메뉴 건너뛰기




Volumn 6, Issue 11, 2014, Pages 800-811

Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease

Author keywords

Drugs; Insulin resistance; Non alcoholic fatty liver disease; Pathogenesis

Indexed keywords


EID: 84912031921     PISSN: None     EISSN: 19485182     Source Type: Journal    
DOI: 10.4254/wjh.v6.i11.800     Document Type: Article
Times cited : (64)

References (146)
  • 1
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: a follow-up study
    • PMID: 7489979
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995; 22: 1714-1719 [PMID: 7489979]
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 2
    • 84862883948 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment
    • PMID: 22722431
    • Milic S, Stimac D. Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment. Dig Dis 2012; 30: 158-162 [PMID: 22722431 DOI: 10.1159/000336669]
    • (2012) Dig Dis , vol.30 , pp. 158-162
    • Milic, S.1    Stimac, D.2
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • PMID: 11961152
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231 [PMID: 11961152 DOI: 10.1056/NEJMra011775]
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 4
    • 65549122652 scopus 로고    scopus 로고
    • Metabolic disturbances in non-alcoholic fatty liver disease
    • PMID: 19243311
    • Byrne CD, Olufadi R, Bruce KD, Cagampang FR, Ahmed MH. Metabolic disturbances in non-alcoholic fatty liver disease. Clin Sci (Lond) 2009; 116: 539-564 [PMID: 19243311 DOI: 10.1042/cs20080253]
    • (2009) Clin Sci (Lond) , vol.116 , pp. 539-564
    • Byrne, C.D.1    Olufadi, R.2    Bruce, K.D.3    Cagampang, F.R.4    Ahmed, M.H.5
  • 5
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in nonalcoholic steatohepatitis
    • PMID: 19501928
    • Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH. Systematic review of risk factors for fibrosis progression in nonalcoholic steatohepatitis. J Hepatol 2009; 51: 371-379 [PMID: 19501928 DOI: 10.1016/j.jhep.2009.03.019]
    • (2009) J Hepatol , vol.51 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.3    Caldwell, S.H.4
  • 6
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • PMID: 20432259
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 2010; 51: 1820-1832 [PMID: 20432259 DOI: 10.1002/hep.23594]
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 9
    • 0035195908 scopus 로고    scopus 로고
    • Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients
    • PMID: 11768156
    • Cassader M, Gambino R, Musso G, Depetris N, Mecca F, Cavallo-Perin P, Pacini G, Rizzetto M, Pagano G. Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients. Lipids 2001; 36: 1117-1124 [PMID: 11768156]
    • (2001) Lipids , vol.36 , pp. 1117-1124
    • Cassader, M.1    Gambino, R.2    Musso, G.3    Depetris, N.4    Mecca, F.5    Cavallo-Perin, P.6    Pacini, G.7    Rizzetto, M.8    Pagano, G.9
  • 10
    • 33746700131 scopus 로고    scopus 로고
    • Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures
    • PMID: 16911469
    • Zelber-Sagi S, Nitzan-Kaluski D, Halpern Z, Oren R. Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006; 26: 856-863 [PMID: 16911469 DOI: 10.1111/j.1478-3231.2006.01311.x]
    • (2006) Liver Int , vol.26 , pp. 856-863
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Halpern, Z.3    Oren, R.4
  • 11
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • PMID: 15864352
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-1351 [PMID: 15864352 DOI: 10.1172/jci23621]
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 12
    • 0036228581 scopus 로고    scopus 로고
    • The concurrent accumulation of intraabdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments
    • PMID: 11916919
    • Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, RetzlaffBM, Walden CE, Knopp RH, Kahn SE. The concurrent accumulation of intraabdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 2002; 51: 1005-1015 [PMID: 11916919]
    • (2002) Diabetes , vol.51 , pp. 1005-1015
    • Cnop, M.1    Landchild, M.J.2    Vidal, J.3    Havel, P.J.4    Knowles, N.G.5    Carr, D.R.6    Wang, F.7    Hull, R.L.8    Boyko, E.J.9    Retzlaff, B.M.10    Walden, C.E.11    Knopp, R.H.12    Kahn, S.E.13
  • 13
    • 0036889453 scopus 로고    scopus 로고
    • Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus
    • PMID: 12424102
    • Miyazaki Y, Glass L, Triplitt C, Wajcberg E, Mandarino LJ, DeFronzo RA. Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 2002; 283: E1135-E1143 [PMID: 12424102 DOI: 10.1152/ajpendo.00327.2001]
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , pp. E1135-E1143
    • Miyazaki, Y.1    Glass, L.2    Triplitt, C.3    Wajcberg, E.4    Mandarino, L.J.5    DeFronzo, R.A.6
  • 15
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • PMID: 15166226
    • Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004; 279: 32345-32353 [PMID: 15166226 DOI: 10.1074/jbc. M313478200]
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3    Elder, B.D.4    Bilz, S.5    Befroy, D.6    Romanelli, A.J.7    Shulman, G.I.8
  • 16
    • 77950543816 scopus 로고    scopus 로고
    • Diacylglycerol-mediated insulin resistance
    • PMID: 20376053
