ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

Molecular Metabolism

Volumn 3, Issue 5, 2014, Pages 544-553

  Egnatchik, Robert A ^a   Leamy, Alexandra K ^a   Jacobson, David A ^b   Shiota, Masakazu ^b   Young, Jamey D ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

ER stress; Fatty liver; Lipotoxicity; Metabolic flux analysis; Oxidative stress

Indexed keywords

BAPTA AM; CALCIUM; CALCIUM CHELATING AGENT; CARBON 13; OLEIC ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CHELATING BAPTA AM AGENT; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CANCER CELL LINE; CELL DEATH; CELL DISRUPTION; CELL LOSS; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ACTIVITY; ENDOPLASMIC RETICULUM; LIPOAPOPTOSIS; LIPOTOXICITY; LIVER CELL; LIVER MITOCHONDRION; MALE; MASS FRAGMENTOGRAPHY; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOTHERAPY; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

EID: 84904288578     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.05.004     Document Type: Article

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