Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

Journal of Hepatology

Volumn 62, Issue 6, 2015, Pages 1367-1374

  Win, Sanda ^a   Than, Tin Aung ^a   Le, Bao Han Allison ^a   García Ruiz, Carmen ^a,b   Fernandez Checa, Jose C ^a,b   Kaplowitz, Neil ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b INST D INVESTIGACIONS B   (Spain)

Author keywords

Apoptosis; Hepatocytes; Mitochondria; Palmitic acid; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; CASPASE; CASPASE 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SH3 HOMOLOGY ASSOCIATED BTK BINDING PROTEIN 5; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; MEMBRANE PROTEIN; SAB PROTEIN, MOUSE; SH3BP5 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FATTY ACID OXIDATION; GENE SILENCING; LIPOTOXICITY; LIVER TOXICITY; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; LIVER CELL; METABOLISM; MITOCHONDRION; NONALCOHOLIC FATTY LIVER;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NON-ALCOHOLIC FATTY LIVER DISEASE; OXYGEN CONSUMPTION; PALMITIC ACID; REACTIVE OXYGEN SPECIES;

EID: 84929607060     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.01.032     Document Type: Article

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