    • Erion DM, Shulman GI. Diacylglycerol-mediated insulin resistance. Nat Med 2010; 16: 400-402 [PMID: 20376053 DOI: 10.1038/nm0410-400]
    • (2010) Nat Med , vol.16 , pp. 400-402
    • Erion, D.M.1    Shulman, G.I.2
  • 17
    • 49649091383 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations
    • PMID: 18662168
    • Preiss D, Sattar N. Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. Clin Sci (Lond) 2008; 115: 141-150 [PMID: 18662168 DOI: 10.1042/cs20070402]
    • (2008) Clin Sci (Lond) , vol.115 , pp. 141-150
    • Preiss, D.1    Sattar, N.2
  • 18
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • PMID: 10949029
    • Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 2000; 6: 77-86 [PMID: 10949029]
    • (2000) Mol Cell , vol.6 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3    Bashmakov, Y.4    Brown, M.S.5    Goldstein, J.L.6
  • 19
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • PMID: 20133650
    • Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci USA 2010; 107: 3441-3446 [PMID: 20133650 DOI: 10.1073/pnas.0914798107]
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 20
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • PMID: 11994399
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-1131 [PMID: 11994399 DOI: 10.1172/jci15593]
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 21
    • 34247884330 scopus 로고    scopus 로고
    • SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
    • PMID: 17279346
    • Shimano H. SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling. J Mol Med (Berl) 2007; 85: 437-444 [PMID: 17279346 DOI: 10.1007/s00109-007-0158-5]
    • (2007) J Mol Med (Berl) , vol.85 , pp. 437-444
    • Shimano, H.1
  • 22
    • 33746536677 scopus 로고    scopus 로고
    • Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
    • PMID: 16890538
    • Uyeda K, Repa JJ. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 2006; 4: 107-110 [PMID: 16890538 DOI: 10.1016/j.cmet.2006.06.008]
    • (2006) Cell Metab , vol.4 , pp. 107-110
    • Uyeda, K.1    Repa, J.J.2
  • 23
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • PMID: 15254578
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114: 147-152 [PMID: 15254578 DOI: 10.1172/jci22422]
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 24
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • PMID: 18082745
    • Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 568-576 [PMID: 18082745 DOI: 10.1053/j.gastro.2007.10.039]
    • (2008) Gastroenterology , vol.134 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3    Natarajan, R.4    Maher, J.W.5    Kellum, J.M.6    Sanyal, A.J.7
  • 25
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes
    • PMID: 20814028
    • Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 2010; 107: 579-591 [PMID: 20814028 DOI: 10.1161/circresaha.110.225698]
    • (2010) Circ Res , vol.107 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2
  • 27
    • 3042739914 scopus 로고    scopus 로고
    • Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes
    • PMID: 14766793
    • Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J 2004; 18: 720-722 [PMID: 14766793 DOI: 10.1096/fj.03-0771fje]
    • (2004) FASEB J , vol.18 , pp. 720-722
    • Schwabe, R.F.1    Uchinami, H.2    Qian, T.3    Bennett, B.L.4    Lemasters, J.J.5    Brenner, D.A.6
  • 28
    • 62749178966 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
    • PMID: 19066313
    • Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009; 58: 693-700 [PMID: 19066313 DOI: 10.2337/db08-1220]
    • (2009) Diabetes , vol.58 , pp. 693-700
    • Gregor, M.F.1    Yang, L.2    Fabbrini, E.3    Mohammed, B.S.4    Eagon, J.C.5    Hotamisligil, G.S.6    Klein, S.7
  • 29
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • PMID: 9547102
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845 [PMID: 9547102]
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 30
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    • PMID: 11668021
    • Robertson G, Leclercq I, Farrell GC. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 2001; 281: G1135-G1139 [PMID: 11668021]
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281 , pp. G1135-G1139
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 31
    • 36749010860 scopus 로고    scopus 로고
    • Biochemistry of oxidative stress
    • PMID: 17956298
    • Halliwell B. Biochemistry of oxidative stress. Biochem Soc Trans 2007; 35: 1147-1150 [PMID: 17956298 DOI: 10.1042/bst0351147]
    • (2007) Biochem Soc Trans , vol.35 , pp. 1147-1150
    • Halliwell, B.1
  • 32
    • 0029765443 scopus 로고    scopus 로고
    • Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
    • PMID: 8870073
    • Skulachev VP. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q Rev Biophys 1996; 29: 169-202 [PMID: 8870073]
    • (1996) Q Rev Biophys , vol.29 , pp. 169-202
    • Skulachev, V.P.1
  • 33
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • PMID: 19061483
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009; 417: 1-13 [PMID: 19061483 DOI: 10.1042/bj20081386]
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 35
    • 84885937939 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?
