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Volumn 123, Issue 1, 2013, Pages 455-468

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CHAPERONE; GLUCOSE; GLYCOGEN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2; INSULIN; MESSENGER RNA; PROTEIN IRE1; TUNICAMYCIN; URIDINE DIPHOSPHATE GLUCOSE 4 EPIMERASE; X BOX BINDING PROTEIN 1;

EID: 84873873215     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI62819     Document Type: Article
Times cited : (116)

References (43)
  • 1
    • 77951427546 scopus 로고    scopus 로고
    • Rapamycin inhibits postprandial- mediated X-box-binding protein-1 splicing in rat liver
    • Pfaffenbach KT, et al. Rapamycin inhibits postprandial- mediated X-box-binding protein-1 splicing in rat liver. J Nutr. 2010;140(5): 879-884.
    • (2010) J Nutr. , vol.140 , Issue.5 , pp. 879-884
    • Pfaffenbach, K.T.1
  • 2
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem. 2005; 74: 739-789.
    • (2005) Annu Rev Biochem. , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 3
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011;334(6059): 1081-1086.
    • (2011) Science. , vol.334 , Issue.6059 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 4
    • 77950537400 scopus 로고    scopus 로고
    • A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
    • Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med. 2010;16(4): 438-445.
    • (2010) Nat Med. , vol.16 , Issue.4 , pp. 438-445
    • Winnay, J.N.1    Boucher, J.2    Mori, M.A.3    Ueki, K.4    Kahn, C.R.5
  • 5
    • 77950523710 scopus 로고    scopus 로고
    • The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
    • Park SW, et al. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med. 2010; 16(4): 429-437.
    • (2010) Nat Med. , vol.16 , Issue.4 , pp. 429-437
    • Park, S.W.1
  • 6
    • 79952381078 scopus 로고    scopus 로고
    • Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
    • Zhou Y, et al. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011; 17(3): 356-365.
    • (2011) Nat Med. , vol.17 , Issue.3 , pp. 356-365
    • Zhou, Y.1
  • 7
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004;306(5695): 457-461.
    • (2004) Science. , vol.306 , Issue.5695 , pp. 457-461
    • Ozcan, U.1
  • 8
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 2008;320(5882): 1492-1496.
    • (2008) Science. , vol.320 , Issue.5882 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 9
    • 0001328767 scopus 로고
    • The enzymatic transformation of uridine diphosphate glucose into a galactose derivative
    • Leloir LF. The enzymatic transformation of uridine diphosphate glucose into a galactose derivative. Arch Biochem Biophys. 1951;33(2): 186-190.
    • (1951) Arch Biochem Biophys. , vol.33 , Issue.2 , pp. 186-190
    • Leloir, L.F.1
  • 10
    • 0023929750 scopus 로고
    • Glycoconjugates as noninvasive probes of intrahepatic metabolism: III. Application to galactose assimilation by the intact rat
    • Hellerstein MK, Munro HN. Glycoconjugates as noninvasive probes of intrahepatic metabolism: III. Application to galactose assimilation by the intact rat. Metabolism. 1988;37(4): 312-317.
    • (1988) Metabolism , vol.37 , Issue.4 , pp. 312-317
    • Hellerstein, M.K.1    Munro, H.N.2
  • 11
    • 26444545103 scopus 로고    scopus 로고
    • Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction
    • Belteki G, et al. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res. 2005;33(5):e51.
    • (2005) Nucleic Acids Res. , vol.33 , Issue.5
    • Belteki, G.1
  • 12
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol. 2003;23(21): 7448-7459.
    • (2003) Mol Cell Biol. , vol.23 , Issue.21 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 13
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2001;107(7): 881-891.
    • (2001) Cell. , vol.107 , Issue.7 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 14
    • 57049111040 scopus 로고    scopus 로고
    • UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
    • Rutkowski DT, et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell. 2008;15(6): 829-840.
    • (2008) Dev Cell. , vol.15 , Issue.6 , pp. 829-840
    • Rutkowski, D.T.1
  • 15
    • 0033549840 scopus 로고    scopus 로고
    • Drug treatment of lipid disorders
    • Knopp RH. Drug treatment of lipid disorders. N Engl J Med. 1999;341(7): 498-511.
    • (1999) N Engl J Med. , vol.341 , Issue.7 , pp. 498-511
    • Knopp, R.H.1
  • 16
    • 78649449365 scopus 로고    scopus 로고
    • Glycogen storage disease type i and G6Pase-beta deficiency: Etiology and therapy
    • Chou JY, Jun HS, Mansfield BC. Glycogen storage disease type I and G6Pase-beta deficiency: etiology and therapy. Nat Rev Endocrinol. 2010;6(12): 676-688.
    • (2010) Nat Rev Endocrinol. , vol.6 , Issue.12 , pp. 676-688
    • Chou, J.Y.1    Jun, H.S.2    Mansfield, B.C.3
  • 17
    • 78650885452 scopus 로고    scopus 로고
    • The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway
    • Fang M, et al. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell. 2010; 143(5): 711-724.
