Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism

Apoptosis

Volumn 21, Issue 6, 2016, Pages 721-736

  Zhang, Xiuli ^a,b   Liang, Dan ^c   Lian, Xu ^d   Jiang, Yan ^a   He, Hui ^a   Liang, Wei ^a   Zhao, Yue ^b   Chi, Zhi Hong ^e  

^a Liaoning Province Benxi Center Hospital   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Troops of 95935 Unit   (China)

^d MUDANJIANG MEDICAL UNIVERSITY   (China)

^e CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Berberine; High glucose; NF E2 related factor 2; Phosphatidylinositol 3 kinase (PI3K) Akt; Renal tubular epithelial cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BERBERINE; CASPASE 3; CASPASE 9; CYTOCHROME C; GLUTATHIONE; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; GLUCOSE; NFE2L2 PROTEIN, RAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KIDNEY TUBULE CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RELEASE ASSAY; SIGNAL TRANSDUCTION; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL NUCLEUS; DRUG EFFECTS; EPITHELIUM CELL; KIDNEY TUBULE; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BERBERINE; CELL LINE; CELL NUCLEUS; EPITHELIAL CELLS; GLUCOSE; HEME OXYGENASE-1; KIDNEY TUBULES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-E2-RELATED FACTOR 2; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84961192769     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-016-1234-5     Document Type: Article

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