    • PMID: 23915028
    • García-Ruiz C, Baulies A, Mari M, García-Rovés PM, Fernandez-Checa JC. Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence? Free Radic Res 2013; 47: 854-868 [PMID: 23915028 DOI: 10.3109/10715762.2013.830717]
    • (2013) Free Radic Res , vol.47 , pp. 854-868
    • García-Ruiz, C.1    Baulies, A.2    Mari, M.3    García-Rovés, P.M.4    Fernandez-Checa, J.C.5
  • 37
    • 0142245750 scopus 로고    scopus 로고
    • Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13Coctanoate breath test
    • PMID: 14572600
    • Miele L, Grieco A, Armuzzi A, Candelli M, Forgione A, Gasbarrini A, Gasbarrini G. Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13Coctanoate breath test. Am J Gastroenterol 2003; 98: 2335-2336 [PMID: 14572600 DOI: 10.1111/j.1572-0241.2003.07725.x]
    • (2003) Am J Gastroenterol , vol.98 , pp. 2335-2336
    • Miele, L.1    Grieco, A.2    Armuzzi, A.3    Candelli, M.4    Forgione, A.5    Gasbarrini, A.6    Gasbarrini, G.7
  • 38
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • PMID: 22064361
    • Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med 2012; 52: 59-69 [PMID: 22064361 DOI: 10.1016/j.freeradbiomed.2011.10.003]
    • (2012) Free Radic Biol Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 39
    • 0019821333 scopus 로고
    • Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats
    • PMID: 7340831
    • McGarry JD, Foster DW. Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats. Biochem J 1981; 200: 217-223 [PMID: 7340831]
    • (1981) Biochem J , vol.200 , pp. 217-223
    • McGarry, J.D.1    Foster, D.W.2
  • 40
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • PMID: 10669761
    • Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 2000; 20: 1868-1876 [PMID: 10669761]
    • (2000) Mol Cell Biol , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 41
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • PMID: 9792666
    • Costet P, Legendre C, Moré J, Edgar A, Galtier P, Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem 1998; 273: 29577-29585 [PMID: 9792666]
    • (1998) J Biol Chem , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    Moré, J.3    Edgar, A.4    Galtier, P.5    Pineau, T.6
  • 42
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • PMID: 12107194
    • Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, Goto T, Westerbacka J, Sovijärvi A, Halavaara J, Yki-Järvinen H. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002; 87: 3023-3028 [PMID: 12107194 DOI: 10.1210/jcem.87.7.8638]
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppälä-Lindroos, A.1    Vehkavaara, S.2    Häkkinen, A.M.3    Goto, T.4    Westerbacka, J.5    Sovijärvi, A.6    Halavaara, J.7    Yki-Järvinen, H.8
  • 43
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
    • PMID: 11681807
    • Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001; 60: 329-339 [PMID: 11681807]
    • (2001) Proc Nutr Soc , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 46
    • 0038293399 scopus 로고    scopus 로고
    • Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    • PMID: 12687327
    • Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, RetzlaffBM, Knopp RH, Brunzell JD, Kahn SE. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003; 46: 459-469 [PMID: 12687327 DOI: 10.1007/s00125-003-1074-z]
    • (2003) Diabetologia , vol.46 , pp. 459-469
    • Cnop, M.1    Havel, P.J.2    Utzschneider, K.M.3    Carr, D.B.4    Sinha, M.K.5    Boyko, E.J.6    Retzlaff, B.M.7    Knopp, R.H.8    Brunzell, J.D.9    Kahn, S.E.10
  • 47
    • 70349678823 scopus 로고    scopus 로고
    • Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
    • PMID: 19788607
    • Asano T, Watanabe K, Kubota N, Gunji T, Omata M, Kadowaki T, Ohnishi S. Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. J Gastroenterol Hepatol 2009; 24: 1669-1676 [PMID: 19788607 DOI: 10.1111/j.1440-1746.2009.06039.x]
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1669-1676
    • Asano, T.1    Watanabe, K.2    Kubota, N.3    Gunji, T.4    Omata, M.5    Kadowaki, T.6    Ohnishi, S.7
  • 48
    • 79751496064 scopus 로고    scopus 로고
    • Alternative macrophage activation and metabolism
    • PMID: 21034223
    • Odegaard JI, Chawla A. Alternative macrophage activation and metabolism. Annu Rev Pathol 2011; 6: 275-297 [PMID: 21034223 DOI: 10.1146/annurev-pathol-011110-130138]
    • (2011) Annu Rev Pathol , vol.6 , pp. 275-297
    • Odegaard, J.I.1    Chawla, A.2
  • 50
    • 0142153909 scopus 로고    scopus 로고
    • Innate immunity in the liver
    • PMID: 15703606
    • Li Z, Diehl AM. Innate immunity in the liver. Curr Opin Gastroenterol 2003; 19: 565-571 [PMID: 15703606]
    • (2003) Curr Opin Gastroenterol , vol.19 , pp. 565-571
    • Li, Z.1    Diehl, A.M.2
  • 51
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • PMID: 11287357
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280: E745-E751 [PMID: 11287357]
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , pp. E745-E751
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 52
    • 41849123475 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment
    • PMID: 18177455
    • Carter-Kent C, Zein NN, Feldstein AE. Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment. Am J Gastroenterol 2008; 103: 1036-1042 [PMID: 18177455 DOI: 10.1111/j.1572-0241.2007.01709.x]
    • (2008) Am J Gastroenterol , vol.103 , pp. 1036-1042
    • Carter-Kent, C.1    Zein, N.N.2    Feldstein, A.E.3
  • 53
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis
    • PMID: 17023554
