rep. 3, 944-950 (2002).
-
(2002)
EMBO Rep.
, vol.3
, pp. 944-950
-
-
Voeltz, G.K.1
Rolls, M.M.2
Rapoport, T.A.3
-
25
-
-
0026078463
-
Biogenesis of the endoplasmic reticulum in activated B lymphocytes: Temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid
-
Rush, J. S., Sweitzer, T., Kent, C., Decker, G. L. & Waechter, C. J. Biogenesis of the endoplasmic reticulum in activated B lymphocytes: temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid. Arch. Biochem. Biophys. 284, 63-70 (1991).
-
(1991)
Arch. Biochem. Biophys.
, vol.284
, pp. 63-70
-
-
Rush, J.S.1
Sweitzer, T.2
Kent, C.3
Decker, G.L.4
Waechter, C.J.5
-
26
-
-
0019505825
-
Stereological analysis of normal rabbit pancreatic islets
-
Sato, T. & Herman, L. Stereological analysis of normal rabbit pancreatic islets. Am. J. Anat. 161, 71-84 (1981).
-
(1981)
Am. J. Anat.
, vol.161
, pp. 71-84
-
-
Sato, T.1
Herman, L.2
-
27
-
-
0015715820
-
Development of rough endoplasmic reticulum in mouse splenic lymphocytes stimulated by mitogens
-
Shohat, M., Janossy, G. & Dourmashkin, R. R. Development of rough endoplasmic reticulum in mouse splenic lymphocytes stimulated by mitogens. Eur. J. Immunol. 3, 680-687 (1973).
-
(1973)
Eur. J. Immunol.
, vol.3
, pp. 680-687
-
-
Shohat, M.1
Janossy, G.2
Dourmashkin, R.R.3
-
28
-
-
0017748186
-
Cytophysiological studies on isolated pancreatic islets in vitro
-
Slavin, B. G., Beigelman, P. M. & Bessman, S. P. Cytophysiological studies on isolated pancreatic islets in vitro. Anat. Rec. 188, 445-452 (1977).
-
(1977)
Anat. Rec.
, vol.188
, pp. 445-452
-
-
Slavin, B.G.1
Beigelman, P.M.2
Bessman, S.P.3
-
29
-
-
0025291580
-
Membrane biogenesis during B cell differentiation: Most endoplasmic reticulum proteins are expressed coordinately
-
Wiest, D. L. et al. Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately. J. Cell Biol. 110, 1501-1511 (1990).
-
(1990)
J. Cell Biol.
, vol.110
, pp. 1501-1511
-
-
Wiest, D.L.1
-
30
-
-
67949115773
-
Peripheral ER structure and function
-
English, A. R., Zurek, N. & Voeltz, G. K. Peripheral ER structure and function. Curr. Opin. Cell Biol. 21, 596-602 (2009).
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 596-602
-
-
English, A.R.1
Zurek, N.2
Voeltz, G.K.3
-
31
-
-
84923195554
-
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
-
Senft, D. & Ronai, Z. A. UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem. Sci. 40, 141-148 (2015).
-
(2015)
Trends Biochem. Sci.
, vol.40
, pp. 141-148
-
-
Senft, D.1
Ronai, Z.A.2
-
32
-
-
0026755363
-
The mechanism of Z α1-antitrypsin accumulation in the liver
-
Lomas, D. A., Evans, D. L., Finch, J. T. & Carrell, R. W. The mechanism of Z α1-antitrypsin accumulation in the liver. Nature 357, 605-607 (1992).
-
(1992)
Nature
, vol.357
, pp. 605-607
-
-
Lomas, D.A.1
Evans, D.L.2
Finch, J.T.3
Carrell, R.W.4
-
33
-
-
84255169603
-
Defining human ERAD networks through an integrative mapping strategy
-
Christianson, J. C. et al. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105 (2012).
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 93-105
-
-
Christianson, J.C.1
-
34
-
-
79952708723
-
Endoplasmic reticulum stress in liver disease
-
Malhi, H. & Kaufman, R. J. Endoplasmic reticulum stress in liver disease. J. Hepatol. 54, 795-809 (2011).
-
(2011)
J. Hepatol.
, vol.54
, pp. 795-809
-
-
Malhi, H.1
Kaufman, R.J.2
-
35
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P. & Ron, D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326-332 (2000).
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
36
-
-
12844257546
-
Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response
-
Shen, J., Snapp, E. L., Lippincott-Schwartz, J. & Prywes, R. Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol. Cell Biol. 25, 921-932 (2005).
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 921-932
-
-
Shen, J.1
Snapp, E.L.2
Lippincott-Schwartz, J.3
Prywes, R.4
-
37
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding, H. P., Zhang, Y. & Ron, D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397, 271-274 (1999).
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
38
-
-
84884353774
-
The eIF2α kinases: Their structures and functions
-
Donnelly, N., Gorman, A. M., Gupta, S. & Samali, A. The eIF2α kinases: their structures and functions. Cell. Mol. Life Sci. 70, 3493-3511 (2013).
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 3493-3511
-
-
Donnelly, N.1
Gorman, A.M.2
Gupta, S.3
Samali, A.4
-
39
-
-
84908078105
-
The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum
-
Reid, D. W., Chen, Q., Tay, A. S., Shenolikar, S. & Nicchitta, C. V. The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell 158, 1362-1374 (2014).
