Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

Journal of Hepatology

Volumn 57, Issue 1, 2012, Pages 141-149

  Leroux, Anne ^a,b   Ferrere, Gladys ^a,b   Godie, Vanessa ^a,b   Cailleux, Frédéric ^a,b   Renoud, Marie Laure ^a,b   Gaudin, Françoise ^a,b,c   Naveau, Sylvie ^a,b,d   Prévot, Sophie ^b,d   Makhzami, Samira ^e   Perlemuter, Gabriel ^a,b,d   Cassard Doulcier, Anne Marie ^a,b  

^a Universite Paris Sud   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c IPSIT   (France)

^d HÔPITAL ANTOINE BÉCLÈRE   (France)

^e CEMAGREF   (France)

Author keywords

Inflammation; Kupffer cells; Lipidomic; NASH; Obesity

Indexed keywords

ACYL COENZYME A DESATURASE 1; CD163 ANTIGEN; CD31 ANTIGEN; CD36 ANTIGEN; DIACYLGLYCEROL ACYLTRANSFERASE 2; FAS ANTIGEN; FAT DROPLET; FATTY ACID BINDING PROTEIN 2; FATTY ACID TRANSPORTER; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPID; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RANTES; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TOXIC LIPID; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL CULTURE; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; KUPFFER CELL; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIPID TRANSPORT; LIPIDOMICS; LIPOGENESIS; MASS SPECTROMETRY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ACETYLTRANSFERASES; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY FATS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACID-BINDING PROTEINS; FATTY LIVER; GENE EXPRESSION; KUPFFER CELLS; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, OBESE; NUCLEAR PROTEINS; OBESITY; PHENOTYPE; PPAR GAMMA; STEAROYL-COA DESATURASE; TRANSCRIPTION FACTORS;

EID: 84862669638     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.02.028     Document Type: Article

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