    • Brun P, Castagliuolo I, Di Leo V, Buda A, Pinzani M, Palù G, Martines D. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292: G518-G525 [PMID: 17023554 DOI: 10.1152/ajpgi.00024.2006]
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G518-G525
    • Brun, P.1    Castagliuolo, I.2    Di Leo, V.3    Buda, A.4    Pinzani, M.5    Palù, G.6    Martines, D.7
  • 54
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • PMID: 12540784
    • Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, Desimone C, Song XY, Diehl AM. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37: 343-350 [PMID: 12540784 DOI: 10.1053/jhep.2003.50048]
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4    Watkins, P.A.5    Moser, A.B.6    Desimone, C.7    Song, X.Y.8    Diehl, A.M.9
  • 55
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of nonalcoholic steatohepatitis
    • PMID: 17644211
    • Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of nonalcoholic steatohepatitis. J Hepatol 2007; 47: 571-579 [PMID: 17644211 DOI: 10.1016/j.jhep.2007.04.019]
    • (2007) J Hepatol , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 56
    • 33846642114 scopus 로고    scopus 로고
    • The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage
    • PMID: 17117477
    • Thobe BM, Frink M, Hildebrand F, Schwacha MG, Hubbard WJ, Choudhry MA, Chaudry IH. The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage. J Cell Physiol 2007; 210: 667-675 [PMID: 17117477 DOI: 10.1002/jcp.20860]
    • (2007) J Cell Physiol , vol.210 , pp. 667-675
    • Thobe, B.M.1    Frink, M.2    Hildebrand, F.3    Schwacha, M.G.4    Hubbard, W.J.5    Choudhry, M.A.6    Chaudry, I.H.7
  • 57
    • 28044463780 scopus 로고    scopus 로고
    • Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages
    • PMID: 16287979
    • Jiang W, Sun R, Wei H, Tian Z. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc Natl Acad Sci USA 2005; 102: 17077-17082 [PMID: 16287979 DOI: 10.1073/pnas.0504570102]
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17077-17082
    • Jiang, W.1    Sun, R.2    Wei, H.3    Tian, Z.4
  • 58
    • 49449083979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    • PMID: 18641190
    • Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Königsrainer A, Maier KP, BischoffSC, Bergheim I. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 2008; 138: 1452-1455 [PMID: 18641190]
    • (2008) J Nutr , vol.138 , pp. 1452-1455
    • Thuy, S.1    Ladurner, R.2    Volynets, V.3    Wagner, S.4    Strahl, S.5    Königsrainer, A.6    Maier, K.P.7    Bischoff, S.C.8    Bergheim, I.9
  • 59
    • 0036074141 scopus 로고    scopus 로고
    • Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation
    • PMID: 12121871
    • Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002; 283: G256-G265 [PMID: 12121871 DOI: 10.1152/ajpgi.00550.2001]
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283 , pp. G256-G265
    • Su, G.L.1
  • 60
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • PMID: 10963608
    • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406: 782-787 [PMID: 10963608 DOI: 10.1038/35021228]
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 61
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • PMID: 16140415
    • Suzuki A, Lindor K, St Saver J, Lymp J, Mendes F, Muto A, Okada T, Angulo P. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005; 43: 1060-1066 [PMID: 16140415 DOI: 10.1016/j.jhep.2005.06.008]
    • (2005) J Hepatol , vol.43 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Saver, J.3    Lymp, J.4    Mendes, F.5    Muto, A.6    Okada, T.7    Angulo, P.8
  • 62
    • 84879273144 scopus 로고    scopus 로고
    • Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges
    • PMID: 23558065
    • Xiao J, Guo R, Fung ML, Liong EC, Tipoe GL. Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges. Hepatobiliary Pancreat Dis Int 2013; 12: 125-135 [PMID: 23558065]
    • (2013) Hepatobiliary Pancreat Dis Int , vol.12 , pp. 125-135
    • Xiao, J.1    Guo, R.2    Fung, M.L.3    Liong, E.C.4    Tipoe, G.L.5
  • 63
    • 0037342842 scopus 로고    scopus 로고
    • Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content
    • PMID: 12606511
    • Tiikkainen M, Bergholm R, Vehkavaara S, Rissanen A, Häkkinen AM, Tamminen M, Teramo K, Yki-Järvinen H. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 2003; 52: 701-707 [PMID: 12606511]
    • (2003) Diabetes , vol.52 , pp. 701-707
    • Tiikkainen, M.1    Bergholm, R.2    Vehkavaara, S.3    Rissanen, A.4    Häkkinen, A.M.5    Tamminen, M.6    Teramo, K.7    Yki-Järvinen, H.8
  • 64
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • PMID: 2210247
    • Palmer M, Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 1990; 99: 1408-1413 [PMID: 2210247]
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 66
    • 19144372447 scopus 로고    scopus 로고
    • Oneyear intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study
    • PMID: 15842581
    • Huang MA, Greenson JK, Chao C, Anderson L, Peterman D, Jacobson J, Emick D, Lok AS, Conjeevaram HS. Oneyear intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol 2005; 100: 1072-1081 [PMID: 15842581 DOI: 10.1111/j.1572-0241.2005.41334.x]
    • (2005) Am J Gastroenterol , vol.100 , pp. 1072-1081
    • Huang, M.A.1    Greenson, J.K.2    Chao, C.3    Anderson, L.4    Peterman, D.5    Jacobson, J.6    Emick, D.7    Lok, A.S.8    Conjeevaram, H.S.9
  • 67
    • 84880949120 scopus 로고    scopus 로고
    • Exercise, GLUT4, and skeletal muscle glucose uptake
    • PMID: 23899560