-
(2014)
Cell
, vol.158
, pp. 1362-1374
-
-
Reid, D.W.1
Chen, Q.2
Tay, A.S.3
Shenolikar, S.4
Nicchitta, C.V.5
-
40
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding, H. P. et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6, 1099-1108 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
-
41
-
-
0036314984
-
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
-
Ma, Y., Brewer, J. W., Diehl, J. A. & Hendershot, L. M. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J. Mol. Biol. 318, 1351-1365 (2002).
-
(2002)
J. Mol. Biol.
, vol.318
, pp. 1351-1365
-
-
Ma, Y.1
Brewer, J.W.2
Diehl, J.A.3
Hendershot, L.M.4
-
42
-
-
60549114848
-
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
-
Harding, H. P. et al. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development. Proc. Natl Acad. Sci. USA 106, 1832-1837 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 1832-1837
-
-
Harding, H.P.1
-
43
-
-
0033610887
-
Characterization of the hemin-sensitive eukaryotic initiation factor 2α kinase from mouse nonerythroid cells
-
Berlanga, J. J., Herrero, S. & de Haro, C. Characterization of the hemin-sensitive eukaryotic initiation factor 2α kinase from mouse nonerythroid cells. J. Biol. Chem. 273, 32340-32346 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32340-32346
-
-
Berlanga, J.J.1
Herrero, S.2
De Haro, C.3
-
44
-
-
0001598487
-
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase
-
Berlanga, J. J., Santoyo, J. & De Haro, C. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase. Eur. J. Biochem. 265, 754-762 (1999).
-
(1999)
Eur. J. Biochem.
, vol.265
, pp. 754-762
-
-
Berlanga, J.J.1
Santoyo, J.2
De Haro, C.3
-
45
-
-
0031899816
-
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2α kinases PKR and GCN2
-
Romano, P. R. et al. Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2α kinases PKR and GCN2. Mol. Cell. Biol. 18, 2282-2297 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2282-2297
-
-
Romano, P.R.1
-
46
-
-
2442542312
-
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
-
Cullinan, S. B. & Diehl, J. A. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J. Biol. Chem. 279, 20108-20117 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20108-20117
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
47
-
-
0034312290
-
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
-
Tirasophon, W., Lee, K., Callaghan, B., Welihinda, A. & Kaufman, R. J. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev. 14, 2725-2736 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 2725-2736
-
-
Tirasophon, W.1
Lee, K.2
Callaghan, B.3
Welihinda, A.4
Kaufman, R.J.5
-
48
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891 (2001).
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
49
-
-
79953794116
-
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
-
Zhang, K. et al. The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J. 30, 1357-1375 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 1357-1375
-
-
Zhang, K.1
-
50
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee, A. H., Scapa, E. F., Cohen, D. E. & Glimcher, L. H. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320, 1492-1496 (2008).
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
51
-
-
84899937866
-
Getting RIDD of RNA: IRE1 in cell fate regulation
-
Maurel, M., Chevet, E., Tavernier, J. & Gerlo, S. Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem. Sci. 39, 245-254 (2014).
-
(2014)
Trends Biochem. Sci.
, vol.39
, pp. 245-254
-
-
Maurel, M.1
Chevet, E.2
Tavernier, J.3
Gerlo, S.4
-
52
-
-
84939442266
-
Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status
-
Moore, K. & Hollien, J. Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status. Mol. Biol. Cell 26, 2873-2884 (2015).
-
(2015)
Mol. Biol. Cell
, vol.26
, pp. 2873-2884
-
-
Moore, K.1
Hollien, J.2
-
53
-
-
84867038186
-
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice
-
So, J. S. et al. Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab. 16, 487-499 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 487-499
-
-
So, J.S.1
-
54
-
-
84937841076
-
IRE1α-dependent decay of CReP/Ppp1r15b mRNA increases eukaryotic initiation factor 2α phosphorylation and suppresses protein synthesis
-
So, J. S., Cho, S., Min, S. H., Kimball, S. R. & Lee, A. H. IRE1α-dependent decay of CReP/Ppp1r15b mRNA increases eukaryotic initiation factor 2α phosphorylation and suppresses protein synthesis. Mol. Cell. Biol. 35, 2761-2770 (2015).
-
(2015)
Mol. Cell. Biol.
, vol.35
, pp. 2761-2770
-
-
So, J.S.1
Cho, S.2
Min, S.H.3
Kimball, S.R.4
Lee, A.H.5
-
55
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin, J. H. et al. IRE1 signaling affects cell fate during the unfolded protein response. Science. 318, 994-999 (2007).
-
(2007)
Science.
, vol.318
, pp. 994-999
-
-
Lin, J.H.1
-
56
-
-
84864682160
-
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
-
Lerner, A. G. et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 16, 250-264 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 250-264
-
-
Lerner, A.G.1
-
57
-
-
84868525253
-
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
-
Upton, J. P. et al. IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science 338, 818-822 (2012).
-
(2012)
Science
, vol.338
, pp. 818-822
-
-
Upton, J.P.1
-
58
-
-
74549184092
-
The NLRP3 inflammasome: A sensor for metabolic danger?
-
Schroder, K., Zhou, R. & Tschopp, J. The NLRP3 inflammasome: a sensor for metabolic danger? Science 327, 296-300 (2010).
