Contributions of de novo synthesis of fatty acids to total VLDL- triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man

Journal of Clinical Investigation

Volumn 98, Issue 9, 1996, Pages 2008-2017

  Aarsland, Asle ^a   Chinkes, David ^a   Wolfe, Robert R ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

carbohydrate; hyperalimentation; liver; stable isotopes; triglycerides

Indexed keywords

ACETIC ACID; CARBON 13; FATTY ACID; ISOTOPE; PALMITIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; ATHEROSCLEROSIS; CARBOHYDRATE INTAKE; DIETARY INTAKE; ENERGY EXPENDITURE; FATTY ACID SYNTHESIS; HUMAN; HUMAN EXPERIMENT; HYPERALIMENTATION; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; ISOTOPE LABELING; LIPID METABOLISM; LIVER METABOLISM; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0029964729     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119005     Document Type: Article

References (58)

1. Steiner, G. 1993. Hyperinsulinemia and VLDL kinetics. Adv. Exp. Med. Biol. 334:287-294.
2. Howard, B.V. 1987. Lipoprotein metabolism in diabetes mellitus. J. Lipid Res. 28:613-628.
3. Steiner, G. 1981. Diabetes and atherosclerosis: an overview. Diabetes. 30(Suppl.2):1-7.
4. Taskinen, M.-R. 1993. Hyperinsulinism and dyslipidemias as coronary heart disease risk factors in NIDDM. Adv. Exp. Med. Biol. 334:295-300.
5. Carlson, L.A., L.E. Bottiger, and P.E. Ahfeldt. 1979. Risk factors for myocardial infarction in the Stockholm Prospective Study: a 14 year follow-up focusing on the role of plasma triglycerides and cholesterol. Acta. Med. Scand. 206:351-360.
6. Castelli, W.P. 1986. The triglyceride issue: a view from Framingham. Am. Heart J. 112:432-437.
7. Reaven, G.M., and Y.D.I. Chen. 1988. Role of insulin in regulation of lipoprotein metabolism in diabetes. Diabetes Metab. Rev. 4:639-652.
8. Taskinen, M.-R. 1987. Lipoprotein lipase in diabetes. Diabetes Metab. Rev. 3:551-570.
9. Berthezene, F. 1992. Hypertriglyceridemia: cause or consequence of insulin resistance? Horm. Res. 38:39-40.
10. Gibbons, G.F. 1989. Insulin, diabetes and hepatic very-low-density lipoprotein metabolism. Biochem. Soc. Trans. 17:49-51.
11. Woodside, W.F., and M. Heimberg. 1976. Effects of anti-insulin serum, insulin, and glucose on output of triglycerides and ketogenesis by the perfused rat liver. J. Biol. Chem. 251:13-23.
12. Shumak, S.L., B. Zinman, S. Zuniga-Guarjardo, M. Poapst, and G. Steiner. 1988. Triglyceride-rich lipoprotein metabolism during acute hyperinsulinemia in hypertriglyceridemic humans. Metab. Clin. Exp. 37:461-466.
13. Havel, R.J., J.P. Kane, E.O. Balasse, N. Segel, and L.V. Basso. 1970. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J. Clin. Invest. 49:2017-2035.
14. Coppack, S.W., M.D. Jensen, and J.M. Miles. 1994. In vivo regulation of lipolysis in humans. J. Lipid Res. 35:177-193.
15. Lewis, G.F. K.D. Uffelman, L. Szeto, B. Weller, and G. Steiner. 1995. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J. Clin. Invest. 95:158-166.
16. Kazumi, T., M. Vranic, and G. Steiner. 1986. Triglyceride kinetics: effects of dietary glucose, sucrose, and fructose alone or with hyperinsulinemia. Am. J. Physiol. 250:E325-E330.
17. Hellerstein, M.K., M. Christiansen, S. Kaempfer, C. Kletke, K. Wu, J.S. Reid, K. Mulligan, N.S. Hellerstein, and C.H. Shackleton. 1991. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87:1841-1852.