    • Richter EA, Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev 2013; 93: 993-1017 [PMID: 23899560 DOI: 10.1152/physrev.00038.2012]
    • (2013) Physiol Rev , vol.93 , pp. 993-1017
    • Richter, E.A.1    Hargreaves, M.2
  • 68
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • PMID: 15185306
    • Dixon JB, Bhathal PS, Hughes NR, O'Brien PE. Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss. Hepatology 2004; 39: 1647-1654 [PMID: 15185306 DOI: 10.1002/hep.20251]
    • (2004) Hepatology , vol.39 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O'Brien, P.E.4
  • 69
    • 0035430576 scopus 로고    scopus 로고
    • Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance
    • PMID: 11473050
    • de Souza CJ, Eckhardt M, Gagen K, Dong M, Chen W, Laurent D, Burkey BF. Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes 2001; 50: 1863-1871 [PMID: 11473050]
    • (2001) Diabetes , vol.50 , pp. 1863-1871
    • de Souza, C.J.1    Eckhardt, M.2    Gagen, K.3    Dong, M.4    Chen, W.5    Laurent, D.6    Burkey, B.F.7
  • 70
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • PMID: 14512888
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003; 38: 1008-1017 [PMID: 14512888 DOI: 10.1053/jhep.2003.50420]
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 75
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • PMID: 17517853
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356: 2457-2471 [PMID: 17517853 DOI: 10.1056/NEJMoa072761]
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 76
    • 53349153475 scopus 로고    scopus 로고
    • Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials
    • PMID: 18505403
    • Mannucci E, Monami M, Lamanna C, Gensini GF, Marchionni N. Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials. Diabetes Obes Metab 2008; 10: 1221-1238 [PMID: 18505403 DOI: 10.1111/j.1463-1326.2008.00892.x]
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1221-1238
    • Mannucci, E.1    Monami, M.2    Lamanna, C.3    Gensini, G.F.4    Marchionni, N.5
  • 77
    • 77649144555 scopus 로고    scopus 로고
    • Pioglitazone: side effect and safety profile
    • PMID: 20175701
    • Shah P, Mudaliar S. Pioglitazone: side effect and safety profile. Expert Opin Drug Saf 2010; 9: 347-354 [PMID: 20175701 DOI: 10.1517/14740331003623218]
    • (2010) Expert Opin Drug Saf , vol.9 , pp. 347-354
    • Shah, P.1    Mudaliar, S.2
  • 78
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • PMID: 22488764
    • Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012; 55: 2005-2023 [PMID: 22488764 DOI: 10.1002/hep.25762]
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6    Charlton, M.7    Sanyal, A.J.8
  • 79
    • 0842313004 scopus 로고    scopus 로고
    • Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients
    • PMID: 14715850
    • Bajaj M, Suraamornkul S, Piper P, Hardies LJ, Glass L, Cersosimo E, Pratipanawatr T, Miyazaki Y, DeFronzo RA. Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients. J Clin Endocrinol Metab 2004; 89: 200-206 [PMID: 14715850 DOI: 10.1210/jc.2003-031315]
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 200-206
    • Bajaj, M.1    Suraamornkul, S.2    Piper, P.3    Hardies, L.J.4    Glass, L.5    Cersosimo, E.6    Pratipanawatr, T.7    Miyazaki, Y.8    DeFronzo, R.A.9
  • 80
    • 0036125944 scopus 로고    scopus 로고
    • Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
    • PMID: 11887166
    • Hirose H, Kawai T, Yamamoto Y, Taniyama M, Tomita M, Matsubara K, Okazaki Y, Ishii T, Oguma Y, Takei I, Saruta T. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism 2002; 51: 314-317 [PMID: 11887166]
    • (2002) Metabolism , vol.51 , pp. 314-317
    • Hirose, H.1    Kawai, T.2    Yamamoto, Y.3    Taniyama, M.4    Tomita, M.5    Matsubara, K.6    Okazaki, Y.7    Ishii, T.8    Oguma, Y.9    Takei, I.10    Saruta, T.11
  • 83
    • 84895741552 scopus 로고    scopus 로고
    • RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
    • PMID: 24606904
    • Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab 2014; 19: 512-526 [PMID: 24606904 DOI: 10.1016/j.cmet.2014.01.018]
    • (2014) Cell Metab , vol.19 , pp. 512-526
    • Moraes-Vieira, P.M.1    Yore, M.M.2    Dwyer, P.M.3    Syed, I.4    Aryal, P.5    Kahn, B.B.6
  • 84
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • PMID: 14679176
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-1808 [PMID: 14679176 DOI: 10.1172/jci19246]
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5    Ferrante, A.W.6
  • 85
    • 84878221256 scopus 로고    scopus 로고
    • Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans
    • PMID: 23349486
    • Koppaka S, Kehlenbrink S, Carey M, Li W, Sanchez E, Lee DE, Lee H, Chen J, Carrasco E, Kishore P, Zhang K, Hawkins M. Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans. Diabetes 2013; 62: 1843-1854 [PMID: 23349486 DOI: 10.2337/db12-0868]
    • (2013) Diabetes , vol.62 , pp. 1843-1854
    • Koppaka, S.1    Kehlenbrink, S.2    Carey, M.3    Li, W.4    Sanchez, E.5    Lee, D.E.6    Lee, H.7    Chen, J.8    Carrasco, E.9    Kishore, P.10    Zhang, K.11    Hawkins, M.12
  • 86
    • 0037023635 scopus 로고    scopus 로고
    • PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis
    • PMID: 11934839
    • Marx N, Kehrle B, Kohlhammer K, Grüb M, Koenig W, Hombach V, Libby P, Plutzky J. PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res 2002; 90: 703-710 [PMID: 11934839]
    • (2002) Circ Res , vol.90 , pp. 703-710
    • Marx, N.1    Kehrle, B.2    Kohlhammer, K.3    Grüb, M.4    Koenig, W.5    Hombach, V.6    Libby, P.7    Plutzky, J.8