-
(2010)
Science
, vol.327
, pp. 296-300
-
-
Schroder, K.1
Zhou, R.2
Tschopp, J.3
-
59
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh, H. et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16, 1345-1355 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
-
60
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano, F. et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664-666 (2000).
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
-
61
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen, J., Chen, X., Hendershot, L. & Prywes, R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3, 99-111 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.3
Prywes, R.4
-
62
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
Ye, J. et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6, 1355-1364 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
-
63
-
-
84934275896
-
Proteostasis control by the unfolded protein response
-
Hetz, C., Chevet, E. & Oakes, S. A. Proteostasis control by the unfolded protein response. Nat. Cell Biol. 17, 829-838 (2015).
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 829-838
-
-
Hetz, C.1
Chevet, E.2
Oakes, S.A.3
-
64
-
-
84959470663
-
Regulation of liver metabolism by autophagy
-
Madrigal-Matute, J. & Cuervo, A. M. Regulation of liver metabolism by autophagy. Gastroenterology 150, 328-329 (2016).
-
(2016)
Gastroenterology
, vol.150
, pp. 328-329
-
-
Madrigal-Matute, J.1
Cuervo, A.M.2
-
65
-
-
84901815187
-
Cargo recognition and trafficking in selective autophagy
-
Stolz, A., Ernst, A. & Dikic, I. Cargo recognition and trafficking in selective autophagy. Nat. Cell Biol. 16, 495-501 (2014).
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 495-501
-
-
Stolz, A.1
Ernst, A.2
Dikic, I.3
-
66
-
-
84885187757
-
The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
-
Salazar, M. et al. The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochim. Biophys. Acta 1831, 1573-1578 (2013).
-
(2013)
Biochim. Biophys. Acta
, vol.1831
, pp. 1573-1578
-
-
Salazar, M.1
-
67
-
-
84919643533
-
A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy
-
Deegan, S. et al. A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. Biochem. Biophys. Res. Commun. 456, 305-311 (2015).
-
(2015)
Biochem. Biophys. Res. Commun.
, vol.456
, pp. 305-311
-
-
Deegan, S.1
-
68
-
-
84883451249
-
Selective autophagy: Talking with the UPS
-
Park, C. & Cuervo, A. M. Selective autophagy: talking with the UPS. Cell Biochem. Biophys. 67, 3-13 (2013).
-
(2013)
Cell Biochem. Biophys.
, vol.67
, pp. 3-13
-
-
Park, C.1
Cuervo, A.M.2
-
69
-
-
84882827495
-
Decoding cell death signals in liver inflammation
-
Brenner, C., Galluzzi, L., Kepp, O. & Kroemer, G. Decoding cell death signals in liver inflammation. J. Hepatol. 59, 583-594 (2013).
-
(2013)
J. Hepatol.
, vol.59
, pp. 583-594
-
-
Brenner, C.1
Galluzzi, L.2
Kepp, O.3
Kroemer, G.4
-
70
-
-
57049117856
-
Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities
-
Kim, I., Xu, W. & Reed, J. C. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discov. 7, 1013-1030 (2008).
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 1013-1030
-
-
Kim, I.1
Xu, W.2
Reed, J.C.3
-
71
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan, U. et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461 (2004).
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
-
72
-
-
30944451788
-
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
-
Wang, D., Wei, Y. & Pagliassotti, M. J. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147, 943-951 (2006).
-
(2006)
Endocrinology
, vol.147
, pp. 943-951
-
-
Wang, D.1
Wei, Y.2
Pagliassotti, M.J.3
-
73
-
-
62749178966
-
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
-
Gregor, M. F. et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 58, 693-700 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 693-700
-
-
Gregor, M.F.1
-
74
-
-
38649124615
-
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
-
Puri, P. et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134, 568-576 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 568-576
-
-
Puri, P.1
-
75
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-κB and endoplasmic reticulum stress
-
Kharroubi, I. et al. Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-Free fatty acids and cytokines induce B and endoplasmic reticulum stress. Endocrinology 145, 5087-5096 (2004).
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
-
76
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
-
Cunha, D. A. et al. Initiation and execution of lipotoxic ER stress in pancreatic β-cells. J. Cell Sci. 121, 2308-2318 (2008).
-
(2008)
J. Cell Sci.
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
-
77
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
-
Karaskov, E. et al. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis. Endocrinology 147, 3398-3407 (2006).
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
-
78
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
Wei, Y., Wang, D., Topczewski, F. & Pagliassotti, M. J. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 291, E275-E281 (2006).
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
, pp. E275-E281
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
79
-
-
0042972934
-
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
-
Feng, B. et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat. Cell Biol. 5, 781-792 (2003).
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 781-792
-
-
Feng, B.1
-
80
-
-
77954579285
-
Decrease in membrane phospholipid unsaturation induces unfolded protein response
-
Ariyama, H., Kono, N., Matsuda, S., Inoue, T. & Arai, H. Decrease in membrane phospholipid unsaturation induces unfolded protein response. J. Biol. Chem. 285, 22027-22035 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 22027-22035
-
-
Ariyama, H.1
Kono, N.2
Matsuda, S.3
Inoue, T.4
Arai, H.5
-
81
-
-
0019986613
-
Changes in the composition and fluidity of membranes in obese (ob/ob) mice: A study of hepatic microsomal NADPH-cytochrome P450 oxidoreductase activity
-
Hyslop, P. A., York, D. A. & Corina, D. L. Changes in the composition and fluidity of membranes in obese (ob/ob) mice: a study of hepatic microsomal NADPH-cytochrome P450 oxidoreductase activity. Int. J. Obes. 6, 279-289 (1982).