    • (2010) Cell. , vol.143 , Issue.5 , pp. 711-724
    • Fang, M.1
  • 18
    • 9144228073 scopus 로고    scopus 로고
    • Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II
    • Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem. 2004;136(3): 343-350.
    • (2004) J Biochem. , vol.136 , Issue.3 , pp. 343-350
    • Yamamoto, K.1    Yoshida, H.2    Kokame, K.3    Kaufman, R.J.4    Mori, K.5
  • 19
    • 0022647588 scopus 로고
    • Structure and function of low-density-lipoprotein receptors in epimerase-deficient galactosemia
    • Kingsley DM, Krieger M, Holton JB. Structure and function of low-density-lipoprotein receptors in epimerase-deficient galactosemia. N Engl J Med. 1986;314(19): 1257-1258.
    • (1986) N Engl J Med. , vol.314 , Issue.19 , pp. 1257-1258
    • Kingsley, D.M.1    Krieger, M.2    Holton, J.B.3
  • 20
    • 34147172715 scopus 로고    scopus 로고
    • Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis
    • Sriburi R, et al. Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem. 2007;282(10): 7024-7034.
    • (2007) J Biol Chem. , vol.282 , Issue.10 , pp. 7024-7034
    • Sriburi, R.1
  • 21
    • 74849108820 scopus 로고    scopus 로고
    • Enhanced protein production using HBV X protein (HBx), and synergy when used in combination with XBP1s in BHK21 cells
    • Jin F, Kretschmer PJ, Harkins RN, Hermiston TW. Enhanced protein production using HBV X protein (HBx), and synergy when used in combination with XBP1s in BHK21 cells. Biotechnol Bioeng. 2009; 105(2): 341-349.
    • (2009) Biotechnol Bioeng. , vol.105 , Issue.2 , pp. 341-349
    • Jin, F.1    Kretschmer, P.J.2    Harkins, R.N.3    Hermiston, T.W.4
  • 22
    • 0029920614 scopus 로고    scopus 로고
    • The Leloir pathway: A mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose
    • Frey PA. The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J. 1996;10(4): 461-470.
    • (1996) FASEB J. , vol.10 , Issue.4 , pp. 461-470
    • Frey, P.A.1
  • 23
    • 0033799301 scopus 로고    scopus 로고
    • Molecular basis of disorders of human galactose metabolism: Past, present, and future
    • Novelli G, Reichardt JK. Molecular basis of disorders of human galactose metabolism: past, present, and future. Mol Genet Metab. 2000;71(1-2): 62-65.
    • (2000) Mol Genet Metab. , vol.7112 , pp. 62-65
    • Novelli, G.1    Reichardt, J.K.2
  • 24
    • 33746867852 scopus 로고    scopus 로고
    • Classical galactosaemia revisited
    • Bosch AM. Classical galactosaemia revisited. J Inherit Metab Dis. 2006;29(4): 516-525.
    • (2006) J Inherit Metab Dis. , vol.29 , Issue.4 , pp. 516-525
    • Bosch, A.M.1
  • 25
    • 0032935597 scopus 로고    scopus 로고
    • Generalised uridine diphosphate galactose-4-epimerase deficiency
    • Walter JH, et al. Generalised uridine diphosphate galactose-4-epimerase deficiency. Arch Dis Child. 1999;80(4): 374-376.
    • (1999) Arch Dis Child. , vol.80 , Issue.4 , pp. 374-376
    • Walter, J.H.1
  • 26
    • 77956531695 scopus 로고    scopus 로고
    • UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster
    • Sanders RD, Sefton JM, Moberg KH, Fridovich-Keil JL. UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. Dis Model Mech. 2010;3(9-10): 628-638.
    • (2010) Dis Model Mech. , vol.3 , Issue.9-10 , pp. 628-638
    • Sanders, R.D.1    Sefton, J.M.2    Moberg, K.H.3    Fridovich-Keil, J.L.4
  • 27
    • 33646245208 scopus 로고    scopus 로고
    • The structural and molecular biology of type III galactosemia
    • Timson DJ. The structural and molecular biology of type III galactosemia. IUBMB Life. 2006;58(2): 83-89.
    • (2006) IUBMB Life. , vol.58 , Issue.2 , pp. 83-89
    • Timson, D.J.1
  • 28
    • 84867277288 scopus 로고    scopus 로고
    • XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy
    • Liu Y, et al. XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy. J Biol Chem. 2012;287(41): 34500-34513.
    • (2012) J Biol Chem. , vol.287 , Issue.41 , pp. 34500-34513
    • Liu, Y.1
  • 29
    • 0035423875 scopus 로고    scopus 로고
    • The glucose-regulated proteins: Stress induction and clinical applications
    • Lee AS. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci. 2001;26(8): 504-510.