  • 89
    • 78751646934 scopus 로고    scopus 로고
    • Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment
    • PMID: 20092860
    • Moon JH, Kim HJ, Kim SK, Kang ES, Lee BW, Ahn CW, Lee HC, Cha BS. Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment. Metabolism 2011; 60: 165-172 [PMID: 20092860 DOI: 10.1016/j.metabol.2009.12.007]
    • (2011) Metabolism , vol.60 , pp. 165-172
    • Moon, J.H.1    Kim, H.J.2    Kim, S.K.3    Kang, E.S.4    Lee, B.W.5    Ahn, C.W.6    Lee, H.C.7    Cha, B.S.8
  • 90
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • PMID: 11872682
    • Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 2002; 51: 797-802 [PMID: 11872682]
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3    Lebon, V.4    Befroy, D.5    Cline, G.W.6    Enocksson, S.7    Inzucchi, S.E.8    Shulman, G.I.9    Petersen, K.F.10
  • 91
    • 84859114508 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor gamma agonist in improving hepatic steatosis: Possible molecular mechanism
    • PMID: 24843551
    • Park CY, Park SW. Role of peroxisome proliferator-activated receptor gamma agonist in improving hepatic steatosis: Possible molecular mechanism. J Diabetes Investig 2012; 3: 93-95 [PMID: 24843551 DOI: 10.1111/j.2040-1124.2012.00204.x]
    • (2012) J Diabetes Investig , vol.3 , pp. 93-95
    • Park, C.Y.1    Park, S.W.2
  • 95
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • PMID: 16308421
    • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310: 1642-1646 [PMID: 16308421 DOI: 10.1126/science.1120781]
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6    Montminy, M.7    Cantley, L.C.8
  • 96
    • 84905757105 scopus 로고    scopus 로고
    • Metformin--mode of action and clinical implications for diabetes and cancer
    • PMID: 24393785
    • Pernicova I, Korbonits M. Metformin--mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014; 10: 143-156 [PMID: 24393785 DOI: 10.1038/nrendo.2013.256]
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 99
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • PMID: 15842582
    • Bugianesi E, Gentilcore E, Manini R, Natale S, Vanni E, Villanova N, David E, Rizzetto M, Marchesini G. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005; 100: 1082-1090 [PMID: 15842582 DOI: 10.1111/j.1572-0241.2005.41583.x]
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3    Natale, S.4    Vanni, E.5    Villanova, N.6    David, E.7    Rizzetto, M.8    Marchesini, G.9
  • 102
    • 67349257934 scopus 로고    scopus 로고
    • The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease
    • PMID: 18839053
    • Nar A, Gedik O. The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. Acta Diabetol 2009; 46: 113-118 [PMID: 18839053 DOI: 10.1007/s00592-008-0067-2]
    • (2009) Acta Diabetol , vol.46 , pp. 113-118
    • Nar, A.1    Gedik, O.2
  • 104
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • PMID: 21623852
    • Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-285 [PMID: 21623852 DOI: 10.1111/j.1365-2036.2011.04724.x]
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 106
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    • PMID: 17327526
    • Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007; 297: 842-857 [PMID: 17327526 DOI: 10.1001/jama.297.8.842]
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 107
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study
    • PMID: 11564008
    • Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther 2001; 15: 1667-1672 [PMID: 11564008]
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 108
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study
    • PMID: 10839868
    • Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr 2000; 136: 734-738 [PMID: 10839868]
    • (2000) J Pediatr , vol.136 , pp. 734-738
    • Lavine, J.E.1
  • 110
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E
    • PMID: 12883485
    • Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 2003; 38: 413-419 [PMID: 12883485 DOI: 10.1053/jhep.2003.50316]
    • (2003) Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3    Marsano, L.4    McClain, C.J.5
  • 111
    • 11144249271 scopus 로고    scopus 로고
    • A pilot trial of pentoxifylline in nonalcoholic steatohepatitis
    • PMID: 15571584
    • Adams LA, Zein CO, Angulo P, Lindor KD. A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am J Gastroenterol 2004; 99: 2365-2368 [PMID: 15571584 DOI: 10.1111/j.1572-0241.2004.40064.x]
    • (2004) Am J Gastroenterol , vol.99 , pp. 2365-2368
    • Adams, L.A.1    Zein, C.O.2    Angulo, P.3    Lindor, K.D.4
  • 112
    • 7044269614 scopus 로고    scopus 로고
    • Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis
    • PMID: 15447754
    • Satapathy SK, Garg S, Chauhan R, Sakhuja P, Malhotra V, Sharma BC, Sarin SK. Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2004; 99: 1946-1952 [PMID: 15447754 DOI: 10.1111/j.1572-0241.2004.40220.x]
    • (2004) Am J Gastroenterol , vol.99 , pp. 1946-1952
    • Satapathy, S.K.1    Garg, S.2    Chauhan, R.3    Sakhuja, P.4    Malhotra, V.5    Sharma, B.C.6    Sarin, S.K.7
  • 113
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • PMID: 10453959
    • Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol 1999; 31: 384 [PMID: 10453959]
    • (1999) J Hepatol , vol.31 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 114
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study
    • PMID: 8675165
    • Laurin J, Lindor KD, Crippin JS, Gossard A, Gores GJ, Ludwig J, Rakela J, McGill DB. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology 1996; 23: 1464-1467 [PMID: 8675165 DOI: 10.1002/hep.510230624]