-
(1982)
Int. J. Obes.
, vol.6
, pp. 279-289
-
-
Hyslop, P.A.1
York, D.A.2
Corina, D.L.3
-
82
-
-
79955433960
-
Metabolomic analysis of livers and serum from high-fat diet induced obese mice
-
Kim, H. J. et al. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J. Proteome Res. 10, 722-731 (2011).
-
(2011)
J. Proteome Res.
, vol.10
, pp. 722-731
-
-
Kim, H.J.1
-
83
-
-
84940721655
-
Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes
-
Arruda, A. P. & Hotamisligil, G. S. Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes. Cell Metab. 22, 381-397 (2015).
-
(2015)
Cell Metab.
, vol.22
, pp. 381-397
-
-
Arruda, A.P.1
Hotamisligil, G.S.2
-
84
-
-
79957605136
-
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
-
Fu, S. et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473, 528-531 (2011).
-
(2011)
Nature
, vol.473
, pp. 528-531
-
-
Fu, S.1
-
85
-
-
80052825784
-
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
-
Promlek, T. et al. Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways. Mol. Biol. Cell 22, 3520-3532 (2011).
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 3520-3532
-
-
Promlek, T.1
-
86
-
-
84875242776
-
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
-
Volmer, R., van der Ploeg, K. & Ron, D. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc. Natl Acad. Sci. USA 110, 4628-4633 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 4628-4633
-
-
Volmer, R.1
Van Der Ploeg, K.2
Ron, D.3
-
87
-
-
0032927776
-
Apolipoprotein B in the rough endoplasmic reticulum: Translation, translocation and the initiation of lipoprotein assembly
-
Shelness, G. S., Ingram, M. F., Huang, X. F. & DeLozier, J. A. Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J. Nutr. 129, 456S-462S (1999).
-
(1999)
J. Nutr.
, vol.129
, pp. 456S-462S
-
-
Shelness, G.S.1
Ingram, M.F.2
Huang, X.F.3
DeLozier, J.A.4
-
88
-
-
84863012179
-
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
-
Lee, J. S., Mendez, R., Heng, H. H., Yang, Z. Q. & Zhang, K. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. Am. J. Transl. Res. 4, 102-113 (2012).
-
(2012)
Am. J. Transl. Res.
, vol.4
, pp. 102-113
-
-
Lee, J.S.1
Mendez, R.2
Heng, H.H.3
Yang, Z.Q.4
Zhang, K.5
-
89
-
-
77957302090
-
Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
-
Ferre, P. & Foufelle, F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes. Metab. 12 (Suppl. 2), 83-92 (2010).
-
(2010)
Diabetes Obes. Metab.
, vol.12
, pp. 83-92
-
-
Ferre, P.1
Foufelle, F.2
-
90
-
-
84945124994
-
Transcriptional regulation of hepatic lipogenesis
-
Wang, Y., Viscarra, J., Kim, S. J. & Sul, H. S. Transcriptional regulation of hepatic lipogenesis. Nat. Rev. Mol. Cell Biol. 16, 678-689 (2015).
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 678-689
-
-
Wang, Y.1
Viscarra, J.2
Kim, S.J.3
Sul, H.S.4
-
91
-
-
14144251157
-
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c
-
Hegarty, B. D. et al. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc. Natl Acad. Sci. USA 102, 791-796 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 791-796
-
-
Hegarty, B.D.1
-
92
-
-
38649116056
-
Selective versus total insulin resistance: A pathogenic paradox
-
Brown, M. S. & Goldstein, J. L. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 7, 95-96 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 95-96
-
-
Brown, M.S.1
Goldstein, J.L.2
-
93
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
Kammoun, H. L. et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119, 1201-1215 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
-
94
-
-
7244221504
-
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1
-
Lee, J. N. & Ye, J. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J. Biol. Chem. 279, 45257-45265 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45257-45265
-
-
Lee, J.N.1
Ye, J.2
-
95
-
-
79956292356
-
Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program
-
Ning, J. et al. Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program. Endocrinology 152, 2247-2255 (2011).
-
(2011)
Endocrinology
, vol.152
, pp. 2247-2255
-
-
Ning, J.1
-
96
-
-
84908200877
-
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
-
Jiang, S. et al. Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. J. Biol. Chem. 289, 29751-29765 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 29751-29765
-
-
Jiang, S.1
-
97
-
-
55849112292
-
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
-
Bobrovnikova-Marjon, E. et al. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc. Natl Acad. Sci. USA 105, 16314-16319 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 16314-16319
-
-
Bobrovnikova-Marjon, E.1
-
98
-
-
44349163999
-
Dephosphorylation of translation initiation factor 2α enhances glucose tolerance and attenuates hepatosteatosis in mice
-
Oyadomari, S., Harding, H. P., Zhang, Y., Oyadomari, M. & Ron, D. Dephosphorylation of translation initiation factor 2α enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 7, 520-532 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 520-532
-
-
Oyadomari, S.1
Harding, H.P.2
Zhang, Y.3
Oyadomari, M.4
Ron, D.5
-
99
-
-
84883348454
-
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice
-
Xiao, G. et al. ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice. J. Biol. Chem. 288, 25350-25361 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 25350-25361
-
-
Xiao, G.1
-
100
-
-
84862577245
-
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
-
Maris, M. et al. Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance. Diabetologia 55, 1167-1178 (2012).