18. Wolfe, R.R., J.H. Shaw, and M.J. Durkot. 1985. Effect of sepsis on VLDL kinetics: responses in basal state and during glucose infusion. Am. J. Physiol. 248:E732-E740.
19. Hellerstein, M.K., and R.K. Neese. 1992. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am. J. Physiol. 263:E988-E1001.
20. Kelleher, J.K., and T.M. Masterson. 1992. Model equations for condensation biosynthesis using stable isotopes and radioisotopes. Am. J. Physiol. 262: E118-E125.
21. 2O) and mass isotopomer analysis. Am. J. Physiol. 266: E372-E383.
22. Wolfe, R.R., T.F. O'Donnell, M.D. Stone, D.A. Richmand, and J.F. Burke. 1980. Investigation of factors determining the optimal glucose infusion rate in total parenteral nutrition. Metab. Clin. Exp. 29:892-900.
23. Wolfe, R.R., J.R. Allsop, and J.F. Burke. 1979. Glucose metabolism in man: responses to intravenous glucose infusion. Metab. Clin. Exp. 28:210-220.
24. Grundy, S.M., H.Y.I. Mok, L. Zech, and D. Steinberg. 1979. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J. Clin. Invest. 63:1274-1283.
25. McGuire, E.A.H., J.H. Helderman, J.D. Tobin, R. Andres, and M. Berman. 1976. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J. Appl. Physiol. 41:565-573.
26. Gotto, A.M., H.J. Pownall, and R.J. Havel. 1986. Introduction to the plasma lipoproteins. In Methods in Enzymology. Plasma Lipoproteins. J.P. Segrest and J.J. Albers, editors. Academic Press, Orlando. 3-40.
27. Havel, R.J., H.A. Eder, and J.H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in humans. J. Clin. Invest. 34:1345-1353.
28. McGowman, M.W., J.D. Artiss, D.R. Strandbergh, and B. Zak. 1983. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin. Chem. 29:538-542.
29. Wolfe, R.R., and E.J. Peters. 1987. Lipolytic response to glucose infusion in human subjects. Am. J. Physiol. 252:E218-E223.
30. Wolfe, R.R. 1992. Radioactive and stable isotope tracers in biomedicine. In Principles and Practice of Kinetic Analysis. Wiley-Liss, New York.
31. Dixon, M., and E.L. Webb. 1979. Enzymes. In Enzymes. Academic Press, New York. 842-843.
32. Newsholme, E.A., and K. Taylor. 1969. Glycerol kinase activities in muscle from vertebrates and invertebrates. Biochem. J. 112:465-474.
33. Wasserman, D.H., D.E. Lacy, R.E. Goldstein, P.E. Williams, and A.P. Cherrington. 1989. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes. 38:484-491.
34. Hellerstein, M.K., C. Kletke, S. Kaempfer, K. Wu, and C.H. Shackleton. 1991. Use of mass isotopomer distributions in secreted lipids to sample lipogenic acetyl-CoA pool in vivo in humans. Am. J. Physiol. 261:E479-E486.
35. Chinkes, D., A. Aarsland, J. Rosenblatt, and R.R. Wolfe. 1996. A comparison of mass isotopomer dilution methods used to compute production of VLDL fatty acids in vivo in human subjects. Am. J. Physiol. 271:E373-E383.
36. Foster, D.M., P.H. Barrett, G. Toffolo, W.F. Beltz, and C. Cobelli. 1993. Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data. J. Lipid Res. 34:2193-2205.
37. Dagher, F.J., J.H. Lyons, D.C. Finlayson, J. Shamsai, and F.D. Moore 1965. Blood volume measurement: a critical study. Adv. Surg. 1:69-109.
38. Cook, H.W. 1991. Fatty acid desaturation and chain elongation in eucaryotes. In Biochemistry of Lipids. Lipoproteins and Membranes. D.E. Vance and J. Vance, editors. Elsevier Science Publishers, Amsterdam. 141-169.
39. Ajie, H.O., M.J. Connor, W.N.P Lee, S. Bassilian, E.A. Bergner, and L.O. Byerley. 1995. In vivo study of the biosynthesis of long-chain fatty acids using deuterated water. Am. J. Physiol. 269:E247-E252.
