Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

Nature

Volumn 473, Issue 7348, 2011, Pages 528-531

  Fu, Suneng ^a   Yang, Ling ^a   Li, Ping ^a   Hofmann, Oliver ^a   Dicker, Lee ^a   Hide, Winston ^a   Lin, Xihong ^a   Watkins, Steven M ^b   Ivanov, Alexander R ^a   Hotamisligil, Gökhan S ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Lipomics Technologies Inc   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CHAPERONE; FATTY ACID; PHOSPHOLIPID;

CALCIUM; GLUCOSE; HOMEOSTASIS; LIPID; MEMBRANE; METABOLISM; OBESITY; PROTEIN;

ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GLUCOSE HOMEOSTASIS; LEAN BODY WEIGHT; LIPID COMPOSITION; LIPID METABOLISM; LIPIDOMICS; LIPOGENESIS; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEOMICS; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM; ENDOPLASMIC RETICULUM; FATTY ACIDS; GLUCOSE; HOMEOSTASIS; LEPTIN; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; PHOSPHATIDYLETHANOLAMINES; PROTEIN BIOSYNTHESIS; PROTEOMICS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STRESS, PHYSIOLOGICAL; THINNESS;

MUS;

EID: 79957605136     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09968     Document Type: Article

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