-
(2012)
Diabetologia
, vol.55
, pp. 1167-1178
-
-
Maris, M.1
-
101
-
-
84925488647
-
The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome
-
Zhang, Z. et al. The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome. Rev. Endocr. Metab. Disord. 16, 35-45 (2015).
-
(2015)
Rev. Endocr. Metab. Disord.
, vol.16
, pp. 35-45
-
-
Zhang, Z.1
-
102
-
-
84876154662
-
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
-
Jo, H. et al. Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor. Hepatology 57, 1366-1377 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 1366-1377
-
-
Jo, H.1
-
103
-
-
84901594244
-
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish
-
Howarth, D. L. et al. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. PLoS Genet. 10, e1004335 (2014).
-
(2014)
PLoS Genet.
, vol.10
-
-
Howarth, D.L.1
-
104
-
-
79959491402
-
Mitochondria and redox signaling in steatohepatitis
-
Morris, E. M., Rector, R. S., Thyfault, J. P. & Ibdah, J. A. Mitochondria and redox signaling in steatohepatitis. Antioxid. Redox Signal. 15, 485-504 (2011).
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 485-504
-
-
Morris, E.M.1
Rector, R.S.2
Thyfault, J.P.3
Ibdah, J.A.4
-
105
-
-
84861451144
-
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
-
Satapati, S. et al. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J. Lipid Res. 53, 1080-1092 (2012).
-
(2012)
J. Lipid Res.
, vol.53
, pp. 1080-1092
-
-
Satapati, S.1
-
106
-
-
82955239838
-
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
-
Sunny, N. E., Parks, E. J., Browning, J. D. & Burgess, S. C. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 14, 804-810 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 804-810
-
-
Sunny, N.E.1
Parks, E.J.2
Browning, J.D.3
Burgess, S.C.4
-
107
-
-
84896871426
-
MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond
-
Vance, J. E. MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond. Biochim. Biophys. Acta. 184, 595-609 (2014).
-
(2014)
Biochim. Biophys. Acta.
, vol.184
, pp. 595-609
-
-
Vance, J.E.1
-
108
-
-
79960435711
-
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
-
Bravo, R. et al. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J. Cell Sci. 124, 2143-2152 (2011).
-
(2011)
J. Cell Sci.
, vol.124
, pp. 2143-2152
-
-
Bravo, R.1
-
109
-
-
84862009457
-
Loss of mitofusin 2 promotes endoplasmic reticulum stress
-
Ngoh, G. A., Papanicolaou, K. N. & Walsh, K. Loss of mitofusin 2 promotes endoplasmic reticulum stress. J. Biol. Chem. 287, 20321-20332 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 20321-20332
-
-
Ngoh, G.A.1
Papanicolaou, K.N.2
Walsh, K.3
-
110
-
-
84908082447
-
Stress-responsive regulation of mitochondria through the ER unfolded protein response
-
Rainbolt, T. K., Saunders, J. M. & Wiseman, R. L. Stress-responsive regulation of mitochondria through the ER unfolded protein response. Trends Endocrinol. Metab. 25, 528-537 (2014).
-
(2014)
Trends Endocrinol. Metab.
, vol.25
, pp. 528-537
-
-
Rainbolt, T.K.1
Saunders, J.M.2
Wiseman, R.L.3
-
111
-
-
57349100367
-
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
-
de Brito, O. M. & Scorrano, L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456, 605-610 (2008).
-
(2008)
Nature
, vol.456
, pp. 605-610
-
-
De Brito, O.M.1
Scorrano, L.2
-
112
-
-
84925581335
-
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity
-
Arruda, A. P. et al. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat. Med. 20, 1427-1435 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 1427-1435
-
-
Arruda, A.P.1
-
113
-
-
68649090226
-
Regulation of mitochondrial dehydrogenases by calcium ions
-
Denton, R. M. Regulation of mitochondrial dehydrogenases by calcium ions. Biochim. Biophys. Acta 1787, 1309-1316 (2009).
-
(2009)
Biochim. Biophys. Acta
, vol.1787
, pp. 1309-1316
-
-
Denton, R.M.1
-
114
-
-
0018363365
-
The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex
-
McCormack, J. G. & Denton, R. M. The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochem. J. 180, 533-544 (1979).
-
(1979)
Biochem. J.
, vol.180
, pp. 533-544
-
-
McCormack, J.G.1
Denton, R.M.2
-
115
-
-
84904288578
-
ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
-
Egnatchik, R. A., Leamy, A. K., Jacobson, D. A., Shiota, M. & Young, J. D. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Mol. Metab. 3, 544-553 (2014).
-
(2014)
Mol. Metab.