40. Gibbons, G.F., and D. Wiggins. 1995. Intracellular triacylglycerol lipase: its role in the assembly of hepatic very-low-density lipoprotein (VLDL). Adv. Enzyme Regul. 35:179-198.
41. Steiner, G., and M.F. Reardon. 1983. A new model of human VLDL metabolism based on simultaneous studies of its Apo B and triglyceride. Metab. Clin. Rev. 32:342-347.
42. Grundy, S.M., H.Y.I. Mok, L. Zech, and M. Berman. 1981. Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man. J. Lipid Res. 22:24-36.
43. Kissebah, A.H., S. Alfarsi, D.J. Evans, and P.W. Adams. 1982. Integrated regulation of very low density lipoprolein triglyceride and apolipoprotein-B kinetics in non-insulin-dependent diabetes mellitus. Diabetes. 31:217-225.
44. Boberg, J., L.A. Carlson, and U. Freyschuss. 1972. Determination of splanchnic secretion rate of plasma triglycerides and of total and splanchnic turnover of plasma free fatty acids in man. Eur. J. Clin. Invest. 2:123-132.
45. Kissebah, A.H., S. Alfarsi, and P.W. Adams. 1981. Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: normolipidemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. Metab. Clin. Exp. 30:856-868.
46. Harris, W.S., W.E. Connor, D.R. Illingworth, D.W. Rothrock, and D.M. Foster. 1990. Effects of fish oil on VLDL triglyceride kinetics in humans. J. Lipid. Res. 31:1549-1558.
47. Cryer, P.E. 1994. Glucose counterregulation: prevention and correction of hypoglycemia in humans. Ant. J. Physiol. 264:E149-E155.
48. Radziuk, J., and R. Inculet. 1983. The effect of ingested and intravenous glucose on forearm uptake of glucose and glucogenic substrate in normal man. Diabetes. 32:977-981.
49. DeFronzo, R.A. 1988. The triumvirate: b-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 37:667-687.
50. Taskinen, M.-R., C.J. Packard, and J. Shepherd. 1990. Effect of insulin therapy on metabolic fate of apolipoprotein B-containing lipoproteins in NIDDM. Diabetes. 39:1017-1027.
51. Durrington, P.N., R.S. Newton, D.B. Weinstein, and D. Steinberg. 1982. Effect of insulin and glucose on very low density lipoprotein triglyceride secretion by cultured rat hepatocytes. J. Clin. Invest. 70:63-73.
52. Vogelberg, K.H., F.A. Gries, and D. Moschinski. 1980. Hepatic production of VLDL-triglycerides. Dependence of portal substrate and insulin concentration. Horm. Metab. Res. 12:688-694.
53. Lewis, G.F. K.D. Uffelman, L.W. Szeto, and G. Steiner. 1993. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes. 42:833-842.
54. Duerden, J.M., S.M. Bartlett, and G.F. Gibbons. 1989. Long-term maintenance of high rates of very-low-density-lipoprotein secretion in hepatocyte cultures. A model for studying the direct effects of insulin and insulin deficiency in vitro. Biochem. J. 263:937-943.
55. Reaven, G.M. 1993. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu. Rev. Med. 44:121-131.
56. Fukuda, N., and J.A. Ontko. 1984. Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver. j. Lipid Res. 25:831-842.
57. Gibbons, G.F., and F.J. Burnham. 1991. Effect of nutritional state on the utilization of fatty acids for hepatic triacylglycerol synthesis and secretion as very-low-density lipoprotein. Biochem. J. 275:87-92.
58. Baba, H., X.J. Zhang, K.R. Kunkel, and R.R. Wolfe. 1994. Effect of hepatectomy on glucose metabolism in the dog. Metab. Clin. Exp. 43:670-676.