Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2α kinases PKR and GCN2

Molecular and Cellular Biology

Volumn 18, Issue 4, 1998, Pages 2282-2297

  Romano, Patrick R ^a   Garcia Barrio, Minerva T ^a   Zhang, Xiaolong ^b   Wang, Qizhi ^c,d   Taylor, Deborah R ^c,e   Zhang, Fan ^a   Herring, Christopher ^b   Mathews, Michael B ^c,f   Qin, Jun ^b   Hinnebusch, Alan G ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DOUBLE STRANDED RNA; INITIATION FACTOR 2; PROTEIN KINASE; SYNTHETIC PEPTIDE; THREONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INTERFERON INDUCTION; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; VIRUS INFECTION; YEAST CELL;

ANIMALIA; EUKARYOTA; FUNGI; MYXOGASTRIA; SACCHAROMYCES CEREVISIAE;

EID: 0031899816     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.4.2282     Document Type: Article

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