, vol.3
, pp. 544-553
-
-
Egnatchik, R.A.1
Leamy, A.K.2
Jacobson, D.A.3
Shiota, M.4
Young, J.D.5
-
116
-
-
84940043387
-
Calcium and ROS: A mutual interplay
-
Gorlach, A., Bertram, K., Hudecova, S. & Krizanova, O. Calcium and ROS: a mutual interplay. Redox Biol. 6, 260-271 (2015).
-
(2015)
Redox Biol.
, vol.6
, pp. 260-271
-
-
Gorlach, A.1
Bertram, K.2
Hudecova, S.3
Krizanova, O.4
-
117
-
-
77955291571
-
Oxidative stress caused by mitochondrial calcium overload
-
Peng, T. I. & Jou, M. J. Oxidative stress caused by mitochondrial calcium overload. Ann. NY Acad. Sci. 1201, 183-188 (2010).
-
(2010)
Ann. NY Acad. Sci.
, vol.1201
, pp. 183-188
-
-
Peng, T.I.1
Jou, M.J.2
-
118
-
-
84937738375
-
Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis
-
Koliaki, C. et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 21, 739-746 (2015).
-
(2015)
Cell Metab.
, vol.21
, pp. 739-746
-
-
Koliaki, C.1
-
119
-
-
84890195141
-
Mitochondrial lipid transport at a glance
-
Scharwey, M., Tatsuta, T. & Langer, T. Mitochondrial lipid transport at a glance. J. Cell Sci. 126, 5317-5323 (2013).
-
(2013)
J. Cell Sci.
, vol.126
, pp. 5317-5323
-
-
Scharwey, M.1
Tatsuta, T.2
Langer, T.3
-
120
-
-
84893820586
-
Formation and regulation of mitochondrial membranes
-
Schenkel, L. C. & Bakovic, M. Formation and regulation of mitochondrial membranes. Int. J. Cell Biol. 2014, 709828 (2014).
-
(2014)
Int. J. Cell Biol.
, vol.2014
, pp. 709828
-
-
Schenkel, L.C.1
Bakovic, M.2
-
121
-
-
84913590552
-
The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway
-
Vernia, S. et al. The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metab. 20, 512-525 (2014).
-
(2014)
Cell Metab.
, vol.20
, pp. 512-525
-
-
Vernia, S.1
-
122
-
-
84956798877
-
The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance
-
Pal, M., Febbraio, M. A. & Lancaster, G. I. The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance. J. Physiol. 594, 267-279 (2016).
-
(2016)
J. Physiol.
, vol.594
, pp. 267-279
-
-
Pal, M.1
Febbraio, M.A.2
Lancaster, G.I.3
-
123
-
-
84891794636
-
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death
-
Win, S., Than, T. A., Fernandez-Checa, J. C. & Kaplowitz, N. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 5, e989 (2014).
-
(2014)
Cell Death Dis.
, vol.5
, pp. e989
-
-
Win, S.1
Than, T.A.2
Fernandez-Checa, J.C.3
Kaplowitz, N.4
-
124
-
-
80053425902
-
C-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
-
Win, S., Than, T. A., Han, D., Petrovic, L. M. & Kaplowitz, N. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J. Biol. Chem. 286, 35071-35078 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 35071-35078
-
-
Win, S.1
Than, T.A.2
Han, D.3
Petrovic, L.M.4
Kaplowitz, N.5
-
125
-
-
84929607060
-
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
-
Win, S. et al. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J. Hepatol. 62, 1367-1374 (2015).
-
(2015)
J. Hepatol.
, vol.62
, pp. 1367-1374
-
-
Win, S.1
-
126
-
-
84978287529
-
JNK mediates mouse liver injury through a novel Sab (SH3BP5) dependent pathway leading to inactivation of intramitochondrial Src
-
Win, S., Than, T. A., Min, R. W., Aghajan, M. & Kaplowitz, N. JNK mediates mouse liver injury through a novel Sab (SH3BP5) dependent pathway leading to inactivation of intramitochondrial Src. Hepatology 63, 1987-1987 (2016).
-
(2016)
Hepatology
, vol.63
, pp. 1987
-
-
Win, S.1
Than, T.A.2
Min, R.W.3
Aghajan, M.4
Kaplowitz, N.5
-
127
-
-
84864684825
-
Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis
-
Liu, T. F. et al. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metab. 16, 213-225 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 213-225
-
-
Liu, T.F.1
-
128
-
-
38149136598
-
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
-
Ota, T., Gayet, C. & Ginsberg, H. N. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J. Clin. Invest. 118, 316-332 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 316-332
-
-
Ota, T.1
Gayet, C.2
Ginsberg, H.N.3
-
129
-
-
79960663655
-
The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2
-
Theesfeld, C. L., Pourmand, D., Davis, T., Garza, R. M. & Hampton, R. Y. The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. J. Biol. Chem. 286, 26298-26307 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 26298-26307
-
-
Theesfeld, C.L.1
Pourmand, D.2
Davis, T.3
Garza, R.M.4
Hampton, R.Y.5
-
130
-
-
73349106233
-
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response
-
Schuck, S., Prinz, W. A., Thorn, K. S., Voss, C. & Walter, P. Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J. Cell Biol. 187, 525-536 (2009).
