TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Science

Volumn 300, Issue 5625, 2003, Pages 1574-1577

  Du, Keyong ^a   Herzig, Stephan ^a   Kulkarni, Rohit N ^b   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; GLUCOSE; MUSCLE;

FASTING CONDITIONS;

INSULIN;

INSULIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE TRB3; RNA; UNCLASSIFIED DRUG;

BIOCHEMISTRY; DISEASE; MEDICINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; GENE OVEREXPRESSION; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RESISTANCE; LIVER; MALE; MOUSE; MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; AMINO ACID SUBSTITUTION; ANIMALS; BLOOD GLUCOSE; CELL CYCLE PROTEINS; CELL LINE; DIABETES MELLITUS; ENZYME ACTIVATION; FASTING; GENETIC VECTORS; GLUCOSE; GLUCOSE INTOLERANCE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; LIVER; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REPRESSOR PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSGENES; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA; MAMMALIA;

EID: 0038242819     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079817     Document Type: Article

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25. We thank B. Spiegelman for the gift of F422A library and T. Roberts for baculovirus-expressed GST-Akt protein. We also thank F. Galimi for help with adenovirus injections and J. Testa (Fox Chase Cancer Center) for the gift of Akt2 expression vector. This work was supported by NIH grants, funds from the Deutsche Forschungsgemeinschaft (He3260/1-1), the American Diabetes Association, and the Hillblom Foundation.