Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis

Endocrinology

Volumn 147, Issue 7, 2006, Pages 3398-3407

  Karaskov, Elizabeth ^a   Scott, Cameron ^b   Zhang, Liling ^a   Teodoro, Tracy ^a   Ravazzola, Mariella ^c   Volchuk, Allen ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CHAPERONE; FATTY ACID; INITIATION FACTOR 2ALPHA; OLEIC ACID; PALMITIC ACID; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EUKARYOTE; EXPOSURE; MORPHOLOGY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; RAT; STRESS; UPREGULATION;

ANIMALS; APOPTOSIS; CALCIUM; CELL LINE; CELL NUCLEUS; ENDOPLASMIC RETICULUM; FATTY ACIDS, NONESTERIFIED; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICROSCOPY, ELECTRON; OLEIC ACID; PALMITIC ACID; PHOSPHORYLATION; RATS;

EID: 33745116619     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-1494     Document Type: Article

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