-
(2009)
J. Cell Biol.
, vol.187
, pp. 525-536
-
-
Schuck, S.1
Prinz, W.A.2
Thorn, K.S.3
Voss, C.4
Walter, P.5
-
131
-
-
84903818479
-
Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation
-
Choi, K. et al. Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation. FEBS J. 281, 3048-3060 (2014).
-
(2014)
FEBS J.
, vol.281
, pp. 3048-3060
-
-
Choi, K.1
-
132
-
-
39849093869
-
Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice
-
Liu, Y. et al. Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. Biochim. Biophys. Acta 1781, 97-104 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 97-104
-
-
Liu, Y.1
-
133
-
-
33645815074
-
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-Free fatty acids and cytokines induce B activation and down-regulation of TRAF2 expression
-
Hu, P., Han, Z., Couvillon, A. D., Kaufman, R. J. & Exton, J. H. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-Free fatty acids and cytokines induce B activation and down-regulation of TRAF2 expression. Mol. Cell. Biol. 26, 3071-3084 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
134
-
-
84862908245
-
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
-
Jurczak, M. J. et al. Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J. Biol. Chem. 287, 2558-2567 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 2558-2567
-
-
Jurczak, M.J.1
-
135
-
-
77955549551
-
Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans
-
Oberkofler, H. et al. Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans. Diabetologia 53, 1971-1975 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 1971-1975
-
-
Oberkofler, H.1
-
136
-
-
0038242819
-
TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
-
Du, K., Herzig, S., Kulkarni, R. N. & Montminy, M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300, 1574-1577 (2003).
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkarni, R.N.3
Montminy, M.4
-
137
-
-
14244265623
-
Lack of evidence for a role of TRB3/ NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes
-
Iynedjian, P. B. Lack of evidence for a role of TRB3/ NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes. Biochem. J. 386, 113-118 (2005).
-
(2005)
Biochem. J.
, vol.386
, pp. 113-118
-
-
Iynedjian, P.B.1
-
138
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang, L., Li, P., Fu, S., Calay, E. S. & Hotamisligil, G. S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11, 467-478 (2010).
-
(2010)
Cell Metab.
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
139
-
-
43949096967
-
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
-
Kim, J. S. et al. Impaired autophagy: a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology 47, 1725-1736 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 1725-1736
-
-
Kim, J.S.1
-
140
-
-
84858659826
-
Inhibitory effect of dietary lipids on chaperone-mediated autophagy
-
Rodriguez-Navarro, J. A. et al. Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc. Natl Acad. Sci. USA 109, E705-E714 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E705-E714
-
-
Rodriguez-Navarro, J.A.1
-
141
-
-
77955789211
-
Altered lipid content inhibits autophagic vesicular fusion
-
Koga, H., Kaushik, S. & Cuervo, A. M. Altered lipid content inhibits autophagic vesicular fusion. FASEB J. 24, 3052-3065 (2010).
-
(2010)
FASEB J.
, vol.24
, pp. 3052-3065
-
-
Koga, H.1
Kaushik, S.2
Cuervo, A.M.3
-
142
-
-
84922116624
-
Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies
-
Park, H. W. & Lee, J. H. Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. Autophagy 10, 2385-2386 (2014).
-
(2014)
Autophagy
, vol.10
, pp. 2385-2386
-
-
Park, H.W.1
Lee, J.H.2
-
143
-
-
84913592131
-
Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation
-
Schneider, J. L., Suh, Y. & Cuervo, A. M. Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab. 20, 417-432 (2014).
-
(2014)
Cell Metab.
, vol.20
, pp. 417-432
-
-
Schneider, J.L.1
Suh, Y.2
Cuervo, A.M.3
-
144
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan, U. et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006).
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
-
145
-
-
1542515099
-
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
-
Lindor, K. D. et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 39, 770-778 (2004).
-
(2004)
Hepatology
, vol.39
, pp. 770-778
-
-
Lindor, K.D.1
-
146
-
-
84961192769
-
Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism
-
Zhang, X. et al. Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism. Apoptosis 21, 721-736 (2016).
-
(2016)
Apoptosis
, vol.21
, pp. 721-736
-
-
Zhang, X.1
-
147
-
-
33644803761
-
Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
-
Ding, X., Saxena, N. K., Lin, S., Gupta, N. A. & Anania, F. A. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43, 173-181 (2006).
-
(2006)
Hepatology
, vol.43
, pp. 173-181
-
-
Ding, X.1
Saxena, N.K.2
Lin, S.3
Gupta, N.A.4
Anania, F.A.5
-
148
-
-
80053001967
-
GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
-
Sharma, S., Mells, J. E., Fu, P. P., Saxena, N. K. & Anania, F. A. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS ONE 6, e25269 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Sharma, S.1
Mells, J.E.2
Fu, P.P.3
Saxena, N.K.4
Anania, F.A.5
-
149
-
-
84957840942
-
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study
-
Armstrong, M. J. et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 387, 679-690 (2016).
-
(2016)
Lancet
, vol.387
, pp. 679-690
-
-
Armstrong, M.J.1
-
150
-
-
58249112749
-
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: Evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis
-
Bowes, A. J., Khan, M. I., Shi, Y., Robertson, L. & Werstuck, G. H. Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis. Am. J. Pathol. 174, 330-342 (2009).
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 330-342
-
-
Bowes, A.J.1
Khan, M.I.2
Shi, Y.3
Robertson, L.4
Werstuck, G.H.5
-
151
-
-
38049170584
-
A molecular chaperone inducer protects neurons from ER stress
-
Kudo, T. et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15, 364-375 (2008).