    • (2001) Trends Biochem Sci. , vol.26 , Issue.8 , pp. 504-510
    • Lee, A.S.1
  • 30
    • 77952964587 scopus 로고    scopus 로고
    • Redox control of endoplasmic reticulum function
    • Csala M, Margittai E, Banhegyi G. Redox control of endoplasmic reticulum function. Antioxid Redox Signal. 2010;13(1): 77-108.
    • (2010) Antioxid Redox Signal. , vol.13 , Issue.1 , pp. 77-108
    • Csala, M.1    Margittai, E.2    Banhegyi, G.3
  • 31
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer. 2008;8(11): 851-864.
    • (2008) Nat Rev Cancer. , vol.8 , Issue.11 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 32
    • 4344660747 scopus 로고    scopus 로고
    • XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
    • Romero-Ramirez L, et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004;64(17): 5943-5947.
    • (2004) Cancer Res. , vol.64 , Issue.17 , pp. 5943-5947
    • Romero-Ramirez, L.1
  • 33
    • 78650034777 scopus 로고    scopus 로고
    • Towards a knowledge-based Human Protein Atlas
    • Uhlen M, et al. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol. 2010;28(12): 1248-1250.
    • (2010) Nat Biotechnol. , vol.28 , Issue.12 , pp. 1248-1250
    • Uhlen, M.1
  • 34
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest. 1996;98(7): 1575-1584.
    • (1996) J Clin Invest. , vol.98 , Issue.7 , pp. 1575-1584
    • Shimano, H.1    Horton, J.D.2    Hammer, R.E.3    Shimomura, I.4    Brown, M.S.5    Goldstein, J.L.6
  • 35
    • 58149500139 scopus 로고    scopus 로고
    • Tissue-specific postprandial clearance is the major determinant of PPARgammainduced triglyceride lowering in the rat
    • Laplante M, et al. Tissue-specific postprandial clearance is the major determinant of PPARgammainduced triglyceride lowering in the rat. Am J Physiol Regul Integr Comp Physiol. 2009;296(1):R57-R66.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296 , Issue.1
    • Laplante, M.1
  • 36
    • 77749242629 scopus 로고    scopus 로고
    • Enhanced metabolic flexibility associated with elevated adiponectin levels
    • Asterholm IW, Scherer PE. Enhanced metabolic flexibility associated with elevated adiponectin levels. Am J Pathol. 2010;176(3): 1364-1376.
    • (2010) Am J Pathol. , vol.176 , Issue.3 , pp. 1364-1376
    • Asterholm, I.W.1    Scherer, P.E.2
  • 37
    • 77952618580 scopus 로고    scopus 로고
    • Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet
    • Sunny NE, et al. Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 2010;298(6):E1226-E1235.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.6
    • Sunny, N.E.1
  • 38
    • 33751017369 scopus 로고    scopus 로고
    • Non-radioactive analysis of lipid-linked oligosaccharide compositions by fluorophore- assisted carbohydrate electrophoresis
    • Gao N, Lehrman MA. Non-radioactive analysis of lipid-linked oligosaccharide compositions by fluorophore- assisted carbohydrate electrophoresis. Methods Enzymol. 2006;415: 3-20.
    • (2006) Methods Enzymol. , vol.415 , pp. 3-20
    • Gao, N.1    Lehrman, M.A.2
  • 39
    • 0035894307 scopus 로고    scopus 로고
    • Microscale nonreductive release of O-linked glycans for subsequent analysis through MALDI mass spectrometry and capillary electrophoresis
    • Huang Y, Mechref Y, Novotny MV. Microscale nonreductive release of O-linked glycans for subsequent analysis through MALDI mass spectrometry and capillary electrophoresis. Anal Chem. 2001; 73(24): 6063-6069.
    • (2001) Anal Chem. , vol.73 , Issue.24 , pp. 6063-6069
    • Huang, Y.1    Mechref, Y.2    Novotny, M.V.3
  • 40
    • 33750597734 scopus 로고    scopus 로고
    • Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
    • Lagace TA, et al. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest. 2006;116(11): 2995-3005.
    • (2006) J Clin Invest. , vol.116 , Issue.11 , pp. 2995-3005
    • Lagace, T.A.1
  • 41
    • 33846132939 scopus 로고    scopus 로고
    • The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters
    • Ferdous A, Sikder D, Gillette T, Nalley K, Kodadek T, Johnston SA. The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters. Genes Dev. 2007;21(1): 112-123.
    • (2007) Genes Dev. , vol.21 , Issue.1 , pp. 112-123
    • Ferdous, A.1    Sikder, D.2    Gillette, T.3    Nalley, K.4    Kodadek, T.5    Johnston, S.A.6
  • 42
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A. 2010; 107(8): 3441-3446.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.8 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 43
    • 0037385313 scopus 로고    scopus 로고
    • Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    • Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol. 2003;4(4): 321-329.
    • (2003) Nat Immunol. , vol.4 , Issue.4 , pp. 321-329
    • Iwakoshi, N.N.1    Lee, A.H.2    Vallabhajosyula, P.3    Otipoby, K.L.4    Rajewsky, K.5    Glimcher, L.H.6


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