Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

Hepatology

Volumn 47, Issue 5, 2008, Pages 1725-1736

  Kim, Jae Sung ^a,c   Nitta, Takashi ^a   Mohuczy, Dagmara ^a   O'Malley, Kerri A ^a   Moldawer, Lyle L ^a   Dunn Jr , William A ^b   Behrns, Kevin E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY REGULATORY PROTEIN 12; AUTOPHAGY REGULATORY PROTEIN 7; BECLIN 1; CALCEIN; CALPAIN 2; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 3; REGULATOR PROTEIN; TETRAMETHYLRHODAMINE; AMINO ACID; AUTOPHAGY RELATED PROTEIN 12; AUTOPHAGY RELATED PROTEIN 7; TETRAMETHYLRHODAMINE METHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOXIA; ARTICLE; AUTOPHAGY; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; LIVER CELL; LIVER INJURY; LIVER ISCHEMIA; LYSOSOME; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; WESTERN BLOTTING; ANIMAL TISSUE; CELL HYPOXIA; CYTOFLUOROMETRY; DEPLETION; ENZYME ACTIVITY; ENZYME INHIBITION; MEMBRANE DEPOLARIZATION; MOUSE;

ANIMALS; ANOXIA; APOPTOSIS; AUTOPHAGY; DISEASE MODELS, ANIMAL; HEPATOCYTES; ISCHEMIA; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; NECROSIS; PERMEABILITY; RATS; REPERFUSION;

EID: 43949096967     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22187     Document Type: Article

References (35)

1. Kim JS, He L, Qian T, Lemasters JJ. Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr Mol Med 2003;3:527-535.
2. Jaeschke H, Lemastets JJ. Apoptosis vetsus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology 2003;125:1246-1257.
3. Kim J-S, Qian T, Lemasters JJ. Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology 2003;124:494-503.
4. Kim J-S, Ohshima S, Pediaditakis P, Lemasters JJ. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. HEPATOLOGY 2004;39:1533-1543.
5. 2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia/reperfusion. Am J Physiol Heart Circ Physiol 2006;290:H2024-H2034.
6. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102:33-42.
7. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-446.
8. Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ 2005;12(Suppl 2):1542-1552.
9. Mortimore GE, Poso AR, Lardeux BR. Mechanism and regulation of protein degradation in liver. Diabetes Metab Rev 1989;5:49-70.
10. Tuttle DL, Lewin AS, Dunn WA Jr. Selective autophagy of peroxisomes in methylotrophic yeasts. Eur J Cell Biol 1993;60:283-290.
11. Kissova I, Deffieu M, Manon S, Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 2004;279:39068-39074.
12. Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, et al. A protein conjugation system essential for autophagy. Nature 1998;395:395-398.
13. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999;402:672-676.
14. Ding WX, Shen HM, Ong CN. Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. Biochem Biophys Res Commun 2002;291:321-331.
15. Dutt P, Arthur JS, Croall DE, Elce JS. m-Calpain subunits remain associated in the presence of calcium. FEBS Lett 1998;436:367-371.
16. Mezey E, Rennie-Tankersley L, Potter JJ. Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway. Biochem Biophys Res Commun 2001;285:644-648.
17. Watanabe T, Kubota S, Nagaya M, Ozaki S, Nagafuchi H, Akashi K, et al. The role of HMGB-1 on the development of necrosis during hepatic ischemia and hepatic ischemia/reperfusion injury in mice. J Surg Res 2005; 124:59-66.
18. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, Brenner DA. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Biol Chem 2000;275:11814-11823.
19. Bronk SF, Gores GJ. pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes. Am J Physiol 1993;264(pt 1): G744-G751.
20. Elmore SP, Qian T, Grissom SF, Lemasters JJ. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 2001;15:2286-2287.
21. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-1111.
22. Kochl R, Hu XW, Chan EY, Tooze SA. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic 2006;7:129-145.
23. Gores GJ, Nieminen AL, Wray BE, Herman B, Lemasters JJ. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death. J Clin Invest 1989;83:386-396.
24. Zahrebelski G, Nieminen AL, al Ghoul K, Qian T, Herman B, Lemasters JJ. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study. HEPATOLOGY 1995;21:1361-1372.
25. Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murachi T. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem 1984;259:12489-12494.
26. Komatsu M, Waguti S, Ueno T, Iwata J, Murata S, Tanida I, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005;169:425-434.
27. Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 2006;281:29776-29787.
28. Kohli V, Madden JF, Bentley RC, Clavien PA. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. Gastroenterology 1999;116:168-178.
29. Wang M, Sakon M, Umeshita K, Okuyama M, Shiozaki K, Nagano H, et al. Prednisolone suppresses ischemia-reperfusion injury of the rat liver by reducing cytokine production and calpain mu activation. J Hepatol 2001;34:278-283.
30. Demarchi F, Bertoli C, Copetti T, Tanida I, Brancolini C, Eskelinen EL, et al. Calpain is required for macroautophagy in mammalian cells. J Cell Biol 2006;175:595-605.
31. Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 2006;8:1124-1132.
32. Kim I, Rodriguez-Enriquez S, Lemasters JJ. Selective degtadation of mitochondria by mitophagy. Arch Biochem Biophys 2007;462:245-253.
33. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007;26:1749-1760.
34. Meley D, Bauvy C, Houben-Weerts JH, Dubbelhuis PF, Helmond MT, Codogno P, et al. AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem 2006;281:34870-34879.
35. Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ. Mdm38 protein depletion causes loss of mitochondrial K(+)/H(+) exchange activity, osmotic swelling and mitophagy. Cell Death Differ 2007;14:1647-1656.