-
(2008)
Cell Death Differ.
, vol.15
, pp. 364-375
-
-
Kudo, T.1
-
152
-
-
84866905708
-
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d] pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
-
Axten, J. M. et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d] pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J. Med. Chem. 55, 7193-7207 (2012).
-
(2012)
J. Med. Chem.
, vol.55
, pp. 7193-7207
-
-
Axten, J.M.1
-
153
-
-
13644256191
-
A selective inhibitor of eIF2αa dephosphorylation protects cells from ER stress
-
Boyce, M. et al. A selective inhibitor of eIF2αa dephosphorylation protects cells from ER stress. Science 307, 935-939 (2005).
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
-
154
-
-
79953288480
-
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
-
Tsaytler, P., Harding, H. P., Ron, D. & Bertolotti, A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science 332, 91-94 (2011).
-
(2011)
Science
, vol.332
, pp. 91-94
-
-
Tsaytler, P.1
Harding, H.P.2
Ron, D.3
Bertolotti, A.4
-
155
-
-
79959481888
-
Protein folding and modification in the mammalian endoplasmic reticulum
-
Braakman, I. & Bulleid, N. J. Protein folding and modification in the mammalian endoplasmic reticulum. Annu. Rev. Biochem. 80, 71-99 (2011).
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 71-99
-
-
Braakman, I.1
Bulleid, N.J.2
-
156
-
-
79960711299
-
Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems
-
Brodsky, J. L. & Skach, W. R. Protein folding and quality control in the endoplasmic reticulum: recent lessons from yeast and mammalian cell systems. Curr. Opin. Cell Biol. 23, 464-475 (2011).
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 464-475
-
-
Brodsky, J.L.1
Skach, W.R.2
-
157
-
-
49649132780
-
Submicrosomal localization of hepatic 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase
-
Goldfarb, S. Submicrosomal localization of hepatic 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase. FEBS Lett. 24, 153-155 (1972).
-
(1972)
FEBS Lett.
, vol.24
, pp. 153-155
-
-
Goldfarb, S.1
-
158
-
-
0026712872
-
Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
-
Mandon, E. C., Ehses, I., Rother, J., van Echten, G. & Sandhoff, K. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem. 267, 11144-11148 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 11144-11148
-
-
Mandon, E.C.1
Ehses, I.2
Rother, J.3
Van Echten, G.4
Sandhoff, K.5
-
159
-
-
78549270833
-
Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation
-
McFie, P. J., Stone, S. L., Banman, S. L. & Stone, S. J. Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation. J. Biol. Chem. 285, 37377-37387 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37377-37387
-
-
McFie, P.J.1
Stone, S.L.2
Banman, S.L.3
Stone, S.J.4
-
160
-
-
84867619217
-
Nonvesicular lipid transfer from the endoplasmic reticulum
-
Lev, S. Nonvesicular lipid transfer from the endoplasmic reticulum. Cold Spring Harb. Perspect. Biol. http://dx.doi.org/10.1101/cshperspect.a013300 (2012).
-
(2012)
Cold Spring Harb. Perspect. Biol
-
-
Lev, S.1
-
162
-
-
0018397777
-
Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes
-
Fujii-Kuriyama, Y., Negishi, M., Mikawa, R. & Tashiro, Y. Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes. J. Cell Biol. 81, 510-519 (1979).
-
(1979)
J. Cell Biol.
, vol.81
, pp. 510-519
-
-
Fujii-Kuriyama, Y.1
Negishi, M.2
Mikawa, R.3
Tashiro, Y.4
-
163
-
-
0021244599
-
A biochemical and electron microscopic study of changes in the content of cytochrome P-450 in rat livers after cessation of treatment with phenobarbital, β-naphtoflavone or 3-methylcholanthrene
-
Masaki, R., Matsuura, S. & Tashiro, Y. A biochemical and electron microscopic study of changes in the content of cytochrome P-450 in rat livers after cessation of treatment with phenobarbital, β-naphtoflavone or 3-methylcholanthrene. Cell Struct. Funct. 9, 53-66 (1984).
-
(1984)
Cell Struct. Funct.
, vol.9
, pp. 53-66
-
-
Masaki, R.1
Matsuura, S.2
Tashiro, Y.3
-
164
-
-
79959630948
-
Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver
-
Boden, G. et al. Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver. Obesity (Silver Spring) 19, 1366-1373 (2011).
-
(2011)
Obesity (Silver Spring)
, vol.19
, pp. 1366-1373
-
-
Boden, G.1
-
165
-
-
84894465374
-
Insulin regulates the unfolded protein response in human adipose tissue
-
Boden, G. et al. Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 63, 912-922 (2014).
-
(2014)
Diabetes
, vol.63
, pp. 912-922
-
-
Boden, G.1
-
166
-
-
84873873215
-
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
-
Deng, Y. et al. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J. Clin. Invest. 123, 455-468 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 455-468
-
-
Deng, Y.1
-
167
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang, K. et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587-599 (2006).
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
-
168
-
-
84856856011
-
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
-
Hur, K. Y. et al. IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. J. Exp. Med. 209, 307-318 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 307-318
-
-
Hur, K.Y.1
|