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippin, J.S.3    Gossard, A.4    Gores, G.J.5    Ludwig, J.6    Rakela, J.7    McGill, D.B.8
  • 115
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    • PMID: 16511589
    • Lefebvre P, Chinetti G, Fruchart JC, Staels B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 2006; 116: 571-580 [PMID: 16511589 DOI: 10.1172/jci27989]
    • (2006) J Clin Invest , vol.116 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.C.3    Staels, B.4
  • 118
    • 78649890465 scopus 로고    scopus 로고
    • Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
    • PMID: 21109302
    • Athyros VG, Tziomalos K, Gossios TD, Griva T, Anagnostis P, Kargiotis K, Pagourelias ED, Theocharidou E, Karagiannis A, Mikhailidis DP. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet 2010; 376: 1916-1922 [PMID: 21109302 DOI: 10.1016/s0140-6736(10)61272-x]
    • (2010) Lancet , vol.376 , pp. 1916-1922
    • Athyros, V.G.1    Tziomalos, K.2    Gossios, T.D.3    Griva, T.4    Anagnostis, P.5    Kargiotis, K.6    Pagourelias, E.D.7    Theocharidou, E.8    Karagiannis, A.9    Mikhailidis, D.P.10
  • 119
    • 79959361457 scopus 로고    scopus 로고
    • Up-regulation of hepatic low-density lipoprotein receptor-related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl-coenzyme A reductase inhibitor Atorvastatin and hepatic LRP1 expression
    • PMID: 20951395
    • Moon JH, Kang SB, Park JS, Lee BW, Kang ES, Ahn CW, Lee HC, Cha BS. Up-regulation of hepatic low-density lipoprotein receptor-related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl-coenzyme A reductase inhibitor Atorvastatin and hepatic LRP1 expression. Metabolism 2011; 60: 930-940 [PMID: 20951395 DOI: 10.1016/j.metabol.2010.08.013]
    • (2011) Metabolism , vol.60 , pp. 930-940
    • Moon, J.H.1    Kang, S.B.2    Park, J.S.3    Lee, B.W.4    Kang, E.S.5    Ahn, C.W.6    Lee, H.C.7    Cha, B.S.8
  • 120
    • 84887589754 scopus 로고    scopus 로고
    • Lipoprotein metabolism in nonalcoholic fatty liver disease
    • PMID: 23554788
    • Jiang ZG, Robson SC, Yao Z. Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res 2013; 27: 1-13 [PMID: 23554788 DOI: 10.7555/jbr.27.20120077]
    • (2013) J Biomed Res , vol.27 , pp. 1-13
    • Jiang, Z.G.1    Robson, S.C.2    Yao, Z.3
  • 121
    • 0035742829 scopus 로고    scopus 로고
    • Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E
    • PMID: 11738112
    • Mensenkamp AR, Havekes LM, Romijn JA, Kuipers F. Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E. J Hepatol 2001; 35: 816-822 [PMID: 11738112]
    • (2001) J Hepatol , vol.35 , pp. 816-822
    • Mensenkamp, A.R.1    Havekes, L.M.2    Romijn, J.A.3    Kuipers, F.4
  • 122
    • 2142768218 scopus 로고    scopus 로고
    • Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
    • PMID: 15131789
    • Chalasani N, Aljadhey H, Kesterson J, Murray MD, Hall SD. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology 2004; 126: 1287-1292 [PMID: 15131789]
    • (2004) Gastroenterology , vol.126 , pp. 1287-1292
    • Chalasani, N.1    Aljadhey, H.2    Kesterson, J.3    Murray, M.D.4    Hall, S.D.5
  • 123
    • 13844255081 scopus 로고    scopus 로고
    • Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes
    • PMID: 15711421
    • Vuppalanchi R, Teal E, Chalasani N. Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes. Am J Med Sci 2005; 329: 62-65 [PMID: 15711421]
    • (2005) Am J Med Sci , vol.329 , pp. 62-65
    • Vuppalanchi, R.1    Teal, E.2    Chalasani, N.3
  • 124
    • 16244384606 scopus 로고    scopus 로고
    • Statins and hepatotoxicity: focus on patients with fatty liver
    • PMID: 15789367
    • Chalasani N. Statins and hepatotoxicity: focus on patients with fatty liver. Hepatology 2005; 41: 690-695 [PMID: 15789367 DOI: 10.1002/hep.20671]
    • (2005) Hepatology , vol.41 , pp. 690-695
    • Chalasani, N.1
  • 125
    • 33747047274 scopus 로고    scopus 로고
    • Statins and hepatic steatosis: perspectives from the Dallas Heart Study
    • PMID: 16871575
    • Browning JD. Statins and hepatic steatosis: perspectives from the Dallas Heart Study. Hepatology 2006; 44: 466-471 [PMID: 16871575 DOI: 10.1002/hep.21248]
    • (2006) Hepatology , vol.44 , pp. 466-471
    • Browning, J.D.1
  • 126
    • 36549013633 scopus 로고    scopus 로고
    • Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome
    • PMID: 18022391
    • Deushi M, Nomura M, Kawakami A, Haraguchi M, Ito M, Okazaki M, Ishii H, Yoshida M. Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Lett 2007; 581: 5664-5670 [PMID: 18022391 DOI: 10.1016/j.febslet.2007.11.023]
    • (2007) FEBS Lett , vol.581 , pp. 5664-5670
    • Deushi, M.1    Nomura, M.2    Kawakami, A.3    Haraguchi, M.4    Ito, M.5    Okazaki, M.6    Ishii, H.7    Yoshida, M.8
  • 129
    • 77955699301 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial
    • PMID: 20683947
    • Leuschner UF, Lindenthal B, Herrmann G, Arnold JC, Rössle M, Cordes HJ, Zeuzem S, Hein J, Berg T. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. Hepatology 2010; 52: 472-479 [PMID: 20683947 DOI: 10.1002/hep.23727]
    • (2010) Hepatology , vol.52 , pp. 472-479
    • Leuschner, U.F.1    Lindenthal, B.2    Herrmann, G.3    Arnold, J.C.4    Rössle, M.5    Cordes, H.J.6    Zeuzem, S.7    Hein, J.8    Berg, T.9
  • 131
    • 84896821256 scopus 로고    scopus 로고
    • Cilostazol inhibits insulinstimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
    • PMID: 24458133
    • Jung YA, Kim HK, Bae KH, Seo HY, Kim HS, Jang BK, Jung GS, Lee IK, Kim MK, Park KG. Cilostazol inhibits insulinstimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1. Exp Mol Med 2014; 46: e73 [PMID: 24458133 DOI: 10.1038/emm.2013.143]
    • (2014) Exp Mol Med , vol.46 , pp. e73
    • Jung, Y.A.1    Kim, H.K.2    Bae, K.H.3    Seo, H.Y.4    Kim, H.S.5    Jang, B.K.6    Jung, G.S.7    Lee, I.K.8    Kim, M.K.9    Park, K.G.10
  • 132
    • 0033821449 scopus 로고    scopus 로고
    • Cilostazol, a selective type III phosphodiesterase inhibitor, decreases triglyceride and increases HDL cholesterol levels by increasing lipoprotein lipase activity in rats
    • PMID: 10998457
    • Tani T, Uehara K, Sudo T, Marukawa K, Yasuda Y, Kimura Y. Cilostazol, a selective type III phosphodiesterase inhibitor, decreases triglyceride and increases HDL cholesterol levels by increasing lipoprotein lipase activity in rats. Atherosclerosis 2000; 152: 299-305 [PMID: 10998457]
    • (2000) Atherosclerosis , vol.152 , pp. 299-305
    • Tani, T.1    Uehara, K.2    Sudo, T.3    Marukawa, K.4    Yasuda, Y.5    Kimura, Y.6
  • 133
    • 84890115520 scopus 로고    scopus 로고
    • The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression
    • PMID: 24139096
    • Kim HJ, Moon JH, Kim HM, Yun MR, Jeon BH, Lee B, Kang ES, Lee HC, Cha BS. The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression. Metabolism 2014; 63: 112-119 [PMID: 24139096 DOI: 10.1016/j.metabol.2013.09.006]
    • (2014) Metabolism , vol.63 , pp. 112-119
    • Kim, H.J.1    Moon, J.H.2    Kim, H.M.3    Yun, M.R.4    Jeon, B.H.5    Lee, B.6    Kang, E.S.7    Lee, H.C.8    Cha, B.S.9
  • 135
    • 84880683621 scopus 로고    scopus 로고
    • Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease
    • PMID: 23862644
    • Scorletti E, Byrne CD. Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. Annu Rev Nutr 2013; 33: 231-248 [PMID: 23862644 DOI: 10.1146/annurevnutr-071812-161230]
    • (2013) Annu Rev Nutr , vol.33 , pp. 231-248
    • Scorletti, E.1    Byrne, C.D.2
  • 136
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • PMID: 14720121
    • Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, Poniachik J. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2004; 106: 635-643 [PMID: 14720121 DOI: 10.1042/cs20030326]
    • (2004) Clin Sci (Lond) , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6    Poniachik, J.7
  • 139
    • 84887612547 scopus 로고    scopus 로고
    • Potential treatment of human nonalcoholic fatty liver disease with longchain omega-3 polyunsaturated fatty acids
    • PMID: 24148001
    • Bouzianas DG, Bouziana SD, Hatzitolios AI. Potential treatment of human nonalcoholic fatty liver disease with longchain omega-3 polyunsaturated fatty acids. Nutr Rev 2013; 71: 753-771 [PMID: 24148001 DOI: 10.1111/nure.12073]
    • (2013) Nutr Rev , vol.71 , pp. 753-771
    • Bouzianas, D.G.1    Bouziana, S.D.2    Hatzitolios, A.I.3
  • 140
    • 78651073543 scopus 로고    scopus 로고
    • Dietary monounsaturated fatty acids but not saturated fatty acids preserve the insulin signaling pathway via IRS-1/PI3K in rat skeletal muscle
    • PMID: 20960069
    • Moon JH, Lee JY, Kang SB, Park JS, Lee BW, Kang ES, Ahn CW, Lee HC, Cha BS. Dietary monounsaturated fatty acids but not saturated fatty acids preserve the insulin signaling pathway via IRS-1/PI3K in rat skeletal muscle. Lipids 2010; 45: 1109-1116 [PMID: 20960069 DOI: 10.1007/s11745-010-3475-3]
    • (2010) Lipids , vol.45 , pp. 1109-1116
    • Moon, J.H.1    Lee, J.Y.2    Kang, S.B.3    Park, J.S.4    Lee, B.W.5    Kang, E.S.6    Ahn, C.W.7    Lee, H.C.8    Cha, B.S.9
  • 141
    • 84888019126 scopus 로고    scopus 로고
    • A diet high in a-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats
    • PMID: 24140006
    • Hanke D, Zahradka P, Mohankumar SK, Clark JL, Taylor CG. A diet high in a-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. Prostaglandins Leukot Essent Fatty Acids 2013; 89: 391-401 [PMID: 24140006 DOI: 10.1016/j.plefa.2013.09.009]
    • (2013) Prostaglandins Leukot Essent Fatty Acids , vol.89 , pp. 391-401
    • Hanke, D.1    Zahradka, P.2    Mohankumar, S.K.3    Clark, J.L.4    Taylor, C.G.5
  • 142
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • PMID: 16374859
    • Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 2006; 43: 173-181 [PMID: 16374859 DOI: 10.1002/hep.21006]
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 143
    • 84892421783 scopus 로고    scopus 로고
    • Exenatide improves type 2 diabetes concomitant with non-alcoholic fatty liver disease
    • PMID: 24402015
    • Fan H, Pan Q, Xu Y, Yang X. Exenatide improves type 2 diabetes concomitant with non-alcoholic fatty liver disease. Arq Bras Endocrinol Metabol 2013; 57: 702-708 [PMID: 24402015]
    • (2013) Arq Bras Endocrinol Metabol , vol.57 , pp. 702-708
    • Fan, H.1    Pan, Q.2    Xu, Y.3    Yang, X.4
  • 145
    • 70349087293 scopus 로고    scopus 로고
    • MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells
    • PMID: 19706286
    • Morimoto Y, Kikuchi K, Ito T, Tokuda M, Matsuyama T, Noma S, Hashiguchi T, Torii M, Maruyama I, Kawahara K. MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells. Biochem Biophys Res Commun 2009; 389: 90-94 [PMID: 19706286 DOI: 10.1016/j.bbrc.2009.08.103]
    • (2009) Biochem Biophys Res Commun , vol.389 , pp. 90-94
    • Morimoto, Y.1    Kikuchi, K.2    Ito, T.3    Tokuda, M.4    Matsuyama, T.5    Noma, S.6    Hashiguchi, T.7    Torii, M.8    Maruyama, I.9    Kawahara, K.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.